| Structural basis for allosteric regulation of human phosphofructokinase-1. | Structural basis for allosteric regulation of human phosphofructokinase-1.
Lynch EM, Hansen H, Salay L, Cooper M, Timr S, Kollman JM, Webb BA., Free PMC Article | 08/30/2024 |
| Ubiquitin-specific protease 14 targets PFKL-mediated glycolysis to promote the proliferation and migration of oral squamous cell carcinoma. | Ubiquitin-specific protease 14 targets PFKL-mediated glycolysis to promote the proliferation and migration of oral squamous cell carcinoma.
Zhang X, Geng L, Tang Y, Wang Y, Zhang Y, Zhu C, Lei H, Xu H, Zhu Q, Wu Y, Gu W., Free PMC Article | 02/28/2024 |
| EGR1 suppresses HCC growth and aerobic glycolysis by transcriptionally downregulating PFKL. | EGR1 suppresses HCC growth and aerobic glycolysis by transcriptionally downregulating PFKL.
Pan M, Luo M, Liu L, Chen Y, Cheng Z, Wang K, Huang L, Tang N, Qiu J, Huang A, Xia J., Free PMC Article | 02/8/2024 |
| miR-21-5p/Tiam1-mediated glycolysis reprogramming drives breast cancer progression via enhancing PFKL stabilization. | miR-21-5p/Tiam1-mediated glycolysis reprogramming drives breast cancer progression via enhancing PFKL stabilization.
Li N, Wang X, Sun J, Liu Y, Han A, Lin Z, Yang Y. | 09/17/2022 |
| Selective activation of PFKL suppresses the phagocytic oxidative burst. | Selective activation of PFKL suppresses the phagocytic oxidative burst.
Amara N, Cooper MP, Voronkova MA, Webb BA, Lynch EM, Kollman JM, Ma T, Yu K, Lai Z, Sangaraju D, Kayagaki N, Newton K, Bogyo M, Staben ST, Dixit VM., Free PMC Article | 01/8/2022 |
| Relocation of phosphofructokinases within epithelial cells is a novel event preceding breast cancer recurrence that accurately predicts patient outcomes. | Relocation of phosphofructokinases within epithelial cells is a novel event preceding breast cancer recurrence that accurately predicts patient outcomes.
Cheung RA, Kraft AM, Petty HR. | 11/13/2021 |
| Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches. | Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches.
Fernandes PM, Kinkead J, McNae I, Michels PAM, Walkinshaw MD., Free PMC Article | 03/13/2021 |
| A20 targets PFKL and glycolysis to inhibit the progression of hepatocellular carcinoma. | A20 targets PFKL and glycolysis to inhibit the progression of hepatocellular carcinoma.
Feng Y, Zhang Y, Cai Y, Liu R, Lu M, Li T, Fu Y, Guo M, Huang H, Ou Y, Chen Y., Free PMC Article | 02/20/2021 |
| (125)I irradiation upregulated the suppression of miR-338 on PFKL to downregulate the Warburg effect. | (125)I suppressed the Warburg effect viaregulating miR-338/PFKL axis in hepatocellular carcinoma.
Zheng J, Luo J, Zeng H, Guo L, Shao G. | 02/29/2020 |
| TAp73 deficiency results in a pronounced reduction in tumorigenic potential, which can be rescued by forced PFKL expression. | TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation.
Li L, Li L, Li W, Chen T, Bin Zou, Zhao L, Wang H, Wang X, Xu L, Liu X, Wang D, Li B, Mak TW, Du W, Yang X, Jiang P., Free PMC Article | 05/4/2019 |
| Liver PFK1 isoform assembles into filaments in a tetramer- and substrate-dependent manner,organizing isoform specific glucose metabolism in cells. | The glycolytic enzyme phosphofructokinase-1 assembles into filaments.
Webb BA, Dosey AM, Wittmann T, Kollman JM, Barber DL., Free PMC Article | 09/30/2017 |
| findings showed glycosylation inhibited PFK1 activity and redirected glucose flux through the pentose phosphate pathway, thereby conferring a selective growth advantage on cancer cells | Phosphofructokinase 1 glycosylation regulates cell growth and metabolism.
Yi W, Clark PM, Mason DE, Keenan MC, Hill C, Goddard WA 3rd, Peters EC, Driggers EM, Hsieh-Wilson LC., Free PMC Article | 11/17/2012 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone.
Ruaño G, Bernene J, Windemuth A, Bower B, Wencker D, Seip RL, Kocherla M, Holford TR, Petit WA, Hanks S. | 03/25/2009 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesPhysiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?
Ruaño G, Thompson PD, Kane JP, Pullinger CR, Windemuth A, Seip RL, Kocherla M, Holford TR, Wu AH. Physiogenomic comparison of human fat loss in response to diets restrictive of carbohydrate or fat.
Seip RL, Volek JS, Windemuth A, Kocherla M, Fernandez ML, Kraemer WJ, Ruaño G. | 04/3/2008 |