| Targeting SOX4/PCK2 signaling suppresses neuroendocrine trans-differentiation of castration-resistant prostate cancer. | Targeting SOX4/PCK2 signaling suppresses neuroendocrine trans-differentiation of castration-resistant prostate cancer.
Jing N, Tao Z, Du X, Wen Z, Gao WQ, Dong B, Fang YX., Free PMC Article | 08/15/2024 |
| Association of mitochondrial phosphoenolpyruvate carboxykinase with prognosis and immune regulation in hepatocellular carcinoma. | Association of mitochondrial phosphoenolpyruvate carboxykinase with prognosis and immune regulation in hepatocellular carcinoma.
Li C, Zhang ED, Ye Y, Xiao Z, Huang H, Zeng Z., Free PMC Article | 06/24/2024 |
| Dysregulation of phosphoenolpyruvate carboxykinase in cancers: A comprehensive analysis. | Dysregulation of phosphoenolpyruvate carboxykinase in cancers: A comprehensive analysis.
Xue S, Cai Y, Liu J, Ji K, Yi P, Long H, Zhang X, Li P, Song Y. | 06/21/2024 |
| AF9 sustains glycolysis in colorectal cancer via H3K9ac-mediated PCK2 and FBP1 transcription. | AF9 sustains glycolysis in colorectal cancer via H3K9ac-mediated PCK2 and FBP1 transcription.
He X, Zhong X, Fang Y, Hu Z, Chen Z, Wang Y, Huang H, Zhao S, Li D, Wei P., Free PMC Article | 08/16/2023 |
| Mitochondrial phosphoenolpyruvate carboxykinase promotes tumor growth in estrogen receptor-positive breast cancer via regulation of the mTOR pathway. | Mitochondrial phosphoenolpyruvate carboxykinase promotes tumor growth in estrogen receptor-positive breast cancer via regulation of the mTOR pathway.
Hsu HP, Chu PY, Chang TM, Huang KW, Hung WC, Jiang SS, Lin HY, Tsai HJ., Free PMC Article | 02/4/2023 |
| Glycosylation defects, offset by PEPCK-M, drive entosis in breast carcinoma cells. | Glycosylation defects, offset by PEPCK-M, drive entosis in breast carcinoma cells.
Hyroššová P, Aragó M, Muñoz-Pinedo C, Viñals F, García-Rovés PM, Escolano C, Méndez-Lucas A, Perales JC., Free PMC Article | 09/3/2022 |
| Low expression of PCK2 in breast tumors contributes to better prognosis by inducing senescence of cancer cells. | Low expression of PCK2 in breast tumors contributes to better prognosis by inducing senescence of cancer cells.
Ma X, Gao Y, Liu J, Xu L, Liu W, Huna A, Wang X, Gong W. | 08/27/2022 |
| Role of PCK2 in the proliferation of vascular smooth muscle cells in neointimal hyperplasia. | Role of PCK2 in the proliferation of vascular smooth muscle cells in neointimal hyperplasia.
Ko DS, Kang J, Heo HJ, Kim EK, Kim K, Kang JM, Jung Y, Baek SE, Kim YH., Free PMC Article | 08/27/2022 |
| A novel mutation in PCK2 gene causes primary angle-closure glaucoma. | A novel mutation in PCK2 gene causes primary angle-closure glaucoma.
Xu M, Yang J, Sun J, Xing X, Liu Z, Liu T., Free PMC Article | 04/30/2022 |
| Phosphoenolpyruvate carboxykinase in cell metabolism: Roles and mechanisms beyond gluconeogenesis. | Phosphoenolpyruvate carboxykinase in cell metabolism: Roles and mechanisms beyond gluconeogenesis.
Yu S, Meng S, Xiang M, Ma H., Free PMC Article | 03/26/2022 |
| PCK2 opposes mitochondrial respiration and maintains the redox balance in starved lung cancer cells. | PCK2 opposes mitochondrial respiration and maintains the redox balance in starved lung cancer cells.
Bluemel G, Planque M, Madreiter-Sokolowski CT, Haitzmann T, Hrzenjak A, Graier WF, Fendt SM, Olschewski H, Leithner K. | 12/18/2021 |
| Proteomic Analysis of Hepatocellular Carcinoma Tissues With Encapsulation Shows Up-regulation of Leucine Aminopeptidase 3 and Phosphoenolpyruvate Carboxykinase 2. | Proteomic Analysis of Hepatocellular Carcinoma Tissues With Encapsulation Shows Up-regulation of Leucine Aminopeptidase 3 and Phosphoenolpyruvate Carboxykinase 2.
Kuhara K, Kitagawa T, Baron B, Tokuda K, Sakamoto K, Nagano H, Nakamura K, Kobayashi M, Nagayasu H, Kuramitsu Y., Free PMC Article | 12/4/2021 |
| PURalpha Promotes the Transcriptional Activation of PCK2 in Oesophageal Squamous Cell Carcinoma Cells. | PURα Promotes the Transcriptional Activation of PCK2 in Oesophageal Squamous Cell Carcinoma Cells.
Sun Y, Gao J, Jing Z, Zhao Y, Sun Y, Zhao X., Free PMC Article | 07/24/2021 |
| Restoring the epigenetically silenced PCK2 suppresses renal cell carcinoma progression and increases sensitivity to sunitinib by promoting endoplasmic reticulum stress. | Restoring the epigenetically silenced PCK2 suppresses renal cell carcinoma progression and increases sensitivity to sunitinib by promoting endoplasmic reticulum stress.
Xiong Z, Yuan C, Shi J, Xiong W, Huang Y, Xiao W, Yang H, Chen K, Zhang X., Free PMC Article | 06/5/2021 |
| Hypoxia increases the rate of renal gluconeogenesis via hypoxia-inducible factor-1-dependent activation of phosphoenolpyruvate carboxykinase expression. | Hypoxia increases the rate of renal gluconeogenesis via hypoxia-inducible factor-1-dependent activation of phosphoenolpyruvate carboxykinase expression.
Owczarek A, Gieczewska K, Jarzyna R, Jagielski AK, Kiersztan A, Gruza A, Winiarska K. | 12/19/2020 |
| The relationship between PEPCK metabolism in the urinary tract and insulin resistance and diabetes is reported. | Phosphoenolpyruvate carboxykinase in urine exosomes reflect impairment in renal gluconeogenesis in early insulin resistance and diabetes.
Sharma R, Kumari M, Prakash P, Gupta S, Tiwari S. | 07/18/2020 |
| This study unveiled a novel role for PCK2 in integrating autophagy and bone formation, providing a potential target for stem cell-based bone tissue engineering that may lead to improved therapies for metabolic bone diseases. | Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Osteogenic Differentiation by Modulating AMPK/ULK1-Dependent Autophagy.
Li Z, Liu X, Zhu Y, Du Y, Liu X, Lv L, Zhang X, Liu Y, Zhang P, Zhou Y., Free PMC Article | 07/4/2020 |
| Our study indicates that the T allele of the rs4982856 single-nucleotide polymorphisms in the PCK2 gene may be a risk factor for glucose intolerance after kidney transplantation | Association of the PCK2 Gene Polymorphism With New-onset Glucose Intolerance in Japanese Kidney Transplant Recipients.
Yokoyama N, Ishimura T, Oda T, Ogawa S, Yamamoto K, Fujisawa M. | 09/1/2018 |
| Downregulation of PCK2 remodels tricarboxylic acid cycle in tumor-repopulating cells of melanoma | Downregulation of PCK2 remodels tricarboxylic acid cycle in tumor-repopulating cells of melanoma.
Luo S, Li Y, Ma R, Liu J, Xu P, Zhang H, Tang K, Ma J, Liu N, Zhang Y, Sun Y, Ji T, Liang X, Yin X, Liu Y, Tong W, Niu Y, Wang N, Wang X, Huang B. | 09/16/2017 |
| ApoA-IV colocalizes with NR4A1, which suppresses G6Pase and PEPCK gene expression at the transcriptional level, reducing hepatic glucose output and lowering blood glucose. | Interaction of ApoA-IV with NR4A1 and NR1D1 Represses G6Pase and PEPCK Transcription: Nuclear Receptor-Mediated Downregulation of Hepatic Gluconeogenesis in Mice and a Human Hepatocyte Cell Line.
Li X, Xu M, Wang F, Ji Y, DavidsoN WS, Li Z, Tso P., Free PMC Article | 06/28/2016 |
| Results indicate that PEPCK promotes tumor growth by increasing glucose and glutamine metabolism, increases anabolic metabolism and promotes mTORC1 activity. | PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth.
Montal ED, Dewi R, Bhalla K, Ou L, Hwang BJ, Ropell AE, Gordon C, Liu WJ, DeBerardinis RJ, Sudderth J, Twaddel W, Boros LG, Shroyer KR, Duraisamy S, Drapkin R, Powers RS, Rohde JM, Boxer MB, Wong KK, Girnun GD., Free PMC Article | 03/12/2016 |
| Mitochondrial PCK2 regulates metabolic adaptation and enables glucose-independent tumor growth in various neoplasms. | Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth.
Vincent EE, Sergushichev A, Griss T, Gingras MC, Samborska B, Ntimbane T, Coelho PP, Blagih J, Raissi TC, Choinière L, Bridon G, Loginicheva E, Flynn BR, Thomas EC, Tavaré JM, Avizonis D, Pause A, Elder DJ, Artyomov MN, Jones RG. | 01/30/2016 |
| When autophagy was blocked, the level of glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK) was reduced in HepG2 cells and not in Hep3B cells. | The regulation of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase by autophagy in low-glycolytic hepatocellular carcinoma cells.
Jeon JY, Lee H, Park J, Lee M, Park SW, Kim JS, Lee M, Cho B, Kim K, Choi AM, Kim CK, Yun M. | 09/12/2015 |
| PEPCK activity was elevated threefold in lung cancer samples over normal lungs and its activation mediates an adaptive response to glucose depletion in lung cancer. | PCK2 activation mediates an adaptive response to glucose depletion in lung cancer.
Leithner K, Hrzenjak A, Trötzmüller M, Moustafa T, Köfeler HC, Wohlkoenig C, Stacher E, Lindenmann J, Harris AL, Olschewski A, Olschewski H. | 05/2/2015 |
| Amino acid limitation and ER stress inducers, conditions that activate the amino acid response (AAR) and the unfolded protein response (UPR), stimulate PCK2 gene transcription in tumor cell lines. | Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) is a pro-survival, endoplasmic reticulum (ER) stress response gene involved in tumor cell adaptation to nutrient availability.
Méndez-Lucas A, Hyroššová P, Novellasdemunt L, Viñals F, Perales JC., Free PMC Article | 02/21/2015 |