| The C-type lectin DCIR contributes to the immune response and pathogenesis of colorectal cancer. | The C-type lectin DCIR contributes to the immune response and pathogenesis of colorectal cancer.
Trimaglio G, Sneperger T, Raymond BBA, Gilles N, Näser E, Locard-Paulet M, Ijsselsteijn ME, Brouwer TP, Ecalard R, Roelands J, Matsumoto N, Colom A, Habch M, de Miranda NFCC, Vergnolle N, Devaud C, Neyrolles O, Rombouts Y., Free PMC Article | 03/29/2024 |
| DCIR suppresses osteoclastic proliferation and resorption by downregulating M-CSF and RANKL signaling. | DCIR suppresses osteoclastic proliferation and resorption by downregulating M-CSF and RANKL signaling.
Kaifu T, Maruhashi T, Chung SH, Shimizu K, Nakamura A, Iwakura Y., Free PMC Article | 10/20/2023 |
| Differential expression of immune-regulatory proteins C5AR1, CLEC4A and NLRP3 on peripheral blood mononuclear cells in early-stage non-small cell lung cancer patients. | Differential expression of immune-regulatory proteins C5AR1, CLEC4A and NLRP3 on peripheral blood mononuclear cells in early-stage non-small cell lung cancer patients.
Pakvisal N, Kongkavitoon P, Sathitruangsak C, Pornpattanarak N, Boonsirikamchai P, Ouwongprayoon P, Aporntewan C, Chantranuwatana P, Mutirangura A, Vinayanuwattikun C., Free PMC Article | 11/12/2022 |
| DCIR and its ligand asialo-biantennary N-glycan regulate DC function and osteoclastogenesis. | DCIR and its ligand asialo-biantennary N-glycan regulate DC function and osteoclastogenesis.
Kaifu T, Yabe R, Maruhashi T, Chung SH, Tateno H, Fujikado N, Hirabayashi J, Iwakura Y., Free PMC Article | 01/1/2022 |
| Pivotal role of the carbohydrate recognition domain in self-interaction of CLEC4A to elicit the ITIM-mediated inhibitory function in murine conventional dendritic cells in vitro. | Pivotal role of the carbohydrate recognition domain in self-interaction of CLEC4A to elicit the ITIM-mediated inhibitory function in murine conventional dendritic cells in vitro.
Nasu J, Uto T, Fukaya T, Takagi H, Fukui T, Miyanaga N, Nishikawa Y, Yamasaki S, Yamashita Y, Sato K. | 10/2/2021 |
| Authors have determined the structure, tissue distribution, and molecular function of the cartilage-specific lectin CLEC3A and show that CLEC3A binds to plasminogen and participates in tPA-mediated plasminogen activation. | The cartilage-specific lectin C-type lectin domain family 3 member A (CLEC3A) enhances tissue plasminogen activator-mediated plasminogen activation.
Lau D, Elezagic D, Hermes G, Mörgelin M, Wohl AP, Koch M, Hartmann U, Höllriegl S, Wagener R, Paulsson M, Streichert T, Klatt AR., Free PMC Article | 12/1/2018 |
| DCIR SNP rs2377422 is a novel genetic susceptibility factor for both SLE and primary SS. | Contribution of dendritic cell immunoreceptor (DCIR) polymorphisms in susceptibility of systemic lupus erythematosus and primary Sjogren's syndrome.
Liu M, Wu X, Liu X, He J, Su Y, Guo J, Li Z. | 08/20/2016 |
| this study shows that sulfo-Lewis(a) is a high affinity ligand for DCIR and that DCIR interacts with ligands from both pathogenic and endogenous origin of which most are shared by DC-SIGN. | DCIR interacts with ligands from both endogenous and pathogenic origin.
Bloem K, Vuist IM, van den Berk M, Klaver EJ, van Die I, Knippels LM, Garssen J, García-Vallejo JJ, van Vliet SJ, van Kooyk Y. | 11/29/2014 |
| No association was found between our inflammatory bowel disease cohort and the candidate single nucleotide polymorphisms for DCIR (CD/HC: P=0.22 and UC/HC: P=0.41) | Single nucleotide polymorphisms in C-type lectin genes, clustered in the IBD2 and IBD6 susceptibility loci, may play a role in the pathogenesis of inflammatory bowel diseases.
Wolfkamp SC, Verstege MI, Vogels EW, Meisner S, Verseijden C, Stokkers PC, te Velde AA. | 12/8/2012 |
| Data provide evidence for association between DCIR rs2377422 and RA in non-Caucasian populations and confirm the influence of DCIR polymorphisms on RA susceptibility, especially on ACPA-negative RA. | A replication study confirms the association of dendritic cell immunoreceptor (DCIR) polymorphisms with ACPA - negative RA in a large Asian cohort.
Guo J, Wu X, Too CL, Yin F, Lu X, He J, Li R, Liu X, Murad S, Padyukov L, Li Z., Free PMC Article | 12/8/2012 |
| An involvement of ITIM domain in HIV-1-mediated signaling events and a relationship between phosphorylation events and DCIR function with respect to HIV-1 biology. | DCIR-mediated enhancement of HIV-1 infection requires the ITIM-associated signal transduction pathway.
Lambert AA, Barabé F, Gilbert C, Tremblay MJ. | 09/3/2011 |
| Data show that antigen targeting via the DCIR receptor allows activation of specific CD8(+) T-cell immunity. | Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR.
Klechevsky E, Flamar AL, Cao Y, Blanck JP, Liu M, O'Bar A, Agouna-Deciat O, Klucar P, Thompson-Snipes L, Zurawski S, Reiter Y, Palucka AK, Zurawski G, Banchereau J., Free PMC Article | 11/6/2010 |
| DCIR as an antigen presenting cell receptor that is endocytosed efficiently in a clathrin-dependent manner and negatively affects TLR8-mediated cytokine production. | DCIR is endocytosed into human dendritic cells and inhibits TLR8-mediated cytokine production.
Meyer-Wentrup F, Cambi A, Joosten B, Looman MW, de Vries IJ, Figdor CG, Adema GJ. | 01/21/2010 |
| The mRNA expression from the four known transcripts of DCIR in IFN-gamma-treated human leukocytes together with fine mapping across the locus was analyzed. | Differential expression of transcripts for the autoimmunity-related human dendritic cell immunoreceptor.
Ronninger M, Eklöw C, Lorentzen JC, Klareskog L, Padyukov L. | 01/21/2010 |
| can participate in the capture of HIV-1 and promote infection in trans and in cis of autologous CD4(+) T cells from human immature monocyte-derived DCs. | The C-type lectin surface receptor DCIR acts as a new attachment factor for HIV-1 in dendritic cells and contributes to trans- and cis-infection pathways.
Lambert AA, Gilbert C, Richard M, Beaulieu AD, Tremblay MJ., Free PMC Article | 01/21/2010 |
| The data show that targeting of DCIR can modulate human plasmacytoid dendritic cell function and may be applied in disease prevention and treatment. | Targeting DCIR on human plasmacytoid dendritic cells results in antigen presentation and inhibits IFN-alpha production.
Meyer-Wentrup F, Benitez-Ribas D, Tacken PJ, Punt CJ, Figdor CG, de Vries IJ, Adema GJ. | 01/21/2010 |
| Human APLEC and DCIR may be associated with susceptibility to anti-CCP-negative rheumatoid arthritis. | Association of arthritis with a gene complex encoding C-type lectin-like receptors.
Lorentzen JC, Flornes L, Eklöw C, Bäckdahl L, Ribbhammar U, Guo JP, Smolnikova M, Dissen E, Seddighzadeh M, Brookes AJ, Alfredsson L, Klareskog L, Padyukov L, Fossum S. | 01/21/2010 |
| The phosphorylation of SHP-2 by GM-CSF promotes the binding of SHP-2 to the GM-CSF receptor to the disadvantage of CLECSF6. | Granulocyte macrophage-colony stimulating factor reduces the affinity of SHP-2 for the ITIM of CLECSF6 in neutrophils: a new mechanism of action for SHP-2.
Richard M, Thibault N, Veilleux P, Gareau-Pagé G, Beaulieu AD. | 01/21/2010 |
| CLECSF6 is involved in the control of inflammation in neutrophils | The ITIM-bearing CLECSF6 (DCIR) is down-modulated in neutrophils by neutrophil activating agents.
Richard M, Thibault N, Veilleux P, Breton R, Beaulieu AD. | 01/21/2010 |