| Genome-wide loss-of-function genetic screen identifies INSIG2 as the vulnerability of hepatitis B virus-integrated hepatoma cells. | Genome-wide loss-of-function genetic screen identifies INSIG2 as the vulnerability of hepatitis B virus-integrated hepatoma cells.
Fukuoka M, Kodama T, Murai K, Hikita H, Sometani E, Sung J, Shimoda A, Shigeno S, Motooka D, Nishio A, Furuta K, Tatsumi T, Yusa K, Takehara T., Free PMC Article | 03/13/2024 |
| Insulin-induced gene 2 expression is associated with cervical adenocarcinoma malignant behavior. | Insulin-induced gene 2 expression is associated with cervical adenocarcinoma malignant behavior.
Qian Y, Li X, Qiu J, Zhang R. | 02/11/2023 |
| Structural basis for sterol sensing by Scap and Insig. | Structural basis for sterol sensing by Scap and Insig.
Yan R, Cao P, Song W, Li Y, Wang T, Qian H, Yan C, Yan N. | 02/12/2022 |
| Insulin-induced genes INSIG1 and INSIG2 mediate oxysterol-dependent activation of the PERK-eIF2alpha-ATF4 axis. | Insulin-induced genes INSIG1 and INSIG2 mediate oxysterol-dependent activation of the PERK-eIF2α-ATF4 axis.
Watanabe Y, Sasaki T, Miyoshi S, Shimizu M, Yamauchi Y, Sato R., Free PMC Article | 12/4/2021 |
| Association of CNR1 and INSIG2 polymorphisms with antipsychotics-induced weight gain: a prospective nested case-control study. | Association of CNR1 and INSIG2 polymorphisms with antipsychotics-induced weight gain: a prospective nested case-control study.
Jimeno N, Velasco-Gonzalez V, Fierro I, Duran M, Carvajal A., Free PMC Article | 11/13/2021 |
| Polymorphic variants INSIG2 rs6726538, HLA-DRB1 rs9272143, and GCNT1P5 rs7780883 contribute to the susceptibility of cervical cancer in the Bangladeshi women. | Polymorphic variants INSIG2 rs6726538, HLA-DRB1 rs9272143, and GCNT1P5 rs7780883 contribute to the susceptibility of cervical cancer in the Bangladeshi women.
Hasan ME, Matin M, Haque ME, Aziz MA, Millat MS, Uddin MS, Moghal MMR, Islam MS., Free PMC Article | 07/17/2021 |
| A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols. | A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols.
Yan R, Cao P, Song W, Qian H, Du X, Coates HW, Zhao X, Li Y, Gao S, Gong X, Liu X, Sui J, Lei J, Yang H, Brown AJ, Zhou Q, Yan C, Yan N. | 04/3/2021 |
| The CC Genotype of Insulin-Induced Gene 2 rs7566605 Is a Protective Factor of Hypercholesteremia Susceptible to Mild Cognitive Impairment, Especially to the Executive Function of Patients with Type 2 Diabetes Mellitus. | The CC Genotype of Insulin-Induced Gene 2 rs7566605 Is a Protective Factor of Hypercholesteremia Susceptible to Mild Cognitive Impairment, Especially to the Executive Function of Patients with Type 2 Diabetes Mellitus.
Zhang H, Huang R, Tian S, An K, Zhu W, Shi J, Cao W, Wang S., Free PMC Article | 03/27/2021 |
| Insulin-Induced Gene 2 Expression Is Associated with Breast Cancer Metastasis. | Insulin-Induced Gene 2 Expression Is Associated with Breast Cancer Metastasis.
Lu N, Zhang M, Lu L, Liu YZ, Liu XD, Zhang HH. | 02/20/2021 |
| the gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis; findings highlight the importance of the protein kinase activity of PCK1 in the activation of SREBPs, lipogenesis and the development of hepatocellular carcinoma | The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis.
Xu D, Wang Z, Xia Y, Shao F, Xia W, Wei Y, Li X, Qian X, Lee JH, Du L, Zheng Y, Lv G, Leu JS, Wang H, Xing D, Liang T, Hung MC, Lu Z. | 06/6/2020 |
| polymorphism rs7566605 of the INSIG2 gene is associated with higher triglycerides levels and blood pressure values, which are also considered as risk factors for the development of metabolic syndrome | INSIG2 gene polymorphism is associated with higher blood pressure and triglyceride levels in Brazilian obese subjects.
Nicoletti CF, Azevedo RG, Pinhel MAS, Delfino HBP, Nonino CB. | 01/11/2020 |
| INSIG2 rs10185316 polymorphism was associated with diastolic blood pressure, pulse pressure and mean arterial pressure among children and adolescents in an independent way from body mass index. | [Association between polymorphism of rs10185316 in insulin-induced gene 2 and blood pressure among children and adolescents].
Yang YD, Song JY, Liu FH, Shang XR, Wang HJ, Ma J. | 02/9/2019 |
| IINSIG2 gene single nucleotide polymorphisms and global DNA methylation are linked with weight loss in obese patients. | INSIG2 rs7566605 single nucleotide variant and global DNA methylation index levels are associated with weight loss in a personalized weight reduction program.
Pirini F, Rodriguez-Torres S, Ayandibu BG, Orera-Clemente M, Gonzalez-de la Vega A, Lawson F, Thorpe RJ Jr, Sidransky D, Guerrero-Preston R., Free PMC Article | 07/21/2018 |
| INSIG2 plays a role in weight gain and obesity during clozapine treatment | INSIG2 polymorphism and weight gain, dyslipidemia and serum adiponectin in Finnish patients with schizophrenia treated with clozapine.
Koskinen S, Kampman O, Solismaa A, Lyytikäinen LP, Seppälä N, Viikki M, Hämäläinen M, Moilanen E, Mononen N, Lehtimäki T, Leinonen E. | 09/2/2017 |
| These results indicate that HIF-mediated induction of Insig-2 and degradation of HMGCR are physiologically relevant events that guard against wasteful oxygen consumption and inappropriate cell growth during hypoxia. | Hypoxia-inducible factor 1α activates insulin-induced gene 2 (Insig-2) transcription for degradation of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase in the liver.
Hwang S, Nguyen AD, Jo Y, Engelking LJ, Brugarolas J, DeBose-Boyd RA., Free PMC Article | 06/10/2017 |
| There may be a connection between INSIG2 expression and metastatic dissemination of colorectal cancer without any effect on tumorigenesis. | Insulin-induced gene 2 expression correlates with colorectal cancer metastasis and disease outcome.
Sun S, Zhang G, Sun Q, Wu Z, Shi W, Yang B, Li Y. | 10/22/2016 |
| Insulin resistance in obese boys leads to up-regulation of INSIG2 gene expression as well as to down-regulation of PFKFB1, PFKFB3, and HK2 genes in the blood cells as compared to obese patients with normal insulin sensitivity. | [EXPRESSION OF GENES, WHICH CONTROL GLUCOSE METABOLISM, IN BLOOD CELLS OF THE OBESE BOYS WITH INSULIN RESISTANCE].
Tiazhka OV, Minchenko DO, Davydov VV, Moliavko OS, Budreiko OA, Kulieshova DK, Minchenko OH. | 02/13/2016 |
| Results confirmed that genetic variation in INSIG2 is associated with both overweight and LDL in non-Hispanic white children. | Association of INSIG2 polymorphism with overweight and LDL in children.
Kaulfers AM, Deka R, Dolan L, Martin LJ., Free PMC Article | 01/16/2016 |
| This study suggests that the G allele in the INSIG2 single nucleotide polymorphism rs7566605 is more relevant for changes in intramuscular adipose tissue following training than for the amount of subcutaneous fat. | Association between intramuscular fat in the arm following arm training and INSIG2.
Popadic Gacesa JZ, Secher NH, Momcilovic M, Grujic NG. | 08/1/2015 |
| INSIG2 is involved in adipogenesis and MC4R effects hormonal appetite control in response to the amount of adipose tissue. | Controversial association results for INSIG2 on body mass index may be explained by interactions with age and with MC4R.
Malzahn D, Müller-Nurasyid M, Heid IM, Wichmann HE, KORA study group, Bickeböller H., Free PMC Article | 06/20/2015 |
| The results provided evidence for identifying genetic factors of nonalcoholic fatty liver disease (NAFLD) and may be useful for risk assessment and personalized medicine of NAFLD. | Association of INSIG2 rs9308762 with ALT level independent of BMI.
Guan L, Shang XR, Liu FH, Song JY, Ma J, Wang HJ. | 04/18/2015 |
| The INSIG2 rs7566605 SNP may not play a role in the development of obesity-related metabolic traits in Malaysian Malays. | Genetic associations of the INSIG2 rs7566605 polymorphism with obesity-related metabolic traits in Malaysian Malays.
Apalasamy YD, Moy FM, Rampal S, Bulgiba A, Mohamed Z. | 04/4/2015 |
| identified interaction of three genes in INSIG-SCAP-SREBP pathway on risk of obesity, revealing that these genes affect obesity more likely through a complex interaction pattern than single gene effect. | The gene-gene interaction of INSIG-SCAP-SREBP pathway on the risk of obesity in Chinese children.
Liu FH, Song JY, Shang XR, Meng XR, Ma J, Wang HJ., Free PMC Article | 03/21/2015 |
| Data show the essential role of PPARgamma and PPARgamma coactivator 1alpha (PGC-1alpha) in up-regulating Insig-1/2 expression, defining a mechanistic pathway triggered by CD36, and leading to cholesterol depletion in hepatocytes. | Scavenger receptor CD36 mediates inhibition of cholesterol synthesis via activation of the PPARγ/PGC-1α pathway and Insig1/2 expression in hepatocytes.
Rodrigue-Way A, Caron V, Bilodeau S, Keil S, Hassan M, Lévy E, Mitchell GA, Tremblay A. | 06/7/2014 |
| Results show significant differences in distribution of single nucleotide polymorphism in this gene amongst whites and hispanics | Frequencies of obesity susceptibility alleles among ethnically and racially diverse bariatric patient populations.
Parikh M, Hetherington J, Sheth S, Seiler J, Ostrer H, Gerhard G, Wood C, Still C., Free PMC Article | 01/25/2014 |