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    NRAS NRAS proto-oncogene, GTPase [ Homo sapiens (human) ]

    Gene ID: 4893, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Loss of Heterozygosity and Mutations in the RAS-ERK Pathway Genes in Tumor Cells of Various Loci in Multiple Myeloma.

    Loss of Heterozygosity and Mutations in the RAS-ERK Pathway Genes in Tumor Cells of Various Loci in Multiple Myeloma.
    Soloveva M, Solovev M, Risinskaya N, Nikulina E, Yakutik I, Biderman B, Obukhova T, Chabaeva Y, Kulikov S, Sudarikov A, Mendeleeva L., Free PMC Article

    11/6/2024
    The prominent pervasive oncogenic role and tissue specific permissiveness of RAS gene mutations.

    The prominent pervasive oncogenic role and tissue specific permissiveness of RAS gene mutations.
    Yi M, Soppet D, McCormick F, Nissley DV., Free PMC Article

    10/31/2024
    eIF4F controls ERK MAPK signaling in melanomas with BRAF and NRAS mutations.

    eIF4F controls ERK MAPK signaling in melanomas with BRAF and NRAS mutations.
    Valcikova B, Vadovicova N, Smolkova K, Zacpalova M, Krejci P, Lee S, Rauch J, Kolch W, von Kriegsheim A, Dorotikova A, Andrysik Z, Vichova R, Vacek O, Soucek K, Uldrijan S., Free PMC Article

    10/30/2024
    Organ involvement in adults with BPDCN is associated with sun exposure history, TET2 and RAS mutations, and survival.

    Organ involvement in adults with BPDCN is associated with sun exposure history, TET2 and RAS mutations, and survival.
    Shimony S, Keating J, Fay CJ, Luskin MR, Neuberg DS, LeBoeuf NR, Lane AA., Free PMC Article

    09/30/2024
    Titration of RAS alters senescent state and influences tumour initiation.

    Titration of RAS alters senescent state and influences tumour initiation.
    Chan ASL, Zhu H, Narita M, Cassidy LD, Young ARJ, Bermejo-Rodriguez C, Janowska AT, Chen HC, Gough S, Oshimori N, Zender L, Aitken SJ, Hoare M, Narita M., Free PMC Article

    09/26/2024
    Mutational cooperativity of RUNX1::RUNX1T1 isoform 9a and oncogenic NRAS in zebrafish myeloid leukaemia.

    Mutational cooperativity of RUNX1::RUNX1T1 isoform 9a and oncogenic NRAS in zebrafish myeloid leukaemia.
    Lints R, Walker CA, Delfi O, Prouse M, PohLui De Silva M, Bohlander SK, Wood AC., Free PMC Article

    09/4/2024
    NRAS[Q61R] mutation drives elevated angiopoietin-2 expression in human endothelial cells and a genetic mouse model.

    NRAS(Q61R) mutation drives elevated angiopoietin-2 expression in human endothelial cells and a genetic mouse model.
    Pastura P, McDaniel CG, Alharbi S, Fox D, Coleman B, Malik P, Adams DM, Le Cras TD.,

    09/4/2024
    Variation in KRAS/NRAS/BRAF-Mutation Status by Age, Sex, and Race/Ethnicity Among a Large Cohort of Patients with Metastatic Colorectal Cancer (mCRC).

    Variation in KRAS/NRAS/BRAF-Mutation Status by Age, Sex, and Race/Ethnicity Among a Large Cohort of Patients with Metastatic Colorectal Cancer (mCRC).
    Booker BD, Markt SC, Schumacher FR, Rose J, Cooper G, Selfridge JE, Koroukian SM.

    08/30/2024
    Amplification of Mutant NRAS in Melanocytic Tumors With Features of Spitz Tumors.

    Amplification of Mutant NRAS in Melanocytic Tumors With Features of Spitz Tumors.
    Cloutier JM, Wang M, Vemula SS, Mirza S, Weier J, Aquino JD, McCalmont TH, LeBoit PE, Bastian BC, Yeh I.

    08/23/2024
    Mechanism of co-operation of mutant IL-7Ralpha and mutant NRAS in acute lymphoblastic leukemia: role of MYC.

    Mechanism of co-operation of mutant IL-7Rα and mutant NRAS in acute lymphoblastic leukemia: role of MYC.
    Winer H, Li W, Rodrigues G, Gower T, Meyer TJ, Hixon J, Durum SK., Free PMC Article

    07/8/2024
    KRAS, NRAS and BRAF Mutational Profile of Colorectal Cancer in a Series of Moroccan Patients.

    KRAS, NRAS and BRAF Mutational Profile of Colorectal Cancer in a Series of Moroccan Patients.
    El Zaitouni S, Laraqui A, Ghaouti M, Benzekri A, Kettani F, Bajjou T, Sekhsokh Y, Benmokhtar S, Jafari M, Baba W, Oukabli M, El Annaz H, Abi R, Tagajdid MR, El Kochri S, Lahlou IA, Ameziane El Hassani R, Ennibi K., Free PMC Article

    06/28/2024
    Deep neural network for the prediction of KRAS, NRAS, and BRAF genotypes in left-sided colorectal cancer based on histopathologic images.

    Deep neural network for the prediction of KRAS, NRAS, and BRAF genotypes in left-sided colorectal cancer based on histopathologic images.
    Li X, Chi X, Huang P, Liang Q, Liu J.

    06/10/2024
    Changes in cell morphology and function induced by the NRAS Q61R mutation in lymphatic endothelial cells.

    Changes in cell morphology and function induced by the NRAS Q61R mutation in lymphatic endothelial cells.
    Yasue S, Ozeki M, Nozawa A, Endo S, Ohnishi H., Free PMC Article

    06/5/2024
    Epidemiological and clinicopathological features of KRAS, NRAS, BRAF mutations and MSI in Chinese patients with stage I-III colorectal cancer.

    Epidemiological and clinicopathological features of KRAS, NRAS, BRAF mutations and MSI in Chinese patients with stage I-III colorectal cancer.
    Wang W, Wang R, Han X, Zhang W, Zhu L, Gu Y., Free PMC Article

    04/16/2024
    NRAS Mutant Dictates AHCYL1-Governed ER Calcium Homeostasis for Melanoma Tumor Growth.

    NRAS Mutant Dictates AHCYL1-Governed ER Calcium Homeostasis for Melanoma Tumor Growth.
    Cai C, Tu J, Najarro J, Zhang R, Fan H, Zhang FQ, Li J, Xie Z, Su R, Dong L, Arellano N, Ciboddo M, Elf SE, Gao X, Chen J, Wu R., Free PMC Article

    04/8/2024
    Targeted next-generation sequencing of Japanese patients with sinonasal mucosal melanomas identifies frequent NRAS and CTNNB1 mutations.

    Targeted next-generation sequencing of Japanese patients with sinonasal mucosal melanomas identifies frequent NRAS and CTNNB1 mutations.
    Tsushima N, Kano S, Hatanaka KC, Suzuki T, Hamada S, Idogawa H, Nakamaru Y, Suzuki M, Hatanaka Y, Homma A.

    04/2/2024
    miR-196b-5p regulates inflammatory process and migration via targeting Nras in trabecular meshwork cells.

    miR-196b-5p regulates inflammatory process and migration via targeting Nras in trabecular meshwork cells.
    Zhang J, Yang X, Zong Y, Yu T, Yang X.

    02/27/2024
    Missense mutation of NRAS is associated with malignant progression in neurocutaneous melanosis.

    Missense mutation of NRAS is associated with malignant progression in neurocutaneous melanosis.
    Takahashi H, Natsumeda M, Hara N, Koyama A, Shimizu H, Miyashita A, Satake D, Mouri Y, Tsukano J, Kawabe K, Tsukamoto Y, Okada M, Ogura R, Yuki A, Umezu H, Kakita A, Ikeuchi T, Oishi M., Free PMC Article

    02/12/2024
    A mutation panel comprising BRAF[V600E], NRAS[Q61R], and NRAS[Q61H] replicated retrospective histopathological examination findings in differentiating benign goitre from malignant papillary thyroid cancer in a cohort of Malaysian patients.

    A mutation panel comprising BRAF(V600E), NRAS(Q61R), and NRAS(Q61H) replicated retrospective histopathological examination findings in differentiating benign goitre from malignant papillary thyroid cancer in a cohort of Malaysian patients.
    Eng ZH, Ahmad Jefry MM, Ng KL, Abdul Aziz A, Mat Junit S.

    01/8/2024
    Characterization of 164 patients with NRAS mutated non-small cell lung cancer (NSCLC).

    Characterization of 164 patients with NRAS mutated non-small cell lung cancer (NSCLC).
    Dehem A, Mazieres J, Chour A, Guisier F, Ferreira M, Boussageon M, Girard N, Moro-Sibilot D, Cadranel J, Zalcman G, Ricordel C, Wislez M, Munck C, Poulet C, Gauvain C, Descarpentries C, Wasielewski E, Cortot AB, Baldacci S.

    12/21/2023
    BRAF and NRAS prognostic values in conjunctival melanoma: analysis and literature review.

    BRAF and NRAS prognostic values in conjunctival melanoma: analysis and literature review.
    Valentín-Bravo FJ, Pérez-Rodríguez Á, García-Álvarez C, García-Lagarto E, Saornil-Álvarez MA.

    10/28/2023
    Anatomical resection improves relapse-free survival in colorectal liver metastases in patients with KRAS/NRAS/BRAF mutations or right-sided colon cancer: a retrospective cohort study.

    Anatomical resection improves relapse-free survival in colorectal liver metastases in patients with KRAS/NRAS/BRAF mutations or right-sided colon cancer: a retrospective cohort study.
    Chang W, Chen Y, Zhou S, Ren L, Xu Y, Zhu D, Tang W, Ye Q, Wang X, Fan J, Wei Y, Xu J., Free PMC Article

    10/24/2023
    RAS gene mutations and histomorphometric measurements in oral squamous cell carcinoma.

    RAS gene mutations and histomorphometric measurements in oral squamous cell carcinoma.
    Mustansar T, Mirza T, Hussain M.

    09/12/2023
    Clinical, Pathological and Molecular Insights on KRAS, NRAS, BRAF, PIK3CA and TP53 Mutations in Metastatic Colorectal Cancer Patients from Northeastern Romania.

    Clinical, Pathological and Molecular Insights on KRAS, NRAS, BRAF, PIK3CA and TP53 Mutations in Metastatic Colorectal Cancer Patients from Northeastern Romania.
    Afrăsânie VA, Marinca MV, Gafton B, Alexa-Stratulat T, Rusu A, Froicu EM, Sur D, Lungulescu CV, Popovici L, Lefter AV, Afrăsânie I, Ivanov AV, Miron L, Rusu C., Free PMC Article

    08/30/2023
    RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia.

    RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia.
    Ren JG, Xing B, Lv K, O'Keefe RA, Wu M, Wang R, Bauer KM, Ghazaryan A, Burslem GM, Zhang J, O'Connell RM, Pillai V, Hexner EO, Philips MR, Tong W., Free PMC Article

    08/28/2023
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