| PAK3 Exacerbates Cardiac Lipotoxicity via SREBP1c in Obesity Cardiomyopathy. | PAK3 Exacerbates Cardiac Lipotoxicity via SREBP1c in Obesity Cardiomyopathy.
Chen X, Ruiz-Velasco A, Zou Z, Hille SS, Ross C, Fonseka O, Gare SR, Alatawi NHO, Raja R, Zhang J, Kaur N, Zhao X, Morrell-Davies H, Miller JM, Abouleisa RRE, Ou Q, Frank D, Rutter MK, Pinali C, Wang T, Mohamed TMA, Müller OJ, Liu W., | 10/30/2024 |
| Porocarcinomas with PAK1/2/3 fusions: a series of 12 cases. | Porocarcinomas with PAK1/2/3 fusions: a series of 12 cases.
Kervarrec T, Westphal D, Pissaloux D, Legrand M, Tirode F, Neuhart A, Drouot F, Becker JC, Macagno N, Seris A, Jouary T, Beltzung F, Jullie ML, Harms PW, Cribier B, Mourah S, Jouenne F, Fromont G, Louveau B, Mancini M, Kazakov DV, de la Fouchardière A, Battistella M. | 09/6/2024 |
| PAK3 is a key signature gene of the glioma proneural subtype and affects its proliferation, differentiation and growth. | PAK3 is a key signature gene of the glioma proneural subtype and affects its proliferation, differentiation and growth.
Magne N, Rousseau V, Duarte K, Poëa-Guyon S, Gleize V, Mutel A, Schmitt C, Castel H, Idbaih A, Huillard E, Sanson M, Barnier JV. | 03/12/2022 |
| The intellectual disability PAK3 R67C mutation impacts cognitive functions and adult hippocampal neurogenesis. | The intellectual disability PAK3 R67C mutation impacts cognitive functions and adult hippocampal neurogenesis.
Castillon C, Gonzalez L, Domenichini F, Guyon S, Da Silva K, Durand C, Lestaevel P, Vaillend C, Laroche S, Barnier JV, Poirier R. | 08/28/2021 |
| Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation. | Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation.
Tan X, Tong L, Li L, Xu J, Xie S, Ji L, Fu J, Liu Q, Shen S, Liu Y, Xiao Y, Gao F, Moses RE, Bardeesy N, Wang Y, Zhang J, Tang L, Li L, Wong KK, Song D, Yang X, Liu J, Li X., Free PMC Article | 08/28/2021 |
| Prognostic significance of PAK family kinases in acute myeloid leukemia. | Prognostic significance of PAK family kinases in acute myeloid leukemia.
Quan L, Cheng Z, Dai Y, Jiao Y, Shi J, Fu L. | 05/15/2021 |
| PAK3 mutations responsible for severe intellectual disability and callosal agenesis inhibit cell migration. | PAK3 mutations responsible for severe intellectual disability and callosal agenesis inhibit cell migration.
Duarte K, Heide S, Poëa-Guyon S, Rousseau V, Depienne C, Rastetter A, Nava C, Attié-Bitach T, Razavi F, Martinovic J, Moutard ML, Cherfils J, Mignot C, Héron D, Barnier JV. | 03/27/2021 |
| Synaptic actin stabilization protein loss in Down syndrome and Alzheimer disease. | Synaptic actin stabilization protein loss in Down syndrome and Alzheimer disease.
Lauterborn JC, Cox CD, Chan SW, Vanderklish PW, Lynch G, Gall CM., Free PMC Article | 01/16/2021 |
| Further delineation of the phenotype of PAK3-associated x-linked intellectual disability: Identification of a novel missense mutation and review of literature. | Further delineation of the phenotype of PAK3-associated x-linked intellectual disability: Identification of a novel missense mutation and review of literature.
Nagy D, Farkas K, Armengol L, Segura M, Esi Zodanu GK, Csányi B, Zimmermann A, Vámos B, Széll M. | 11/21/2020 |
| Integration of hepatitis B virus DNA into p21-activated kinase 3 (PAK3) gene in HepG2.2.15 cells. | Integration of hepatitis B virus DNA into p21-activated kinase 3 (PAK3) gene in HepG2.2.15 cells.
Ruan P, Dai X, Sun J, He C, Huang C, Zhou R, Chemin I. | 09/19/2020 |
| PAK3 regulates the Akt-GSK3beta-beta-catenin signaling by acting as Ser(473)-Akt kinase in several pancreatic cancer cell lines, promoting cancer stem cell phenotypes. | p21-Activated kinase 3 promotes cancer stem cell phenotypes through activating the Akt-GSK3β-β-catenin signaling pathway in pancreatic cancer cells.
Wu HY, Yang MC, Ding LY, Chen CS, Chu PC. | 04/18/2020 |
| We diagnosed two male siblings with developmental delays as having a PAK3 likely pathogenic variant. This finding expands the list of PAK3 gene mutations associated with neurodevelopmental disorders and provides further details on its clinical features | Novel PAK3 gene missense variant associated with two Chinese siblings with intellectual disability: a case report.
Qian Y, Wu B, Lu Y, Zhou W, Wang S, Wang H., Free PMC Article | 03/7/2020 |
| Determined the crystal structure of the PAK3 catalytic domain and by small angle X-ray scattering, the solution-phase structures of full-length inactive PAK1 and PAK3. The structures reveal a compact but elongated molecular shape. | Solution structures and biophysical analysis of full-length group A PAKs reveal they are monomeric and auto-inhibited in cis.
Sorrell FJ, Kilian LM, Elkins JM., Free PMC Article | 02/15/2020 |
| The miR-193b-3p/PAK3 axis might be a potential novel therapeutic target for OC. | miR-193b-3p possesses anti-tumor activity in ovarian carcinoma cells by targeting p21-activated kinase 3.
Zhang J, Qin J, Su Y. | 07/28/2018 |
| Authors have identified mutations in PAK3, CASK, and MECP2 that likely contribute to intellectual disability, and the findings extend the spectrum of mutations and phenotypes associated with X-linked intellectual disability. | Next-Generation Sequencing Reveals Novel Mutations in X-linked Intellectual Disability.
Muthusamy B, Selvan LDN, Nguyen TT, Manoj J, Stawiski EW, Jaiswal BS, Wang W, Raja R, Ramprasad VL, Gupta R, Murugan S, Kadandale JS, Prasad TSK, Reddy K, Peterson A, Pandey A, Seshagiri S, Girimaji SC, Gowda H., Free PMC Article | 02/24/2018 |
| Abnormalities in the PAK1 and PAK3 mRNA levels as well as their altered coexpression patterns were observed in the postmortem brain of subjects with depression. Dysregulated PAK1/PAK3 dependent signaling may be a key factor responsible for volumetric abnormalities observed in the hippocampus and in the prefrontal cortex in depression resulting in altered connectivity of these regions. | Expression of p21-activated kinases 1 and 3 is altered in the brain of subjects with depression.
Fuchsova B, Alvarez Juliá A, Rizavi HS, Frasch AC, Pandey GN., Free PMC Article | 09/9/2017 |
| This study showed that PARK3 messenger RNA levels was significantly upregulated in subjects with schizophrenia in laminar and cellular samples. | Altered expression of CDC42 signaling pathway components in cortical layer 3 pyramidal cells in schizophrenia.
Datta D, Arion D, Corradi JP, Lewis DA., Free PMC Article | 08/13/2016 |
| This study identified predicted pathogenic, hemizygous variants on chromosome X in disease genes PAK3. | Whole-exome sequencing points to considerable genetic heterogeneity of cerebral palsy.
McMichael G, Bainbridge MN, Haan E, Corbett M, Gardner A, Thompson S, van Bon BW, van Eyk CL, Broadbent J, Reynolds C, O'Callaghan ME, Nguyen LS, Adelson DL, Russo R, Jhangiani S, Doddapaneni H, Muzny DM, Gibbs RA, Gecz J, MacLennan AH. | 03/5/2016 |
| Data show that group I p21-activated kinases (Paks) Pak1 and Pak2 were much more abundant than Pak3 in meningioma. | Group I Paks as therapeutic targets in NF2-deficient meningioma.
Chow HY, Dong B, Duron SG, Campbell DA, Ong CC, Hoeflich KP, Chang LS, Welling DB, Yang ZJ, Chernoff J., Free PMC Article | 12/5/2015 |
| Cdc42Hs binds to the effector domain of PAK3 | Dynamic and thermodynamic response of the Ras protein Cdc42Hs upon association with the effector domain of PAK3.
Moorman VR, Valentine KG, Bédard S, Kasinath V, Dogan J, Love FM, Wand AJ., Free PMC Article | 02/7/2015 |
| Results show elevated PAK3 expression at both the mRNA and protein level in cJun/AP-1-over-expressing Rat1a fibroblasts, as well as in transformed human fibroblasts. | p21-activated kinase 3 (PAK3) is an AP-1 regulated gene contributing to actin organisation and migration of transformed fibroblasts.
Holderness Parker N, Donninger H, Birrer MJ, Leaner VD., Free PMC Article | 02/1/2014 |
| Group I p21-activated kinases augment Tax-mediated transcriptional activation of human T-cell leukemia virus type 1 long terminal repeats in a kinase-independent manner. | Group I p21-activated kinases facilitate Tax-mediated transcriptional activation of the human T-cell leukemia virus type 1 long terminal repeats.
Chan CP, Siu YT, Kok KH, Ching YP, Tang HM, Jin DY., Free PMC Article | 09/21/2013 |
| p21-Activated kinase 3 (PAK3) protein regulates synaptic transmission through its interaction with the Nck2/Grb4 protein adaptor. | p21-Activated kinase 3 (PAK3) protein regulates synaptic transmission through its interaction with the Nck2/Grb4 protein adaptor.
Thévenot E, Moreau AW, Rousseau V, Combeau G, Domenichini F, Jacquet C, Goupille O, Amar M, Kreis P, Fossier P, Barnier JV., Free PMC Article | 01/7/2012 |
| potential role of PAK3 in the progression of ACTH-producing thymic carcinoid | p21-activated kinase 3 is overexpressed in thymic neuroendocrine tumors (carcinoids) with ectopic ACTH syndrome and participates in cell migration.
Liu RX, Wang WQ, Ye L, Bi YF, Fang H, Cui B, Zhou WW, Dai M, Zhang J, Li XY, Ning G. | 02/5/2011 |
| PAK3 mutations result in a specific form of X-linked mental retardation with fairly constant clinical features. | A novel splice mutation in PAK3 gene underlying mental retardation with neuropsychiatric features.
Rejeb I, Saillour Y, Castelnau L, Julien C, Bienvenu T, Taga P, Chaabouni H, Chelly J, Ben Jemaa L, Bahi-Buisson N. | 01/21/2010 |