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    PIM1 Pim-1 proto-oncogene, serine/threonine kinase [ Homo sapiens (human) ]

    Gene ID: 5292, updated on 9-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    [Effects of PIM1 Gene on Proliferation, Apoptosis and JAK2/STAT3 Signaling Pathway of Acute Myeloid Leukemia U937 Cells].

    [Effects of PIM1 Gene on Proliferation, Apoptosis and JAK2/STAT3 Signaling Pathway of Acute Myeloid Leukemia U937 Cells].
    Gao X, Chu LJ, Yan ZH.

    07/16/2024
    NUP98-BPTF promotes oncogenic transformation through PIM1 upregulation.

    NUP98-BPTF promotes oncogenic transformation through PIM1 upregulation.
    Noura M, Tomita S, Yasuda T, Tsuzuki S, Kiyoi H, Hayakawa F., Free PMC Article

    07/3/2024
    What doesn't fit is made to fit: Pim-1 kinase adapts to the configuration of stilbene-based inhibitors.

    What doesn't fit is made to fit: Pim-1 kinase adapts to the configuration of stilbene-based inhibitors.
    Hochban PMM, Heyder L, Heine A, Diederich WE.

    06/14/2024
    Kinase PIM1 governs ferroptosis to reduce retinal microvascular endothelial cell dysfunction triggered by high glucose.

    Kinase PIM1 governs ferroptosis to reduce retinal microvascular endothelial cell dysfunction triggered by high glucose.
    Xie HB, Guo JH, Yang MM, Wang JT.

    05/1/2024
    The impact of MYD88 and PIM1 in mature large B-cell non-Hodgkin lymphomas: Defining element of their evolution and prognosis.

    The impact of MYD88 and PIM1 in mature large B-cell non-Hodgkin lymphomas: Defining element of their evolution and prognosis.
    Cristian M, Așchie M, Mitroi AF, Deacu M, Boșoteanu M, Bălțătescu GI, Stoica AG, Nicolau AA, Enciu M, Crețu AM, Caloian AD, Orășanu CI, Poinăreanu I., Free PMC Article

    02/27/2024
    PIM1 targeted degradation prevents the emergence of chemoresistance in prostate cancer.

    PIM1 targeted degradation prevents the emergence of chemoresistance in prostate cancer.
    Torres-Ayuso P, Katerji M, Mehlich D, Lookingbill SA, Sabbasani VR, Liou H, Casillas AL, Chauhan SS, Serwa R, Rubin MR, Marusiak AA, Swenson RE, Warfel NA, Brognard J.,

    02/22/2024
    Mesenchymal stem cells attenuate systemic lupus erythematosus by inhibiting NLRP3 inflammasome activation through Pim-1 kinase.

    Mesenchymal stem cells attenuate systemic lupus erythematosus by inhibiting NLRP3 inflammasome activation through Pim-1 kinase.
    Yu H, Li Q, Zhu H, Liu C, Chen W, Sun L.

    01/4/2024
    PIM1 phosphorylates ABI2 to enhance actin dynamics and promote tumor invasion.

    PIM1 phosphorylates ABI2 to enhance actin dynamics and promote tumor invasion.
    Jensen CC, Clements AN, Liou H, Ball LE, Bethard JR, Langlais PR, Toth RK, Chauhan SS, Casillas AL, Daulat SR, Kraft AS, Cress AE, Miranti CK, Mouneimne G, Rogers GC, Warfel NA., Free PMC Article

    04/14/2023
    Pim-1 kinase is a positive feedback regulator of the senescent lung fibroblast inflammatory secretome.

    Pim-1 kinase is a positive feedback regulator of the senescent lung fibroblast inflammatory secretome.
    Gao AY, Diaz Espinosa AM, Gianì F, Pham TX, Carver CM, Aravamudhan A, Bartman CM, Ligresti G, Caporarello N, Schafer MJ, Haak AJ., Free PMC Article

    12/31/2022
    PIM1-Induced Cytoplasmic Expression of RBMY Mediates Hepatocellular Carcinoma Metastasis.

    PIM1-Induced Cytoplasmic Expression of RBMY Mediates Hepatocellular Carcinoma Metastasis.
    Chua HH, Chang MH, Chen YH, Tsuei DJ, Jeng YM, Lee PH, Ni YH., Free PMC Article

    12/31/2022
    Multicellular immune dynamics implicate PIM1 as a potential therapeutic target for uveitis.

    Multicellular immune dynamics implicate PIM1 as a potential therapeutic target for uveitis.
    Li H, Xie L, Zhu L, Li Z, Wang R, Liu X, Huang Z, Chen B, Gao Y, Wei L, He C, Ju R, Liu Y, Liu X, Zheng Y, Su W., Free PMC Article

    10/8/2022
    PIM1 promotes hepatic conversion by suppressing reprogramming-induced ferroptosis and cell cycle arrest.

    PIM1 promotes hepatic conversion by suppressing reprogramming-induced ferroptosis and cell cycle arrest.
    Yuan Y, Wang C, Zhuang X, Lin S, Luo M, Deng W, Zhou J, Liu L, Mao L, Peng W, Chen J, Wang Q, Shu Y, Xue Y, Huang P., Free PMC Article

    09/17/2022
    KLF2-induced circZKSCAN1 potentiates the tumorigenic properties of clear cell renal cell carcinoma by targeting the miR-1294/PIM1 axis.

    KLF2-induced circZKSCAN1 potentiates the tumorigenic properties of clear cell renal cell carcinoma by targeting the miR-1294/PIM1 axis.
    Li M, Zhang M, Chen M, Xiao J, Mu X, Peng J, Fan J., Free PMC Article

    07/16/2022
    Long Noncoding RNA KCNQ1OT1 Confers Gliomas Resistance to Temozolomide and Enhances Cell Growth by Retrieving PIM1 From miR-761.

    Long Noncoding RNA KCNQ1OT1 Confers Gliomas Resistance to Temozolomide and Enhances Cell Growth by Retrieving PIM1 From miR-761.
    Wang W, Han S, Gao W, Feng Y, Li K, Wu D.

    07/2/2022
    Relationship between the transcriptional expression of PIM1 and local control in patients with head and neck squamous cell carcinomas treated with radiotherapy.

    Relationship between the transcriptional expression of PIM1 and local control in patients with head and neck squamous cell carcinomas treated with radiotherapy.
    León X, García J, Pujol A, de Juan J, Vásquez R, Quer M, Camacho M., Free PMC Article

    05/28/2022
    PIM1 kinase facilitates Zika virus replication by suppressing host cells' natural immunity.

    PIM1 kinase facilitates Zika virus replication by suppressing host cells' natural immunity.
    Zhou F, Wan Q, Chen Y, Chen S, He ML., Free PMC Article

    03/26/2022
    Increased Expression of the lncRNA NRON Along With NFATc1/PIM-1 in Labial Salivary Glands of Sjogren's Syndrome Patients.

    Increased Expression of the lncRNA NRON Along With NFATc1/PIM-1 in Labial Salivary Glands of Sjögren's Syndrome Patients.
    Horai Y, Nakamura H, Shimizu T, Nishihata S, Iwamoto N, Kuroki T, Okano S, Kawakami A., Free PMC Article

    03/12/2022
    PIM kinases inhibit AMPK activation and promote tumorigenicity by phosphorylating LKB1.

    PIM kinases inhibit AMPK activation and promote tumorigenicity by phosphorylating LKB1.
    Mung KL, Eccleshall WB, Santio NM, Rivero-Müller A, Koskinen PJ., Free PMC Article

    01/29/2022
    Mesenchymal stem cell conditioned medium attenuates oxidative stress injury in hepatocytes partly by regulating the miR-486-5p/PIM1 axis and the TGF-beta/Smad pathway.

    Mesenchymal stem cell conditioned medium attenuates oxidative stress injury in hepatocytes partly by regulating the miR-486-5p/PIM1 axis and the TGF-β/Smad pathway.
    Ma N, Li S, Lin C, Cheng X, Meng Z., Free PMC Article

    01/15/2022
    Direct phosphorylation and stabilization of HIF-1alpha by PIM1 kinase drives angiogenesis in solid tumors.

    Direct phosphorylation and stabilization of HIF-1α by PIM1 kinase drives angiogenesis in solid tumors.
    Casillas AL, Chauhan SS, Toth RK, Sainz AG, Clements AN, Jensen CC, Langlais PR, Miranti CK, Cress AE, Warfel NA., Free PMC Article

    01/8/2022
    PIM kinases mediate resistance to cisplatin chemotherapy in hepatoblastoma.

    PIM kinases mediate resistance to cisplatin chemotherapy in hepatoblastoma.
    Marayati R, Stafman LL, Williams AP, Bownes LV, Quinn CH, Aye JM, Stewart JE, Yoon KJ, Anderson JC, Willey CD, Beierle EA., Free PMC Article

    12/18/2021
    Prognostic and immunomodulatory effects of PIM1 in colorectal carcinoma.

    Prognostic and immunomodulatory effects of PIM1 in colorectal carcinoma.
    Zhou Y, Zhou Y, Liu S, Wang J, Ji R, Yan X.

    12/18/2021
    Overexpression of microRNA486 affects the proliferation and chemosensitivity of mesothelioma cell lines by targeting PIM1.

    Overexpression of microRNA‑486 affects the proliferation and chemosensitivity of mesothelioma cell lines by targeting PIM1.
    Pinelli S, Alinovi R, Poli D, Corradi M, Pelosi G, Tiseo M, Goldoni M, Cavallo D, Mozzoni P., Free PMC Article

    11/22/2021
    PIM1 inhibition attenuated endotoxin-induced acute lung injury through modulating ELK3/ICAM1 axis on pulmonary microvascular endothelial cells.

    PIM1 inhibition attenuated endotoxin-induced acute lung injury through modulating ELK3/ICAM1 axis on pulmonary microvascular endothelial cells.
    Cao Y, Chen X, Liu Y, Zhang X, Zou Y, Li J.

    10/9/2021
    PIM kinase inhibition: co-targeted therapeutic approaches in prostate cancer.

    PIM kinase inhibition: co-targeted therapeutic approaches in prostate cancer.
    Luszczak S, Kumar C, Sathyadevan VK, Simpson BS, Gately KA, Whitaker HC, Heavey S., Free PMC Article

    10/9/2021
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