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    ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 [ Homo sapiens (human) ]

    Gene ID: 488, updated on 10-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Persistent Cutaneous Lesions of Darier Disease and Second-Hit Somatic Variants in ATP2A2 Gene.

    Persistent Cutaneous Lesions of Darier Disease and Second-Hit Somatic Variants in ATP2A2 Gene.
    Atzmony L, Zagairy F, Mawassi B, Shehade M, Tatour Y, Danial-Farran N, Khayat M, Warrour N, Dodiuk-Gad R, Cohen-Barak E.,

    07/31/2024
    IL-37 Modulates Myocardial Calcium Handling via the p-STAT3/SERCA2a Axis in HF-Related Engineered Human Heart Tissue.

    IL-37 Modulates Myocardial Calcium Handling via the p-STAT3/SERCA2a Axis in HF-Related Engineered Human Heart Tissue.
    Yin D, Liu Y, Xue B, Ding R, Wang G, Xia S, Zhang D.

    07/19/2024
    Familial comedonal Darier's disease: a new ATP2A2 mutation with intra-family clinical heterogeneity.

    Familial comedonal Darier's disease: a new ATP2A2 mutation with intra-family clinical heterogeneity.
    Civico-Ruiz MB, Zulueta-Dorado T, López-Delgado JJ, Fernández-Rosado F, Coronel-Pérez IM, Martínez-Barranca ML.

    11/15/2023
    SERCA2 phosphorylation at the heart of the disease.

    SERCA2 phosphorylation at the heart of the disease.
    Brini M, Calì T.

    11/10/2023
    Mitochondria-ER contact mediated by MFN2-SERCA2 interaction supports CD8[+] T cell metabolic fitness and function in tumors.

    Mitochondria-ER contact mediated by MFN2-SERCA2 interaction supports CD8(+) T cell metabolic fitness and function in tumors.
    Yang JF, Xing X, Luo L, Zhou XW, Feng JX, Huang KB, Liu H, Jin S, Liu YN, Zhang SH, Pan YH, Yu B, Yang JY, Cao YL, Cao Y, Yang CY, Wang Y, Zhang Y, Li J, Xia X, Kang T, Xu RH, Lan P, Luo JH, Han H, Bai F, Gao S.

    09/28/2023
    Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure.

    Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure.
    Skogestad J, Albert I, Hougen K, Lothe GB, Lunde M, Eken OS, Veras I, Huynh NTT, Børstad M, Marshall S, Shen X, Louch WE, Robinson EL, Cleveland JC Jr, Ambardekar AV, Schwisow JA, Jonas E, Calejo AI, Morth JP, Taskén K, Melleby AO, Lunde PK, Sjaastad I, Carlson CR, Aronsen JM.

    08/11/2023
    Association of Somatic ATP2A2 Damaging Variants With Grover Disease.

    Association of Somatic ATP2A2 Damaging Variants With Grover Disease.
    Seli D, Ellis KT, Goldust M, Shah K, Hu R, Zhou J, McNiff JM, Choate KA., Free PMC Article

    07/24/2023
    SERCA2 phosphorylation at serine 663 is a key regulator of Ca[2+] homeostasis in heart diseases.

    SERCA2 phosphorylation at serine 663 is a key regulator of Ca(2+) homeostasis in heart diseases.
    Gonnot F, Boulogne L, Brun C, Dia M, Gouriou Y, Bidaux G, Chouabe C, Crola Da Silva C, Ducreux S, Pillot B, Kaczmarczyk A, Leon C, Chanon S, Perret C, Sciandra F, Dargar T, Gache V, Farhat F, Sebbag L, Bochaton T, Thibault H, Ovize M, Paillard M, Gomez L., Free PMC Article

    06/21/2023
    Identification and Characterization of p300-Mediated Lysine Residues in Cardiac SERCA2a.

    Identification and Characterization of p300-Mediated Lysine Residues in Cardiac SERCA2a.
    Gorski PA, Lee A, Lee P, Oh JG, Vangheluwe P, Ishikawa K, Hajjar R, Kho C., Free PMC Article

    03/16/2023
    A motor neuron disease-associated mutation produces non-glycosylated Seipin that induces ER stress and apoptosis by inactivating SERCA2b.

    A motor neuron disease-associated mutation produces non-glycosylated Seipin that induces ER stress and apoptosis by inactivating SERCA2b.
    Saito S, Ishikawa T, Ninagawa S, Okada T, Mori K., Free PMC Article

    12/3/2022
    MicroRNA-200c-3p Negatively Regulates ATP2A2 and Promotes the Progression of Papillary Thyroid Carcinoma.

    MicroRNA-200c-3p Negatively Regulates ATP2A2 and Promotes the Progression of Papillary Thyroid Carcinoma.
    Feng YL, Ke T, Wang GL, Qi HY, Xiao Y., Free PMC Article

    09/24/2022
    Expression of TSP50, SERCA2 and IL-8 in Colorectal Adenoma and Carcinoma: Correlation to Clinicopathological Factors.

    Expression of TSP50, SERCA2 and IL-8 in Colorectal Adenoma and Carcinoma: Correlation to Clinicopathological Factors.
    Youssef HMK, Radi DA, Abd El-Azeem MA., Free PMC Article

    02/12/2022
    Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activity is required for V(D)J recombination.

    Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activity is required for V(D)J recombination.
    Chen CC, Chen BR, Wang Y, Curman P, Beilinson HA, Brecht RM, Liu CC, Farrell RJ, de Juan-Sanz J, Charbonnier LM, Kajimura S, Ryan TA, Schatz DG, Chatila TA, Wikstrom JD, Tyler JK, Sleckman BP., Free PMC Article

    11/6/2021
    Combination Therapy with STAT3 Inhibitor Enhances SERCA2a-Induced BMPR2 Expression and Inhibits Pulmonary Arterial Hypertension.

    Combination Therapy with STAT3 Inhibitor Enhances SERCA2a-Induced BMPR2 Expression and Inhibits Pulmonary Arterial Hypertension.
    Bisserier M, Katz MG, Bueno-Beti C, Brojakowska A, Zhang S, Gubara S, Kohlbrenner E, Fazal S, Fargnoli A, Dorfmuller P, Humbert M, Hata A, Goukassian DA, Sassi Y, Hadri L., Free PMC Article

    10/30/2021
    A novel mutation in exon 1 of the ATP2A2 gene in four members of one Chinese family with Darier disease.

    A novel mutation in exon 1 of the ATP2A2 gene in four members of one Chinese family with Darier disease.
    Li C, Xiao Z, Peng Y, Liu Z, Zhang Y.

    10/2/2021
    The transmembrane peptide DWORF activates SERCA2a via dual mechanisms.

    The transmembrane peptide DWORF activates SERCA2a via dual mechanisms.
    Li A, Yuen SL, Stroik DR, Kleinboehl E, Cornea RL, Thomas DD., Free PMC Article

    08/28/2021
    Trans-2-enoyl-CoA reductase limits Ca(2+) accumulation in the endoplasmic reticulum by inhibiting the Ca(2+) pump SERCA2b.

    Trans-2-enoyl-CoA reductase limits Ca(2+) accumulation in the endoplasmic reticulum by inhibiting the Ca(2+) pump SERCA2b.
    Uchida Y, Yamamoto Y, Sakisaka T., Free PMC Article

    08/28/2021
    Clioquinol inhibits cell growth in a SERCA2-dependent manner.

    Clioquinol inhibits cell growth in a SERCA2-dependent manner.
    Lv X, Zhang W, Xia S, Huang Z, Shi P.

    07/31/2021
    SMN-deficiency disrupts SERCA2 expression and intracellular Ca(2+) signaling in cardiomyocytes from SMA mice and patient-derived iPSCs.

    SMN-deficiency disrupts SERCA2 expression and intracellular Ca(2+) signaling in cardiomyocytes from SMA mice and patient-derived iPSCs.
    Khayrullina G, Moritz KE, Schooley JF, Fatima N, Viollet C, McCormack NM, Smyth JT, Doughty ML, Dalgard CL, Flagg TP, Burnett BG., Free PMC Article

    07/31/2021
    Dimerization of SERCA2a Enhances Transport Rate and Improves Energetic Efficiency in Living Cells.

    Dimerization of SERCA2a Enhances Transport Rate and Improves Energetic Efficiency in Living Cells.
    Bovo E, Nikolaienko R, Cleary SR, Seflova J, Kahn D, Robia SL, Zima AV., Free PMC Article

    07/10/2021
    Reduced sarcoplasmic reticulum Ca(2+) ATPase activity underlies skeletal muscle wasting in asthma.

    Reduced sarcoplasmic reticulum Ca(2+) ATPase activity underlies skeletal muscle wasting in asthma.
    Qaisar R, Qayum M, Muhammad T.

    04/13/2021
    Involvement of sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) in mPRalpha (PAQR7)-mediated progesterone induction of vascular smooth muscle relaxation.

    Involvement of sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) in mPRα (PAQR7)-mediated progesterone induction of vascular smooth muscle relaxation.
    Pang Y, Thomas P.

    03/28/2021
    Novel ATP2A2 mutation in a large Chinese pedigree with extensive Darier's disease.

    Novel ATP2A2 mutation in a large Chinese pedigree with extensive Darier's disease.
    Zhang W, Wang C, Guo B, Sun J.

    03/20/2021
    Viral expression of a SERCA2a-activating PLB mutant improves calcium cycling and synchronicity in dilated cardiomyopathic hiPSC-CMs.

    Viral expression of a SERCA2a-activating PLB mutant improves calcium cycling and synchronicity in dilated cardiomyopathic hiPSC-CMs.
    Stroik DR, Ceholski DK, Bidwell PA, Mleczko J, Thanel PF, Kamdar F, Autry JM, Cornea RL, Thomas DD., Free PMC Article

    01/23/2021
    The role of phospholamban and GSK3 in regulating rodent cardiac SERCA function.

    The role of phospholamban and GSK3 in regulating rodent cardiac SERCA function.
    Hamstra SI, Whitley KC, Baranowski RW, Kurgan N, Braun JL, Messner HN, Fajardo VA.

    12/19/2020
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