| Prokineticin 2 is a catabolic regulator of osteoarthritic cartilage destruction in mouse. | Prokineticin 2 is a catabolic regulator of osteoarthritic cartilage destruction in mouse.
Yang J, Shin Y, Kim HJ, Kim HE, Chun JS., Free PMC Article | 01/31/2024 |
| Single-cell transcriptomics of suprachiasmatic nuclei reveal a Prokineticin-driven circadian network. | Single-cell transcriptomics of suprachiasmatic nuclei reveal a Prokineticin-driven circadian network.
Morris EL, Patton AP, Chesham JE, Crisp A, Adamson A, Hastings MH., Free PMC Article | 12/18/2021 |
| Prokineticin-2 prevents neuronal cell deaths in a model of traumatic brain injury. | Prokineticin-2 prevents neuronal cell deaths in a model of traumatic brain injury.
Bao Z, Liu Y, Chen B, Miao Z, Tu Y, Li C, Chao H, Ye Y, Xu X, Sun G, Zhao P, Liu N, Liu Y, Wang X, Lam SM, Kagan VE, Bayır H, Ji J., Free PMC Article | 07/24/2021 |
| The PROK2/PROKR2 signaling pathway is required for the migration of most olfactory bulb interneurons. | The PROK2/PROKR2 signaling pathway is required for the migration of most olfactory bulb interneurons.
Wen Y, Zhang Z, Li Z, Liu G, Tao G, Song X, Xu Z, Shang Z, Guo T, Su Z, Chen H, You Y, Li J, Yang Z. | 10/10/2020 |
| Prokineticin 2 promotes and sustains neuroinflammation in vincristine treated mice: Focus on pain and emotional like behavior. | Prokineticin 2 promotes and sustains neuroinflammation in vincristine treated mice: Focus on pain and emotional like behavior.
Moschetti G, Amodeo G, Paladini MS, Molteni R, Balboni G, Panerai A, Sacerdote P, Franchi S. | 09/19/2020 |
| We demonstrated a significant upregulation of PROK2 levels in brain tissues of Abeta1-42 i.c.v. injected rats, transgenic AD mice (Tg2576), and in the hippocampus of AD patients. Additionally, through a pilot study, an approximate twofold increase of PROK2 levels has been proved in the serum of AD patients, compared to the control subjects, identifying a potential blood-based biomarker of the disease. | Involvement of the Chemokine Prokineticin-2 (PROK2) in Alzheimer's Disease: From Animal Models to the Human Pathology.
Lattanzi R, Maftei D, Petrella C, Pieri M, Sancesario G, Schirinzi T, Bernardini S, Barbato C, Ralli M, Greco A, Possenti R, Sancesario G, Severini C., Free PMC Article | 07/11/2020 |
| Prok2-shRNA injection resulted in a higher dietary consumption characterized by increased feeding frequency and decreased meal size. Additionally, Prok2 underexpression in the main olfactory bulb induced insulin resistance compared to scrambled shRNA-injected mice. | New roles for prokineticin 2 in feeding behavior, insulin resistance and type 2 diabetes: Studies in mice and humans.
Mortreux M, Foppen E, Denis RG, Montaner M, Kassis N, Denom J, Vincent M, Fumeron F, Kujawski-Lafourcade M, Andréelli F, Balkau B, Marre M, Roussel R, Magnan C, Gurden H, Migrenne-Li S., Free PMC Article | 05/30/2020 |
| TBX20 is a novel transcription factor regulating angiogenesis through the PROK2-PROKR1 (prokineticin receptor 1) pathway in both development and disease. | TBX20 Regulates Angiogenesis Through the Prokineticin 2-Prokineticin Receptor 1 Pathway.
Meng S, Gu Q, Yang X, Lv J, Owusu I, Matrone G, Chen K, Cooke JP, Fang L., Free PMC Article | 09/28/2019 |
| demonstrate that cells expressing PROK2 in vitro directionally attract subventricular zone cells | A new function for Prokineticin 2: Recruitment of SVZ-derived neuroblasts to the injured cortex in a mouse model of traumatic brain injury.
Mundim MV, Zamproni LN, Pinto AAS, Galindo LT, Xavier AM, Glezer I, Porcionatto M. | 04/20/2019 |
| Results reveal that PK2 regulates a novel neuron-astrocyte signaling mechanism by promoting an alternative A2 protective phenotype in astrocytes. PK2-induced astrocyte reactivity leads to an increase in antioxidant and anti-inflammatory proteins while increasing glutamate uptake, along with decreased inflammatory factors. | Prokineticin-2 promotes chemotaxis and alternative A2 reactivity of astrocytes.
Neal M, Luo J, Harischandra DS, Gordon R, Sarkar S, Jin H, Anantharam V, Désaubry L, Kanthasamy A, Kanthasamy A., Free PMC Article | 03/23/2019 |
| The study shows that PK2beta ligand, a splice variant of prokineticin 2, is able to modulate and drive signaling through prokineticin receptor 1. | PK2β ligand, a splice variant of prokineticin 2, is able to modulate and drive signaling through PKR1 receptor.
Lattanzi R, Maftei D, Negri L, Fusco I, Miele R. | 11/17/2018 |
| Prokineticin-2 is upregulated during neuronal injury, and it mediates a compensatory protective response against dopaminergic neuronal degeneration | Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration.
Gordon R, Neal ML, Luo J, Langley MR, Harischandra DS, Panicker N, Charli A, Jin H, Anantharam V, Woodruff TM, Zhou QY, Kanthasamy AG, Kanthasamy A., Free PMC Article | 09/15/2018 |
| mammalian diurnality or nocturnality is likely determined by the differential signaling of prokineticin 2 from the intrinsically photosensitive retinal ganglion cells onto their retinorecipient brain targets. | Differential arousal regulation by prokineticin 2 signaling in the nocturnal mouse and the diurnal monkey.
Zhou QY, Burton KJ, Neal ML, Qiao Y, Kanthasamy AG, Sun Y, Xu X, Ma Y, Li X., Free PMC Article | 11/11/2017 |
| In mouse models, PK2 over-expression aggravated psoriasis while its knock-down inhibited pathological development. The results indicate that PK2 over-production perpetuates psoriatic symptoms by creating PK-2-IL-1 vicious loop. PK2 is a central player in psoriasis and a promising psoriasis-specific target. | Prokineticin 2 Plays a Pivotal Role in Psoriasis.
He X, Shen C, Lu Q, Li J, Wei Y, He L, Bai R, Zheng J, Luan N, Zhang Z, Rong M, Lai R., Free PMC Article | 02/18/2017 |
| PROK2 plays a role in cerebral amyloidosis and that PROK2 antagonists may represent a new approach for ameliorating the defining pathology of AD. | Bv8/prokineticin 2 is involved in Aβ-induced neurotoxicity.
Severini C, Lattanzi R, Maftei D, Marconi V, Ciotti MT, Petrocchi Passeri P, Florenzano F, Del Duca E, Caioli S, Zona C, Balboni G, Salvadori S, Nisticò R, Negri L., Free PMC Article | 08/20/2016 |
| Data show that the prokineticins and their receptors PROK2, PKR1 and PKR2 contributes to altered sensitivity in diabetic neuropathy and its inhibition blocked both allodynia and inflammatory events underlying disease. | Antagonism of the Prokineticin System Prevents and Reverses Allodynia and Inflammation in a Mouse Model of Diabetes.
Castelli M, Amodeo G, Negri L, Lattanzi R, Maftei D, Gotti C, Pistillo F, Onnis V, Congu C, Panerai AE, Sacerdote P, Franchi S., Free PMC Article | 08/13/2016 |
| These findings suggest that PROK2 plays a crucial role in neuropathic pain and might represent a novel target of treatment for this disease. | Prokineticin 2 upregulation in the peripheral nervous system has a major role in triggering and maintaining neuropathic pain in the chronic constriction injury model.
Lattanzi R, Maftei D, Marconi V, Florenzano F, Franchi S, Borsani E, Rodella LF, Balboni G, Salvadori S, Sacerdote P, Negri L., Free PMC Article | 11/14/2015 |
| Controlling the activation of the Bv8/prokineticin system reduces neuroinflammation and abolishes thermal and tactile hyperalgesia in neuropathic animals | Controlling the activation of the Bv8/prokineticin system reduces neuroinflammation and abolishes thermal and tactile hyperalgesia in neuropathic animals.
Maftei D, Marconi V, Florenzano F, Giancotti LA, Castelli M, Moretti S, Borsani E, Rodella LF, Balboni G, Luongo L, Maione S, Sacerdote P, Negri L, Lattanzi R., Free PMC Article | 06/27/2015 |
| PK2 plays an important role in energy intake and expenditure. | Prokineticin 2 is involved in the thermoregulation and energy expenditure.
Zhou W, Li JD, Hu WP, Cheng MY, Zhou QY. | 03/23/2013 |
| Induction of Bv8 expression by granulocyte colony-stimulating factor in CD11b+Gr1+ cells: key role of Stat3 signaling. | Induction of Bv8 expression by granulocyte colony-stimulating factor in CD11b+Gr1+ cells: key role of Stat3 signaling.
Qu X, Zhuang G, Yu L, Meng G, Ferrara N., Free PMC Article | 08/25/2012 |
| Data suggest that elevated prokineticin 2 levels, as a consequence of gastrointestinal tract inflammation, induce visceral pain via prokineticin receptors. | Increased prokineticin 2 expression in gut inflammation: role in visceral pain and intestinal ion transport.
Watson RP, Lilley E, Panesar M, Bhalay G, Langridge S, Tian SS, McClenaghan C, Ropenga A, Zeng F, Nash MS. | 04/14/2012 |
| Intracerebroventricular administration of PK2 affects regulation of food intake. | Prokineticin 2 is a hypothalamic neuropeptide that potently inhibits food intake.
Gardiner JV, Bataveljic A, Patel NA, Bewick GA, Roy D, Campbell D, Greenwood HC, Murphy KG, Hameed S, Jethwa PH, Ebling FJ, Vickers SP, Cheetham S, Ghatei MA, Bloom SR, Dhillo WS., Free PMC Article | 03/1/2010 |
| Data show that the inflammation-induced up-regulation of PK2 was significantly less in pkr1 null mice than in WT and pkr2 null mice, demonstrating a role of PKR1 in setting PK2 levels during inflammation. | The chemokine Bv8/prokineticin 2 is up-regulated in inflammatory granulocytes and modulates inflammatory pain.
Giannini E, Lattanzi R, Nicotra A, Campese AF, Grazioli P, Screpanti I, Balboni G, Salvadori S, Sacerdote P, Negri L., Free PMC Article | 01/21/2010 |
| Bv8 was elevated in the synovium and bone marrow of CIA mice, suggesting that Bv8 plays an important role in the pathogenesis of arthritis. | Elevation of Bombina variegata peptide 8 in mice with collagen-induced arthritis.
Kurosaka D, Noda K, Yoshida K, Furuya K, Ukichi T, Takahashi E, Yanagimachi M, Kingetsu I, Saito S, Yamada A., Free PMC Article | 01/21/2010 |
| study indicates that PK2 signaling plays a critical role in the stress-related traits in mice, and establish a possible molecular link between circadian rhythms and mood regulation | Disruption of the circadian output molecule prokineticin 2 results in anxiolytic and antidepressant-like effects in mice.
Li JD, Hu WP, Zhou QY., Free PMC Article | 01/21/2010 |