| PLA2G4A and ACHE modulate lipid profiles via glycerophospholipid metabolism in platinum-resistant gastric cancer. | PLA2G4A and ACHE modulate lipid profiles via glycerophospholipid metabolism in platinum-resistant gastric cancer.
Chen M, Zhang C, Li H, Zheng S, Li Y, Yuan M, Chen Y, Wu J, Sun Q., Free PMC Article | 03/13/2024 |
| The ERK-cPLA2-ACSL4 axis mediating M2 macrophages ferroptosis impedes mucosal healing in ulcerative colitis. | The ERK-cPLA2-ACSL4 axis mediating M2 macrophages ferroptosis impedes mucosal healing in ulcerative colitis.
Ye Y, Liu L, Feng Z, Liu Y, Miao J, Wei X, Li H, Yang J, Cao X, Zhao J. | 03/6/2024 |
| Association between PLA2G4A and P2RX7 genes and eosinophilic phenotype and environment with pediatric asthma. | Association between PLA2G4A and P2RX7 genes and eosinophilic phenotype and environment with pediatric asthma.
Ren M, Li L, Jia J, Wei B. | 02/25/2023 |
| Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4. | Calcium-dependent cytosolic phospholipase A(2) activation is implicated in neuroinflammation and oxidative stress associated with ApoE4.
Wang S, Li B, Solomon V, Fonteh A, Rapoport SI, Bennett DA, Arvanitakis Z, Chui HC, Sullivan PM, Yassine HN., Free PMC Article | 06/25/2022 |
| Genetic polymorphism data support a relationship between schizophrenia and microsatellite variability in PLA2G4A in Northern Europeans not Han Chinese. | Genetic polymorphism data support a relationship between schizophrenia and microsatellite variability in PLA2G4A in Northern Europeans not Han Chinese.
Hudson CJ, Groh AMR, Macciardi F, Hudson RC., Free PMC Article | 05/14/2022 |
| Omega-3 versus Omega-6 fatty acid availability is controlled by hydrophobic site geometries of phospholipase A2s. | Omega-3 versus Omega-6 fatty acid availability is controlled by hydrophobic site geometries of phospholipase A(2)s.
Hayashi D, Mouchlis VD, Dennis EA., Free PMC Article | 03/26/2022 |
| A synergy between mechanosensitive calcium- and membrane-binding mediates tension-sensing by C2-like domains. | A synergy between mechanosensitive calcium- and membrane-binding mediates tension-sensing by C2-like domains.
Shen Z, Belcheva KT, Jelcic M, Hui KL, Katikaneni A, Niethammer P., Free PMC Article | 02/26/2022 |
| PLA2G4A promotes right-sided colorectal cancer progression by inducing CD39+gammadelta Treg polarization. | PLA2G4A promotes right-sided colorectal cancer progression by inducing CD39+γδ Treg polarization.
Zhan Y, Zheng L, Liu J, Hu D, Wang J, Liu K, Guo J, Zhang T, Kong D., Free PMC Article | 02/26/2022 |
| Inhibition of Cytosolic Phospholipase A2alpha Induces Apoptosis in Multiple Myeloma Cells. | Inhibition of Cytosolic Phospholipase A2α Induces Apoptosis in Multiple Myeloma Cells.
Mahammad N, Ashcroft FJ, Feuerherm AJ, Elsaadi S, Vandsemb EN, Børset M, Johansen B., Free PMC Article | 02/12/2022 |
| Protein dynamics analysis identifies candidate cancer driver genes and mutations in TCGA data. | Protein dynamics analysis identifies candidate cancer driver genes and mutations in TCGA data.
Sayılgan JF, Haliloğlu T, Gönen M. | 01/1/2022 |
| A Multiplex CRISPR-Screen Identifies PLA2G4A as Prognostic Marker and Druggable Target for HOXA9 and MEIS1 Dependent AML. | A Multiplex CRISPR-Screen Identifies PLA2G4A as Prognostic Marker and Druggable Target for HOXA9 and MEIS1 Dependent AML.
Hassan JJ, Lieske A, Dörpmund N, Klatt D, Hoffmann D, Kleppa MJ, Kustikova OS, Stahlhut M, Schwarzer A, Schambach A, Maetzig T., Free PMC Article | 12/25/2021 |
| Re-analysis of genetic polymorphism data supports a relationship between schizophrenia and microsatellite variability in PLA2G4A. | Re-analysis of genetic polymorphism data supports a relationship between schizophrenia and microsatellite variability in PLA2G4A.
Hudson CJ, Zhu JXG, Durocher AM., Free PMC Article | 12/25/2021 |
| Targeting cPLA2alpha inhibits gastric cancer and augments chemotherapy efficacy via suppressing Ras/MEK/ERK and Akt/beta-catenin pathways. | Targeting cPLA2α inhibits gastric cancer and augments chemotherapy efficacy via suppressing Ras/MEK/ERK and Akt/β-catenin pathways.
Liao Y, Chen W, Shi W, Zha H. | 11/22/2021 |
| Quantitative proteomics analysis of glioblastoma cell lines after lncRNA HULC silencing. | Quantitative proteomics analysis of glioblastoma cell lines after lncRNA HULC silencing.
Ye S, Wu J, Wang Y, Hu Y, Yin T, He J., Free PMC Article | 10/30/2021 |
| cPLA2alpha Enzyme Inhibition Attenuates Inflammation and Keratinocyte Proliferation. | cPLA(2)α Enzyme Inhibition Attenuates Inflammation and Keratinocyte Proliferation.
Ashcroft FJ, Mahammad N, Midtun Flatekvål H, Jullumstrø Feuerherm A, Johansen B., Free PMC Article | 07/3/2021 |
| Updating Phospholipase A2 Biology. | Updating Phospholipase A(2) Biology.
Murakami M, Sato H, Taketomi Y., Free PMC Article | 06/26/2021 |
| PLA2G4A upregulation has multiple effects on the malignant phenotype of Acute Myeloid Leukemia cells together with its partners. | PLA2G4A Is a Potential Biomarker Predicting Shorter Overall Survival in Patients with Non-M3/NPM1 Wildtype Acute Myeloid Leukemia.
Bai H, Zhou M, Zeng M, Han L. | 04/18/2020 |
| Tyr96 plays a key role in lipid headgroup recognition via cation-pi interaction with the phosphatidylcholine trimethylammonium group. Mutagenesis analyses confirm that Tyr96 and Asn65 function in phosphatidylcholine binding selectivity by the C2-domain and in the regulation of cPLA2alpha activity. | Structural basis of phosphatidylcholine recognition by the C2-domain of cytosolic phospholipase A(2)α.
Hirano Y, Gao YG, Stephenson DJ, Vu NT, Malinina L, Simanshu DK, Chalfant CE, Patel DJ, Brown RE., Free PMC Article | 02/22/2020 |
| It catalyzes the initial step in the generation of lipid mediators, including eicosanoids and lysophospholipids, in the progression of hepatic fibrosis. | [Inhibition of Group IVA Phospholipase A(2) as a Novel Therapeutic Strategy for Nonalcoholic Steatohepatitis].
Akiba S, Kawashita E, Ishihara K. | 02/8/2020 |
| cPLA2a could promote osteosarcoma cell invasion via inducing the epithelial-mesenchymal transition process, indicating that cPLA2a was an independent prognostic biomarker and may be an effective drug target for osteosarcoma | cPLA(2)a correlates with metastasis and poor prognosis of osteosarcoma by facilitating epithelial-mesenchymal transition.
Pang X, Yin P, Han J, Wang Z, Zheng F, Chen X. | 01/11/2020 |
| The expression of cPLA2alpha varies in multiple glioblastoma cell lines and is associated with chemoresistance rather than tumor development. cPLA2alpha depletion moderately inhibits glioblastoma growth and survival but remarkably sensitizes chemo-resistant glioblastoma cells to several chemotherapeutic agents. | Expression of Cytosolic Phospholipase A2 Alpha in Glioblastoma Is Associated With Resistance to Chemotherapy.
Yang L, Zhang H. | 08/10/2019 |
| Study provides evidence that BanI polymorphism of cPLA2 gene may be associated with somatic symptoms in patients with major depressive disorder in the Taiwanese population. | BanI polymorphism of cytosolic phospholipase A2 gene and somatic symptoms in medication-free acute depressed patients.
Chang JP, Guu TW, Chen YC, Gałecki P, Walczewska A, Su KP. | 07/6/2019 |
| Results indicate that the BanI polymorphic variant contributes significantly to plasma glucose levels in female patients with schizophrenia. Females carrying the PLA2G4A-G allele (PLA2G4A-GG homozygous and PLA2G4A-AG heterozygous) presented with lower glucose levels than PLA2G4A-AA homozygous carriers, and the PLA2G4A genotype contributed approximately 6% of plasma glucose level variability in this group of patients. | An association between the BanI polymorphism of the PLA2G4A gene for calcium-dependent phospholipase A2 and plasma glucose levels among females with schizophrenia.
Nadalin S, Buretić-Tomljanović A. | 04/6/2019 |
| High PLA2G4A expression is associated with obesity. | A collective diabetes cross in combination with a computational framework to dissect the genetics of human obesity and Type 2 diabetes.
Vogel H, Kamitz A, Hallahan N, Lebek S, Schallschmidt T, Jonas W, Jähnert M, Gottmann P, Zellner L, Kanzleiter T, Damen M, Altenhofen D, Burkhardt R, Renner S, Dahlhoff M, Wolf E, Müller TD, Blüher M, Joost HG, Chadt A, Al-Hasani H, Schürmann A., Free PMC Article | 03/9/2019 |
| PLA2G4A up-regulated the protein expression of E-cadherin and down-regulated the protein expression of vimentin, which inhibited ESCC cell mobility and invasiveness. | MiR-543 Promotes Migration, Invasion and Epithelial-Mesenchymal Transition of Esophageal Cancer Cells by Targeting Phospholipase A2 Group IVA.
Zhao H, Diao C, Wang X, Xie Y, Liu Y, Gao X, Han J, Li S. | 09/15/2018 |