| N6-methyladenosine-modified circCDK14 promotes ossification of the ligamentum flavum via epigenetic modulation by targeting AFF4. | N6-methyladenosine-modified circCDK14 promotes ossification of the ligamentum flavum via epigenetic modulation by targeting AFF4.
Zhao Y, Chen L, Xiang Q, Lin J, Jiang S, Li W., Free PMC Article | 10/25/2024 |
| Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy. | Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy.
Parmasad JA, Ricke KM, Nguyen B, Stykel MG, Buchner-Duby B, Bruce A, Geertsma HM, Lian E, Lengacher NA, Callaghan SM, Joselin A, Tomlinson JJ, Schlossmacher MG, Stanford WL, Ma J, Brundin P, Ryan SD, Rousseaux MWC., Free PMC Article | 04/12/2024 |
| P300/SP1 complex mediating elevated METTL1 regulates CDK14 mRNA stability via internal m7G modification in CRPC. | P300/SP1 complex mediating elevated METTL1 regulates CDK14 mRNA stability via internal m7G modification in CRPC.
Zhang M, Kan D, Zhang B, Chen X, Wang C, Chen S, Gao W, Yang Z, Li Y, Chen Y, Zhu S, Wen S, Niu Y, Shang Z., Free PMC Article | 08/22/2023 |
| LncRNA NORAD accelerates the progression of non-small cell lung cancer via targeting miRNA-455/CDK14 axis. | LncRNA NORAD accelerates the progression of non-small cell lung cancer via targeting miRNA-455/CDK14 axis.
Wang C, Wu D, He M, Guan L, Bai D, Liang B. | 12/17/2022 |
| CircCDK14 Promotes Tumor Progression and Resists Ferroptosis in Glioma by Regulating PDGFRA. | CircCDK14 Promotes Tumor Progression and Resists Ferroptosis in Glioma by Regulating PDGFRA.
Chen S, Zhang Z, Zhang B, Huang Q, Liu Y, Qiu Y, Long X, Wu M, Zhang Z., Free PMC Article | 03/26/2022 |
| Depletion of circRNA circ_CDK14 inhibits osteosarcoma progression by regulating the miR-520a-3p/GAB1 axis. | Depletion of circRNA circ_CDK14 inhibits osteosarcoma progression by regulating the miR-520a-3p/GAB1 axis.
Wu PF, Tang XM, Sun HL, Jiang HT, Ma J, Kong YH. | 09/18/2021 |
| MiR-205 Inhibits Sporadic Vestibular Schwannoma Cell Proliferation by Targeting Cyclin-Dependent Kinase 14. | MiR-205 Inhibits Sporadic Vestibular Schwannoma Cell Proliferation by Targeting Cyclin-Dependent Kinase 14.
Yin X, Huo Z, Yan S, Wang Z, Yang T, Wu H, Zhang Z. | 07/10/2021 |
| CircCDK14 protects against Osteoarthritis by sponging miR-125a-5p and promoting the expression of Smad2. | CircCDK14 protects against Osteoarthritis by sponging miR-125a-5p and promoting the expression of Smad2.
Shen P, Yang Y, Liu G, Chen W, Chen J, Wang Q, Gao H, Fan S, Shen S, Zhao X., Free PMC Article | 06/5/2021 |
| Upregulation of miR-1825 inhibits the progression of glioblastoma by suppressing CDK14 though Wnt/beta-catenin signaling pathway. | Upregulation of miR-1825 inhibits the progression of glioblastoma by suppressing CDK14 though Wnt/β-catenin signaling pathway.
Lu F, Li C, Sun Y, Jia T, Li N, Li H., Free PMC Article | 04/17/2021 |
| we demonstrated that MSC-AS1/miR-29b-3p axis modulates the cell proliferation and GEM-induced cell apoptosis in PDAC cell lines through CDK14. We provided a novel experimental basis for PDAC treatment from the perspective of lncRNA-miRNA-mRNA network. | The role of lncRNA MSC-AS1/miR-29b-3p axis-mediated CDK14 modulation in pancreatic cancer proliferation and Gemcitabine-induced apoptosis.
Sun Y, Wang P, Yang W, Shan Y, Zhang Q, Wu H., Free PMC Article | 08/1/2020 |
| LncRNA H19/miR-194/PFTK1 axis modulates the cell proliferation and migration of pancreatic cancer. | LncRNA H19/miR-194/PFTK1 axis modulates the cell proliferation and migration of pancreatic cancer.
Sun Y, Zhu Q, Yang W, Shan Y, Yu Z, Zhang Q, Wu H. | 06/20/2020 |
| our findings indicated that NEAT1/miR-107/CDK14 axis participated in glioma development. NEAT1 could act as a significant prognostic biomarker in glioma progression. | Knockdown of NEAT1 repressed the malignant progression of glioma through sponging miR-107 and inhibiting CDK14.
Zhen Y, Nan Y, Guo S, Zhang L, Li G, Yue S, Liu X. | 05/16/2020 |
| MiR-431 expression was reduced both in pancreatic cancer tissues and cell lines. Cell proliferative ability was effectively lessened after up-regulating miR-431. Elevated miR-431 significantly induced cell apoptosis and modulated cell cycle arrest. Meanwhile, CDK14 was a direct target gene of miR-431, and over-expression of miR-431 decreased the level of CDK14. | MiR-431 inhibits cell proliferation and induces cell apoptosis by targeting CDK14 in pancreatic cancer.
Yang J, Zhu H, Jin Y, Song Y. | 12/14/2019 |
| the ectopic overexpression of SNHG15 contribute to the non-small cell lung cancer tumorigenesis by regulating CDK14 protein via sponging miR-486. | Long non-coding RNA SNHG15 promotes CDK14 expression via miR-486 to accelerate non-small cell lung cancer cells progression and metastasis.
Jin B, Jin H, Wu HB, Xu JJ, Li B., Free PMC Article | 10/5/2019 |
| Data suggest the risk-associated single nucleotide polymorphism (SNP) rs10272859 of cyclin dependent kinase 14 (CDK14) gene at 7q21.13 conferring both susceptibility and prognosis to HBV-related hepatocellular carcinoma (HCC). | Genome-Wide Association Study Identifies a New Locus at 7q21.13 Associated with Hepatitis B Virus-Related Hepatocellular Carcinoma.
Li Y, Zhai Y, Song Q, Zhang H, Cao P, Ping J, Liu X, Guo B, Liu G, Song J, Zhang Y, Yang A, Yan H, Yang L, Cui Y, Ma Y, Xing J, Shen X, Liu T, Zhang H, An J, Bei JX, Jia W, Kang L, Liu L, Yuan D, Hu Z, Shen H, Lu L, Wang X, Li H, He F, Zhang H, Zhou G. | 09/28/2019 |
| CDK14 overexpression reversed the suppressive effects of miR-542-3p in ovarian cancer cells. | MiR-542-3p, a microRNA targeting CDK14, suppresses cell proliferation, invasiveness, and tumorigenesis of epithelial ovarian cancer.
Li J, Shao W, Feng H. | 04/20/2019 |
| OIP5-AS1 acts as a miR-223 'sponge' to trigger CDK14 expression to promote osteosarcoma tumorigenesis. | Long noncoding RNA OIP5-AS1 accelerates CDK14 expression to promote osteosarcoma tumorigenesis via targeting miR-223.
Dai J, Xu L, Hu X, Han G, Jiang H, Sun H, Zhu G, Tang X. | 12/1/2018 |
| knockdown of E2F5 and PFTK1 mimicked the tumor-suppressive effects of miR-1-3p overexpression on PCa progression. Conversely, concomitant knockdown of miR-1-3p and E2F5 and PFTK1 substantially reversed the inhibitory effects of either E2F5 or PFTK1 silencing alone. | The putative tumour suppressor miR-1-3p modulates prostate cancer cell aggressiveness by repressing E2F5 and PFTK1.
Li SM, Wu HL, Yu X, Tang K, Wang SG, Ye ZQ, Hu J., Free PMC Article | 10/20/2018 |
| CDK14 mediated miR-1202 to exert its anti-tumor effects. | MiR-1202 suppresses hepatocellular carcinoma cells migration and invasion by targeting cyclin dependent kinase 14.
Du B, Zhang P, Tan Z, Xu J. | 07/28/2018 |
| CDK14 expression was closely associated with poor prognosis and overall survival of Osteosarcoma patients. miR-216a inhibits CDK14 expression by binding to the 3'-untranslated region of CDK14. | miR-216a inhibits osteosarcoma cell proliferation, invasion and metastasis by targeting CDK14.
Ji Q, Xu X, Li L, Goodman SB, Bi W, Xu M, Xu Y, Fan Z, Maloney WJ, Ye Q, Wang Y., Free PMC Article | 06/9/2018 |
| PFTK1 expression is significantly higher in CRC tissues compared with matched adjacent noncancerous colorectal tissues. The associations between PFTK1 expression and clinicopathological characters, and PFTK1 expression and the OS rate following resection suggested that PFTK1 may represent a novel biomarker of poor prognosis in CRC | High expression of PFTK1 in cancer cells predicts poor prognosis in colorectal cancer.
Mao Y, Jia Y, Zhu H, Wang W, Jin Q, Huang F, Zhang S, Li X. | 03/31/2018 |
| Results show that CDK14 and DYRK2 expression were inversely correlated in human breast cancer tissues and identified CDK14 as a target of DYRK2. | Downregulation of dual-specificity tyrosine-regulated kinase 2 promotes tumor cell proliferation and invasion by enhancing cyclin-dependent kinase 14 expression in breast cancer.
Imawari Y, Mimoto R, Hirooka S, Morikawa T, Takeyama H, Yoshida K., Free PMC Article | 02/10/2018 |
| miR-455 inhibits breast cancer cell proliferation through targeting CDK14 | miR-455 inhibits breast cancer cell proliferation through targeting CDK14.
Wang B, Zou A, Ma L, Chen X, Wang L, Zeng X, Tan T. | 12/9/2017 |
| findings revealed an unrecognized role of Caprin-2 in facilitating LRP5/6 constitutive phosphorylation at G2/M through forming a quaternary complex with CDK14, Cyclin Y, and LRP5/6. | Activation/Proliferation-associated Protein 2 (Caprin-2) Positively Regulates CDK14/Cyclin Y-mediated Lipoprotein Receptor-related Protein 5 and 6 (LRP5/6) Constitutive Phosphorylation.
Wang X, Jia Y, Fei C, Song X, Li L., Free PMC Article | 06/3/2017 |
| we report that PFTK1 downregulation might inhibit the proliferation and invasion of NSCLC cells by suppressing the Wnt/beta-catenin signaling pathway. | Knockdown of PFTK1 Expression by RNAi Inhibits the Proliferation and Invasion of Human Non-Small Lung Adenocarcinoma Cells.
Liu MH, Shi SM, Li K, Chen EQ., Free PMC Article | 03/18/2017 |