| TMT-based quantitative proteomic analysis revealed that FBLN2 and NPR3 are involved in the early osteogenic differentiation of mesenchymal stem cells (MSCs). | TMT-based quantitative proteomic analysis revealed that FBLN2 and NPR3 are involved in the early osteogenic differentiation of mesenchymal stem cells (MSCs).
Liu J, He S, Ma B, Li X, Wang Y, Xiong J., Free PMC Article | 08/25/2023 |
| NPRC deletion mitigated atherosclerosis by inhibiting oxidative stress, inflammation and apoptosis in ApoE knockout mice. | NPRC deletion mitigated atherosclerosis by inhibiting oxidative stress, inflammation and apoptosis in ApoE knockout mice.
Cheng C, Zhang J, Li X, Xue F, Cao L, Meng L, Sui W, Zhang M, Zhao Y, Xi B, Yu X, Xu F, Yang J, Zhang Y, Zhang C., Free PMC Article | 08/10/2023 |
| Genetic evidence implicating natriuretic peptide receptor-3 in cardiovascular disease risk: a Mendelian randomization study. | Genetic evidence implicating natriuretic peptide receptor-3 in cardiovascular disease risk: a Mendelian randomization study.
Cronjé HT, Karhunen V, Hovingh GK, Coppieters K, Lagerstedt JO, Nyberg M, Gill D., Free PMC Article | 05/3/2023 |
| NPR3, transcriptionally regulated by POU2F1, inhibits osteosarcoma cell growth through blocking the PI3K/AKT pathway. | NPR3, transcriptionally regulated by POU2F1, inhibits osteosarcoma cell growth through blocking the PI3K/AKT pathway.
Li S, Guo R, Peng Z, Quan B, Hu Y, Wang Y, Wang Y. | 04/9/2022 |
| Oxygen and steroids affect the regulatory role of natriuretic peptide receptor-C on surfactant secretion by type II cells. | Oxygen and steroids affect the regulatory role of natriuretic peptide receptor-C on surfactant secretion by type II cells.
Ryan RM, Paintlia MK, Newton DA, Spyropoulos DD, Kemp M, Jobe AH, Baatz JE., Free PMC Article | 02/19/2022 |
| LncRNA FENDRR Upregulation Promotes Hepatic Carcinoma Cells Apoptosis by Targeting miR-362-5p Via NPR3 and p38-MAPK Pathway. | LncRNA FENDRR Upregulation Promotes Hepatic Carcinoma Cells Apoptosis by Targeting miR-362-5p Via NPR3 and p38-MAPK Pathway.
Qian G, Jin X, Zhang L. | 07/17/2021 |
| A role of NPR-C mutation in pulmonary arterial hypertension is reviewed. | Pulmonary Arterial Hypertension Due to NPR-C Mutation: A Novel Paradigm for Normal and Pathologic Remodeling?
Egom EE., Free PMC Article | 01/25/2020 |
| The levels of ANP, NPRA, IL-4 and GATA3 increased in peripheral blood of children with respiratory syncytial virus bronchiolitis. | [Up-regulation of atrial natriuretic peptide and GATA3 levels in peripheral blood of children with respiratory syncytial virus bronchiolitis].
He X, Shi Y, Wu F, Zhang X. | 07/20/2019 |
| loss of NPR-C reduces HRV due to perturbations in the regulation of the heart by the autonomic nervous system | Altered heart rate regulation by the autonomic nervous system in mice lacking natriuretic peptide receptor C (NPR-C).
Moghtadaei M, Langille E, Rafferty SA, Bogachev O, Rose RA., Free PMC Article | 07/13/2019 |
| It was the aim to investigate the expression of natriuretic peptide receptors NPR-A, NPR-B and NPR-C during adipocyte differentiation (AD), upon stimulation with fatty acids (FA), and in murine and human adipose tissue depots. | Regulation of natriuretic peptides postprandially in vivo and of their receptors in adipocytes by fatty acids in vitro.
Schmid A, Albrecht J, Brock J, Koukou M, Arapogianni E, Schäffler A, Karrasch T. | 04/27/2019 |
| study identifies novel, putative mechanisms for BP-associated variants at the NPR3 locus to elevate blood pressure. | The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle.
Ren M, Ng FL, Warren HR, Witkowska K, Baron M, Jia Z, Cabrera C, Zhang R, Mifsud B, Munroe PB, Xiao Q, Townsend-Nicholson A, Hobbs AJ, Ye S, Caulfield MJ., Free PMC Article | 01/5/2019 |
| Suggest that pro-ANP/corin/NPR-C signaling is dominant in the vascular system in preeclampsia. | Aberrant pro-atrial natriuretic peptide/corin/natriuretic peptide receptor signaling is present in maternal vascular endothelium in preeclampsia.
Gu Y, Thompson D, Xu J, Lewis DF, Morgan JA, Cooper DB, McCathran CE, Wang Y., Free PMC Article | 09/22/2018 |
| NPR3 expression is downregulated by MRCCAT1 in the in metastatic clear cell renal cell carcinoma. | Long noncoding RNA MRCCAT1 promotes metastasis of clear cell renal cell carcinoma via inhibiting NPR3 and activating p38-MAPK signaling.
Li JK, Chen C, Liu JY, Shi JZ, Liu SP, Liu B, Wu DS, Fang ZY, Bao Y, Jiang MM, Yuan JH, Qu L, Wang LH., Free PMC Article | 08/18/2018 |
| This study suggested that NPR3 rs2270915 polymorphism was associated with decreased systolic blood pressure level marginally in essential hypertension patients in a Chinese Han population; the polymorphism may function through decreasing NPR3 mRNA expression and ANP level. | Association of NPR3 polymorphism with risk of essential hypertension in a Chinese population.
Kuang DB, Zhou JP, Li MP, Tang J, Chen XP. | 05/12/2018 |
| NPR-C gene single nucleotide polymorphisms significantly contribute to CAD susceptibility in the Chinese Han population | NPR-C gene polymorphism is associated with increased susceptibility to coronary artery disease in Chinese Han population: a multicenter study.
Hu Q, Liu Q, Wang S, Zhen X, Zhang Z, Lv R, Jiang G, Ma Z, He H, Li D, Liu X, Gao F, Li J, Li L, Zhang M, Ji X, Chen Y, Wang D, Huang D, Ma A, Huang W, Zhao Y, Gong Y, Zhang C, Zhang Y., Free PMC Article | 01/20/2018 |
| The NPRC genetic variant,Rs1847018, is a genetic marker of essential hypertension. | Association of NPRA and NPRC gene variants and hypertension in Mongolian population.
Chang PY, Liu ZY, Qin L, Zhao P. | 12/24/2016 |
| This study focused on the natriuretic peptide receptor C gene (NPR3). The correlation analysis between NPR3 and hypertension was replicated in 450 Chinese Dai and 484 Chinese Mongolian individuals. | Correlation between natriuretic peptide receptor C (NPR3) gene polymorphisms and hypertension in the Dai people of China.
Sun H, Yang ZQ, Liu SY, Yu L, Huang K, Lin KQ, Chu JY, Huang XQ. | 06/28/2016 |
| Angiotensin II downregulates vascular smooth muscle cell NPR-C gene expression by destabilizing its mRNA. | Downregulation of natriuretic peptide clearance receptor mRNA in vascular smooth muscle cells by angiotensin II.
Jiao Y, Yang Q. | 02/13/2016 |
| Results from this study point to a role for miR-100 in the regulation of NPR3 expression, and suggest a possible therapeutic target for modulation of NP bioactivity in heart disease. | Natriuretic peptide receptor 3 (NPR3) is regulated by microRNA-100.
Wong LL, Wee AS, Lim JY, Ng JY, Chong JP, Liew OW, Lilyanna S, Martinez EC, Ackers-Johnson MA, Vardy LA, Armugam A, Jeyaseelan K, Ng TP, Lam CS, Foo RS, Richards AM, Chen YT. | 01/16/2016 |
| Data show that natriuretic peptide receptor 3 (NPR3) single nucleotide polymorphism (SNP) is independently associated with diastolic dysfunction and does not appear to be related to alterations in circulating levels of natriuretic peptides. | A functional genetic variant (N521D) in natriuretic peptide receptor 3 is associated with diastolic dysfunction: the prevalence of asymptomatic ventricular dysfunction study.
Pereira NL, Redfield MM, Scott C, Tosakulwong N, Olson TM, Bailey KR, Rodeheffer RJ, Burnett JC Jr., Free PMC Article | 12/6/2014 |
| The significant change in NPR3 protein was observed for the Arg146 variant allozyme, with 20% of wild-type protein, primarily because of autophagy-dependent degradation. | Natriuretic peptide receptor-3 gene (NPR3): nonsynonymous polymorphism results in significant reduction in protein expression because of accelerated degradation.
Pereira NL, Lin D, Pelleymounter L, Moon I, Stilling G, Eckloff BW, Wieben ED, Redfield MM, Burnett JC Jr, Yee VC, Weinshilboum RM., Free PMC Article | 10/26/2013 |
| polymorphisms or haplotype in NPR3 gene may influence the risk of ischemic stroke or hypertension independently in Chinese population. | Association of natriuretic peptide receptor-C gene with ischemic stroke and hypertension in Chinese Han population.
Liu Y, Li S, Chen X, Zheng L, Yang Y, Jin L, Wang X. | 06/1/2013 |
| a NPR3 promoter gene variant could have a role on cerebrovascular disease susceptibility | Association of a single nucleotide polymorphism of the NPR3 gene promoter with early onset ischemic stroke in an Italian cohort.
Rubattu S, Giusti B, Lotta LA, Peyvandi F, Cotugno M, Stanzione R, Marchitti S, Palombella AM, Di Castro S, Rasura M, Mannucci PM, Volpe M. | 06/1/2013 |
| Report the presence of CNP and its receptors, NPR2/3 in atherosclerotic plaques of human carotid artery, with increased expression of NPR3 in histologically unstable plaques. | C-type natriuretic peptide and its receptors in atherosclerotic plaques of the carotid artery of clinically asymptomatic patients.
Kuehnl A, Pelisek J, Pongratz J, Eckstein HH. | 07/28/2012 |
| Results demonstrate the opposite effects of NPR-A and NPR-C in LPS-mediated endothelial permeability and lung injury. | Opposite effects of ANP receptors in attenuation of LPS-induced endothelial permeability and lung injury.
Xing J, Yakubov B, Poroyko V, Birukova AA., Free PMC Article | 06/9/2012 |