| Characteristics of autosomal dominant WFS1-associated optic neuropathy and its comparability to OPA1-associated autosomal dominant optic atrophy. | Characteristics of autosomal dominant WFS1-associated optic neuropathy and its comparability to OPA1-associated autosomal dominant optic atrophy.
de Muijnck C, Haer-Wigman L, van Everdingen JAM, Lushchyk T, Heutinck PAT, van Dooren MF, Kievit AJA, Verhoeven VJM, Simon MEH, Wasmann RA, Notting IC, De Baere E, Walraedt S, De Zaeytijd J, Van den Broeck F, Leroy BP, Boon CJF, van Genderen MM., Free PMC Article | 10/10/2024 |
| Drosophila model to clarify the pathological significance of OPA1 in autosomal dominant optic atrophy. | Drosophila model to clarify the pathological significance of OPA1 in autosomal dominant optic atrophy.
Nitta Y, Osaka J, Maki R, Hakeda-Suzuki S, Suzuki E, Ueki S, Suzuki T, Sugie A., Free PMC Article | 10/3/2024 |
| OPA1, a molecular regulator of dilated cardiomyopathy. | OPA1, a molecular regulator of dilated cardiomyopathy.
Chen J, Shao J, Wang Y, Wu K, Huang M., Free PMC Article | 10/2/2024 |
| OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response. | OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response.
Liang FG, Zandkarimi F, Lee J, Axelrod JL, Pekson R, Yoon Y, Stockwell BR, Kitsis RN., | 08/27/2024 |
| Melatonin Rescues Influenza A Virus-Induced Cellular Energy Exhaustion via OMA1-OPA1-S in Acute Exacerbation of COPD. | Melatonin Rescues Influenza A Virus-Induced Cellular Energy Exhaustion via OMA1-OPA1-S in Acute Exacerbation of COPD.
Wei YY, Ye JJ, Zhang DW, Hu L, Wu HM, Fei GH. | 07/23/2024 |
| OPA1 mutation affects autophagy and triggers senescence in autosomal dominant optic atrophy plus fibroblasts. | OPA1 mutation affects autophagy and triggers senescence in autosomal dominant optic atrophy plus fibroblasts.
Zanfardino P, Amati A, Doccini S, Cox SN, Tullo A, Longo G, D'Erchia A, Picardi E, Nesti C, Santorelli FM, Petruzzella V. | 05/9/2024 |
| Human Platelet Derived Mitochondrial OPA-1 Isoforms and Interaction With TDP-43 in Neurodegenerative Diseases. | Human Platelet Derived Mitochondrial OPA-1 Isoforms and Interaction With TDP-43 in Neurodegenerative Diseases.
Lee SH, Pham D, Kosa E, Agbas A., Free PMC Article | 04/17/2024 |
| p32/OPA1 axis-mediated mitochondrial dynamics contributes to cisplatin resistance in non-small cell lung cancer. | p32/OPA1 axis-mediated mitochondrial dynamics contributes to cisplatin resistance in non-small cell lung cancer.
Yu CX, Peng ZQ, Wang T, Qu XH, Yang P, Huang SR, Jiang LP, Tou FF, Han XJ., Free PMC Article | 02/5/2024 |
| Human retinal organoids with an OPA1 mutation are defective in retinal ganglion cell differentiation and function. | Human retinal organoids with an OPA1 mutation are defective in retinal ganglion cell differentiation and function.
Lei Q, Xiang K, Cheng L, Xiang M., Free PMC Article | 01/15/2024 |
| Role of mitochondrial fusion proteins MFN2 and OPA1 on lung cellular senescence in chronic obstructive pulmonary disease. | Role of mitochondrial fusion proteins MFN2 and OPA1 on lung cellular senescence in chronic obstructive pulmonary disease.
Li C, Liu Q, Chang Q, Xie M, Weng J, Wang X, Li M, Chen J, Huang Y, Yang X, Wang K, Zhang N, Chung KF, Adcock IM, Zhang H, Li F., Free PMC Article | 01/3/2024 |
| Multi-omics analysis of the oncogenic role of optic atrophy 1 in human cancer. | Multi-omics analysis of the oncogenic role of optic atrophy 1 in human cancer.
Wu Z, Xu N, Li G, Yang W, Zhang C, Zhong H, Wu G, Chen F, Li D., Free PMC Article | 12/15/2023 |
| BCL11B and the NuRD complex cooperatively guard T-cell fate and inhibit OPA1-mediated mitochondrial fusion in T cells. | BCL11B and the NuRD complex cooperatively guard T-cell fate and inhibit OPA1-mediated mitochondrial fusion in T cells.
Liao R, Wu Y, Qin L, Jiang Z, Gou S, Zhou L, Hong Q, Li Y, Shi J, Yao Y, Lai L, Li Y, Liu P, Thiery JP, Qin D, Graf T, Liu X, Li P., Free PMC Article | 11/8/2023 |
| OPA1 deficiency impairs oxidative metabolism in cycling cells, underlining a translational approach for degenerative diseases. | OPA1 deficiency impairs oxidative metabolism in cycling cells, underlining a translational approach for degenerative diseases.
Millet AMC, Coustham C, Champigny C, Botella M, Demeilliers C, Devin A, Galinier A, Belenguer P, Bordeneuve-Guibé J, Davezac N, Merabet N., Free PMC Article | 09/23/2023 |
| OPA1 helical structures give perspective to mitochondrial dysfunction. | OPA1 helical structures give perspective to mitochondrial dysfunction.
Nyenhuis SB, Wu X, Strub MP, Yim YI, Stanton AE, Baena V, Syed ZA, Canagarajah B, Hammer JA, Hinshaw JE. | 09/15/2023 |
| Structural mechanism of mitochondrial membrane remodelling by human OPA1. | Structural mechanism of mitochondrial membrane remodelling by human OPA1.
von der Malsburg A, Sapp GM, Zuccaro KE, von Appen A, Moss FR 3rd, Kalia R, Bennett JA, Abriata LA, Dal Peraro M, van der Laan M, Frost A, Aydin H., Free PMC Article | 09/14/2023 |
| Mitochondrial dynamics-related genes DRP1 and OPA1 contributes to early diagnosis of cognitive impairment in diabetes. | Mitochondrial dynamics-related genes DRP1 and OPA1 contributes to early diagnosis of cognitive impairment in diabetes.
Liu M, Gong C, Shen X, Jiang Y, Xu Y, Zhong W, Chen Y, Dong N, Liao J, Yin N., Free PMC Article | 08/16/2023 |
| [Research progress of optic atrophy 1-mediated mitochondrial dynamics in skeletal system diseases]. | [Research progress of optic atrophy 1-mediated mitochondrial dynamics in skeletal system diseases].
Sun K, Wu Y, Zeng Y, Li M, Wu L, Shen B., Free PMC Article | 06/23/2023 |
| Reduced OPA1, Mitochondrial Fragmentation and Increased Susceptibility to Apoptosis in Granular Corneal Dystrophy Type 2 Corneal Fibroblasts. | Reduced OPA1, Mitochondrial Fragmentation and Increased Susceptibility to Apoptosis in Granular Corneal Dystrophy Type 2 Corneal Fibroblasts.
Choi SI, Lee GH, Woo JH, Jun I, Kim EK., Free PMC Article | 04/14/2023 |
| OPA1 disease-causing mutants have domain-specific effects on mitochondrial ultrastructure and fusion. | OPA1 disease-causing mutants have domain-specific effects on mitochondrial ultrastructure and fusion.
Cartes-Saavedra B, Lagos D, Macuada J, Arancibia D, Burté F, Sjöberg-Herrera MK, Andrés ME, Horvath R, Yu-Wai-Man P, Hajnóczky G, Eisner V., Free PMC Article | 03/20/2023 |
| Mechanistic study of optic atrophy 1 in ischemia-reperfusion disease. | Mechanistic study of optic atrophy 1 in ischemia-reperfusion disease.
Yuan Y, Zhang XM. | 03/6/2023 |
| p53 Regulates Mitochondrial Dynamics in Vascular Smooth Muscle Cell Calcification. | p53 Regulates Mitochondrial Dynamics in Vascular Smooth Muscle Cell Calcification.
Phadwal K, Tang QY, Luijten I, Zhao JF, Corcoran B, Semple RK, Ganley IG, MacRae VE., Free PMC Article | 02/4/2023 |
| SIRT3 promotes metabolic maturation of human iPSC-derived cardiomyocytes via OPA1-controlled mitochondrial dynamics. | SIRT3 promotes metabolic maturation of human iPSC-derived cardiomyocytes via OPA1-controlled mitochondrial dynamics.
Wang R, Xu H, Tan B, Yi Q, Sun Y, Xiang H, Chen T, Liu H, Xie Q, Wang L, Tian J, Zhu J. | 01/21/2023 |
| Opa1 and Drp1 reciprocally regulate cristae morphology, ETC function, and NAD[+] regeneration in KRas-mutant lung adenocarcinoma. | Opa1 and Drp1 reciprocally regulate cristae morphology, ETC function, and NAD(+) regeneration in KRas-mutant lung adenocarcinoma.
Sessions DT, Kim KB, Kashatus JA, Churchill N, Park KS, Mayo MW, Sesaki H, Kashatus DF., Free PMC Article | 12/24/2022 |
| Modelling autosomal dominant optic atrophy associated with OPA1 variants in iPSC-derived retinal ganglion cells. | Modelling autosomal dominant optic atrophy associated with OPA1 variants in iPSC-derived retinal ganglion cells.
Sladen PE, Jovanovic K, Guarascio R, Ottaviani D, Salsbury G, Novoselova T, Chapple JP, Yu-Wai-Man P, Cheetham ME., Free PMC Article | 10/22/2022 |
| OPA1 regulation of mitochondrial dynamics in skeletal and cardiac muscle. | OPA1 regulation of mitochondrial dynamics in skeletal and cardiac muscle.
Noone J, O'Gorman DJ, Kenny HC. | 10/1/2022 |