| A human cancer cell line initiates DNA replication normally in the absence of ORC5 and ORC2 proteins. | A human cancer cell line initiates DNA replication normally in the absence of ORC5 and ORC2 proteins.
Shibata E, Dutta A., Free PMC Article | 04/13/2021 |
| The circ_ORC2 binds with miR-19a and enhances its expression, thereby inhibiting downstream PTEN expression and activating Akt pathway to promote osteosarcoma cell growth and invasion. | Circ_ORC2 enhances the regulatory effect of miR-19a on its target gene PTEN to affect osteosarcoma cell growth.
Li X, Sun XH, Xu HY, Pan HS, Liu Y, He L. | 07/25/2020 |
| The authors have discovered that human cell lines in culture proliferate with intact chromosomal origins of replication after disruption of both alleles of ORC2 or of the ATPase subunit, ORC1. | Two subunits of human ORC are dispensable for DNA replication and proliferation.
Shibata E, Kiran M, Shibata Y, Singh S, Kiran S, Dutta A., Free PMC Article | 11/4/2017 |
| the ORC2 complex with E2 restricts viral replication in the maintenance phase of the viral replication program | The Replicative Consequences of Papillomavirus E2 Protein Binding to the Origin Replication Factor ORC2.
DeSmet M, Kanginakudru S, Rietz A, Wu WH, Roden R, Androphy EJ., Free PMC Article | 05/20/2017 |
| ORC2 SUMOylation promotes recruitment of KDM5A to centromeres. | SUMOylated ORC2 Recruits a Histone Demethylase to Regulate Centromeric Histone Modification and Genomic Stability.
Huang C, Cheng J, Bawa-Khalfe T, Yao X, Chin YE, Yeh ETH. | 12/24/2016 |
| Protein phosphatase 1 dephosphorylates Orc2 to promote the binding of ORC to chromatin and replication origins for the subsequent round of the cell cycle. | Dephosphorylation of Orc2 by protein phosphatase 1 promotes the binding of the origin recognition complex to chromatin.
Lee KY, Bae JS, Yoon S, Hwang DS. | 08/16/2014 |
| These results suggest that PP1 dephosphorylates Orc2 to promote the binding of ORC to chromatin. | Protein phosphatase 1 dephosphorylates Orc2.
Lee KY, Bae JS, Kim GS, Hwang DS. | 08/9/2014 |
| Gemcitabine resistance is dependent on Plk1-mediated phosphorylation of Orc2 and Hbo1. | Plk1 phosphorylation of orc2 and hbo1 contributes to gemcitabine resistance in pancreatic cancer.
Song B, Liu XS, Rice SJ, Kuang S, Elzey BD, Konieczny SF, Ratliff TL, Hazbun T, Chiorean EG, Liu X., Free PMC Article | 06/29/2013 |
| Orc2 protects ORCA from ubiquitin-mediated degradation in vivo. | Orc2 protects ORCA from ubiquitin-mediated degradation.
Shen Z, Prasanth SG., Free PMC Article | 03/2/2013 |
| The phosphorylation of ORC2 dissociates origin recognition complex (ORC) from chromatin and replication origins and inhibits binding of ORC to newly replicated DNA. | Phosphorylation of ORC2 protein dissociates origin recognition complex from chromatin and replication origins.
Lee KY, Bang SW, Yoon SW, Lee SH, Yoon JB, Hwang DS., Free PMC Article | 06/9/2012 |
| Plk1 phosphorylation of Orc2 promotes DNA replication under conditions of stress | Plk1 phosphorylation of Orc2 promotes DNA replication under conditions of stress.
Song B, Liu XS, Davis K, Liu X., Free PMC Article | 12/31/2011 |
| ORC2 physically interacts with ORC1 on non-chromatin nuclear structures | Nuclear organization of DNA replication initiation proteins in mammalian cells.
Fujita M, Ishimi Y, Nakamura H, Kiyono T, Tsurumi T. | 01/21/2010 |
| Study using HCT116 haplo-insufficient cells and Orc2 hypomorphic cells demonstrates that human Ku80 and Orc2 bind to replication origins independently of each other. | Ku80 binds to human replication origins prior to the assembly of the ORC complex.
Sibani S, Price GB, Zannis-Hadjopoulos M. | 01/21/2010 |
| The low level of Orc2 in Orc2 hypomorphic cells hinders normal cell cycle progression by delaying the activation of G1 cyclin-dependent kinases. | Proliferating human cells hypomorphic for origin recognition complex 2 and pre-replicative complex formation have a defect in p53 activation and Cdk2 kinase activation.
Teer JK, Machida YJ, Labit H, Novac O, Hyrien O, Marheineke K, Zannis-Hadjopoulos M, Dutta A. | 01/21/2010 |
| The precise nucleotide of binding for ORC2 was identified near the stgart site for leading-strand synthesis; the transition to the post-replicative complex is accompanied by a 17 bp displacement of ORC2 towards the start site. | Localization of proteins bound to a replication origin of human DNA along the cell cycle.
Abdurashidova G, Danailov MB, Ochem A, Triolo G, Djeliova V, Radulescu S, Vindigni A, Riva S, Falaschi A., Free PMC Article | 01/21/2010 |
| the human origin recognition complex has a role in sequence-independent DNA binding and replication initiation | Sequence-independent DNA binding and replication initiation by the human origin recognition complex.
Vashee S, Cvetic C, Lu W, Simancek P, Kelly TJ, Walter JC., Free PMC Article | 01/21/2010 |
| human Orc2 has specific domains that are required in vivo for assembly and nuclear localization of the origin recognition complex | Genetic analysis of human Orc2 reveals specific domains that are required in vivo for assembly and nuclear localization of the origin recognition complex.
Radichev I, Kwon SW, Zhao Y, DePamphilis ML, Vassilev A. | 01/21/2010 |