| ANXA2, SP17, SERPINA5, PRDX2 genes, and sperm DNA fragmentation differentially represented in male partners of infertile couples with normal and abnormal sperm parameters. | ANXA2, SP17, SERPINA5, PRDX2 genes, and sperm DNA fragmentation differentially represented in male partners of infertile couples with normal and abnormal sperm parameters.
Afsari M, Fesahat F, Talebi AR, Agarwal A, Henkel R, Zare F, Gül M, Iraci N, Cannarella R, Makki M, Anvari M, Sarcheshmeh AA, Talebi AH. | 10/22/2022 |
| Serum Sp17 Autoantibody Serves as a Potential Specific Biomarker in Patients with SAPHO Syndrome. | Serum Sp17 Autoantibody Serves as a Potential Specific Biomarker in Patients with SAPHO Syndrome.
You H, Dang G, Lu B, Zhang S, Li C, Wang L, Hu Y, Chen H, Zhang J, He W., Free PMC Article | 01/29/2022 |
| data suggests that SPA17, ANXA2, and SERPINA5 may potentially serve as non-invasive protein biomarkers associated with the fertilization process of the spermatozoa in unexplained male infertility | Sperm Proteome Analysis and Identification of Fertility-Associated Biomarkers in Unexplained Male Infertility.
Panner Selvam MK, Agarwal A, Pushparaj PN, Baskaran S, Bendou H., Free PMC Article | 01/4/2020 |
| Results find that Sp17 is highly expressed in benign, borderline, and low grade malignant serous ovarian neoplasms and can be quantified in serum. Sp17 expression may have diagnostic significance in this subset of patients. | Validity and prognostic significance of sperm protein 17 as a tumor biomarker for epithelial ovarian cancer: a retrospective study.
Brunette LL, Mhawech-Fauceglia PY, Ji L, Skeate JG, Brand HE, Lawrenson K, Walia S, Chiriva-Internati M, Groshen S, Roman LD, Kast WM, Da Silva DM., Free PMC Article | 01/12/2019 |
| Sp17 and ASP cancer/testis antigens were found in ciliated cells of four ciliated hepatic foregut cysts (CHFCs). Further characterization of Sp17 and ASP in patients with CHFCs may provide significant clues for understanding the molecular mechanisms underlying their predisposition to develop squamous cell carcinomas. | Sperm protein 17 and AKAP-associated sperm protein cancer/testis antigens are expressed in ciliated hepatic foregut cysts.
Grizzi F, Franceschini B, Di Biccari S, Musardo S, Pedretti E, Chiriva-Internati M, Osipov V, Fernández-Aceñero MJ. | 11/5/2016 |
| dendritic cells from human umbilical cord blood modulated for SP17 expression induced antigen-specific anti-tumor immunity against SP17(+) non-small cell lung cancer. | Umbilical cord blood-derived dendritic cells infected by adenovirus for SP17 expression induce antigen-specific cytotoxic T cells against NSCLC cells.
Liu Y, Tian X, Jiang S, Ren X, Liu F, Yang J, Chen Y, Jiang Y. | 04/30/2016 |
| SP17/AKAP4/PTTG1 are expressed in both human NSCLC cell lines and primary tumors and can elicit an immunogenic response in lung cancer patients. | Novel antigens in non-small cell lung cancer: SP17, AKAP4, and PTTG1 are potential immunotherapeutic targets.
Mirandola L, Figueroa JA, Phan TT, Grizzi F, Kim M, Rahman RL, Jenkins MR, Cobos E, Jumper C, Alalawi R, Chiriva-Internati M., Free PMC Article | 12/5/2015 |
| NY-ESO-1 and SP17 was not significantly associated with a specific histotype, but high-level GAGE expression was more frequent in squamous cell carcinoma. GAGE expression was demonstrated to be significantly higher in stage II-IIIa than stage I NSCLC. | Analysis of GAGE, NY-ESO-1 and SP17 cancer/testis antigen expression in early stage non-small cell lung carcinoma.
Gjerstorff MF, Pøhl M, Olsen KE, Ditzel HJ., Free PMC Article | 06/28/2014 |
| Sp17 is highly expressed in hepatocellular carcinoma cells | Sperm protein 17, MAGE-C1 and NY-ESO-1 in hepatocellular carcinoma: expression frequency and their correlation with clinical parameters.
Xia QY, Liu S, Li FQ, Huang WB, Shi LN, Zhou XJ., Free PMC Article | 03/22/2014 |
| SP17 was expressed in many cancer types with an overall frequency of 12%. SP17 was most frequently expressed in a different set of cancer types than MAGE-A and GAGE antigens and rarely overlapped with these proteins. | Limited SP17 expression within tumors diminishes its therapeutic potential.
Gjerstorff MF, Ditzel HJ. | 02/23/2013 |
| Sperm protein 17 is highly expressed in endometrial and cervical cancers. | Sperm protein 17 is highly expressed in endometrial and cervical cancers.
Li FQ, Liu Q, Han YL, Wu B, Yin HL., Free PMC Article | 02/5/2011 |
| Data show that cisplatin induced decrease in Sp17 levels was due to transcriptional inhibition and cisplatin-resistant cell lines did not show this decrease in Sp17 levels in response to cisplatin treatment. | Sperm protein 17 is a novel marker for predicting cisplatin response in esophageal squamous cancer cell lines.
Kausar T, Ahsan A, Hasan MR, Lin L, Beer DG, Ralhan R. | 03/1/2010 |
| Results suggest a possible role of Sp17 in regulating sperm maturation, capacitation, acrosomal reaction and interactions with the oocyte zona pellucida during the fertilization process. | Sperm protein 17 is expressed in the sperm fibrous sheath.
Chiriva-Internati M, Gagliano N, Donetti E, Costa F, Grizzi F, Franceschini B, Albani E, Levi-Setti PE, Gioia M, Jenkins M, Cobos E, Kast WM., Free PMC Article | 01/21/2010 |
| HSp17 plays a role in metastatic disease and resistance of epithelial ovarian carcinoma to chemotherapy | Overexpression of human sperm protein 17 increases migration and decreases the chemosensitivity of human epithelial ovarian cancer cells.
Li FQ, Han YL, Liu Q, Wu B, Huang WB, Zeng SY., Free PMC Article | 01/21/2010 |
| in vitro cultured, monoclonal, cytotoxic T lymphocytes (derived either from advanced OC patients or from healthy donors), specific for sperm protein 17, can eradicate human metastatic OC cells. | Sperm protein 17 is a suitable target for adoptive T-cell-based immunotherapy in human ovarian cancer.
Chiriva-Internati M, Weidanz JA, Yu Y, Frezza EE, Jenkins MR, Kennedy RC, Cobos E, Kast WM. | 01/21/2010 |
| focuses on the characterization of the genomic organization of an intron-containing gene and establishes a new transcription model | Genomic organization of an intron-containing sperm protein 17 gene (Sp17-1) and an intronless pseudogene (Sp17-2) in humans: a new model.
Buchli R, De Jong A, Robbins DL. | 01/21/2010 |
| Sp17 gene expression in myeloma cells is regulated by promoter methylation | Sp17 gene expression in myeloma cells is regulated by promoter methylation.
Wang Z, Zhang Y, Ramsahoye B, Bowen D, Lim SH., Free PMC Article | 01/21/2010 |
| Sp17 is expressed in the cell nucleus of ovarian neoplasms | Expression of sperm protein 17 (Sp17) in ovarian cancer.
Straughn JM Jr, Shaw DR, Guerrero A, Bhoola SM, Racelis A, Wang Z, Chiriva-Internati M, Grizzle WE, Alvarez RD, Lim SH, Strong TV. | 01/21/2010 |
| Overexpression of sperm protein 17 is associated with esophageal cancer | Clinical significance of sperm protein 17 expression and immunogenicity in esophageal cancer.
Gupta G, Sharma R, Chattopadhyay TK, Gupta SD, Ralhan R. | 01/21/2010 |
| identification of a nonapeptide sequence within the Sp17 protein that is predicted to have a high binding affinity for HLA-A1 molecules | Identification of a sperm protein 17 CTL epitope restricted by HLA-A1.
Chiriva-Internati M, Wang Z, Pochopien S, Salati E, Lim SH. | 01/21/2010 |
| expression of Sp17, a thought to be gamete-specific protein, in the synoviocytes of 8/8 female rheumatoid arthritis patients | Developmental considerations of sperm protein 17 gene expression in rheumatoid arthritis synoviocytes.
Takeoka Y, Kenny TP, Yago H, Naiki M, Gershwin ME, Robbins DL., Free PMC Article | 01/21/2010 |
| Sp17 has different expression patterns in cancer cell lines as compared to normal non-testes tissues and a potential pathogenic role in diseased cells | Characterization of sperm protein 17 in human somatic and neoplastic tissue.
De Jong A, Buchli R, Robbins D. | 01/21/2010 |