| Mitotic gene regulation by the N-MYC-WDR5-PDPK1 nexus. | Mitotic gene regulation by the N-MYC-WDR5-PDPK1 nexus.
Streeter SA, Williams AG, Evans JR, Wang J, Guarnaccia AD, Florian AC, Al-Tobasei R, Liu Q, Tansey WP, Weissmiller AM., Free PMC Article | 04/29/2024 |
| KLK10 promotes the progression of KRAS mutant colorectal cancer via PAR1-PDK1-AKT signaling pathway. | KLK10 promotes the progression of KRAS mutant colorectal cancer via PAR1-PDK1-AKT signaling pathway.
Wu K, Wu B, Yan K, Ding Q, Miao Z. | 03/26/2024 |
| CPT1A mediates the succinylation of SP5 which activates transcription of PDPK1 to promote the viability and glycolysis of prostate cancer cells. | CPT1A mediates the succinylation of SP5 which activates transcription of PDPK1 to promote the viability and glycolysis of prostate cancer cells.
Liu S, Chen X, Zhang L, Lu B., Free PMC Article | 03/19/2024 |
| SDC2 Stabilization by USP14 Promotes Gastric Cancer Progression through Co-option of PDK1. | SDC2 Stabilization by USP14 Promotes Gastric Cancer Progression through Co-option of PDK1.
You L, Dou Y, Zhang Y, Xiao H, Lv H, Wei GH, Xu D., Free PMC Article | 08/9/2023 |
| Cooperative activation of PDK1 and AKT by MAPK4 enhances cancer growth and resistance to therapy. | Cooperative activation of PDK1 and AKT by MAPK4 enhances cancer growth and resistance to therapy.
Han D, Wang W, Jeon JH, Shen T, Huang X, Yi P, Dong B, Yang F., Free PMC Article | 08/4/2023 |
| Hsa_circ_0000851 promotes PDK1/p-AKT-mediated cell proliferation and migration by regulating miR-1183 in triple-negative breast cancer. | Hsa_circ_0000851 promotes PDK1/p-AKT-mediated cell proliferation and migration by regulating miR-1183 in triple-negative breast cancer.
Ji C, Zhu L, Fang L. | 12/10/2022 |
| Hsa_circ_0000081 promotes the function of gastric cancer through sponging hsa-miR-423-5p to influence 3-phosphoinositide-dependent kinase 1 expression. | Hsa_circ_0000081 promotes the function of gastric cancer through sponging hsa-miR-423-5p to influence 3-phosphoinositide-dependent kinase 1 expression.
Jiang F, Hu X, Cao H, Shen X., Free PMC Article | 05/7/2022 |
| MiR-34b-3p Impaired HUVECs Viability and Migration via Targeting PDK1 in an In Vitro Model of Gestational Diabetes Mellitus. | MiR-34b-3p Impaired HUVECs Viability and Migration via Targeting PDK1 in an In Vitro Model of Gestational Diabetes Mellitus.
Song F, Cai A, Ye Q, Chen X, Lin L, Hao X. | 04/30/2022 |
| TMEM116 is required for lung cancer cell motility and metastasis through PDK1 signaling pathway. | TMEM116 is required for lung cancer cell motility and metastasis through PDK1 signaling pathway.
Zhang S, Dai H, Li W, Wang R, Wu H, Shen M, Hu Y, Xie L, Xing Y., Free PMC Article | 04/16/2022 |
| Copper Promotes Tumorigenesis by Activating the PDK1-AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner. | Copper Promotes Tumorigenesis by Activating the PDK1-AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner.
Guo J, Cheng J, Zheng N, Zhang X, Dai X, Zhang L, Hu C, Wu X, Jiang Q, Wu D, Okada H, Pandolfi PP, Wei W., Free PMC Article | 02/26/2022 |
| A PDK-1 allosteric agonist neutralizes insulin signaling derangements and beta-amyloid toxicity in neuronal cells and in vitro. | A PDK-1 allosteric agonist neutralizes insulin signaling derangements and beta-amyloid toxicity in neuronal cells and in vitro.
Querfurth H, Marshall J, Parang K, Rioult-Pedotti MS, Tiwari R, Kwon B, Reisinger S, Lee HK., Free PMC Article | 02/19/2022 |
| SPOP-mediated ubiquitination and degradation of PDK1 suppresses AKT kinase activity and oncogenic functions. | SPOP-mediated ubiquitination and degradation of PDK1 suppresses AKT kinase activity and oncogenic functions.
Jiang Q, Zheng N, Bu L, Zhang X, Zhang X, Wu Y, Su Y, Wang L, Zhang X, Ren S, Dai X, Wu D, Xie W, Wei W, Zhu Y, Guo J., Free PMC Article | 02/5/2022 |
| POU2F2 regulates glycolytic reprogramming and glioblastoma progression via PDPK1-dependent activation of PI3K/AKT/mTOR pathway. | POU2F2 regulates glycolytic reprogramming and glioblastoma progression via PDPK1-dependent activation of PI3K/AKT/mTOR pathway.
Yang R, Wang M, Zhang G, Li Y, Wang L, Cui H., Free PMC Article | 10/9/2021 |
| Binding of Avibirnavirus VP3 to the PIK3C3-PDPK1 complex inhibits autophagy by activating the AKT-MTOR pathway. | Binding of Avibirnavirus VP3 to the PIK3C3-PDPK1 complex inhibits autophagy by activating the AKT-MTOR pathway.
Zhang Y, Hu B, Li Y, Deng T, Xu Y, Lei J, Zhou J., Free PMC Article | 07/31/2021 |
| Phosphoinositide-dependent Kinase-1 (PDPK1) regulates serum/glucocorticoid-regulated Kinase 3 (SGK3) for prostate cancer cell survival. | Phosphoinositide-dependent Kinase-1 (PDPK1) regulates serum/glucocorticoid-regulated Kinase 3 (SGK3) for prostate cancer cell survival.
Nalairndran G, Hassan Abdul Razack A, Mai CW, Fei-Lei Chung F, Chan KK, Hii LW, Lim WM, Chung I, Leong CO., Free PMC Article | 05/8/2021 |
| Serine 389 phosphorylation of 3-phosphoinositide-dependent kinase 1 by UNC-51-like kinase 1 affects its ability to regulate Akt and p70 S6kinase. | Serine 389 phosphorylation of 3-phosphoinositide-dependent kinase 1 by UNC-51-like kinase 1 affects its ability to regulate Akt and p70 S6kinase.
Kim K, Park SG, Park BC, Kim JH, Kim S., Free PMC Article | 05/8/2021 |
| Long non-coding RNA ABHD11-AS1 boosts gastric cancer development by regulating miR-361-3p/PDPK1 signalling. | Long non-coding RNA ABHD11-AS1 boosts gastric cancer development by regulating miR-361-3p/PDPK1 signalling.
Xin H, Yan Z, Cao J. | 03/6/2021 |
| Elevated PDK1 Expression Drives PI3K/AKT/MTOR Signaling Promotes Radiation-Resistant and Dedifferentiated Phenotype of Hepatocellular Carcinoma. | Elevated PDK1 Expression Drives PI3K/AKT/MTOR Signaling Promotes Radiation-Resistant and Dedifferentiated Phenotype of Hepatocellular Carcinoma.
Bamodu OA, Chang HL, Ong JR, Lee WH, Yeh CT, Tsai JT., Free PMC Article | 02/13/2021 |
| Inhibition of 3-phosphoinositide-dependent protein kinase 1 (PDK1) can revert cellular senescence in human dermal fibroblasts. | Inhibition of 3-phosphoinositide-dependent protein kinase 1 (PDK1) can revert cellular senescence in human dermal fibroblasts.
An S, Cho SY, Kang J, Lee S, Kim HS, Min DJ, Son E, Cho KH., Free PMC Article | 01/23/2021 |
| LncRNA KTN1-AS1 promotes the progression of non-small cell lung cancer via sponging of miR-130a-5p and activation of PDPK1. | LncRNA KTN1-AS1 promotes the progression of non-small cell lung cancer via sponging of miR-130a-5p and activation of PDPK1.
Li C, Zhao W, Pan X, Li X, Yan F, Liu S, Feng J, Lu J. | 01/16/2021 |
| LncRNA CAR10 Upregulates PDPK1 to Promote Cervical Cancer Development by Sponging miR-125b-5p. | LncRNA CAR10 Upregulates PDPK1 to Promote Cervical Cancer Development by Sponging miR-125b-5p.
Hu T, Zhang Q, Gao L., Free PMC Article | 11/21/2020 |
| FKBP4 connects mTORC2 and PI3K to activate the PDK1/Akt-dependent cell proliferation signaling in breast cancer. | FKBP4 connects mTORC2 and PI3K to activate the PDK1/Akt-dependent cell proliferation signaling in breast cancer.
Mangé A, Coyaud E, Desmetz C, Laurent E, Béganton B, Coopman P, Raught B, Solassol J., Free PMC Article | 10/24/2020 |
| PDK1 (PDPK1) promotes metastasis by inducing epithelial-mesenchymal transition in hypopharyngeal carcinoma via the Notch1 signaling pathway. | PDK1 promotes metastasis by inducing epithelial-mesenchymal transition in hypopharyngeal carcinoma via the Notch1 signaling pathway.
Jing P, Zhou S, Xu P, Cui P, Liu X, Liu X, Liu X, Wang H, Xu W. | 08/1/2020 |
| The key observations of this study provide evidence suggesting that high expressions of 3-phosphoinositide-dependent protein kinase 1 (PDK1) are found in RCC, while highlighting that silencing PDK1 could inhibit renal cell carcinoma cell proliferation, migration, invasion and epithelial mesenchymal transition by repressing the PI3K-PDK1-Akt pathway. | Low expression of PDK1 inhibits renal cell carcinoma cell proliferation, migration, invasion and epithelial mesenchymal transition through inhibition of the PI3K-PDK1-Akt pathway.
Zhou WM, Wu GL, Huang J, Li JG, Hao C, He QM, Chen XD, Wang GX, Tu XH. | 05/23/2020 |
| The present observations reveal a pivotal role of PDPK1 (PDK1) in the regulation of megakaryocyte cytoskeletal dynamics and polarization, proplatelet formation, and thrombopoiesis. | Pivotal role of PDK1 in megakaryocyte cytoskeletal dynamics and polarization during platelet biogenesis.
Geue S, Aurbach K, Manke MC, Manukjan G, Münzer P, Stegner D, Brähler C, Walker-Allgaier B, Märklin M, Borst CE, Quintanilla-Fend L, Rath D, Geisler T, Salih HR, Seizer P, Lang F, Nieswandt B, Gawaz M, Schulze H, Pleines I, Borst O. | 03/7/2020 |