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    P2RX7 purinergic receptor P2X 7 [ Homo sapiens (human) ]

    Gene ID: 5027, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    P2X7 Variants in Pathophysiology.

    P2X7 Variants in Pathophysiology.
    Pegoraro A, Grignolo M, Ruo L, Ricci L, Adinolfi E., Free PMC Article

    11/7/2024
    Inhibition of P2RX7 contributes to cytotoxicity by suppression of glycolysis and AKT activation in human hepatocellular carcinoma.

    Inhibition of P2RX7 contributes to cytotoxicity by suppression of glycolysis and AKT activation in human hepatocellular carcinoma.
    Yang JK, Kim J, Ahn YH, Bae SH, Baek MJ, Lee SH, Moon JS., Free PMC Article

    11/6/2024
    Functional expression of the ATP-gated P2X7 receptor in human iPSC-derived astrocytes.

    Functional expression of the ATP-gated P2X7 receptor in human iPSC-derived astrocytes.
    Kesavan J, Watters O, de Diego-Garcia L, Méndez AM, Alves M, Dinkel K, Hamacher M, Prehn JHM, Henshall DC, Engel T., Free PMC Article

    10/23/2024
    Potential role of the P2X7 receptor in the proliferation of human diffused large B-cell lymphoma.

    Potential role of the P2X7 receptor in the proliferation of human diffused large B-cell lymphoma.
    Yang X, Ji Y, Mei L, Jing W, Yang X, Liu Q., Free PMC Article

    10/23/2024
    Increased concentrations of P2X7R in oligodendrocyte derived extracellular vesicles of Multiple sclerosis patients.

    Increased concentrations of P2X7R in oligodendrocyte derived extracellular vesicles of Multiple sclerosis patients.
    Agliardi C, Guerini FR, Zanzottera M, Bolognesi E, Caputo D, Rovaris M, Clerici M.

    09/5/2024
    P2X7R Modulates NEK7-NLRP3 Interaction to Exacerbate Experimental Autoimmune Prostatitis via GSDMD-mediated Prostate Epithelial Cell Pyroptosis.

    P2X7R Modulates NEK7-NLRP3 Interaction to Exacerbate Experimental Autoimmune Prostatitis via GSDMD-mediated Prostate Epithelial Cell Pyroptosis.
    Chen L, Liu Y, Yue S, Wang H, Chen J, Ma W, Xu W, Xu M, Chen Z, Chen X, Zhang L, Liang C., Free PMC Article

    07/18/2024
    Extracellular ATP/P2X7 receptor, a regulatory axis of migration in ovarian carcinoma-derived cells.

    Extracellular ATP/P2X7 receptor, a regulatory axis of migration in ovarian carcinoma-derived cells.
    Nuñez-Ríos JD, Reyna-Jeldes M, Mata-Martínez E, Campos-Contreras ADR, Lazcano-Sánchez I, González-Gallardo A, Díaz-Muñoz M, Coddou C, Vázquez-Cuevas FG., Free PMC Article

    06/26/2024
    Genetic Polymorphisms of P2RX7 but Not of ADORA2A Are Associated with the Severity of SARS-CoV-2 Infection.

    Genetic Polymorphisms of P2RX7 but Not of ADORA2A Are Associated with the Severity of SARS-CoV-2 Infection.
    Lindo J, Nogueira C, Soares R, Cunha N, Almeida MR, Rodrigues L, Coelho P, Rodrigues F, Cunha RA, Gonçalves T., Free PMC Article

    06/24/2024
    P2RX7 gene variants associate with altered inflammasome assembly and reduced pyroptosis in chronic nonbacterial osteomyelitis (CNO).

    P2RX7 gene variants associate with altered inflammasome assembly and reduced pyroptosis in chronic nonbacterial osteomyelitis (CNO).
    Charras A, Hofmann SR, Cox A, Schulze F, Russ S, Northey S, Liu X, Fang Y, Haldenby S, Hartmann H, Bassuk AG, Carvalho A, Sposito F, Grinstein L, Rösen-Wolff A, Meyer-Bahlburg A, Beresford MW, Lainka E, Foell D, Wittkowski H, Girschick HJ, Morbach H, Uebe S, Hüffmeier U, Ferguson PJ, Hedrich CM.

    05/6/2024
    The impact of the P2X7 receptor on the tumor immune microenvironment and its effects on tumor progression.

    The impact of the P2X7 receptor on the tumor immune microenvironment and its effects on tumor progression.
    Zou YT, Li JY, Chai JY, Hu YS, Zhang WJ, Zhang Q.

    04/10/2024
    P2X7 Receptor in Dendritic Cells and Macrophages: Implications in Antigen Presentation and T Lymphocyte Activation.

    P2X7 Receptor in Dendritic Cells and Macrophages: Implications in Antigen Presentation and T Lymphocyte Activation.
    Acuña-Castillo C, Escobar A, García-Gómez M, Bachelet VC, Huidobro-Toro JP, Sauma D, Barrera-Avalos C., Free PMC Article

    03/14/2024
    Sex-dependent expression levels of VAV1 and P2X7 in PBMC of multiple sclerosis patients.

    Sex-dependent expression levels of VAV1 and P2X7 in PBMC of multiple sclerosis patients.
    Rump A, Ratas K, Lepasepp TK, Suurväli J, Smolander OP, Gross-Paju K, Toomsoo T, Kanellopoulos J, Rüütel Boudinot S.

    03/6/2024
    P2X7R influences tau aggregate burden in human tauopathies and shows distinct signalling in microglia and astrocytes.

    P2X(7)R influences tau aggregate burden in human tauopathies and shows distinct signalling in microglia and astrocytes.
    Beltran-Lobo P, Hughes MM, Troakes C, Croft CL, Rupawala H, Jutzi D, Ruepp MD, Jimenez-Sanchez M, Perkinton MS, Kassiou M, Golde TE, Hanger DP, Verkhratsky A, Perez-Nievas BG, Noble W., Free PMC Article

    03/4/2024
    P2X7 Receptor-Induced Human Mast Cell Degranulation Is Enhanced by Interleukin 33.

    P2X7 Receptor-Induced Human Mast Cell Degranulation Is Enhanced by Interleukin 33.
    Salcman B, Bahri R, West PW, Tontini C, Affleck K, Bulfone-Paus S., Free PMC Article

    02/23/2024
    Embers of the Past: Early Childhood Traumas Interact with Variation in P2RX7 Gene Implicated in Neuroinflammation on Markers of Current Suicide Risk.

    Embers of the Past: Early Childhood Traumas Interact with Variation in P2RX7 Gene Implicated in Neuroinflammation on Markers of Current Suicide Risk.
    Kristof Z, Gal Z, Torok D, Eszlari N, Sutori S, Sperlagh B, Anderson IM, Deakin B, Bagdy G, Juhasz G, Gonda X., Free PMC Article

    02/1/2024
    The P2X7 receptor in mucosal adaptive immunity.

    The P2X7 receptor in mucosal adaptive immunity.
    Grassi F, Marino R., Free PMC Article

    02/1/2024
    Characterization of Common Genetic Variants in P2RX7 and Their Contribution to Chronic Pain Conditions.

    Characterization of Common Genetic Variants in P2RX7 and Their Contribution to Chronic Pain Conditions.
    Zorina-Lichtenwalter K, Ase AR, Verma V, Parra AIM, Komarova S, Khadra A, Séguéla P, Diatchenko L.

    01/30/2024
    P2X7 receptor promotes migration and invasion of non-small cell lung cancer A549 cells through the PI3K/Akt pathways.

    P2X7 receptor promotes migration and invasion of non-small cell lung cancer A549 cells through the PI3K/Akt pathways.
    Bai X, Li Q, Peng X, Li X, Qiao C, Tang Y, Zhao R., Free PMC Article

    01/5/2024
    Purinergic P2X7 receptor expression increases in leukocytes from intra-abdominal septic patients.

    Purinergic P2X7 receptor expression increases in leukocytes from intra-abdominal septic patients.
    Martínez-Banaclocha H, García-Palenciano C, Martínez-Alarcón L, Amores-Iniesta J, Martín-Sánchez F, Ercole GA, González-Lisorge A, Fernández-Pacheco J, Martínez-Gil P, Padilla-Rodríguez J, Baroja-Mazo A, Pelegrín P, Martínez-García JJ., Free PMC Article

    12/20/2023
    P2X7 receptor activation leads to NLRP3-independent IL-1beta release by human macrophages.

    P2X7 receptor activation leads to NLRP3-independent IL-1β release by human macrophages.
    Bockstiegel J, Engelhardt J, Weindl G., Free PMC Article

    11/28/2023
    Purinergic receptor P2X7 activates NOX2/JNK signaling to participate in granulosa cell inflammation and apoptosis in polycystic ovary syndrome.

    Purinergic receptor P2X7 activates NOX2/JNK signaling to participate in granulosa cell inflammation and apoptosis in polycystic ovary syndrome.
    Shen C, Jiang Y, Lin J, He Y, Liu Y, Fang D.

    09/15/2023
    P2X7 Receptor Regulates Collagen Expression in Human Intestinal Fibroblasts: Relevance in Intestinal Fibrosis.

    P2X7 Receptor Regulates Collagen Expression in Human Intestinal Fibroblasts: Relevance in Intestinal Fibrosis.
    Lis-López L, Bauset C, Seco-Cervera M, Macias-Ceja D, Navarro F, Álvarez Á, Esplugues JV, Calatayud S, Barrachina MD, Ortiz-Masià D, Cosín-Roger J., Free PMC Article

    08/31/2023
    The functional change of the P2X7R containing the Ala[348] to Thr polymorphism is associated with the pathogenesis of gout.

    The functional change of the P2X7R containing the Ala(348) to Thr polymorphism is associated with the pathogenesis of gout.
    Li MY, Fang X, Ma Y, Pan XY, Dai XJ, Li XM, Li XL, Wang YP, Tao JH, Li XP., Free PMC Article

    08/10/2023
    Expression in skin biopsies supports genetic evidence linking CAMKK2, P2X7R and P2X4R with HIV-associated sensory neuropathy.

    Expression in skin biopsies supports genetic evidence linking CAMKK2, P2X7R and P2X4R with HIV-associated sensory neuropathy.
    Gaff J, Octaviana F, Jackaman C, Kamerman P, Papadimitriou J, Lee S, Mountford J, Price P., Free PMC Article

    08/10/2023
    The P2X7 Receptor, a Multifaceted Receptor in Alzheimer's Disease.

    The P2X7 Receptor, a Multifaceted Receptor in Alzheimer's Disease.
    Ronning KE, Déchelle-Marquet PA, Che Y, Guillonneau X, Sennlaub F, Delarasse C., Free PMC Article

    08/3/2023
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