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    Uchl3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) [ Mus musculus (house mouse) ]

    Gene ID: 50933, updated on 9-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Activation of CTNNB1 by deubiquitinase UCHL3-mediated stabilization facilitates bladder cancer progression.

    Activation of CTNNB1 by deubiquitinase UCHL3-mediated stabilization facilitates bladder cancer progression.
    Liu T, Fan MQ, Xie XX, Shu QP, Du XH, Qi LZ, Zhang XD, Zhang MH, Shan G, Du RL, Li SZ., Free PMC Article

    09/26/2023
    The deubiquitinase UCHL3 mediates p300-dependent chemokine signaling in alveolar type II cells to promote pulmonary fibrosis.

    The deubiquitinase UCHL3 mediates p300-dependent chemokine signaling in alveolar type II cells to promote pulmonary fibrosis.
    Lee SY, Park SY, Lee SH, Kim H, Kwon JH, Yoo JY, Kim K, Park MS, Lee CG, Elias JA, Sohn MH, Shim HS, Yoon HG., Free PMC Article

    09/8/2023
    Data suggest that the activity of oocyte UCHL-1 and -3 contributes to oocyte maturation by regulating the oocyte cortex and meiotic spindle.

    Essential role of ubiquitin C-terminal hydrolases UCHL1 and UCHL3 in mammalian oocyte maturation.
    Mtango NR, Sutovsky M, Vandevoort CA, Latham KE, Sutovsky P., Free PMC Article

    04/7/2012
    subfertile Uchl1(gad-/-) mutant mice showed an intriguing pattern of switched UCH localization, with UCHL3 replacing UCHL1 in the oocyte cortex

    Essential role of maternal UCHL1 and UCHL3 in fertilization and preimplantation embryo development.
    Mtango NR, Sutovsky M, Susor A, Zhong Z, Latham KE, Sutovsky P., Free PMC Article

    03/10/2012
    impaired UCH-L3 function may contribute to the accumulation of full length UBB(+1) in various pathologie

    Mutant ubiquitin (UBB+1) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3).
    Dennissen FJ, Kholod N, Hermes DJ, Kemmerling N, Steinbusch HW, Dantuma NP, van Leeuwen FW.

    10/15/2011
    Results suggest that Uch-L3 enhances osteoblast differentiation through the stabilization of Smad1 signaling

    Ubiquitin C-terminal hydrolase-L3 regulates Smad1 ubiquitination and osteoblast differentiation.
    Kim JY, Lee JM, Cho JY.

    08/6/2011
    Polyubiquitinated proteins accumulate in skeletal muscle as well as in mouse embryonic fibroblasts derived from Uchl3-deficient mice.

    Skeletal muscles of Uchl3 knockout mice show polyubiquitinated protein accumulation and stress responses.
    Setsuie R, Suzuki M, Tsuchiya Y, Wada K.

    12/4/2010
    Results suggest that UCH-L3 promotes adipogenesis by enhancing insulin signaling in a hydrolase activity-dependent manner.

    Ubiquitin carboxyl-terminal hydrolase l3 promotes insulin signaling and adipogenesis.
    Suzuki M, Setsuie R, Wada K.

    01/25/2010
    The role of ubiquitin C-terminal hydrolase (UCH)-L3 in the regulation of AMP-activated protein kinase activity and whole-body energy metabolism are reportedl

    Ubiquitin C-terminal hydrolase-L3-knockout mice are resistant to diet-induced obesity and show increased activation of AMP-activated protein kinase in skeletal muscle.
    Setsuie R, Suzuki M, Kabuta T, Fujita H, Miura S, Ichihara N, Yamada D, Wang YL, Ezaki O, Suzuki Y, Wada K.

    01/25/2010
    Data show that Uchl3 and mitofilin are differentially expressed in the hippocampi of inbred senescence-acclerated mice compared to normally-aging mice.

    The hippocampal proteomic analysis of senescence-accelerated mouse: implications of Uchl3 and mitofilin in cognitive disorder and mitochondria dysfunction in SAMP8.
    Wang Q, Liu Y, Zou X, Wang Q, An M, Guan X, He J, Tong Y, Ji J.

    01/21/2010
    UCH-L3 regulates the apical membrane recycling of the epithelial sodium channel

    The deubiquitinating enzyme UCH-L3 regulates the apical membrane recycling of the epithelial sodium channel.
    Butterworth MB, Edinger RS, Ovaa H, Burg D, Johnson JP, Frizzell RA.

    01/21/2010
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