| GRIM-19 deficiency promotes macrophage polarization to the M1 phenotype partly through glycolysis in unexplained recurrent spontaneous abortiondagger. | GRIM-19 deficiency promotes macrophage polarization to the M1 phenotype partly through glycolysis in unexplained recurrent spontaneous abortion†.
Wang B, Yang Y, Ye J, Han X, Yang L, Huang Y, Chao L. | 04/29/2024 |
| GRIM19 deficiency aggravates metabolic disorder and ovarian dysfunction in PCOS. | GRIM19 deficiency aggravates metabolic disorder and ovarian dysfunction in PCOS.
Yang L, Yang Y, Han X, Huang C, Wang Y, Jiang D, Chao L. | 04/16/2024 |
| Mitochondrial GRIM-19 loss in parietal cells promotes spasmolytic polypeptide-expressing metaplasia through NLR family pyrin domain-containing 3 (NLRP3)-mediated IL-33 activation via a reactive oxygen species (ROS) -NRF2- Heme oxygenase-1(HO-1)-NF-small ka, CyrillicB axis. | Mitochondrial GRIM-19 loss in parietal cells promotes spasmolytic polypeptide-expressing metaplasia through NLR family pyrin domain-containing 3 (NLRP3)-mediated IL-33 activation via a reactive oxygen species (ROS) -NRF2- Heme oxygenase-1(HO-1)-NF-кB axis.
Zeng X, Yang M, Ye T, Feng J, Xu X, Yang H, Wang X, Bao L, Li R, Xue B, Zang J, Huang Y. | 06/2/2023 |
| Grim-19 deficiency promotes decidual macrophage autophagy in recurrent spontaneous abortion. | Grim-19 deficiency promotes decidual macrophage autophagy in recurrent spontaneous abortion.
Yang Y, Liu H, Zhao Y, Geng C, Chao L, Hao A., Free PMC Article | 11/26/2022 |
| Decreased expression of GRIM-19 induces autophagy through the AMPK/ULK1 signaling pathway during adenomyosisdagger. | Decreased expression of GRIM-19 induces autophagy through the AMPK/ULK1 signaling pathway during adenomyosis†.
Huang Y, Zhao Y, Liu H, Yang Y, Cheng L, Deng X, Chao L. | 10/22/2022 |
| GRIM19 downregulation-induced pyroptosis of macrophages through NLRP3 pathway in adenomyosis. | GRIM19 downregulation-induced pyroptosis of macrophages through NLRP3 pathway in adenomyosis.
Liu H, Zhao Y, Yang Y, Huang W, Chao L. | 04/23/2022 |
| GRIM-19 is a target of mycobacterial Zn(2+) metalloprotease 1 and indispensable for NLRP3 inflammasome activation. | GRIM-19 is a target of mycobacterial Zn(2+) metalloprotease 1 and indispensable for NLRP3 inflammasome activation.
Kurane T, Matsunaga T, Ida T, Sawada K, Nishimura A, Fukui M, Umemura M, Nakayama M, Ohara N, Matsumoto S, Akaike T, Matsuzaki G, Takaesu G. | 01/15/2022 |
| GRIM-19 inhibits proliferation and induces apoptosis in a p53-dependent manner in colorectal cancer cells through the SIRT7/PCAF/MDM2 axis. | GRIM-19 inhibits proliferation and induces apoptosis in a p53-dependent manner in colorectal cancer cells through the SIRT7/PCAF/MDM2 axis.
Wang D, Wei X, Chen X, Wang Q, Zhang J, Kalvakolanu DV, Guo B, Zhang L. | 11/13/2021 |
| Interaction of M2 macrophages and endometrial cells induces downregulation of GRIM-19 in endometria of adenomyosis. | Interaction of M2 macrophages and endometrial cells induces downregulation of GRIM-19 in endometria of adenomyosis.
Wang B, Yang Y, Deng X, Ban Y, Chao L. | 09/25/2021 |
| [Mechanism of hepatocyte mitochondrial NDUFA13 deficiency-induced liver fibrogenesis: the role of abnormal hepatic stellate cell activation]. | [Mechanism of hepatocyte mitochondrial NDUFA13 deficiency-induced liver fibrogenesis: the role of abnormal hepatic stellate cell activation].
Xu X, Zeng X, Li R, Feng J, Huang D, Huang Y., Free PMC Article | 05/15/2021 |
| Upregulation of GRIM-19 augments the sensitivity of prostate cancer cells to docetaxel by targeting Rad23b. | Upregulation of GRIM-19 augments the sensitivity of prostate cancer cells to docetaxel by targeting Rad23b.
Lin H, Shen Z, Liu H, Yang M, Lin J, Luo L, Liu L, Chen H. | 05/8/2021 |
| overexpression of GRIM-19 markedly ameliorated the accumulation of HIF-1alpha triggered by hypoxia accompanied by an inhibition of vascular endothelial growth factor | GRIM-19 repressed hypoxia-induced invasion and EMT of colorectal cancer by repressing autophagy through inactivation of STAT3/HIF-1α signaling axis.
Zhang J, Chu D, Kawamura T, Tanaka K, He S. | 05/16/2020 |
| GRIM-19 deficiency may play a role in regulating Treg/Th17 balance partly through ROS-mTOR signaling axis in URSA. The present study offers a new perspective to the roles of GRIM-19 in immunoregulation. | Expression of GRIM-19 in unexplained recurrent spontaneous abortion and possible pathogenesis.
Yang Y, Cheng L, Deng X, Yu H, Chao L. | 06/22/2019 |
| Inhibition of miR-423-5p suppressed PC through targeting GRIM-19. | Inhibition of miR-423-5p suppressed prostate cancer through targeting GRIM-19.
Lin H, Lin T, Lin J, Yang M, Shen Z, Liu H, Zou Z, Zheng Z. | 02/9/2019 |
| These results indicated that rAd-Grim-19 may regulate tumor cell growth and apoptosis. Additionally, the results demonstrated that rAdGrim19 led to beneficial outcomes and prolonged the survival of esophageal tumorbearing mice. In conclusion, the present study demonstrated that rAdGrim19 may have potential as an antitumor agent for esophageal neoplasms | Grim-19 expressed by recombinant adenovirus for esophageal neoplasm target therapy.
Song J, Shi W, Wang W, Zhang Y, Zheng S. | 09/15/2018 |
| GRIM-19 is a potential predictor of prognosis and disease recurrence in high grade serous carcinoma | Prognostic value of GRIM-19, NF-κB and IKK2 in patients with high-grade serous ovarian cancer.
Ilelis F, do Amaral NS, Alves MR, da Costa AABA, Calsavara VF, Lordello L, De Brot L, Soares FA, Rodrigues IS, Rocha RM. | 09/1/2018 |
| Promoting the expression of GRIM19 may yield therapeutic benefits in the treatment of RA. | Retinoid interferon-induced mortality19 (GRIM19) inhibits proliferation and invasion in rheumatoid arthritis fibroblast-like synoviocytes.
Zhao D, Jiang Z, Wang Z, Gao J. | 08/18/2018 |
| MiR-6743-5p may act as an oncomiRNA in glioma by targetting GRIM-19 and STAT3. | miR-6743-5p, as a direct upstream regulator of GRIM-19, enhances proliferation and suppresses apoptosis in glioma cells.
Cao F, Zhang Q, Chen W, Zheng F, Ran Q, He Y, Gao Y, Yao S., Free PMC Article | 07/21/2018 |
| GRIM-19 suppresses the proliferation and invasion of cutaneous squamous cell carcinoma cells associated with downregulation of STAT3 signaling. | GRIM-19 represses the proliferation and invasion of cutaneous squamous cell carcinoma cells associated with downregulation of STAT3 signaling.
Wu N, Hui H, Cui L, Yang F. | 06/16/2018 |
| Mitochondrial GRIM-19 could not only serve as an valuable prognostic biomarker for gastric cancer development, but also as a potential therapeutic target for STAT3-dependent carcinogenesis of Gastric cancer. | Mitochondrial GRIM-19 as a potential therapeutic target for STAT3-dependent carcinogenesis of gastric cancer.
Huang Y, Yang M, Hu H, Zhao X, Bao L, Huang D, Song L, Li Y., Free PMC Article | 01/13/2018 |
| GRIM-19 expression in cervical cancer cells could inhibit telomerase activity by inhibiting the transactivation of the hTERT promoter by E6, thereby promoting cervical cancer cell senescence. | GRIM-19 Restores Cervical Cancer Cell Senescence by Repressing hTERT Transcription.
Zhou Y, Xu F, Tao F, Feng D, Ling B, Qian L, Yang X, Wang Q, Wang H, Zhao W, Cheng Y, Shan G, Kalvakolanu DV, Xiao W. | 01/13/2018 |
| NDUFA13 deficiency may be associated with asthenozoospermia through the disturbance of spermatozoa mitochondrial membrane potential and by increasing apoptosis and intracellular reactive oxygen species | Expression of NDUFA13 in asthenozoospermia and possible pathogenesis.
Yang Y, Cheng L, Wang Y, Han Y, Liu J, Deng X, Chao L. | 08/19/2017 |
| GRIM-19 overexpression suppressed hepatocellular carcinoma (HCC) growth and downregulated AKT1 expression, suggesting that GRIM-19 might play a crucial role in hepatocarcinogenesis through negatively regulating the PI3K/AKT signaling pathway. | Overexpression of GRIM-19, a mitochondrial respiratory chain complex I protein, suppresses hepatocellular carcinoma growth.
Kong D, Zhao L, Du Y, He P, Zou Y, Yang L, Sun L, Wang H, Xu D, Meng X, Sun X., Free PMC Article | 04/15/2017 |
| Low GRIM-19 expression is associated with paclitaxel resistance in cervical cancer. | GRIM-19 inhibition induced autophagy through activation of ERK and HIF-1α not STAT3 in Hela cells.
Yue X, Zhao P, Wu K, Huang J, Zhang W, Wu Y, Liang X, He X. | 03/4/2017 |
| activation of AMPKalpha by metformin was associated with a reversal of the suppressed GRIM-19 expression in H9C2 cells, the fold of changes in GRIM-19 expression by metformin were much less in HeLa cells | High Glucose Induces Down-Regulated GRIM-19 Expression to Activate STAT3 Signaling and Promote Cell Proliferation in Cell Culture.
Li YG, Han BB, Li F, Yu JW, Dong ZF, Niu GM, Qing YW, Li JB, Wei M, Zhu W., Free PMC Article | 02/18/2017 |