| MAGUKs are essential, but redundant, in long-term potentiation. | MAGUKs are essential, but redundant, in long-term potentiation.
Chen X, Fukata Y, Fukata M, Nicoll RA., Free PMC Article | 12/4/2021 |
| Our findings provide fundamental data to support the functional differences of SAP102 in different hippocampal subregions during postnatal periods | Dynamic SAP102 expression in the hippocampal subregions of rats and APP/PS1 mice of various ages.
Su D, Liu H, Liu T, Zhang X, Yang W, Song Y, Liu J, Wu Y, Chang L., Free PMC Article | 11/9/2019 |
| Following the critical period NMDA receptor function was unaffected by loss of SAP102 but there was a reduction in the divergence of TC connectivity. These data suggest that changes in synaptic function early in development caused by mutations in SAP102 result in changes in network connectivity later in life. | Altered thalamocortical development in the SAP102 knockout model of intellectual disability.
Crocker-Buque A, Currie SP, Luz LL, Grant SG, Duffy KR, Kind PC, Daw MI., Free PMC Article | 07/22/2017 |
| our current study identified a functional interplay between PSD-95 and synapse-associated protein 102 (SAP102) to regulate synaptic AMPA receptors | Synaptic state-dependent functional interplay between postsynaptic density-95 and synapse-associated protein 102.
Bonnet SA, Akad DS, Samaddar T, Liu Y, Huang X, Dong Y, Schlüter OM., Free PMC Article | 10/26/2013 |
| SAP102 has a fundamental role in trafficking the NMDA receptor complex to the synaptic sites. | Ligand binding of PDZ domains has various roles in the synaptic clustering of SAP102 and PSD-95.
Minatohara K, Ichikawa SH, Seki T, Fujiyoshi Y, Doi T. | 05/25/2013 |
| The Dlg3 have functions in complex cognitive processes. | Synaptic scaffold evolution generated components of vertebrate cognitive complexity.
Nithianantharajah J, Komiyama NH, McKechanie A, Johnstone M, Blackwood DH, St Clair D, Emes RD, van de Lagemaat LN, Saksida LM, Bussey TJ, Grant SG., Free PMC Article | 02/23/2013 |
| Synapse associated protein 102 (SAP102) binds the C-terminal part of the scaffolding protein neurobeachin. | Synapse associated protein 102 (SAP102) binds the C-terminal part of the scaffolding protein neurobeachin.
Lauks J, Klemmer P, Farzana F, Karupothula R, Zalm R, Cooke NE, Li KW, Smit AB, Toonen R, Verhage M., Free PMC Article | 12/8/2012 |
| Dlg3 exerts a distinct function by recruiting the ubiquitin ligases Nedd4 and Nedd4-2 through its PPxY motifs. These interactions are required for Dlg3 monoubiquitination, apical membrane recruitment, and tight junction consolidation. | Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases.
Van Campenhout CA, Eitelhuber A, Gloeckner CJ, Giallonardo P, Gegg M, Oller H, Grant SG, Krappmann D, Ueffing M, Lickert H., Free PMC Article | 11/26/2011 |
| Membrane-associated guanylate kinase homolog SAP102 is a central organizers of the postsynaptic density at excitatory synapses on pyramidal neurons. | Expression pattern of membrane-associated guanylate kinases in interneurons of the visual cortex.
Akgul G, Wollmuth LP., Free PMC Article | 09/17/2011 |
| SAP102 and PSD-95 regulate the synaptic trafficking of distinct glutamate receptor subtypes at different developmental stages, thereby playing necessary roles in excitatory synapse development. | Differential trafficking of AMPA and NMDA receptors by SAP102 and PSD-95 underlies synapse development.
Elias GM, Elias LA, Apostolides PF, Kriegstein AR, Nicoll RA., Free PMC Article | 01/21/2010 |
| Results describe E-dlg, a mouse homologue of the Drosophila discs large tumor suppressor (Dlg, also known as SAP97), that binds preferentially to SAP102. | Cloning and characterization of E-dlg, a novel splice variant of mouse homologue of the Drosophila discs large tumor suppressor binds preferentially to SAP102.
Mao P, Tao YX, Fukaya M, Tao F, Li D, Watanabe M, Johns RA., Free PMC Article | 01/21/2010 |
| SAP102 was required for normal spatial learning. Loss of SAP102 results in changes in spatial strategy usage. Altered long term potentiation and spike-timing-dependent plasticity in SAP102 mutants. Couples NMDA receptors to MAPK/ERK pathway. | Synapse-associated protein 102/dlgh3 couples the NMDA receptor to specific plasticity pathways and learning strategies.
Cuthbert PC, Stanford LE, Coba MP, Ainge JA, Fink AE, Opazo P, Delgado JY, Komiyama NH, O'Dell TJ, Grant SG., Free PMC Article | 01/21/2010 |
| SAP102 interacts with the PDZ-binding domain of Sec8, a member of the exocyst complex. nteractions between the two proteins are involved in the delivery of N-methyl-D-aspartate receptors to the cell surface in heterologous cells and neurons. | NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex.
Sans N, Prybylowski K, Petralia RS, Chang K, Wang YX, Racca C, Vicini S, Wenthold RJ. | 01/21/2010 |