| Atox1-cyclin D1 loop activity is critical for survival of tumor cells with inactivated TP53. | Atox1-cyclin D1 loop activity is critical for survival of tumor cells with inactivated TP53.
Kuchur OA, Pogodaeva SS, Shcherbakova AV, Tsymbal SA., Free PMC Article | 11/5/2024 |
| Cuproptosis-related gene LIPT1 as a prognostic indicator in non-small cell lung cancer: Functional involvement and regulation of ATOX1 expression. | Cuproptosis-related gene LIPT1 as a prognostic indicator in non-small cell lung cancer: Functional involvement and regulation of ATOX1 expression.
Deng R, Zhu L, Jiang J, Chen J, Li H., Free PMC Article | 05/30/2024 |
| Copper coordination states affect the flexibility of copper Metallochaperone Atox1: Insights from molecular dynamics simulations. | Copper coordination states affect the flexibility of copper Metallochaperone Atox1: Insights from molecular dynamics simulations.
Schwartz R, Ruthstein S, Major DT., Free PMC Article | 12/3/2022 |
| Crystal Structure of the Human Copper Chaperone ATOX1 Bound to Zinc Ion. | Crystal Structure of the Human Copper Chaperone ATOX1 Bound to Zinc Ion.
Mangini V, Belviso BD, Nardella MI, Natile G, Arnesano F, Caliandro R., Free PMC Article | 11/5/2022 |
| Memo1 binds reduced copper ions, interacts with copper chaperone Atox1, and protects against copper-mediated redox activity in vitro. | Memo1 binds reduced copper ions, interacts with copper chaperone Atox1, and protects against copper-mediated redox activity in vitro.
Zhang X, Walke GR, Horvath I, Kumar R, Blockhuys S, Holgersson S, Walton PH, Wittung-Stafshede P., Free PMC Article | 09/10/2022 |
| Copper enhances genotoxic drug resistance via ATOX1 activated DNA damage repair. | Copper enhances genotoxic drug resistance via ATOX1 activated DNA damage repair.
Jin J, Ma M, Shi S, Wang J, Xiao P, Yu HF, Zhang C, Guo Q, Yu Z, Lou Z, Teng CB. | 04/23/2022 |
| APEX2-based Proximity Labeling of Atox1 Identifies CRIP2 as a Nuclear Copper-binding Protein that Regulates Autophagy Activation. | APEX2-based Proximity Labeling of Atox1 Identifies CRIP2 as a Nuclear Copper-binding Protein that Regulates Autophagy Activation.
Chen L, Li N, Zhang M, Sun M, Bian J, Yang B, Li Z, Wang J, Li F, Shi X, Wang Y, Yuan F, Zou P, Shan C, Wang J. | 12/18/2021 |
| Cu(I) Controls Conformational States in Human Atox1 Metallochaperone: An EPR and Multiscale Simulation Study. | Cu(I) Controls Conformational States in Human Atox1 Metallochaperone: An EPR and Multiscale Simulation Study.
Perkal O, Qasem Z, Turgeman M, Schwartz R, Gevorkyan-Airapetov L, Pavlin M, Magistrato A, Major DT, Ruthstein S., Free PMC Article | 06/12/2021 |
| An EPR Study on the Interaction between the Cu(I) Metal Binding Domains of ATP7B and the Atox1 Metallochaperone. | An EPR Study on the Interaction between the Cu(I) Metal Binding Domains of ATP7B and the Atox1 Metallochaperone.
Zaccak M, Qasem Z, Gevorkyan-Airapetov L, Ruthstein S., Free PMC Article | 02/27/2021 |
| Evaluation of copper chaperone ATOX1 as prognostic biomarker in breast cancer. | Evaluation of copper chaperone ATOX1 as prognostic biomarker in breast cancer.
Blockhuys S, Brady DC, Wittung-Stafshede P., Free PMC Article | 02/6/2021 |
| Genetic deletion of ATOX1 decreased MAPK pathway activation in BRAF V600E mutant melanoma. | Copper chaperone ATOX1 is required for MAPK signaling and growth in BRAF mutation-positive melanoma.
Kim YJ, Bond GJ, Tsang T, Posimo JM, Busino L, Brady DC., Free PMC Article | 06/27/2020 |
| The authors findings represent a functional role for Atox1 in colorectal cancer metastasis. | Nuclear translocation of Atox1 potentiates activin A-induced cell migration and colony formation in colon cancer.
Jana A, Das A, Krett NL, Guzman G, Thomas A, Mancinelli G, Bauer J, Ushio-Fukai M, Fukai T, Jung B., Free PMC Article | 05/16/2020 |
| High Atox1 expression is associated with breast cancer cell migration. | Single-cell tracking demonstrates copper chaperone Atox1 to be required for breast cancer cell migration.
Blockhuys S, Zhang X, Wittung-Stafshede P., Free PMC Article | 05/16/2020 |
| Cu-dependent Atox1 binding to TRAF4 plays an important role in Atox1 nuclear translocation and ROS-dependent inflammatory responses in TNF-alpha-stimulated vascular endothelial cells. | Novel interaction of antioxidant-1 with TRAF4: role in inflammatory responses in endothelial cells.
Das A, Sudhahar V, Ushio-Fukai M, Fukai T., Free PMC Article | 04/11/2020 |
| Here, we show that DCAC50, a recently developed small-molecule inhibitor of the intracellular copper chaperones, ATOX1 and CCS, reduces cell proliferation and elevates oxidative stress, triggering apoptosis in a panel of triple-negative breast cancer (TNBC) cells. | Inhibition of Copper Transport Induces Apoptosis in Triple-Negative Breast Cancer Cells and Suppresses Tumor Angiogenesis.
Karginova O, Weekley CM, Raoul A, Alsayed A, Wu T, Lee SS, He C, Olopade OI. | 03/28/2020 |
| we found four novel variants viz. c.6 + 30G > A, c.207 + 32dup, c.207 + 43G > A, and c.40G > A, p.(Gly14Ser) in ATOX1 in Indian Wilson disease patients. p.(Gly14Ser) located in the second exon appears to aggravate the effect of ATP7B mutation p.(Ile1102Thr), probably by restricting the downstream flow of copper. | In-silico analysis of novel p.(Gly14Ser) variant of ATOX1 gene: plausible role in modulating ATOX1-ATP7B interaction.
Kumari N, Kumar A, Pal A, Thapa BR, Modi M, Prasad R. | 01/11/2020 |
| Copper chaperone Atox-1 is involved in the induction of SOD3 in a monocyte cell line. | Copper chaperone antioxidant-1, Atox-1, is involved in the induction of SOD3 in THP-1 cells.
Kamiya T, Takeuchi K, Fukudome S, Hara H, Adachi T. | 08/11/2018 |
| Since full occupancy of the tetrahedral cavity is a common feature of all Atox1 dimeric structures obtained with other metal ions (Cu(+), Cd(2+), and Hg(2+)), we propose that in the case of platinum, where the occupancy is only 0.4, the remaining cavities are occupied by Cu(+) ions | Oxaliplatin Binding to Human Copper Chaperone Atox1 and Protein Dimerization.
Belviso BD, Galliani A, Lasorsa A, Mirabelli V, Caliandro R, Arnesano F, Natile G. | 02/3/2018 |
| Data suggest that N-terminal segment of metal-binding domains (MBDs) 1-3 of ATOX1 interact with nucleotide-binding domain of ATP7B, thus physically coupling the domains involved in copper binding and those involved in ATP hydrolysis; interactions with MBDs 1-3 of ATOX1 activate ATP7B ATP hydrolysis. (ATOX1 = copper transport protein ATOX1; ATP7B = Cu-binding P type ATPase ATP7B) | The metal chaperone Atox1 regulates the activity of the human copper transporter ATP7B by modulating domain dynamics.
Yu CH, Yang N, Bothe J, Tonelli M, Nokhrin S, Dolgova NV, Braiterman L, Lutsenko S, Dmitriev OY., Free PMC Article | 11/26/2017 |
| It show that copper(I) and glutathione form large polymers with a molecular mass of approximately 8 kDa, which can transfer copper to Atox1. | Binding of Copper and Cisplatin to Atox1 Is Mediated by Glutathione through the Formation of Metal-Sulfur Clusters.
Dolgova NV, Yu C, Cvitkovic JP, Hodak M, Nienaber KH, Summers KL, Cotelesage JJH, Bernholc J, Kaminski GA, Pickering IJ, George GN, Dmitriev OY. | 09/30/2017 |
| Highlighted in this review are unique redox properties of Atox1 and other copper chaperones. Also, summarized are the redox nodes in the cytosol which potentially play dominant roles in the redox regulation of copper chaperones | Thiol-based copper handling by the copper chaperone Atox1.
Hatori Y, Inouye S, Akagi R. | 09/16/2017 |
| The structural flexibility of the human copper chaperone Atox1 has been reported based on insights from combined pulsed EPR studies and computations. | The structural flexibility of the human copper chaperone Atox1: Insights from combined pulsed EPR studies and computations.
Levy AR, Turgeman M, Gevorkyan-Aiapetov L, Ruthstein S., Free PMC Article | 08/26/2017 |
| Cu chaperone Atox1 has a role in breast cancer cell migration | Copper chaperone Atox1 plays role in breast cancer cell migration.
Blockhuys S, Wittung-Stafshede P. | 06/10/2017 |
| Multiple genetic models identified genetic associations with systolic blood pressure and ATOX1. | Longitudinal analytical approaches to genetic data.
Chiu YF, Justice AE, Melton PE., Free PMC Article | 11/5/2016 |
| In addition to Atox1, the human cytoplasm also contains Cu chaperones for loading of superoxide dismutase 1 (i.e. CCS) and cytochrome c oxidase in mitochondria (i.e. Cox17). [review] | Extended functional repertoire for human copper chaperones.
Matson Dzebo M, Ariöz C, Wittung-Stafshede P. | 10/22/2016 |