| Structural basis for the conserved roles of PI4KA and its regulatory partners and their misregulation in disease. | Structural basis for the conserved roles of PI4KA and its regulatory partners and their misregulation in disease.
Suresh S, Burke JE. | 01/5/2024 |
| Adaptor proteins mediate CXCR4 and PI4KA crosstalk in prostate cancer cells and the significance of PI4KA in bone tumor growth. | Adaptor proteins mediate CXCR4 and PI4KA crosstalk in prostate cancer cells and the significance of PI4KA in bone tumor growth.
Govindarajan B, Sbrissa D, Pressprich M, Kim S, Rishi AK, Vaishampayan U, Cher ML, Chinni SR., Free PMC Article | 12/1/2023 |
| CircPI4KA Overexpression Enhances Carcinogenesis and Glycolysis Metabolism in Papillary Thyroid Carcinoma by Causing the miR-1287-5p-Mediated NRP2 Expression Elevation. | CircPI4KA Overexpression Enhances Carcinogenesis and Glycolysis Metabolism in Papillary Thyroid Carcinoma by Causing the miR-1287-5p-Mediated NRP2 Expression Elevation.
Sun H, Xu F, You D. | 10/11/2023 |
| Actin dynamics regulation by TTC7A/PI4KIIIalpha limits DNA damage and cell death under confinement. | Actin dynamics regulation by TTC7A/PI4KIIIα limits DNA damage and cell death under confinement.
Gajardo T, Bernard M, Lô M, Turck E, Leveau C, El-Daher MT, Deslys A, Panikulam P, Menche C, Kurowska M, Le Lay G, Barbier L, Moshous D, Neven B, Farin HF, Fischer A, Ménasché G, de Saint Basile G, Vargas P, Sepulveda FE. | 10/10/2023 |
| PI4KA and PIKfyve: Essential phosphoinositide signaling enzymes involved in myriad human diseases. | PI4KA and PIKfyve: Essential phosphoinositide signaling enzymes involved in myriad human diseases.
Barlow-Busch I, Shaw AL, Burke JE. | 08/10/2023 |
| A synonymous mutation in <i>PI4KA</i> impacts the transcription and translation process of gene expression. | A synonymous mutation in PI4KA impacts the transcription and translation process of gene expression.
Zhang K, Kang L, Zhang H, Bai L, Pang H, Liu Q, Zhang X, Chen D, Yu H, Lv Y, Gao M, Liu Y, Gai Z, Wang D, Li X., Free PMC Article | 11/12/2022 |
| Biallelic PI4KA variants cause neurological, intestinal and immunological disease. | Biallelic PI4KA variants cause neurological, intestinal and immunological disease.
Salter CG, Cai Y, Lo B, Helman G, Taylor H, McCartney A, Leslie JS, Accogli A, Zara F, Traverso M, Fasham J, Lees JA, Ferla MP, Chioza BA, Wenger O, Scott E, Cross HE, Crawford J, Warshawsky I, Keisling M, Agamanolis D, Ward Melver C, Cox H, Elawad M, Marton T, Wakeling MN, Holzinger D, Tippelt S, Munteanu M, Valcheva D, Deal C, Van Meerbeke S, Walsh Vockley C, Butte MJ, Acar U, van der Knaap MS, Korenke GC, Kotzaeridou U, Balla T, Simons C, Uhlig HH, Crosby AH, De Camilli P, Wolf NI, Baple EL., Free PMC Article | 02/26/2022 |
| Biallelic PI4KA variants cause a novel neurodevelopmental syndrome with hypomyelinating leukodystrophy. | Biallelic PI4KA variants cause a novel neurodevelopmental syndrome with hypomyelinating leukodystrophy.
Verdura E, Rodríguez-Palmero A, Vélez-Santamaria V, Planas-Serra L, de la Calle I, Raspall-Chaure M, Roubertie A, Benkirane M, Saettini F, Pavinato L, Mandrile G, O'Leary M, O'Heir E, Barredo E, Chacón A, Michaud V, Goizet C, Ruiz M, Schlüter A, Rouvet I, Sala-Coromina J, Fossati C, Iascone M, Canonico F, Marcé-Grau A, de Souza P, Adams DR, Casasnovas C, Rehm HL, Mefford HC, González Gutierrez-Solana L, Brusco A, Koenig M, Macaya A, Pujol A., Free PMC Article | 12/18/2021 |
| Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity. | Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity.
Adhikari H, Kattan WE, Kumar S, Zhou P, Hancock JF, Counter CM., Free PMC Article | 10/9/2021 |
| we provide evidence linking PI4KAP2, previously considered a pseudogene, to human myeloid and erythroid leukemia. | A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis.
Ziyad S, Riordan JD, Cavanaugh AM, Su T, Hernandez GE, Hilfenhaus G, Morselli M, Huynh K, Wang K, Chen JN, Dupuy AJ, Iruela-Arispe ML., Free PMC Article | 06/1/2019 |
| Architecture of the human PI4KIIIalpha lipid kinase complex. | Architecture of the human PI4KIIIα lipid kinase complex.
Lees JA, Zhang Y, Oh MS, Schauder CM, Yu X, Baskin JM, Dobbs K, Notarangelo LD, De Camilli P, Walz T, Reinisch KM., Free PMC Article | 07/14/2018 |
| hCKalpha functions as an indispensable regulator that bridges PI4KIIIalpha and hepatitis C virus NS5A and potentiates NS5A-stimulated PI4KIIIalpha activity, which then facilitates the targeting of the ternary complex to the endoplasmic reticulum for viral replication. | Hepatitis C Virus Subverts Human Choline Kinase-α To Bridge Phosphatidylinositol-4-Kinase IIIα (PI4KIIIα) and NS5A and Upregulates PI4KIIIα Activation, Thereby Promoting the Translocation of the Ternary Complex to the Endoplasmic Reticulum for Viral Replication.
Wong MT, Chen SS., Free PMC Article | 08/12/2017 |
| Blockade of IQGAP1 interaction with PIPKIalpha or PI(3)K inhibited PtdIns(3,4,5)P3 generation and signalling, and selectively diminished cancer cell survival. | Agonist-stimulated phosphatidylinositol-3,4,5-trisphosphate generation by scaffolded phosphoinositide kinases.
Choi S, Hedman AC, Sayedyahossein S, Thapa N, Sacks DB, Anderson RA., Free PMC Article | 06/3/2017 |
| The results showed that, in contrast to the enteroviruses and the cardioviruses, foot-and-mouth disease virus replication does not require PI4KIII (PI4KIIIalpha and PI4KIIIbeta), and phosphatidylinositol 4-phosphate levels do not increase in foot-and-mouth disease virus-infected cells and phosphatidylinositol 4-phosphate is not seen at replication organelles. | Foot-and-mouth disease virus replicates independently of phosphatidylinositol 4-phosphate and type III phosphatidylinositol 4-kinases.
Berryman S, Moffat K, Harak C, Lohmann V, Jackson T., Free PMC Article | 05/13/2017 |
| Missense mutations in PI4KA are associated with perisylvian polymicrogyria, cerebellar hypoplasia and arthrogryposis. | Germline recessive mutations in PI4KA are associated with perisylvian polymicrogyria, cerebellar hypoplasia and arthrogryposis.
Pagnamenta AT, Howard MF, Wisniewski E, Popitsch N, Knight SJ, Keays DA, Quaghebeur G, Cox H, Cox P, Balla T, Taylor JC, Kini U., Free PMC Article | 04/30/2016 |
| Our results suggest a plasticity of the molecular interactions that control PI4KIIIalpha localization and functions at the plasma membrane. | Plasticity of PI4KIIIα interactions at the plasma membrane.
Chung J, Nakatsu F, Baskin JM, De Camilli P., Free PMC Article | 12/12/2015 |
| PI4K III alpha plays a role in biosynthetic trafficking of two different classes of proteins from the ER to the Golgi complex. | A novel fluorescence-based biosynthetic trafficking method provides pharmacologic evidence that PI4-kinase IIIα is important for protein trafficking from the endoplasmic reticulum to the plasma membrane.
Bryant KL, Baird B, Holowka D., Free PMC Article | 11/14/2015 |
| PI4KA and GRM3 polymorphisms have potential to jointly modulate antipsychotic response | Synergistic association of PI4KA and GRM3 genetic polymorphisms with poor antipsychotic response in south Indian schizophrenia patients with low severity of illness.
Kaur H, Jajodia A, Grover S, Baghel R, Jain S, Kukreti R. | 08/29/2015 |
| our results suggest a mechanism of PI4K IIalpha recruitment, regulation, and function at the membrane. | The crystal structure of the phosphatidylinositol 4-kinase IIα.
Baumlova A, Chalupska D, Róźycki B, Jovic M, Wisniewski E, Klima M, Dubankova A, Kloer DP, Nencka R, Balla T, Boura E., Free PMC Article | 06/20/2015 |
| These results suggest that type II PtdIns 4-kinases are part of piperine-mediated anti-inflammatory signaling mechanisms | Piperine inhibits type II phosphatidylinositol 4-kinases: a key component in phosphoinositides turnover.
Bojjireddy N, Sinha RK, Subrahmanyam G. | 02/14/2015 |
| The N-terminal 1,152 amino acids were dispensable for hepatitis C virus replication, phosphatidylinositol 4-phosphate induction, and enzymatic function, thereby defining the minimal PI4KIIIalpha core enzyme at a size of ca. 108 kDa. | Mapping of functional domains of the lipid kinase phosphatidylinositol 4-kinase type III alpha involved in enzymatic activity and hepatitis C virus replication.
Harak C, Radujkovic D, Taveneau C, Reiss S, Klein R, Bressanelli S, Lohmann V., Free PMC Article | 12/20/2014 |
| PI4KA mRNA could be used as a new molecular marker to improve established prognostic models for hepatocellular carcinoma. | Overexpression of phosphatidylinositol 4-kinase type IIIα is associated with undifferentiated status and poor prognosis of human hepatocellular carcinoma.
Ilboudo A, Nault JC, Dubois-Pot-Schneider H, Corlu A, Zucman-Rossi J, Samson M, Le Seyec J., Free PMC Article | 09/6/2014 |
| Descriptive Statement The genetic interactions associated with ILVatrophy rate in this study may be mapping variants inSYNJ2andPI4KAthat interact to decrease synthesisof PIP. | Genetic interactions within inositol-related pathways are associated with longitudinal changes in ventricle size.
Koran ME, Hohman TJ, Meda SA, Thornton-Wells TA., Free PMC Article | 06/21/2014 |
| PI4KA is essential for the maintenance of plasma membrane phosphatidylinositol 4,5-bisphosphate pools but only during strong stimulation of receptors coupled to phospholipase C activation. | Pharmacological and genetic targeting of the PI4KA enzyme reveals its important role in maintaining plasma membrane phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate levels.
Bojjireddy N, Botyanszki J, Hammond G, Creech D, Peterson R, Kemp DC, Snead M, Brown R, Morrison A, Wilson S, Harrison S, Moore C, Balla T., Free PMC Article | 04/26/2014 |
| we demonstrate that PI4KIIIalpha activity affects the NS5A phosphorylation status. | The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A.
Reiss S, Harak C, Romero-Brey I, Radujkovic D, Klein R, Ruggieri A, Rebhan I, Bartenschlager R, Lohmann V., Free PMC Article | 09/21/2013 |