| Neural EGFL like 1 as a novel gene for Trabecular Bone Score in older adults: The Bushehr Elderly Health (BEH) program. | Neural EGFL like 1 as a novel gene for Trabecular Bone Score in older adults: The Bushehr Elderly Health (BEH) program.
Bidkhori M, Akbarzadeh M, Fahimfar N, Jahangiri M, Seddiq S, Larijani B, Nabipour I, Mohammad Amoli M, Panahi N, Dehghan A, Holakouie-Naieni K, Ostovar A., Free PMC Article | 11/1/2024 |
| [Clinical Significance of Thrombospondin Type 1 Domain-Containing 7A and Neural Epidermal Growth Factor-Like 1 Protein in M-Type Phospholipase A2 Receptor-Negative Membranous Nephropathy]. | [Clinical Significance of Thrombospondin Type 1 Domain-Containing 7A and Neural Epidermal Growth Factor-Like 1 Protein in M-Type Phospholipase A2 Receptor-Negative Membranous Nephropathy].
Tang XL, DU YY, Yu J, Ye T, Zhu H, Chen YF, Li XH. | 05/13/2023 |
| Runx2 and Nell-1 in dental follicle progenitor cells regulate bone remodeling and tooth eruption. | Runx2 and Nell-1 in dental follicle progenitor cells regulate bone remodeling and tooth eruption.
Zeng L, He H, Sun M, Gong X, Zhou M, Hong Y, Wu Y, Chen X, Chen Q., Free PMC Article | 10/15/2022 |
| Conformational Change of the Hairpin-like-structured Robo2 Ectodomain Allows NELL1/2 Binding. | Conformational Change of the Hairpin-like-structured Robo2 Ectodomain Allows NELL1/2 Binding.
Miyaguchi M, Nakanishi Y, Maturana AD, Mizutani K, Niimi T. | 10/1/2022 |
| NELL1 Regulates the Matrisome to Promote Osteosarcoma Progression. | NELL1 Regulates the Matrisome to Promote Osteosarcoma Progression.
Qin Q, Gomez-Salazar M, Tower RJ, Chang L, Morris CD, McCarthy EF, Ting K, Zhang X, James AW., Free PMC Article | 08/13/2022 |
| NELL1 augments osteogenesis and inhibits inflammation of human periodontal ligament stem cells induced by BMP9. | NELL1 augments osteogenesis and inhibits inflammation of human periodontal ligament stem cells induced by BMP9.
Wang L, Li X, Song Y, Zhang L, Ye L, Zhou X, Song D, Huang D. | 08/6/2022 |
| NELL-1 in Genome-Wide Association Studies across Human Diseases. | NELL-1 in Genome-Wide Association Studies across Human Diseases.
Cheng X, Shi J, Jia Z, Ha P, Soo C, Ting K, James AW, Shi B, Zhang X., Free PMC Article | 07/30/2022 |
| METTL3-Mediated lncRNA m(6)A Modification in the Osteogenic Differentiation of Human Adipose-Derived Stem Cells Induced by NEL-Like 1 Protein. | METTL3-Mediated lncRNA m(6)A Modification in the Osteogenic Differentiation of Human Adipose-Derived Stem Cells Induced by NEL-Like 1 Protein.
Song Y, Pan Y, Wu M, Sun W, Luo L, Zhao Z, Liu J. | 04/16/2022 |
| Prevalence of neural epidermal growth factor-like 1- and exostosin 1/exostosin 2-associated membranous nephropathy: a single-center retrospective study in Japan. | Prevalence of neural epidermal growth factor-like 1- and exostosin 1/exostosin 2-associated membranous nephropathy: a single-center retrospective study in Japan.
Iwakura T, Ema C, Isobe S, Fujikura T, Ohashi N, Kato A, Yasuda H., Free PMC Article | 03/26/2022 |
| NELL1 is a target antigen in malignancy-associated membranous nephropathy. | NELL1 is a target antigen in malignancy-associated membranous nephropathy.
Caza TN, Hassen SI, Dvanajscak Z, Kuperman M, Edmondson R, Herzog C, Storey A, Arthur J, Cossey LN, Sharma SG, Kenan DJ, Larsen CP., Free PMC Article | 08/14/2021 |
| Anoctamin 5 promotes osteosarcoma development by increasing degradation of Nel-like proteins 1 and 2. | Anoctamin 5 promotes osteosarcoma development by increasing degradation of Nel-like proteins 1 and 2.
Pan R, Lu Q, Ren C, Li H, Zeng F, Tian X, Chen H., Free PMC Article | 07/31/2021 |
| NELL-1 Increased the Osteogenic Differentiation and mRNA Expression of Spheroids Composed of Stem Cells. | NELL-1 Increased the Osteogenic Differentiation and mRNA Expression of Spheroids Composed of Stem Cells.
Lee JH, Song YM, Min SK, Lee HJ, Lee HL, Kim MJ, Park YH, Park JU, Park JB., Free PMC Article | 07/24/2021 |
| Neural epidermal growth factor-like 1 protein (NELL-1) associated membranous nephropathy. | Neural epidermal growth factor-like 1 protein (NELL-1) associated membranous nephropathy.
Sethi S, Debiec H, Madden B, Charlesworth MC, Morelle J, Gross L, Ravindran A, Buob D, Jadoul M, Fervenza FC, Ronco P. | 04/17/2021 |
| Nell-1 could reciprocally interact with APR3 and stimulate the differentiation and mineralization of human dental pulp cells. | Interaction of Nel-like molecule 1 with apoptosis related protein 3 with its influence on human dental pulp cells proliferation and differentiation into odontoblasts.
Tian X, Wang Q, Wu J, Han Q, Shen L, Wei C, Song H, Li M, Fang Y, Wang X, Sun Q. | 06/20/2020 |
| The expression levels of neural markers were increased in rat pulp and in cultured human dental pulp stem cells stimulated with Nell-1 protein. This is the first study to demonstrate the effect of Nell-1 on dental pulp cells neural-like differentiation. | Nell-1 promotes the neural-like differentiation of dental pulp cells.
Han Q, Wang Q, Wu J, Li M, Fang Y, Zhu H, Wang X. | 05/2/2020 |
| results suggest that Robo2 functions as a receptor for NELL1/2, particularly under circumstances where Robo2 undergoes proteolytic digestion | Robo2 contains a cryptic binding site for neural EGFL-like (NELL) protein 1/2.
Yamamoto N, Kashiwagi M, Ishihara M, Kojima T, Maturana AD, Kuroda S, Niimi T., Free PMC Article | 12/14/2019 |
| Study results suggest that NELL1 induces lung cancer stemlike cell differentiation, which provides a new potential therapeutic target for cancer stem cells. | Effect of NELL1 on lung cancer stem‑like cell differentiation.
Zhai Y, Wei R, Sha S, Lin C, Wang H, Jiang X, Liu G. | 03/16/2019 |
| Results show that NELL1 methylation level was 6.8% higher in renal cell cancer (RCC) tissues associated with advanced disease of distant metastases, and shorter RFS. Analyses suggested that NELL1 DNA methylation is a promising candidate prognostic epigenetic biomarker for more detailed analyses of RCC disease. | DNA methylation of neural EGFL like 1 (NELL1) is associated with advanced disease and the metastatic state of renal cell cancer patients.
Peters I, Dubrowinskaja N, Hennenlotter J, Antonopoulos WI, Von Klot CAJ, Tezval H, Stenzl A, Kuczyk MA, Serth J. | 12/22/2018 |
| This work indicates that NELL-1, HMGB1, and CCN2 might enhance bone defect healing via the recruitment of endogenous cells and induction of vascularization and act via different processes than BMP2. | NELL-1, HMGB1, and CCN2 Enhance Migration and Vasculogenesis, But Not Osteogenic Differentiation Compared to BMP2.
Fahmy-Garcia S, van Driel M, Witte-Buoma J, Walles H, van Leeuwen JPTM, van Osch GJVM, Farrell E. | 11/10/2018 |
| NELL1 variant is associated with tobacco- and HPV-mediated oral oncogenesis. | Association of DFNA5, SYK, and NELL1 variants along with HPV infection in oral cancer among the prolonged tobacco-chewers.
Kundu S, Ramshankar V, Verma AK, Thangaraj SV, Krishnamurthy A, Kumar R, Kannan R, Ghosh SK. | 08/18/2018 |
| Results demonstrate that NELL1 is differentially expressed in fusion-positive alveolar rhabdomyosarcoma (ARMS) and in embryonal rhabdomyosarcoma (ERMS) samples, and they show that this transcriptional difference partially depends on genomic DNA methylation. The study also found that high NELL1 levels are correlated with negative RMS prognostic factors and with poor tumor outcomes. | NELL1, whose high expression correlates with negative outcomes, has different methylation patterns in alveolar and embryonal rhabdomyosarcoma.
Tombolan L, Poli E, Martini P, Zin A, Romualdi C, Bisogno G, Lanfranchi G., Free PMC Article | 03/17/2018 |
| lipoaspirate-derived hPSCs present a novel and abundant cell source of MSCs for cartilage regeneration, and the combinatorial application of NELL-1, TGF-beta3, and BMP-6 with hPSCs may remarkably enhance and accelerate cartilage repair. | Accelerated Chondrogenic Differentiation of Human Perivascular Stem Cells with NELL-1.
Li CS, Zhang X, Péault B, Jiang J, Ting K, Soo C, Zhou YH., Free PMC Article | 11/5/2016 |
| establish the feasibility of combining NELL-1 with BMP2 to improve clinical bone regeneration and provide mechanistic insight into canonical Wnt pathway activity during NELL-1 and BMP2 osteogenesis | Novel Wnt Regulator NEL-Like Molecule-1 Antagonizes Adipogenesis and Augments Osteogenesis Induced by Bone Morphogenetic Protein 2.
Shen J, James AW, Zhang X, Pang S, Zara JN, Asatrian G, Chiang M, Lee M, Khadarian K, Nguyen A, Lee KS, Siu RK, Tetradis S, Ting K, Soo C., Free PMC Article | 06/28/2016 |
| Data suggest that TSPN (N-terminal thrombospondin-1-like) domain of NELL1 exhibits major heparin-binding sites which may be involved in interaction of NELL1 with cell surface heparan sulfate proteoglycans. | Mapping the heparin-binding site of the osteoinductive protein NELL1 by site-directed mutagenesis.
Takahashi K, Imai A, Iijima M, Yoshimoto N, Maturana AD, Kuroda S, Niimi T. | 05/14/2016 |
| NELL-1 signaling activates Wnt/beta-catenin signaling. | NELL-1 in the treatment of osteoporotic bone loss.
James AW, Shen J, Zhang X, Asatrian G, Goyal R, Kwak JH, Jiang L, Bengs B, Culiat CT, Turner AS, Seim Iii HB, Wu BM, Lyons K, Adams JS, Ting K, Soo C., Free PMC Article | 04/23/2016 |