| Histone methyltransferase SUV420H1/KMT5B contributes to poor prognosis in hepatocellular carcinoma. | Histone methyltransferase SUV420H1/KMT5B contributes to poor prognosis in hepatocellular carcinoma.
Kato H, Hayami S, Ueno M, Suzaki N, Nakamura M, Yoshimura T, Miyamoto A, Shigekawa Y, Okada KI, Miyazawa M, Kitahata Y, Ehata S, Hamamoto R, Yamaue H, Kawai M., Free PMC Article | 02/16/2024 |
| Mechanism of KMT5B haploinsufficiency in neurodevelopment in humans and mice. | Mechanism of KMT5B haploinsufficiency in neurodevelopment in humans and mice.
Sheppard SE, Bryant L, Wickramasekara RN, Vaccaro C, Robertson B, Hallgren J, Hulen J, Watson CJ, Faundes V, Duffourd Y, Lee P, Simon MC, de la Cruz X, Padilla N, Flores-Mendez M, Akizu N, Smiler J, Pellegrino Da Silva R, Li D, March M, Diaz-Rosado A, Peixoto de Barcelos I, Choa ZX, Lim CY, Dubourg C, Journel H, Demurger F, Mulhern M, Akman C, Lippa N, Andrews M, Baldridge D, Constantino J, van Haeringen A, Snoeck-Streef I, Chow P, Hing A, Graham JM Jr, Au M, Faivre L, Shen W, Mao R, Palumbos J, Viskochil D, Gahl W, Tifft C, Macnamara E, Hauser N, Miller R, Maffeo J, Afenjar A, Doummar D, Keren B, Arn P, Macklin-Mantia S, Meerschaut I, Callewaert B, Reis A, Zweier C, Brewer C, Saggar A, Smeland MF, Kumar A, Elmslie F, Deshpande C, Nizon M, Cogne B, van Ierland Y, Wilke M, van Slegtenhorst M, Koudijs S, Chen JY, Dredge D, Pier D, Wortmann S, Kamsteeg EJ, Koch J, Haynes D, Pollack L, Titheradge H, Ranguin K, Denommé-Pichon AS, Weber S, Pérez de la Fuente R, Sánchez Del Pozo J, Lezana Rosales JM, Joset P, Steindl K, Rauch A, Mei D, Mari F, Guerrini R, Lespinasse J, Tran Mau-Them F, Philippe C, Dauriat B, Raymond L, Moutton S, Cueto-González AM, Tan TY, Mignot C, Grotto S, Renaldo F, Drivas TG, Hennessy L, Raper A, Parenti I, Kaiser FJ, Kuechler A, Busk ØL, Islam L, Siedlik JA, Henderson LB, Juusola J, Person R, Schnur RE, Vitobello A, Banka S, Bhoj EJ, Stessman HAF., Free PMC Article | 10/26/2023 |
| Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1. | Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1.
Abini-Agbomson S, Gretarsson K, Shih RM, Hsieh L, Lou T, De Ioannes P, Vasilyev N, Lee R, Wang M, Simon MD, Armache JP, Nudler E, Narlikar G, Liu S, Lu C, Armache KJ. | 08/25/2023 |
| Loss-of-function of KMT5B leads to neurodevelopmental disorder and impairs neuronal development and neurogenesis. | Loss-of-function of KMT5B leads to neurodevelopmental disorder and impairs neuronal development and neurogenesis.
Chen G, Han L, Tan S, Jia X, Wu H, Quan Y, Zhang Q, Yu B, Hu Z, Xia K, Guo H. | 10/1/2022 |
| Epigenetic Regulation by Suv4-20h1 in Cardiopulmonary Progenitor Cells Is Required to Prevent Pulmonary Hypertension and Chronic Obstructive Pulmonary Disease. | Epigenetic Regulation by Suv4-20h1 in Cardiopulmonary Progenitor Cells Is Required to Prevent Pulmonary Hypertension and Chronic Obstructive Pulmonary Disease.
Qi H, Liu H, Pullamsetti SS, Günther S, Kuenne C, Atzberger A, Sommer N, Hadzic S, Günther A, Weissmann N, Zhou Y, Yuan X, Braun T. | 01/1/2022 |
| Genome-wide association study identifies susceptibility loci for acute myeloid leukemia. | Genome-wide association study identifies susceptibility loci for acute myeloid leukemia.
Lin WY, Fordham SE, Hungate E, Sunter NJ, Elstob C, Xu Y, Park C, Quante A, Strauch K, Gieger C, Skol A, Rahman T, Sucheston-Campbell L, Wang J, Hahn T, Clay-Gilmour AI, Jones GL, Marr HJ, Jackson GH, Menne T, Collin M, Ivey A, Hills RK, Burnett AK, Russell NH, Fitzgibbon J, Larson RA, Le Beau MM, Stock W, Heidenreich O, Alharbi A, Allsup DJ, Houlston RS, Norden J, Dickinson AM, Douglas E, Lendrem C, Daly AK, Palm L, Piechocki K, Jeffries S, Bornhäuser M, Röllig C, Altmann H, Ruhnke L, Kunadt D, Wagenführ L, Cordell HJ, Darlay R, Andersen MK, Fontana MC, Martinelli G, Marconi G, Sanz MA, Cervera J, Gómez-Seguí I, Cluzeau T, Moreilhon C, Raynaud S, Sill H, Voso MT, Lo-Coco F, Dombret H, Cheok M, Preudhomme C, Gale RE, Linch D, Gaal-Wesinger J, Masszi A, Nowak D, Hofmann WK, Gilkes A, Porkka K, Milosevic Feenstra JD, Kralovics R, Grimwade D, Meggendorfer M, Haferlach T, Krizsán S, Bödör C, Stölzel F, Onel K, Allan JM., Free PMC Article | 12/4/2021 |
| Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells. | Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells.
Vilema-Enríquez G, Quinlan R, Kilfeather P, Mazzone R, Saqlain S, Del Molino Del Barrio I, Donato A, Corda G, Li F, Vedadi M, Németh AH, Brennan PE, Wade-Martins R., Free PMC Article | 03/28/2021 |
| SUV420H1 is a protein lysine methyltransferase that introduces di- and trimethylation of H4K20 and is frequently mutated in human cancers. Somatic Cancer Mutations in the SUV420H1 Protein Lysine Methyltransferase Modulate Its Catalytic Activity. | Somatic Cancer Mutations in the SUV420H1 Protein Lysine Methyltransferase Modulate Its Catalytic Activity.
Bröhm A, Elsawy H, Rathert P, Kudithipudi S, Schoch T, Schuhmacher MK, Weirich S, Jeltsch A. | 06/13/2020 |
| epsilon-globin expression is regulated by SUV4-20h1. | ε-globin expression is regulated by SUV4-20h1.
Wang Y, Rank G, Li Z, Wang Y, Ju J, Nuber A, Wu Y, Liu M, Nie M, Huang F, Cerruti L, Ma C, Tan R, Schotta G, Jane SM, Zeng CK, Zhao Q., Free PMC Article | 01/27/2018 |
| Altogether, these results reveal Suv4-20h-mediated histone H4K20 tri-methylation as a critical determinant in the selection of active replication initiation sites in heterochromatin regions of mammalian genomes. | Histone H4K20 tri-methylation at late-firing origins ensures timely heterochromatin replication.
Brustel J, Kirstein N, Izard F, Grimaud C, Prorok P, Cayrou C, Schotta G, Abdelsamie AF, Déjardin J, Méchali M, Baldacci G, Sardet C, Cadoret JC, Schepers A, Julien E., Free PMC Article | 09/30/2017 |
| overexpression of SUV420H1 may result in activation of the ERK signaling pathway | SUV420H1 enhances the phosphorylation and transcription of ERK1 in cancer cells.
Vougiouklakis T, Sone K, Saloura V, Cho HS, Suzuki T, Dohmae N, Alachkar H, Nakamura Y, Hamamoto R., Free PMC Article | 10/8/2016 |
| Strong statistical evidence for a causal role of SUV420H1 in autism. | Incorporating Functional Information in Tests of Excess De Novo Mutational Load.
Jiang Y, Han Y, Petrovski S, Owzar K, Goldstein DB, Allen AS., Free PMC Article | 10/31/2015 |
| This study suggests a novel role of FRG1 as epigenetic regulator of muscle differentiation and indicates that Suv4-20h1 has a gene-specific function in myogenesis. | FSHD muscular dystrophy region gene 1 binds Suv4-20h1 histone methyltransferase and impairs myogenesis.
Neguembor MV, Xynos A, Onorati MC, Caccia R, Bortolanza S, Godio C, Pistoni M, Corona DF, Schotta G, Gabellini D. | 04/26/2014 |
| The crystal structure of SUV420H1 was used to characterize substrate selectivity and product specificity. | Crystal structures of the human histone H4K20 methyltransferases SUV420H1 and SUV420H2.
Wu H, Siarheyeva A, Zeng H, Lam R, Dong A, Wu XH, Li Y, Schapira M, Vedadi M, Min J. | 01/18/2014 |
| SUV420H1 and SUV420H2 isoforms have different in their cellular localization and effects on myogenic differentiation | Comparative analyses of SUV420H1 isoforms and SUV420H2 reveal differences in their cellular localization and effects on myogenic differentiation.
Tsang LW, Hu N, Underhill DA., Free PMC Article | 07/9/2011 |
| The data indicate that Suv4-20 generates nearly ubiquitous dimethylation that facilitates the DNA damage response and selective trimethylation that is involved in heterochromatin formation.[Suv4-20] | Preferential dimethylation of histone H4 lysine 20 by Suv4-20.
Yang H, Pesavento JJ, Starnes TW, Cryderman DE, Wallrath LL, Kelleher NL, Mizzen CA., Free PMC Article | 01/21/2010 |
| dissect the GRIP1:Suv4-20h1 interaction in vitro and in vivo and examine its potential involvement in hormone-dependent transcriptional regulation by GR | GRIP1-associated SET-domain methyltransferase in glucocorticoid receptor target gene expression.
Chinenov Y, Sacta MA, Cruz AR, Rogatsky I., Free PMC Article | 01/21/2010 |