| CYRI-B-mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake. | CYRI-B-mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake.
Nikolaou S, Juin A, Whitelaw JA, Paul NR, Fort L, Nixon C, Spence HJ, Bryson S, Machesky LM., Free PMC Article | 07/11/2024 |
| LANCL1, a cell surface protein, promotes liver tumor initiation through FAM49B-Rac1 axis to suppress oxidative stress. | LANCL1, a cell surface protein, promotes liver tumor initiation through FAM49B-Rac1 axis to suppress oxidative stress.
Huang H, Tsui YM, Ho DW, Chung CY, Sze KM, Lee E, Cheung GC, Zhang VX, Wang X, Lyu X, Ng IO., Free PMC Article | 01/26/2024 |
| A genome-wide genetic screen identifies CYRI-B as a negative regulator of CEACAM3-mediated phagocytosis. | A genome-wide genetic screen identifies CYRI-B as a negative regulator of CEACAM3-mediated phagocytosis.
Kuiper JWP, Krause J, Potgeter L, Adrian J, Hauck CR. | 06/7/2023 |
| GOLM1 and FAM49B: Potential Biomarkers in HNSCC Based on Bioinformatics and Immunohistochemical Analysis. | GOLM1 and FAM49B: Potential Biomarkers in HNSCC Based on Bioinformatics and Immunohistochemical Analysis.
Xi Y, Zhang T, Sun W, Liang R, Ganesh S, Chen H., Free PMC Article | 01/11/2023 |
| Structural Basis of CYRI-B Direct Competition with Scar/WAVE Complex for Rac1. | Structural Basis of CYRI-B Direct Competition with Scar/WAVE Complex for Rac1.
Yelland T, Le AH, Nikolaou S, Insall R, Machesky L, Ismail S., Free PMC Article | 11/27/2021 |
| TASP1 Promotes Gallbladder Cancer Cell Proliferation and Metastasis by Up-regulating FAM49B via PI3K/AKT Pathway. | TASP1 Promotes Gallbladder Cancer Cell Proliferation and Metastasis by Up-regulating FAM49B via PI3K/AKT Pathway.
Zhang Y, Du P, Li Y, Zhu Q, Song X, Liu S, Hao J, Liu L, Liu F, Hu Y, Jiang L, Ma Q, Lu W, Liu Y., Free PMC Article | 06/12/2021 |
| CYFIP related Rac1 interactor B (CYRI) binds to the small GTPase RAC1 through a conserved domain present in CYFIP proteins. CYRI negatively regulates RAC1 signalling, thereby attenuating processes such as macropinocytosis, phagocytosis and cell migration. This enables CYRI to counteract Salmonella at various stages of infection. The bacterial effector SopE, a RAC1 activator, selectively targets CYRI following infection. | CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection.
Yuki KE, Marei H, Fiskin E, Eva MM, Gopal AA, Schwartzentruber JA, Majewski J, Cellier M, Mandl JN, Vidal SM, Malo D, Dikic I. | 01/25/2020 |
| Low fam49B expression is associated with pancreatic ductal adenocarcinoma metastasis. | FAM49B, a novel regulator of mitochondrial function and integrity that suppresses tumor metastasis.
Chattaragada MS, Riganti C, Sassoe M, Principe M, Santamorena MM, Roux C, Curcio C, Evangelista A, Allavena P, Salvia R, Rusev B, Scarpa A, Cappello P, Novelli F., Free PMC Article | 03/16/2019 |
| FAM49B inhibits T cell activation by repressing Rac activity and modulating cytoskeleton reorganization. | Genome-wide CRISPR screen identifies FAM49B as a key regulator of actin dynamics and T cell activation.
Shang W, Jiang Y, Boettcher M, Ding K, Mollenauer M, Liu Z, Wen X, Liu C, Hao P, Zhao S, McManus MT, Wei L, Weiss A, Wang H., Free PMC Article | 08/18/2018 |
| Three proteins-matrix metalloproteinase-9, neutrophil elastase, and FAM49B-were significantly lower in abundance in samples from women with endometriosis. | Urine, peritoneal fluid and omental fat proteomes of reproductive age women: Endometriosis-related changes and associations with endocrine disrupting chemicals.
Williams KE, Miroshnychenko O, Johansen EB, Niles RK, Sundaram R, Kannan K, Albertolle M, Zhou Y, Prasad N, Drake PM, Giudice LC, Hall SC, Witkowska HE, Buck Louis GM, Fisher SJ., Free PMC Article | 08/8/2015 |
| FAM49B is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. | The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.
Warnatz HJ, Schmidt D, Manke T, Piccini I, Sultan M, Borodina T, Balzereit D, Wruck W, Soldatov A, Vingron M, Lehrach H, Yaspo ML., Free PMC Article | 09/14/2011 |