| MiR-125b aggregates osteoporosis in postmenopausal rats via targeting Smad4. | MiR-125b aggregates osteoporosis in postmenopausal rats via targeting Smad4.
Wang Z, Chen Q, Yang Z, Long R. | 01/28/2023 |
| The results showed that Bcl6 overexpression induced decreased proliferation and reduced activation of fibroblasts which were stimulated with TGFb1. It was found that activated smad2 and smad3 were not changed by overexpressing Bcl6, but smad4 was decreased. | Bcl6 Suppresses Cardiac Fibroblast Activation and Function via Directly Binding to Smad4.
Ni J, Wu QQ, Liao HH, Fan D, Tang QZ. | 12/28/2019 |
| Synergistic effects may exist among Smad4, Smad7 and caveolin-1 in carcinogenesis of oral cancer. | [Significance of Smad4, Smad7 and Caveolin-1 expression in oral mucosa carcinogenesis of Wistar rats].
Li Y, Zhou JW, Li HL, Liu JZ. | 02/16/2019 |
| This study identified a novel role of Smad4 SUMOylation and TPM2 in learning and memory formation. These results suggest that patients with skeletal myopathies who carry the TPM2E122K mutation may also have deficits in learning and memory functions. | Smad4 SUMOylation is essential for memory formation through upregulation of the skeletal myopathy gene TPM2.
Hsu WL, Ma YL, Liu YC, Lee EHY., Free PMC Article | 06/30/2018 |
| The results demonstrate that miR124 upregulation inhibits the growth of C6 glioma cells by targeting Smad4 directly. | MicroRNA-124 inhibits the proliferation of C6 glioma cells by targeting Smad4.
Zhang Z, Gong Q, Li M, Xu J, Zheng Y, Ge P, Chi G. | 05/19/2018 |
| Smad4-dependent TGF-beta signaling in smooth muscle cells protects against aortic aneurysm formation and dissection. | Smad4 Deficiency in Smooth Muscle Cells Initiates the Formation of Aortic Aneurysm.
Zhang P, Hou S, Chen J, Zhang J, Lin F, Ju R, Cheng X, Ma X, Song Y, Zhang Y, Zhu M, Du J, Lan Y, Yang X. | 07/2/2016 |
| These results suggest that high glucose may activate TGF- beta/Smad signaling through sumoylation of Samd4 by SUMO2/3 in mesangial cells. | High glucose induces sumoylation of Smad4 via SUMO2/3 in mesangial cells.
Zhou X, Gao C, Huang W, Yang M, Chen G, Jiang L, Gou F, Feng H, Ai N, Xu Y., Free PMC Article | 09/12/2015 |
| It is a one of fibrotic genes in kidney fibrosis. | Melittin inhibits TGF-β-induced pro-fibrotic gene expression through the suppression of the TGFβRII-Smad, ERK1/2 and JNK-mediated signaling pathway.
Park SH, Cho HJ, Jeong YJ, Shin JM, Kang JH, Park KK, Choe JY, Park YY, Bae YS, Han SM, Moon SK, Kim WJ, Choi YH, Chang YC. | 04/4/2015 |
| The data indicated that inhibition of Smad4 diminished both AdBMP2 induced and basal histone acetylation levels in the promoter regions of GATA4 and Nkx2.5. | Smad4 mediated BMP2 signal is essential for the regulation of GATA4 and Nkx2.5 by affecting the histone H3 acetylation in H9c2 cells.
Si L, Shi J, Gao W, Zheng M, Liu L, Zhu J, Tian J. | 09/27/2014 |
| miR-146a is overexpressed in an experimentally induced osteoarthritis model, accompanied by upregulation of VEGF and downregulation of Smad4 in vivo | miR-146a, an IL-1β responsive miRNA, induces vascular endothelial growth factor and chondrocyte apoptosis by targeting Smad4.
Li J, Huang J, Dai L, Yu D, Chen Q, Zhang X, Dai K., Free PMC Article | 05/25/2013 |
| Bioinformatics analyses predict that Smad4 is the potential target of miR-146a. | MicroRNA-146a modulates TGF-beta1-induced hepatic stellate cell proliferation by targeting SMAD4.
He Y, Huang C, Sun X, Long XR, Lv XW, Li J. | 11/24/2012 |
| MicroRNA mimics, inhibitors and siRNA studies indicate the role of SMAD4 as inhibitory for glucose transport activities in normal physiological condition. | MicroRNAs overexpressed in growth-restricted rat skeletal muscles regulate the glucose transport in cell culture targeting central TGF-β factor SMAD4.
Raychaudhuri S., Free PMC Article | 10/20/2012 |
| Schisandrin B can reduce pulmonary fibrosis induced by SiO2 through inhibition of mRNA expression of TGF-beta1 and Smad4 in the lung tissue. | [Effect of schisandrin B on lung mRNA expression of transforming growth factor-beta1 signal transduction molecule in rat lungs exposed to silica].
Fan LH, Liu TF, Guo M, Liu ML, Wang ZP, Si SJ. | 09/15/2012 |
| CRMP2 suppression by BMP2, BMP4, SMAD1 and SMAD4 gradient signaling controls multiple stages of neuronal development | The suppression of CRMP2 expression by bone morphogenetic protein (BMP)-SMAD gradient signaling controls multiple stages of neuronal development.
Sun Y, Fei T, Yang T, Zhang F, Chen YG, Li H, Xu Z., Free PMC Article | 01/15/2011 |
| TGF-beta1 and Smad4 may be involved in the pathogenesis of chronic nonbacterial prostatitis. | [Expressions of transforming growth factor-beta(1) and Smad4 in rat models of chronic nonbacterial prostatitis and their clinical significance].
Wang YM, Lu SL, Zhao ZQ, Zhao YH, Wang N, Jing DS, Dong YC. | 10/23/2010 |
| The results showed that the protein of Smad4 was present in rats from 3 days of age to adulthood, and the immunoreactivity for Smad4 was exclusively localized to the cytoplasm of Leydig cells with negative nuclei in the interstitial tissue. | [Location studies of Smad4 protein in the rat testis during postnatal development].
Zhang YQ, Hu J, Liu XP, Wang RA, Xu RJ. | 06/14/2010 |
| Data show that SMAD4 triggers the transition from hypertrophy to apoptosis in ventricular cardiomyocytes, and suggest that it may trigger apoptosis induction and therefore contributes to negative remodeling and heart failure progression. | SMAD-proteins as a molecular switch from hypertrophy to apoptosis induction in adult ventricular cardiomyocytes.
Heger J, Peters SC, Piper HM, Euler G. | 01/21/2010 |
| results suggest that Smad2 and SMAD4 proteins are involved in the tissue remodeling of cycling and pregnant rat uteri and transforming growth factor-beta signaling functions | Expression of Smad2 and Smad4, transforming growth factor-beta signal transducers in rat endometrium during the estrous cycle, pre-, and peri-implantation.
Lin HY, Wang HM, Li QL, Liu DL, Zhang X, Liu GY, Qian D, Zhu C. | 01/21/2010 |
| results suggest involvement in downstream cellular processes mediated by cellular polyamines, and that increased TGF-beta/TGF-beta receptor signaling after polyamine depletion activates Smads, resulting in stimulation of Smad target gene expression | Activation of TGF-beta-Smad signaling pathway following polyamine depletion in intestinal epithelial cells.
Liu L, Santora R, Rao JN, Guo X, Zou T, Zhang HM, Turner DJ, Wang JY. | 01/21/2010 |
| TGR1, Smad2, Smad4 and Smad7 might have roles in progression of rat preneoplastic lesions during chemical hepatocarcinogenesis | Expression and localization of the transforming growth factor-beta type I receptor and Smads in preneoplastic lesions during chemical hepatocarcinogenesis in rats.
Park DY, Lee CH, Sol MY, Suh KS, Yoon SY, Kim JW., Free PMC Article | 01/21/2010 |
| Expression of BMP receptors Ib and II, and Smad 4 was downregulated in lungs but not kidneys of MCT-treated rats. | Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertension.
Morty RE, Nejman B, Kwapiszewska G, Hecker M, Zakrzewicz A, Kouri FM, Peters DM, Dumitrascu R, Seeger W, Knaus P, Schermuly RT, Eickelberg O. | 01/21/2010 |
| The more serious the hepatic fibrosis is in the injured liver, the higher the level of Smad2 and Smad4 gene expression is during and after fibrogenesis respectively. | Expression and location of Smad2, 4 mRNAs during and after liver fibrogenesis of rats.
Liu Y, Wang LF, Zou HF, Song XY, Xu HF, Lin P, Zheng HH, Yu XG., Free PMC Article | 01/21/2010 |