| Structural basis for Y2 receptor-mediated neuropeptide Y and peptide YY signaling. | Structural basis for Y2 receptor-mediated neuropeptide Y and peptide YY signaling.
Kang H, Park C, Choi YK, Bae J, Kwon S, Kim J, Choi C, Seok C, Im W, Choi HJ. | 01/14/2023 |
| Inhibition of epileptiform activity by neuropeptide Y in brain tissue from drug-resistant temporal lobe epilepsy patients. | Inhibition of epileptiform activity by neuropeptide Y in brain tissue from drug-resistant temporal lobe epilepsy patients.
Wickham J, Ledri M, Bengzon J, Jespersen B, Pinborg LH, Englund E, Woldbye DPD, Andersson M, Kokaia M., Free PMC Article | 11/21/2020 |
| The analysis of the distribution of genotypes in CEP135 rs4865047 and NPY2R rs1902491 detected significant differences only in the single nucleotide polymorphism rs4865047 genotype between the case and control group in comparison to the reference group. No significant association was found for the NPY2R SNP rs1902491 genotype. | The Association of CEP135 rs4865047 and NPY2R rs1902491 Single Nucleotide Polymorphisms (SNPs) with Rapid Progression of Proliferative Diabetic Retinopathy in Patients with Type 1 Diabetes Mellitus.
Derkac I, Januleviciene I, Sepetiene R, Valiauga R, Velickiene D., Free PMC Article | 03/9/2019 |
| genetic variation in NPY and NPY2R is at low frequency and thus does not make a major contribution to the obese phenotype in the general population | Evaluation of a Role for NPY and NPY2R in the Pathogenesis of Obesity by Mutation and Copy Number Variation Analysis in Obese Children and Adolescents.
Aerts E, Geets E, Sorber L, Beckers S, Verrijken A, Massa G, Van Hoorenbeeck K, Verhulst SL, Van Gaal LF, Van Hul W. | 01/6/2018 |
| The present study explored whether functional NPY2R variant rs6857715 (C-599T) showed an association with Major Depressive Disorder. Analysis of the overall sample (595 MDD cases; 1295 controls) showed an association with the AD risk allele C. The present findings suggest that the NPY2R rs6857715 C-allele makes a genuine contribution toward MDD | Association between neuropeptide Y receptor Y2 promoter variant rs6857715 and major depressive disorder.
Treutlein J, Strohmaier J, Frank J, Witt SH, Rietschel L, Forstner AJ, Lang M, Degenhardt F, Dukal H, Herms S, Streit F, Hoffmann P, Cichon S, Nöthen MM, Rietschel M. | 12/16/2017 |
| not detected in infantile hemanogiomas | Neuropeptide Y receptor 1 is expressed by B and T lymphocytes and mast cells in infantile haemangiomas.
Tan EM, Blackwell MG, Dunne JC, Marsh R, Tan ST, Itinteang T. | 04/1/2017 |
| polymorphisms in the NPY2R gene may be useful in identifying women at risk for osteoporosis. | Polymorphisms in neuropeptide genes and bone mineral density in Korean postmenopausal women.
Chun EH, Kim H, Suh CS, Kim JH, Kim DY, Kim JG. | 08/20/2016 |
| The C-terminal alpha-helix of Neuropeptide Y, which is formed in a membrane environment in the absence of the receptor, is unwound starting at T(32) to provide optimal contacts in a binding pocket within the transmembrane bundle of the NPY-Y2 receptor. | Unwinding of the C-Terminal Residues of Neuropeptide Y is critical for Y₂ Receptor Binding and Activation.
Kaiser A, Müller P, Zellmann T, Scheidt HA, Thomas L, Bosse M, Meier R, Meiler J, Huster D, Beck-Sickinger AG, Schmidt P., Free PMC Article | 03/19/2016 |
| Data show that the Y2-receptor high expression G allele is associated with a less efficient mode of action cascading where different task goals are activated in parallel. | On the relevance of the NPY2-receptor variation for modes of action cascading processes.
Beste C, Stock AK, Epplen JT, Arning L. | 08/8/2015 |
| The molecular mobility of the human neuropeptide Y receptor type 2 reconstituted into dimyristoylphosphatidylcholine (DMPC) membranes was investigated by means of solid-state NMR spectroscopy. | The G-protein-coupled neuropeptide Y receptor type 2 is highly dynamic in lipid membranes as revealed by solid-state NMR spectroscopy.
Schmidt P, Thomas L, Müller P, Scheidt HA, Huster D. | 04/25/2015 |
| The results of this study provide evidence that the functionally relevant single nucleotide polymorphism (SNP) in the NPY2R promoter gene affect circumscribed processes of early sensory processing | NPY2-receptor variation modulates iconic memory processes.
Arning L, Stock AK, Kloster E, Epplen JT, Beste C. | 04/4/2015 |
| Data indicate modest association of the age at onset (AO) with two neuropeptide Y (NPY) promoter variations and a highly significant association with NPY receptor NPY2R promoter single nucleotide polymorphism (SNP rs2234759). | Association of age at onset in Huntington disease with functional promoter variations in NPY and NPY2R.
Kloster E, Saft C, Akkad DA, Epplen JT, Arning L. | 09/27/2014 |
| This study reviews neuropeptide Y2 receptor modulators (mainly non-peptidic antagonists) and their structure-activity relationships. | Ligands of the neuropeptide Y Y2 receptor.
Mittapalli GK, Roberts E., Free PMC Article | 08/30/2014 |
| this study concludes that common genetic variation in the proximal NPY2R promoter influences transcription factor binding so as to alter gene expression in neuroendocrine cells, and consequently cardiometabolic traits in humans. | Heredity and cardiometabolic risk: naturally occurring polymorphisms in the human neuropeptide Y(2) receptor promoter disrupt multiple transcriptional response motifs.
Wei Z, Zhang K, Wen G, Balasubramanian K, Shih PA, Rao F, Friese RS, Miramontes-Gonzalez JP, Schmid-Schoenbein GW, Kim HS, Mahata SK, O'Connor DT., Free PMC Article | 07/13/2013 |
| we determined the role of the C-terminus in the anterograde transport of the human neuropeptide Y receptor (hYR) type 2 | The anterograde transport of the human neuropeptide Y2 receptor is regulated by a subtype specific mechanism mediated by the C-terminus.
Walther C, Lotze J, Beck-Sickinger AG, Mörl K. | 05/11/2013 |
| Surface masking of the Y2 receptor could to a degree reflect restricted access of the large (34-36-residue) physiological agonists. | Surface masking shapes the traffic of the neuropeptide Y Y2 receptor.
Parker MS, Sah R, Parker SL., Free PMC Article | 01/12/2013 |
| NPY2R expression in neonatal saliva is predictive of an immature feeding pattern. | Neuropeptide Y2 receptor (NPY2R) expression in saliva predicts feeding immaturity in the premature neonate.
Maron JL, Johnson KL, Dietz JA, Chen ML, Bianchi DW., Free PMC Article | 12/22/2012 |
| The influence of beta-arrestin adaptors and endocytosis mechanisms on plasma membrane diffusion and particle brightness of GFP-tagged neuropeptide Y (NPY) receptors, was investigated. | Fluorescence correlation spectroscopy, combined with bimolecular fluorescence complementation, reveals the effects of β-arrestin complexes and endocytic targeting on the membrane mobility of neuropeptide Y receptors.
Kilpatrick LE, Briddon SJ, Holliday ND., Free PMC Article | 11/17/2012 |
| Four genetic loci were strongly and independently associated with obesity, NPY2R, NPFFR2, MC4R, and FTO. | Polymorphisms in the NPY2R gene show significant associations with BMI that are additive to FTO, MC4R, and NPFFR2 gene effects.
Hunt SC, Hasstedt SJ, Xin Y, Dalley BK, Milash BA, Yakobson E, Gress RE, Davidson LE, Adams TD., Free PMC Article | 02/25/2012 |
| protocol for the preparation of fully active Y2 G protein-coupled receptor | Assessment of a fully active class A G protein-coupled receptor isolated from in vitro folding.
Bosse M, Thomas L, Hassert R, Beck-Sickinger AG, Huster D, Schmidt P. | 01/7/2012 |
| Data present a site-directed mutagenesis study of four amino acid positions in the human Y2 receptor. | Identification of positions in the human neuropeptide Y/peptide YY receptor Y2 that contribute to pharmacological differences between receptor subtypes.
Fällmar H, Åkerberg H, Gutiérrez-de-Terán H, Lundell I, Mohell N, Larhammar D. | 12/10/2011 |
| Results report on the functional reconstitution of the hY(2)R and the hY(4)R in Sf9 insect cells using the baculovirus system. | Functional reconstitution of human neuropeptide Y (NPY) Y(2) and Y(4) receptors in Sf9 insect cells.
Pop N, Igel P, Brennauer A, Cabrele C, Bernhardt GN, Seifert R, Buschauer A. | 11/19/2011 |
| neuropeptide Y1 and Y2 receptors were expressed in 33 percent of testicular tumors and Y1 on intratumoral blood vessels in 50 percent of testicular tumors | High expression of NPY receptors in the human testis.
Körner M, Waser B, Thalmann GN, Reubii JC. | 10/1/2011 |
| Increased expression of NPY-Y2 receptors in symptomatic carotid plaque vascular smooth muscle cells. | Neuropeptide Y receptors in carotid plaques of symptomatic and asymptomatic patients: effect of inflammatory cytokines.
Pankajakshan D, Jia G, Pipinos I, Tyndall SH, Agrawal DK., Free PMC Article | 07/23/2011 |
| These results suggest that the rs4425326 polymorphism in NPY2R may be a possible genetic factor for nicotine dependence in the Japanese elderly population. | Association between neuropeptide Y receptor 2 polymorphism and the smoking behavior of elderly Japanese.
Sato N, Kageyama S, Chen R, Suzuki M, Mori H, Tanioka F, Yamada H, Kamo T, Tao H, Shinmura K, Nozawa A, Sugimura H. | 03/26/2011 |