| Downregulation of GPX8 in hepatocellular carcinoma: impact on tumor stemness and migration. | Downregulation of GPX8 in hepatocellular carcinoma: impact on tumor stemness and migration.
Tao CY, Wu XL, Song SS, Tang Z, Zhou YF, Tian MX, Jiang XF, Fang Y, Zhu GQ, Huang R, Qu WF, Gao J, Chu TH, Yang R, Chen JF, Zhao QF, Ding ZB, Dai Z, Zhou J, Liu WR, Shi YH, Fan J., Free PMC Article | 09/25/2024 |
| GPX8[+] cancer-associated fibroblast, as a cancer-promoting factor in lung adenocarcinoma, is related to the immunosuppressive microenvironment. | GPX8(+) cancer-associated fibroblast, as a cancer-promoting factor in lung adenocarcinoma, is related to the immunosuppressive microenvironment.
Bai Y, Han T, Dong Y, Liang C, Gao L, Liu Y, Zhou J, Guo J, Ge D, Wu J, Hu D., Free PMC Article | 03/27/2024 |
| GPX8 regulates pan-apoptosis in gliomas to promote microglial migration and mediate immunotherapy responses. | GPX8 regulates pan-apoptosis in gliomas to promote microglial migration and mediate immunotherapy responses.
Chen Z, Zheng D, Lin Z, Zhang C, Wei C, Deng X, Yan P, Zheng C, Lan C, Qin C, Wei X, Qin D, Wu Y, Peng J, Miao C, Lu L, Xia Y, Luo Q., Free PMC Article | 11/13/2023 |
| GPX8 deficiency-induced oxidative stress reprogrammed m6A epitranscriptome of oral cancer cells. | GPX8 deficiency-induced oxidative stress reprogrammed m6A epitranscriptome of oral cancer cells.
Chen X, Yuan L, Zhang L, Chen L, He Y, Wang C, Wu J, Chen S, Zhao W, Yu D., Free PMC Article | 05/18/2023 |
| GPX8 as a Novel Prognostic Factor and Potential Therapeutic Target in Primary Glioma. | GPX8 as a Novel Prognostic Factor and Potential Therapeutic Target in Primary Glioma.
Yang ZS, Yang Q, Sun XX, Xiong K, Zhu XT, Wang YC, Ren QY, Wu GH, Wang SM, Cao XQ, Yang XR, Jiang WG., Free PMC Article | 09/10/2022 |
| GPx8 regulates apoptosis and autophagy in esophageal squamous cell carcinoma through the IRE1/JNK pathway. | GPx8 regulates apoptosis and autophagy in esophageal squamous cell carcinoma through the IRE1/JNK pathway.
Yin X, Zhang P, Xia N, Wu S, Liu B, Weng L, Shang M. | 05/7/2022 |
| GPX8 promotes migration and invasion by regulating epithelial characteristics in non-small cell lung cancer. | GPX8 promotes migration and invasion by regulating epithelial characteristics in non-small cell lung cancer.
Zhang J, Liu Y, Guo Y, Zhao Q., Free PMC Article | 08/7/2021 |
| Characterization of the endoplasmic reticulum-resident peroxidases GPx7 and GPx8 shows the higher oxidative activity of GPx7 and its linkage to oxidative protein folding. | Characterization of the endoplasmic reticulum-resident peroxidases GPx7 and GPx8 shows the higher oxidative activity of GPx7 and its linkage to oxidative protein folding.
Kanemura S, Sofia EF, Hirai N, Okumura M, Kadokura H, Inaba K., Free PMC Article | 02/2/2021 |
| Glutathione Peroxidase 8 as a Prognostic Biomarker of Gastric Cancer: An Analysis of The Cancer Genome Atlas (TCGA) Data. | Glutathione Peroxidase 8 as a Prognostic Biomarker of Gastric Cancer: An Analysis of The Cancer Genome Atlas (TCGA) Data.
Zhang X, Zhan D, Li Y, Wang H, Cheng C, Yao Y, Jia J., Free PMC Article | 02/2/2021 |
| The glutathione peroxidase 8 (GPX8)/IL-6/STAT3 axis is essential in maintaining an aggressive breast cancer phenotype. | The glutathione peroxidase 8 (GPX8)/IL-6/STAT3 axis is essential in maintaining an aggressive breast cancer phenotype.
Khatib A, Solaimuthu B, Ben Yosef M, Abu Rmaileh A, Tanna M, Oren G, Schlesinger Frisch M, Axelrod JH, Lichtenstein M, Shaul YD., Free PMC Article | 10/24/2020 |
| Study provides evidence that the conserved N-terminal transmembrane domain of GPX8, in addition to its enzymatic activity, is essential for regulating Ca(2+) dynamics revealing a novel level of integration between redox-related proteins and Ca(2+) signaling/homeostasis. | Regulation of Calcium Fluxes by GPX8, a Type-II Transmembrane Peroxidase Enriched at the Mitochondria-Associated Endoplasmic Reticulum Membrane.
Yoboue ED, Rimessi A, Anelli T, Pinton P, Sitia R. | 03/10/2018 |
| GPX8 is transcriptionally regulated by HIFalpha and modulates growth factor signaling in HeLa cells. | Glutathione peroxidase 8 is transcriptionally regulated by HIFα and modulates growth factor signaling in HeLa cells.
Bosello-Travain V, Forman HJ, Roveri A, Toppo S, Ursini F, Venerando R, Warnecke C, Zaccarin M, Maiorino M. | 12/5/2015 |
| Along with the induction of GPX8 in ER-stressed cells, these findings question a ubiquitous role of Ero1alpha as a producer of cytoplasmic ROS under ER stress | GPx8 peroxidase prevents leakage of H2O2 from the endoplasmic reticulum.
Ramming T, Hansen HG, Nagata K, Ellgaard L, Appenzeller-Herzog C. | 12/20/2014 |
| Quantitative proteomics identifies the membrane-associated peroxidase GPx8 as a cellular substrate of the hepatitis C virus NS3-4A protease. | Quantitative proteomics identifies the membrane-associated peroxidase GPx8 as a cellular substrate of the hepatitis C virus NS3-4A protease.
Morikawa K, Gouttenoire J, Hernandez C, Dao Thi VL, Tran HT, Lange CM, Dill MT, Heim MH, Donzé O, Penin F, Quadroni M, Moradpour D. | 05/31/2014 |
| GPx8 labeled as secreted glutathione peroxidase, is actually endoplasmic reticulum-resident protein disulfide isomerase peroxidase | Two endoplasmic reticulum PDI peroxidases increase the efficiency of the use of peroxide during disulfide bond formation.
Nguyen VD, Saaranen MJ, Karala AR, Lappi AK, Wang L, Raykhel IB, Alanen HI, Salo KE, Wang CC, Ruddock LW. | 06/18/2011 |