| these findings indicate that intestinal L cells are responsive to PANDER, and elevated PANDER levels impair GLP-1 production in vitro and in vivo. | Pancreatic-derived factor impaired glucagon-like Peptide-1 production from GLUTag enterendorine L-cell line and intestines.
Lai F, Chen Y, Lin H, Wang X, Zhu X, Li Y, Xiao H, Cao X. | 03/31/2018 |
| PANDER strongly impacts hepatic lipid metabolism across metabolic states and may induce a selective hepatic insulin resistant phenotype via the LXR pathway. | Quantitative proteomic profiling reveals hepatic lipogenesis and liver X receptor activation in the PANDER transgenic model.
Athanason MG, Ratliff WA, Chaput D, MarElia CB, Kuehl MN, Stevens SM Jr, Burkhardt BR., Free PMC Article | 11/18/2017 |
| in-vitro and in-vivo glucose is a potent stimulator of the PANDER promoter within the liver and this response may be facilitated by ChREBP. | Hepatic nutrient and hormonal regulation of the PANcreatic-DERived factor (PANDER) promoter.
Ratliff WA, Athanason MG, Chechele AC, Kuehl MN, Fernandez AM, MarElia CB, Burkhardt BR. | 04/9/2016 |
| F3MB(PANDER) decreases mice hepatic triglyceride and is associated with decreased DGAT1 expression | F3MB(PANDER) decreases mice hepatic triglyceride and is associated with decreased DGAT1 expression.
Mo X, Yang C, Wang X, Burkhardt BR, Li Y, Xia H, Cao X., Free PMC Article | 01/2/2016 |
| X-ray crystal structure of the mouse FAM3B protein. | FAM3B PANDER and FAM3C ILEI represent a distinct class of signaling molecules with a non-cytokine-like fold.
Johansson P, Bernström J, Gorman T, Oster L, Bäckström S, Schweikart F, Xu B, Xue Y, Schiavone LH. | 08/3/2013 |
| these results demonstrated that the JNK-mediated signaling mechanism of palmitic acid -induced beta-cell apoptosis involves up-regulated expression of PANDER and activation of caspase-3. | Effect of PANDER in βTC6-cell lipoapoptosis and the protective role of exendin-4.
Xiang JN, Chen DL, Yang LY. | 08/18/2012 |
| Data suggest a new link between the endocrine and immune systems and provide useful information for further investigating the physiological functions of PANDER and its involvement in inflammation-related pancreatic disorders. | Upregulation of pancreatic derived factor (FAM3B) expression in pancreatic β-cells by MCP-1 (CCL2).
Hou X, Wang O, Li Z, Mou H, Chen J, Deng B, Qian L, Liu X, Le Y. | 03/3/2012 |
| Palmitic acid induces the expression of PANDER and the apoptosis of beta-TC3 cells while glucagon-like peptide-1 counteracts the above effects through an activation of Akt signaling. | [Effects of glucagon-like peptide-1 on the free fatty acid-induced expression of pancreatic derived factor in cultured β-TC3 cell line].
Chen S, Cao XP, Xiao HP, Li YB. | 02/4/2012 |
| PANDER promotes lipogenesis and compromises insulin signaling in the liver by increasing FOXO1 activity. | Pancreatic-derived factor promotes lipogenesis in the mouse liver: role of the Forkhead box 1 signaling pathway.
Li J, Chi Y, Wang C, Wu J, Yang H, Zhang D, Zhu Y, Wang N, Yang J, Guan Y. | 09/3/2011 |
| Findings further indicate PANDER impacts glycemic levels and may represent a potential but complicated therapeutic target. | PANDER KO mice on high-fat diet are glucose intolerant yet resistant to fasting hyperglycemia and hyperinsulinemia.
Robert-Cooperman CE, Wilson CG, Burkhardt BR., Free PMC Article | 08/6/2011 |
| A paracrine/endocrine effect of insulin on Pander release and a potential glucose-regulatory role for Pander. | Characterization of the expression, localization, and secretion of PANDER in alpha-cells.
Carnegie JR, Robert-Cooperman CE, Wu J, Young RA, Wolf BA, Burkhardt BR., Free PMC Article | 11/27/2010 |
| we provide evidence that identifies PANDER as a regulator of hepatic glucose metabolism, where it amplifies hepatic cAMP and cAMP-response element-binding protein signaling to induce gluconeogenic gene expression and glucose output. | Liver-specific overexpression of pancreatic-derived factor (PANDER) induces fasting hyperglycemia in mice.
Wilson CG, Schupp M, Burkhardt BR, Wu J, Young RA, Wolf BA., Free PMC Article | 11/6/2010 |
| Potential role of PANDER in the pancreatic beta-cell for regulation or facilitation of insulin secretion, shown in PANDER knockout mice. | Targeted disruption of pancreatic-derived factor (PANDER, FAM3B) impairs pancreatic beta-cell function.
Robert-Cooperman CE, Carnegie JR, Wilson CG, Yang J, Cook JR, Wu J, Young RA, Wolf BA, Burkhardt BR., Free PMC Article | 09/27/2010 |
| liver is a target for PANDER, and PANDER may be involved in the progression of diabetes by regulating hepatic insulin signaling pathways. | PANDER binds to the liver cell membrane and inhibits insulin signaling in HepG2 cells.
Yang J, Wang C, Li J, Burkhardt BR, Robert-Cooperman CE, Wilson C, Gao Z, Wolf BA. | 01/21/2010 |
| PANDER is a potential PDX-1 target gene and the A box sites within the promoter region are critical for basal and glucose-stimulated PANDER expression. | PDX-1 interaction and regulation of the Pancreatic Derived Factor (PANDER, FAM3B) promoter.
Burkhardt BR, Cook JR, Young RA, Wolf BA., Free PMC Article | 01/21/2010 |
| Because PANDER (FAM3B) is expressed by pancreatic beta-cells and in response to glucose in a similar way to those of insulin, PANDER may be involved in glucose homeostasis | Mechanisms of glucose-induced expression of pancreatic-derived factor in pancreatic beta-cells.
Wang O, Cai K, Pang S, Wang T, Qi D, Zhu Q, Ni Z, Le Y. | 01/21/2010 |
| Tissue-specific and glucose-responsive expression of FAM3B promoter were studied. | Tissue-specific and glucose-responsive expression of the pancreatic derived factor (PANDER) promoter.
Burkhardt BR, Yang MC, Robert CE, Greene SR, McFadden KK, Yang J, Wu J, Gao Z, Wolf BA. | 01/21/2010 |
| In conclusion, Ad-PANDER infection is as effective as truncated recombinant PANDER to induce betaTC3 cell and mouse islet apoptosis. | Effects of overexpression of pancreatic derived factor (FAM3B) in isolated mouse islets and insulin-secreting betaTC3 cells.
Cao X, Yang J, Burkhardt BR, Gao Z, Wong RK, Greene SR, Wu J, Wolf BA. | 01/21/2010 |
| Because FAM3B (PANDER) mRNA expression is up-regulated by IFNgamma, a cytokine implicated in the pathogenesis of type 1 diabetes, PANDER may contribute to the pathogenesis of beta-cell death. (FAM3B) | Interferon-gamma-induced regulation of the pancreatic derived cytokine FAM3B in islets and insulin-secreting betaTC3 cells.
Xu W, Gao Z, Wu J, Wolf BA. | 01/21/2010 |