| POFUT1 and PLAGL2 are characteristic markers of mucinous colorectal cancer associated with MUC2 expression. | POFUT1 and PLAGL2 are characteristic markers of mucinous colorectal cancer associated with MUC2 expression.
Monno M, Ogiri M, Seishima R, Suzuki Y, Hattori K, Matsui S, Shigeta K, Okabayashi K, Kitagawa Y. | 03/20/2024 |
| PLAGL2 promotes Snail expression and gastric cancer progression via UCA1/miR-145-5p/YTHDF1 axis. | PLAGL2 promotes Snail expression and gastric cancer progression via UCA1/miR-145-5p/YTHDF1 axis.
Chen W, He Q, Liu J, Li N, Xiao K, Chen H. | 06/30/2023 |
| Long non-coding RNA LGALS8-AS1 facilitates PLAGL2-mediated malignant phenotypes in gastric cancer. | Long non-coding RNA LGALS8-AS1 facilitates PLAGL2-mediated malignant phenotypes in gastric cancer.
Wang G, Shen K, Xiao J, Fan H, Wang Y, Liu K, Zhou X, Cheng Q, Miao Y, Xu Z, Yang L. | 06/5/2023 |
| PLAGL2 promotes the stemness and is upregulated by transcription factor E2F1 in human lung cancer. | PLAGL2 promotes the stemness and is upregulated by transcription factor E2F1 in human lung cancer.
Lin Y, Lin P, Guo W, Huang J, Xu X, Zhuang X. | 03/15/2023 |
| PLAGL2 increases adriamycin resistance and EMT in breast cancer cells by activating the Wnt pathway. | PLAGL2 increases adriamycin resistance and EMT in breast cancer cells by activating the Wnt pathway.
Li Y, Liu R, Han X, Xu W, Liu Y. | 01/14/2023 |
| Amplification of the PLAG-family genes-PLAGL1 and PLAGL2-is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification. | Amplification of the PLAG-family genes-PLAGL1 and PLAGL2-is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification.
Keck MK, Sill M, Wittmann A, Joshi P, Stichel D, Beck P, Okonechnikow K, Sievers P, Wefers AK, Roncaroli F, Avula S, McCabe MG, Hayden JT, Wesseling P, Øra I, Nistér M, Kranendonk MEG, Tops BBJ, Zapotocky M, Zamecnik J, Vasiljevic A, Fenouil T, Meyronet D, von Hoff K, Schüller U, Loiseau H, Figarella-Branger D, Kramm CM, Sturm D, Scheie D, Rauramaa T, Pesola J, Gojo J, Haberler C, Brandner S, Jacques T, Sexton Oates A, Saffery R, Koscielniak E, Baker SJ, Yip S, Snuderl M, Ud Din N, Samuel D, Schramm K, Blattner-Johnson M, Selt F, Ecker J, Milde T, von Deimling A, Korshunov A, Perry A, Pfister SM, Sahm F, Solomon DA, Jones DTW., Free PMC Article | 01/7/2023 |
| LncRNA HCP5 acts as a miR-128-3p sponge to promote the progression of multiple myeloma through activating Wnt/beta-catenin/cyclin D1 signaling via PLAGL2. | LncRNA HCP5 acts as a miR-128-3p sponge to promote the progression of multiple myeloma through activating Wnt/β-catenin/cyclin D1 signaling via PLAGL2.
Liu Q, Ran R, Song M, Li X, Wu Z, Dai G, Xia R. | 12/24/2022 |
| PLAGL2 Promotes the Proliferation and Migration of Diffuse Large B-cell Lymphoma Cells via Wnt/beta-catenin Pathway. | PLAGL2 Promotes the Proliferation and Migration of Diffuse Large B-cell Lymphoma Cells via Wnt/β-catenin Pathway.
Jin W, Wang X. | 07/23/2022 |
| Selenium sulfide disrupts the PLAGL2/C-MET/STAT3-induced resistance against mitochondrial apoptosis in hepatocellular carcinoma. | Selenium sulfide disrupts the PLAGL2/C-MET/STAT3-induced resistance against mitochondrial apoptosis in hepatocellular carcinoma.
Yang T, Huo J, Xu R, Su Q, Tang W, Zhang D, Zhu M, Zhan Y, Dai B, Zhang Y., Free PMC Article | 02/12/2022 |
| MiR-22-3p Suppresses Cell Migration and Invasion by Targeting PLAGL2 in Breast Cancer. | MiR-22-3p Suppresses Cell Migration and Invasion by Targeting PLAGL2 in Breast Cancer.
Fan T, Wang CQ, Li XT, Yang H, Zhou J, Song YJ. | 09/18/2021 |
| Hsa-circRNA-103809 Promotes Hepatocellular Carcinoma Development via MicroRNA-1270/PLAG1 Like Zinc Finger 2 Axis. | Hsa-circRNA-103809 Promotes Hepatocellular Carcinoma Development via MicroRNA-1270/PLAG1 Like Zinc Finger 2 Axis.
Cao Y, Tao Q, Kao X, Zhu X. | 09/4/2021 |
| PLAGL2 promotes the proliferation and migration of gastric cancer cells via USP37-mediated deubiquitination of Snail1. | PLAGL2 promotes the proliferation and migration of gastric cancer cells via USP37-mediated deubiquitination of Snail1.
Wu L, Zhao N, Zhou Z, Chen J, Han S, Zhang X, Bao H, Yuan W, Shu X., Free PMC Article | 08/7/2021 |
| The PLAGL2/MYCN/miR-506-3p interplay regulates neuroblastoma cell fate and associates with neuroblastoma progression. | The PLAGL2/MYCN/miR-506-3p interplay regulates neuroblastoma cell fate and associates with neuroblastoma progression.
Zhao Z, Shelton SD, Oviedo A, Baker AL, Bryant CP, Omidvarnia S, Du L., Free PMC Article | 10/24/2020 |
| PLAGL2 promotes epithelial-mesenchymal transition and mediates colorectal cancer metastasis via beta-catenin-dependent regulation of ZEB1. | PLAGL2 promotes epithelial-mesenchymal transition and mediates colorectal cancer metastasis via β-catenin-dependent regulation of ZEB1.
Wu L, Zhou Z, Han S, Chen J, Liu Z, Zhang X, Yuan W, Ji J, Shu X., Free PMC Article | 10/24/2020 |
| Increased miR-214 expression suppresses cell migration and proliferation in Hirschsprung disease by interacting with PLAGL2. | Increased miR-214 expression suppresses cell migration and proliferation in Hirschsprung disease by interacting with PLAGL2.
Wu L, Yuan W, Chen J, Zhou Z, Shu Y, Ji J, Liu Z, Tang Q, Zhang X, Shu X., Free PMC Article | 09/19/2020 |
| PLAGL2 and POFUT1 were common and upregulated in tumor samples in colorectal cancer (CRC). Survival analysis of PLAGL2 and POFUT1 expression revealed differences between proximal and distal CRC. PLAGL2 and POFUT1, which have the highest correlation with tumor location, may serve as biomarkers and therapeutic targets for the precise diagnosis and treatment of CRC in the future. | Weighted gene coexpression analysis indicates that PLAGL2 and POFUT1 are related to the differential features of proximal and distal colorectal cancer.
Lv Y, Xie B, Bai B, Shan L, Zheng W, Huang X, Zhu H., Free PMC Article | 04/11/2020 |
| Our team identified for the first time a bidirectional promoter pair oncogene, PLAGL2-POFUT1, in colorectal cancer (CRC). | PLAGL2 and POFUT1 are regulated by an evolutionarily conserved bidirectional promoter and are collaboratively involved in colorectal cancer by maintaining stemness.
Li D, Lin C, Li N, Du Y, Yang C, Bai Y, Feng Z, Su C, Wu R, Song S, Yan P, Chen M, Jain A, Huang L, Zhang Y, Li X., Free PMC Article | 01/11/2020 |
| DJ-1 can promote CRC metastasis by activating PLAGL2-Wnt-BMP4 axis. | DJ-1 promotes colorectal cancer progression through activating PLAGL2/Wnt/BMP4 axis.
Zhou J, Liu H, Zhang L, Liu X, Zhang C, Wang Y, He Q, Zhang Y, Li Y, Chen Q, Zhang L, Wang K, Bu Y, Lei Y., Free PMC Article | 11/23/2019 |
| PLAGL2 expression is strongly associated with an IESC signature in colorectal cancer and may be responsible for contributing to the aberrant activation of an immature phenotype. | The Zinc Finger Transcription Factor PLAGL2 Enhances Stem Cell Fate and Activates Expression of ASCL2 in Intestinal Epithelial Cells.
Strubberg AM, Veronese Paniagua DA, Zhao T, Dublin L, Pritchard T, Bayguinov PO, Fitzpatrick JAJ, Madison BB., Free PMC Article | 10/5/2019 |
| PLAGL2 is highly expressed in the bladder urothelial carcinoma tissue and metastatic lymph node relative to the normal bladder tissue. | Expression of PLAGL2 in bladder urothelial carcinoma and its relationship to lymph node metastasis and survival.
Qu G, Xu Y, Wan SP, Yang G., Free PMC Article | 10/5/2019 |
| Study results indicated that PLAGL2 was overexpressed in colorectal cancer (CRC) as a protooncogene and that it could active the Wnt/betacatenin pathway as a transcription factor by binding with the promoter region of Wnt6. | Overexpressed PLAGL2 transcriptionally activates Wnt6 and promotes cancer development in colorectal cancer.
Li N, Li D, Du Y, Su C, Yang C, Lin C, Li X, Hu G., Free PMC Article | 02/2/2019 |
| overexpression of miR-449a inhibited the expression of PLAGL2 significantly and the knockdown of PLAGL2 expression inhibited the breast cancer cell proliferation and metastasis | MiR-449a suppresses cell migration and invasion by targeting PLAGL2 in breast cancer.
Xu B, Zhang X, Wang S, Shi B. | 09/29/2018 |
| increased expression correlates to prostate cancer progression following radical prostatectomy and may serve as novel poor prognostic marker | Overexpression of Pleomorphic Adenoma Gene-Like 2 Is a Novel Poor Prognostic Marker of Prostate Cancer.
Guo J, Wang M, Wang Z, Liu X., Free PMC Article | 07/29/2017 |
| Our findings indicated that PLAGL2 might be a very upstream key molecule regulating Epithelial-mesenchymal transition involved in Wnt/bcatenin signaling pathway in Colorectal adenocarcinoma | Pleomorphic adenoma gene like-2 induces epithelial-mesenchymal transition via Wnt/β-catenin signaling pathway in human colorectal adenocarcinoma.
Wang YP, Guo PT, Zhu Z, Zhang H, Xu Y, Chen YZ, Liu F, Ma SP., Free PMC Article | 04/22/2017 |
| Our findings indicate that PALGL2 serves as a tumor oncoprotein in the development and progression of colorectal cancer | The role of pleomorphic adenoma gene-like 2 in gastrointestinal cancer development, progression, and prognosis.
Liu B, Lu C, Song YX, Gao P, Sun JX, Chen XW, Wang MX, Dong YL, Xu HM, Wang ZN., Free PMC Article | 05/30/2015 |