| A positive feedback loop between PFKP and c-Myc drives head and neck squamous cell carcinoma progression. | A positive feedback loop between PFKP and c-Myc drives head and neck squamous cell carcinoma progression.
Liu W, Ding Z, Tao Y, Liu S, Jiang M, Yi F, Wang Z, Han Y, Zong H, Li D, Zhu Y, Xie Z, Sang S, Chen X, Miao M, Chen X, Lin W, Zhao Y, Zheng G, Zafereo M, Li G, Wu J, Zha X, Liu Y., Free PMC Article | 08/5/2024 |
| PFKP deubiquitination and stabilization by USP5 activate aerobic glycolysis to promote triple-negative breast cancer progression. | PFKP deubiquitination and stabilization by USP5 activate aerobic glycolysis to promote triple-negative breast cancer progression.
Peng ZM, Han XJ, Wang T, Li JJ, Yang CX, Tou FF, Zhang Z., Free PMC Article | 01/17/2024 |
| Inhibition of PFKP in renal tubular epithelial cell restrains TGF-beta induced glycolysis and renal fibrosis. | Inhibition of PFKP in renal tubular epithelial cell restrains TGF-β induced glycolysis and renal fibrosis.
Yang S, Wu H, Li Y, Li L, Xiang J, Kang L, Yang G, Liang Z., Free PMC Article | 12/20/2023 |
| p53-responsive CMBL reprograms glucose metabolism and suppresses cancer development by destabilizing phosphofructokinase PFKP. | p53-responsive CMBL reprograms glucose metabolism and suppresses cancer development by destabilizing phosphofructokinase PFKP.
Huang Y, Xiong C, Wang C, Deng J, Zuo Z, Wu H, Xiong J, Wu X, Lu H, Hao Q, Zhou X. | 12/6/2023 |
| Glycolysis regulator PFKP induces human melanoma cell proliferation and tumor growth. | Glycolysis regulator PFKP induces human melanoma cell proliferation and tumor growth.
Chen C, Zhang X. | 06/21/2023 |
| Phosphofructokinase 1 Platelet Isoform Enhances VEGF Expression in Part Through HIF-1alpha Up-regulation in Breast Cancer. | Phosphofructokinase 1 Platelet Isoform Enhances VEGF Expression in Part Through HIF-1α Up-regulation in Breast Cancer.
Lee JH. | 02/11/2023 |
| Mutual regulation between phosphofructokinase 1 platelet isoform and VEGF promotes glioblastoma tumor growth. | Mutual regulation between phosphofructokinase 1 platelet isoform and VEGF promotes glioblastoma tumor growth.
Lim JS, Shi Y, Park SH, Jeon SM, Zhang C, Park YY, Liu R, Li J, Cho WS, Du L, Lee JH., Free PMC Article | 12/3/2022 |
| Phosphofructokinase 1 platelet isoform induces PD-L1 expression to promote glioblastoma immune evasion. | Phosphofructokinase 1 platelet isoform induces PD-L1 expression to promote glioblastoma immune evasion.
Wang S, Park SH, Lim JS, Park YY, Du L, Lee JH. | 12/3/2022 |
| PFKP Activation Ameliorates Foot Process Fusion in Podocytes in Diabetic Kidney Disease. | PFKP Activation Ameliorates Foot Process Fusion in Podocytes in Diabetic Kidney Disease.
Zhang Z, Liang W, Luo Q, Hu H, Yang K, Hu J, Chen Z, Zhu J, Feng J, Zhu Z, Chi Q, Ding G., Free PMC Article | 03/5/2022 |
| PFKP facilitates ATG4B phosphorylation during amino acid deprivation-induced autophagy. | PFKP facilitates ATG4B phosphorylation during amino acid deprivation-induced autophagy.
Li X, Sun L, Yan G, Yan X. | 01/22/2022 |
| Platelet isoform of phosphofructokinase accelerates malignant features in breast cancer. | Platelet isoform of phosphofructokinase accelerates malignant features in breast cancer.
Inaishi T, Shibata M, Ichikawa T, Kanda M, Hayashi M, Soeda I, Takeuchi D, Takano Y, Tsunoda N, Kodera Y, Kikumori T. | 01/15/2022 |
| Silencing PFKP restrains the stemness of hepatocellular carcinoma cells. | Silencing PFKP restrains the stemness of hepatocellular carcinoma cells.
Sha X, Wang K, Wang F, Zhang C, Yang L, Zhu X. | 11/13/2021 |
| Nuclear PFKP promotes CXCR4-dependent infiltration by T cell acute lymphoblastic leukemia. | Nuclear PFKP promotes CXCR4-dependent infiltration by T cell acute lymphoblastic leukemia.
Gao X, Qin S, Wu Y, Chu C, Jiang B, Johnson RH, Kuang D, Zhang J, Wang X, Mehta A, Tew KD, Leone GW, Yu XZ, Wang H., Free PMC Article | 11/13/2021 |
| Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer. | Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer.
Xu C, Tsai YH, Galbo PM, Gong W, Storey AJ, Xu Y, Byrum SD, Xu L, Whang YE, Parker JS, Mackintosh SG, Edmondson RD, Tackett AJ, Huang J, Zheng D, Earp HS, Wang GG, Cai L., Free PMC Article | 07/10/2021 |
| PFKP is highly expressed in lung cancer and regulates glucose metabolism. | PFKP is highly expressed in lung cancer and regulates glucose metabolism.
Shen J, Jin Z, Lv H, Jin K, Jonas K, Zhu C, Chen B. | 06/5/2021 |
| PFKP phenotype in lung cancer: prognostic potential and beyond. | PFKP phenotype in lung cancer: prognostic potential and beyond.
Ganapathy-Kanniappan S. | 05/22/2021 |
| Platelet isoform of phosphofructokinase promotes aerobic glycolysis and the progression of nonsmall cell lung cancer. | Platelet isoform of phosphofructokinase promotes aerobic glycolysis and the progression of non‑small cell lung cancer.
Wang F, Li L, Zhang Z., Free PMC Article | 05/8/2021 |
| Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches. | Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches.
Fernandes PM, Kinkead J, McNae I, Michels PAM, Walkinshaw MD., Free PMC Article | 03/13/2021 |
| Prognostic and therapeutic relevance of phosphofructokinase platelet-type (PFKP) in breast cancer. | Prognostic and therapeutic relevance of phosphofructokinase platelet-type (PFKP) in breast cancer.
Umar SM, Kashyap A, Kahol S, Mathur SR, Gogia A, Deo SVS, Prasad CP. | 03/13/2021 |
| The observed changes are suggestive of compositional changes in the subunit makeup of HK and PFK. The implication of these findings in relation to energy status of the diabetic erythrocyte and its interrelationship with loss of cell deformability are discussed here. | Type 2 diabetes differentially affects the substrate saturation kinetic attributes of erythrocyte hexokinase and phosphofructokinase.
Bhise S, Rao J, Hegde M, Katyare S. | 07/25/2020 |
| PFKP expression was significantly increased in OSCC patients. | Silencing PFKP inhibits starvation-induced autophagy, glycolysis, and epithelial mesenchymal transition in oral squamous cell carcinoma.
Chen G, Liu H, Zhang Y, Liang J, Zhu Y, Zhang M, Yu D, Wang C, Hou J. | 09/21/2019 |
| EGFR-phosphorylated platelet isoform of phosphofructokinase 1 promotes PI3K activation, promoting the Warburg effect, tumor cell proliferation, and brain tumorigenesis. | EGFR-Phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3K Activation.
Lee JH, Liu R, Li J, Wang Y, Tan L, Li XJ, Qian X, Zhang C, Xia Y, Xu D, Guo W, Ding Z, Du L, Zheng Y, Chen Q, Lorenzi PL, Mills GB, Jiang T, Lu Z., Free PMC Article | 02/9/2019 |
| Snail functions as a metabolic switch between aerobic glycolysis and pentose phosphate pathway by repressing PFKP, a cancer-specific PFK-1, allowing cancer cell survival under metabolic stress. | Snail reprograms glucose metabolism by repressing phosphofructokinase PFKP allowing cancer cell survival under metabolic stress.
Kim NH, Cha YH, Lee J, Lee SH, Yang JH, Yun JS, Cho ES, Zhang X, Nam M, Kim N, Yuk YS, Cha SY, Lee Y, Ryu JK, Park S, Cheong JH, Kang SW, Kim SY, Hwang GS, Yook JI, Kim HS., Free PMC Article | 11/17/2018 |
| Here the authors show that PFK1 platelet isoform is upregulated in Glioblastoma and is required for tumor growth mechanistically, such upregulation is due to an increased stability induced by AKT activation via phosphorylation on residue S386. | Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis.
Lee JH, Liu R, Li J, Zhang C, Wang Y, Cai Q, Qian X, Xia Y, Zheng Y, Piao Y, Chen Q, de Groot JF, Jiang T, Lu Z., Free PMC Article | 02/17/2018 |
| Data indicate that platelet isoform of phosphofructokinase (PFKP) not only is required for metabolic reprogramming and maintaining cell proliferation, but also may be a valid target for anti-renal cancer pharmaceutical agents. | The platelet isoform of phosphofructokinase contributes to metabolic reprogramming and maintains cell proliferation in clear cell renal cell carcinoma.
Wang J, Zhang P, Zhong J, Tan M, Ge J, Tao L, Li Y, Zhu Y, Wu L, Qiu J, Tong X., Free PMC Article | 12/16/2017 |