| Antigen Nonspecific Induction of Distinct Regulatory T Cell States in Oncogene-Driven Hyperproliferative Skin. | Antigen Nonspecific Induction of Distinct Regulatory T Cell States in Oncogene-Driven Hyperproliferative Skin.
Zhou C, Tuong ZK, Lukowski SW, Chandra J, Frazer IH. | 01/22/2022 |
| Single-Cell Sequencing Reveals the Novel Role of Ezh2 in NK Cell Maturation and Function. | Single-Cell Sequencing Reveals the Novel Role of Ezh2 in NK Cell Maturation and Function.
Yu M, Su Z, Huang X, Wang X., Free PMC Article | 12/25/2021 |
| Ptpn2 and KLRG1 regulate the generation and function of tissue-resident memory CD8+ T cells in skin. | Ptpn2 and KLRG1 regulate the generation and function of tissue-resident memory CD8+ T cells in skin.
Hochheiser K, Wiede F, Wagner T, Freestone D, Enders MH, Olshansky M, Russ B, Nüssing S, Bawden E, Braun A, Bachem A, Gressier E, McConville R, Park SL, Jones CM, Davey GM, Gyorki DE, Tscharke D, Parish IA, Turner S, Herold MJ, Tiganis T, Bedoui S, Gebhardt T., Free PMC Article | 10/2/2021 |
| KLRG1(+) Memory CD8 T Cells Combine Properties of Short-Lived Effectors and Long-Lived Memory. | KLRG1(+) Memory CD8 T Cells Combine Properties of Short-Lived Effectors and Long-Lived Memory.
Renkema KR, Huggins MA, Borges da Silva H, Knutson TP, Henzler CM, Hamilton SE., Free PMC Article | 03/27/2021 |
| This paper demonstrates that developmental plasticity of KLRG1(+) effector CD8(+) T cells is important in promoting functionally versatile memory cells and long-term protective immunity. | KLRG1(+) Effector CD8(+) T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity.
Herndler-Brandstetter D, Ishigame H, Shinnakasu R, Plajer V, Stecher C, Zhao J, Lietzenmayer M, Kroehling L, Takumi A, Kometani K, Inoue T, Kluger Y, Kaech SM, Kurosaki T, Okada T, Flavell RA., Free PMC Article | 01/12/2019 |
| KLRG1 expression identifies short-lived Foxp3(+) Treg effector cells with functional plasticity in islets of NOD mice. | KLRG1 expression identifies short-lived Foxp3(+) T(reg) effector cells with functional plasticity in islets of NOD mice.
Kornete M, Mason E, Istomine R, Piccirillo CA. | 05/19/2018 |
| Although absence of KLRG1 is not enough to increase intestinal Treg cells in KLRG1 knockout mice, KLRG1 ligation reduces T-cell receptor signals and the competitive fitness of individual Treg cells in the intestine. | KLRG1 impairs regulatory T-cell competitive fitness in the gut.
Meinicke H, Bremser A, Brack M, Schrenk K, Pircher H, Izcue A., Free PMC Article | 09/23/2017 |
| Treg cell accumulation in intestinal tumours from APC(min/+) mice was exclusively due to the increase in KLRG1(+) GATA3(+) Treg cells. | Tumour-associated changes in intestinal epithelial cells cause local accumulation of KLRG1(+) GATA3(+) regulatory T cells in mice.
Meinicke H, Bremser A, Brack M, Akeus P, Pearson C, Bullers S, Hoffmeyer K, Stemmler MP, Quiding-Järbrink M, Izcue A., Free PMC Article | 09/23/2017 |
| Ly6C, 4-1BB, and KLRG1 have roles in the activation of lamina propria lymphocytes in the small intestine in a mouse model of Crohn's disease | Involvement of Ly6C, 4-1BB, and KLRG1 in the activation of lamina propria lymphocytes in the small intestine of sanroque mice.
Montufar-Solis D, Williams A, Vigneswaran N, Klein JR., Free PMC Article | 06/10/2017 |
| This finding provides a rationale for the reciprocal expression of KLRG1 and CD103 in different CD8(+) T-cell subsets. | TGF-β downregulates KLRG1 expression in mouse and human CD8(+) T cells.
Schwartzkopff S, Woyciechowski S, Aichele U, Flecken T, Zhang N, Thimme R, Pircher H. | 10/31/2015 |
| Cytotoxic KLRG1-expressed CD8 effector cells and defective T regulatory cells cause murine autoimmune cholangitis. | Murine autoimmune cholangitis requires two hits: cytotoxic KLRG1(+) CD8 effector cells and defective T regulatory cells.
Huang W, Kachapati K, Adams D, Wu Y, Leung PS, Yang GX, Zhang W, Ansari AA, Flavell RA, Gershwin ME, Ridgway WM., Free PMC Article | 12/6/2014 |
| KLRG1(+) iNKT cells coexpressing CD49d and granzyme A persisted for several months and displayed a potent secondary response to cognate antigen. | KLRG+ invariant natural killer T cells are long-lived effectors.
Shimizu K, Sato Y, Shinga J, Watanabe T, Endo T, Asakura M, Yamasaki S, Kawahara K, Kinjo Y, Kitamura H, Watarai H, Ishii Y, Tsuji M, Taniguchi M, Ohara O, Fujii S., Free PMC Article | 11/29/2014 |
| high levels of TfRs such as those found on activated lymphocytes were found to be associated with decreased KLRG1 inhibitory function, indicating that TfRs may sequester KLRG1 from interacting with cadherins. | Transferrin' activation: bonding with transferrin receptors tunes KLRG1 function.
Steinle A. | 07/26/2014 |
| data further demonstrate that the inhibitory activity of KLRG1 is decreased in T cells expressing high levels of TfR, indicating that association of KLRG1 with TfR hinders KLRG1-mediated silencing. | KLRG1 activity is regulated by association with the transferrin receptor.
Schweier O, Hofmann M, Pircher H. | 07/26/2014 |
| Data indicate that CD103(+)CD8(+) T(RM) cells developed in the skin from epithelium-infiltrating precursor cells that lacked expression of the effector-cell marker KLRG1. | The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin.
Mackay LK, Rahimpour A, Ma JZ, Collins N, Stock AT, Hafon ML, Vega-Ramos J, Lauzurica P, Mueller SN, Stefanovic T, Tscharke DC, Heath WR, Inouye M, Carbone FR, Gebhardt T. | 01/25/2014 |
| Data indicate that increments of CD8 + effector memory T cells in human and mouse chronic lymphocytic leukemia (CLL)(Emu-TCL1 model) were due to an expansion of the inhibitory killer cell lectin-like receptor G1 (KLRG1) expressing cellular subset. | Expanded CD8+ T cells of murine and human CLL are driven into a senescent KLRG1+ effector memory phenotype.
Göthert JR, Eisele L, Klein-Hitpass L, Weber S, Zesewitz ML, Sellmann L, Röth A, Pircher H, Dührsen U, Dürig J., Free PMC Article | 01/4/2014 |
| Despite their differences, KLRG1+ and KLRG1- Treg cells proved similarly potent in suppressing experimental autoimmune encephalomyelitis. | Diversification and senescence of Foxp3+ regulatory T cells during experimental autoimmune encephalomyelitis.
Tauro S, Nguyen P, Li B, Geiger TL., Free PMC Article | 06/22/2013 |
| KLRG1(-/-) mice had a significant survival extension after Mycobacterium tuberculosis infection compared to wild-type controls, and maintained a significantly lower level of pulmonary bacterial load throughout chronic infection. | Killer cell lectin-like receptor G1 deficiency significantly enhances survival after Mycobacterium tuberculosis infection.
Cyktor JC, Carruthers B, Stromberg P, Flaño E, Pircher H, Turner J., Free PMC Article | 05/18/2013 |
| CD8+ T cells lacking Id2 do not generate a robust terminally differentiated killer cell lectin-like receptor G1 (KLRG1hi) effector population, but display a cell-surface phenotype and cytokine profile consistent with memory precursors. | Id2 influences differentiation of killer cell lectin-like receptor G1(hi) short-lived CD8+ effector T cells.
Knell J, Best JA, Lind NA, Yang E, D'Cruz LM, Goldrath AW., Free PMC Article | 03/30/2013 |
| The lower inhibitory capacity of mKLRG1 compared with hKLRG1 can thus be rationalized by a decreased proportion of dimeric entities, which can be pinpointed to a single amino acid. | Different inhibitory capacities of human and mouse KLRG1 are linked to distinct disulfide-mediated oligomerizations.
Hofmann M, Schweier O, Pircher H. | 02/9/2013 |
| KLRG1high-expressiong CD8 T cells isolated from the lung during the peak of influenza infection could long survive in vitro and participate in a recall response to influenza virus infection upon adoptive transfer. | Contribution of pulmonary KLRG1(high) and KLRG1(low) CD8 T cells to effector and memory responses during influenza virus infection.
Ye F, Turner J, Flaño E., Free PMC Article | 01/26/2013 |
| T-cell co-inhibitory blockade combined with alphaCTLA-4 and active co-stimulation with alpha4-1BB promotes rejection of B16 melanoma in with a vaccine; KLRG1 is a useful marker for monitoring the anti-tumor immune response elicited by this therapy | Combination CTLA-4 blockade and 4-1BB activation enhances tumor rejection by increasing T-cell infiltration, proliferation, and cytokine production.
Curran MA, Kim M, Montalvo W, Al-Shamkhani A, Allison JP., Free PMC Article | 12/3/2011 |
| The KLRG1+NKG2A+ positive phenotype correlates with protective efficacy for generating effector and proliferative memory responses from a pool of CD8 T cells during persistent gamma-herpesvirus 68 infection. | KLRG1+NKG2A+ CD8 T cells mediate protection and participate in memory responses during γ-herpesvirus infection.
Cush SS, Flaño E., Free PMC Article | 06/18/2011 |
| Interleukin-2-activated natural killer cells interact with tumor necrosis factor-alpha-stimulated endothelial cells to induce their proliferation and promote angiogenesis through a mechanism involving alpha4beta7 integrin and KLRG1. | Induction of cardiac angiogenesis requires killer cell lectin-like receptor 1 and α4β7 integrin expression by NK cells.
Bouchentouf M, Forner KA, Cuerquis J, Michaud V, Zheng J, Paradis P, Schiffrin EL, Galipeau J. | 01/15/2011 |
| KLRG1 does not play a deterministic role in the generation & functional characteristics of NK & T-cell subsets. The inhibitory potential of KLRG1 in mice is weak. Strong activation signals during viral infections may override the inhibitory signal. | The NK receptor KLRG1 is dispensable for virus-induced NK and CD8+ T-cell differentiation and function in vivo.
Gründemann C, Schwartzkopff S, Koschella M, Schweier O, Peters C, Voehringer D, Pircher H. | 06/28/2010 |