| Metabolic Enzyme SLC27A5 Regulates PIP4K2A pre-mRNA Splicing as a Noncanonical Mechanism to Suppress Hepatocellular Carcinoma Metastasis. | Metabolic Enzyme SLC27A5 Regulates PIP4K2A pre-mRNA Splicing as a Noncanonical Mechanism to Suppress Hepatocellular Carcinoma Metastasis.
Nie D, Tang X, Deng H, Yang X, Tao J, Xu F, Liu Y, Wu K, Wang K, Mei Z, Huang A, Tang N., Free PMC Article | 02/7/2024 |
| Contributions of ARID5B, IKZF1, PIP4K2A, and GATA3 Gene Polymorphisms to Childhood Acute Lymphoblastic Leukemia in a Chinese Population. | Contributions of ARID5B, IKZF1, PIP4K2A, and GATA3 Gene Polymorphisms to Childhood Acute Lymphoblastic Leukemia in a Chinese Population.
Liu X, Xiao M, Xing Z, Jiang H, Zhu C, Zhang X, Li W, Wang Z, Wu F, Chen Y. | 03/27/2023 |
| Association of PIP4K2A Polymorphisms with Alcohol Use Disorder. | Association of PIP4K2A Polymorphisms with Alcohol Use Disorder.
Fedorenko OY, Mikhalitskaya EV, Toshchakova VA, Loonen AJM, Bokhan NA, Ivanova SA., Free PMC Article | 02/12/2022 |
| Distribution and localization of phosphatidylinositol 5-phosphate, 4-kinase alpha and beta in the brain. | Distribution and localization of phosphatidylinositol 5-phosphate, 4-kinase alpha and beta in the brain.
Noch EK, Yim I, Milner TA, Cantley LC., Free PMC Article | 12/18/2021 |
| Pharmacological inhibition of PI5P4Kalpha/beta disrupts cell energy metabolism and selectively kills p53-null tumor cells. | Pharmacological inhibition of PI5P4Kα/β disrupts cell energy metabolism and selectively kills p53-null tumor cells.
Chen S, Chandra Tjin C, Gao X, Xue Y, Jiao H, Zhang R, Wu M, He Z, Ellman J, Ha Y., Free PMC Article | 12/4/2021 |
| PI5P4Ks drive metabolic homeostasis through peroxisome-mitochondria interplay. | PI5P4Ks drive metabolic homeostasis through peroxisome-mitochondria interplay.
Ravi A, Palamiuc L, Loughran RM, Triscott J, Arora GK, Kumar A, Tieu V, Pauli C, Reist M, Lew RJ, Houlihan SL, Fellmann C, Metallo C, Rubin MA, Emerling BM., Free PMC Article | 10/23/2021 |
| Thermal proteome profiling identifies PIP4K2A and ZADH2 as off-targets of Polo-like kinase 1 inhibitor volasertib. | Thermal proteome profiling identifies PIP4K2A and ZADH2 as off-targets of Polo-like kinase 1 inhibitor volasertib.
Goroshchuk O, Kolosenko I, Kunold E, Vidarsdottir L, Pirmoradian M, Azimi A, Jafari R, Palm-Apergi C. | 07/17/2021 |
| Discovery and Differential Processing of HLA Class II-Restricted Minor Histocompatibility Antigen LB-PIP4K2A-1S and Its Allelic Variant by Asparagine Endopeptidase. | Discovery and Differential Processing of HLA Class II-Restricted Minor Histocompatibility Antigen LB-PIP4K2A-1S and Its Allelic Variant by Asparagine Endopeptidase.
Kremer AN, Bausenwein J, Lurvink E, Kremer AE, Rutten CE, van Bergen CAM, Kretschmann S, van der Meijden E, Honders MW, Mazzeo D, Watts C, Mackensen A, Falkenburg JHF, Griffioen M., Free PMC Article | 03/27/2021 |
| Genetic polymorphisms of PIP5K2A and course of schizophrenia. | Genetic polymorphisms of PIP5K2A and course of schizophrenia.
Poltavskaya EG, Fedorenko OY, Vyalova NM, Kornetova EG, Bokhan NA, Loonen AJM, Ivanova SA., Free PMC Article | 01/9/2021 |
| the loss of PIP4Ks (PIP4K2A, PIP4K2B, and PIP4K2C) in vitro results in a paradoxical increase in PI(4,5)P2 and a concomitant increase in insulin-stimulated production of PI(3,4,5)P3. | PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism.
Wang DG, Paddock MN, Lundquist MR, Sun JY, Mashadova O, Amadiume S, Bumpus TW, Hodakoski C, Hopkins BD, Fine M, Hill A, Yang TJ, Baskin JM, Dow LE, Cantley LC., Free PMC Article | 07/4/2020 |
| PIP4K2A competes with PTEN for physical interaction with p85 and induces proteasome-mediated degradation, thus, demonstrating an essential tumor suppressive role in glioblastoma. | PIP4K2A as a negative regulator of PI3K in PTEN-deficient glioblastoma.
Shin YJ, Sa JK, Lee Y, Kim D, Chang N, Cho HJ, Son M, Oh MYT, Shin K, Lee JK, Park J, Jo YK, Kim M, Paddison PJ, Tergaonkar V, Lee J, Nam DH., Free PMC Article | 05/9/2020 |
| study provides additional evidence of the involvement of members of the PIP4K2 family, in particular PIP4K2A and PIP4K2C, in AML | PIP4K2A and PIP4K2C transcript levels are associated with cytogenetic risk and survival outcomes in acute myeloid leukemia.
Lima K, Coelho-Silva JL, Kinker GS, Pereira-Martins DA, Traina F, Fernandes PACM, Markus RP, Lucena-Araujo AR, Machado-Neto JA. | 02/15/2020 |
| The PIP4K2A plays a critical role in intracellular cholesterol transport by upregulating PI(4,5)P2 levels in the peroxisomal membrane. | PIP4K2A regulates intracellular cholesterol transport through modulating PI(4,5)P(2) homeostasis.
Hu A, Zhao XT, Tu H, Xiao T, Fu T, Wang Y, Liu Y, Shi XJ, Luo J, Song BL., Free PMC Article | 07/27/2019 |
| Fine-mapping at chromosome 10p12 identified rs4748812 variant in PIP4K2A which alters a RUNX1 binding motif and demonstrated chromosomal looping to the PIP4K2A promoter. This variant was found associated with childhood acute lymphoblastic leukemia. | BMI1 enhancer polymorphism underlies chromosome 10p12.31 association with childhood acute lymphoblastic leukemia.
de Smith AJ, Walsh KM, Francis SS, Zhang C, Hansen HM, Smirnov I, Morimoto L, Whitehead TP, Kang A, Shao X, Barcellos LF, McKean-Cowdin R, Zhang L, Fu C, Wang R, Yu H, Hoh J, Dewan AT, Metayer C, Ma X, Wiemels JL., Free PMC Article | 02/23/2019 |
| Recombinant PIP4K2A has the RNA binding activity and can associate specifically with Plasmodium 3'UTR RNAs. | Identification of human Phosphatidyl Inositol 5-Phosphate 4-Kinase as an RNA binding protein that is imported into Plasmodium falciparum.
Vindu A, Dandewad V, Seshadri V. | 05/5/2018 |
| the rs7088318 (PIP4K2A) and rs2239633 (CEBPE) polymorphisms were not associated with ALL risk. | ARID5B, CEBPE and PIP4K2A Germline Genetic Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia in Mexican Patients: A MIGICCL Study.
Bekker-Méndez VC, Núñez-Enríquez JC, Torres Escalante JL, Alvarez-Olmos E, González-Montalvoc PM, Jiménez-Hernández E, Sansón AM, Leal YA, Ramos-Cervantes MT, Guerra-Castillo FX, Ortiz-Maganda MP, Flores-Lujano J, Pérez-Saldivar ML, Velazquez-Aviña MM, Bolea-Murga V, Torres-Nava JR, Amador-Sanchez R, Solis-Labastida KA, Rámirez-Bello J, Fragoso JM, Mejía-Aranguré JM, MIGICCL. | 07/8/2017 |
| meta-analysis of association of SNPs rs7088318 and rs4748793 and acute lymphoblastic leukemia susceptibility | Association Between PIP4K2A Polymorphisms and Acute Lymphoblastic Leukemia Susceptibility.
Liao F, Yin D, Zhang Y, Hou Q, Zheng Z, Yang L, Shu Y, Xu H, Li Y., Free PMC Article | 02/4/2017 |
| PIP5K2A is possibly involved in a mechanism protecting against tardive dyskinesia-inducing neurotoxicity. | Association study indicates a protective role of phosphatidylinositol-4-phosphate-5-kinase against tardive dyskinesia.
Fedorenko OY, Loonen AJ, Lang F, Toshchakova VA, Boyarko EG, Semke AV, Bokhan NA, Govorin NV, Aftanas LI, Ivanova SA., Free PMC Article | 01/16/2016 |
| The diplotype ATTGCT/ATTGCT of the PIP4K2A gene confers approximately three-times higher incomplete responsiveness towards antipsychotics in severely ill patients. | Genetic variations of PIP4K2A confer vulnerability to poor antipsychotic response in severely ill schizophrenia patients.
Kaur H, Jajodia A, Grover S, Baghel R, Gupta M, Jain S, Kukreti R., Free PMC Article | 10/17/2015 |
| PIP4K2A to be essential for the clonogenic and leukemia-initiating potential of human AML cells, and for the clonogenic potential of murine MLL-AF9 AML cells. | A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival.
Jude JG, Spencer GJ, Huang X, Somerville TDD, Jones DR, Divecha N, Somervaille TCP., Free PMC Article | 06/20/2015 |
| We also showed that PIPKIIalpha silencing can induce alpha and gamma globin expression and decrease cell proliferation in K562 cells. | PIPKIIα is widely expressed in hematopoietic-derived cells and may play a role in the expression of alpha- and gamma-globins in K562 cells.
Peretti de Albuquerque Wobeto V, Machado-Neto JA, Zaccariotto TR, Ribeiro DM, da Silva Santos Duarte A, Saad ST, Costa FF, de Fatima Sonati M. | 02/14/2015 |
| Overexpression of type 2A PI(4)P5-kinase (PIP5K 2A) significantly reduced tamoxifen inhibition of Kv7.2/Kv7.3 and Kv7.2 R463Q channels. | Tamoxifen inhibition of kv7.2/kv7.3 channels.
Ferrer T, Aréchiga-Figueroa IA, Shapiro MS, Tristani-Firouzi M, Sanchez-Chapula JA., Free PMC Article | 07/19/2014 |
| The data suggest that PI5P4Ka N251S does not significantly differ in activity from the wild-type enzyme, throwing a new light on its association with schizophrenia. | Enzyme activity of the PIP4K2A gene product polymorphism that is implicated in schizophrenia.
Clarke JH, Irvine RF., Free PMC Article | 06/28/2014 |
| Knocking down PI5P4Kalpha and beta in a breast cancer cell line bearing an amplification of the gene encoding PI5P4K beta and deficient for p53 impaired growth on plastic and in xenografts. | Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors.
Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, Denicola GM, Song J, Brown V, Signoretti S, Cantley LC., Free PMC Article | 01/25/2014 |
| Variation at 10p12.2 (PIP4K2A) and 10p14 (GATA3) influences risk of acute lymphoblastic anemia and tumor subtype. (Meta-analysis) | Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype.
Migliorini G, Fiege B, Hosking FJ, Ma Y, Kumar R, Sherborne AL, da Silva Filho MI, Vijayakrishnan J, Koehler R, Thomsen H, Irving JA, Allan JM, Lightfoot T, Roman E, Kinsey SE, Sheridan E, Thompson P, Hoffmann P, Nöthen MM, Mühleisen TW, Eisele L, Zimmermann M, Bartram CR, Schrappe M, Greaves M, Stanulla M, Hemminki K, Houlston RS. | 01/11/2014 |