| Peroxiredoxin 4 deficiency induces accelerated ovarian aging through destroyed proteostasis in granulosa cells. | Peroxiredoxin 4 deficiency induces accelerated ovarian aging through destroyed proteostasis in granulosa cells.
Zou X, Liang X, Dai W, Zhu T, Wang C, Zhou Y, Qian Y, Yan Z, Gao C, Gao L, Cui Y, Liu J, Meng Y. | 08/22/2024 |
| Revealing Prdx4 as a potential diagnostic and therapeutic target for acute pancreatitis based on machine learning analysis. | Revealing Prdx4 as a potential diagnostic and therapeutic target for acute pancreatitis based on machine learning analysis.
Lu Z, Tang Y, Qin R, Han Z, Chen H, Cao L, Zhang P, Yang X, Yu W, Cheng N, Sun Y., Free PMC Article | 05/1/2024 |
| Endothelial peroxiredoxin-4 is indispensable for blood-brain barrier integrity and long-term functional recovery after ischemic stroke. | Endothelial peroxiredoxin-4 is indispensable for blood-brain barrier integrity and long-term functional recovery after ischemic stroke.
Xu N, Jiang X, Zhang W, Shi Y, Leak RK, Keep RF, Ye Q, Yang T, Li S, Hu X, Stetler RA, Bennett MVL, Chen J., Free PMC Article | 03/6/2024 |
| Peroxiredoxin-4 and Dopamine D5 Receptor Interact to Reduce Oxidative Stress and Inflammation in the Kidney. | Peroxiredoxin-4 and Dopamine D5 Receptor Interact to Reduce Oxidative Stress and Inflammation in the Kidney.
Amatya B, Yang S, Yu P, Vaz de Castro PAS, Armando I, Zeng C, Felder RA, Asico LD, Jose PA, Lee H., Free PMC Article | 06/2/2023 |
| Peroxiredoxin 4 secreted by cumulus cells ameliorates the maturation of oocytes in vitro. | Peroxiredoxin 4 secreted by cumulus cells ameliorates the maturation of oocytes in vitro.
Dai W, Zou X, Jia H, Peng Y, La B, Yan Z, Gao L, Qin L, Diao F, Ma X, Meng Y, Cui Y, Liu J. | 11/19/2022 |
| Consequences of a peroxiredoxin 4 (Prdx4) deficiency on learning and memory in mice. | Consequences of a peroxiredoxin 4 (Prdx4) deficiency on learning and memory in mice.
Homma T, Fujiwara H, Osaki T, Fujii S, Fujii J. | 08/13/2022 |
| Peroxiredomin-4 ameliorates lipotoxicity-induced oxidative stress and apoptosis in diabetic cardiomyopathy. | Peroxiredomin-4 ameliorates lipotoxicity-induced oxidative stress and apoptosis in diabetic cardiomyopathy.
Zhang B, Li X, Liu G, Zhang C, Zhang X, Shen Q, Sun G, Sun X. | 12/18/2021 |
| PRDX4 Improved Aging-Related Delayed Wound Healing in Mice. | PRDX4 Improved Aging-Related Delayed Wound Healing in Mice.
Yamaguchi R, Guo X, Zheng J, Zhang J, Han J, Shioya A, Uramoto H, Mochizuki T, Yamada S. | 12/11/2021 |
| Overexpression of PRDX4 Modulates Tumor Microenvironment and Promotes Urethane-Induced Lung Tumorigenesis. | Overexpression of PRDX4 Modulates Tumor Microenvironment and Promotes Urethane-Induced Lung Tumorigenesis.
Zheng J, Guo X, Nakamura Y, Zhou X, Yamaguchi R, Zhang J, Ishigaki Y, Uramoto H, Yamada S., Free PMC Article | 09/11/2021 |
| Peroxiredoxin 4 protects against ovarian ageing by ameliorating D-galactose-induced oxidative damage in mice. | Peroxiredoxin 4 protects against ovarian ageing by ameliorating D-galactose-induced oxidative damage in mice.
Liang X, Yan Z, Ma W, Qian Y, Zou X, Cui Y, Liu J, Meng Y., Free PMC Article | 04/13/2021 |
| Testis-specific peroxiredoxin 4 variant is not absolutely required for spermatogenesis and fertility in mice. | Testis-specific peroxiredoxin 4 variant is not absolutely required for spermatogenesis and fertility in mice.
Homma T, Kurahashi T, Ishii N, Shirasawa N, Fujii J., Free PMC Article | 04/13/2021 |
| Peroxiredoxin 4 inhibits insulin-induced adipogenesis through regulation of ER stress in 3T3-L1 cells. | Peroxiredoxin 4 inhibits insulin-induced adipogenesis through regulation of ER stress in 3T3-L1 cells.
Kim JY, Kim MH, Lee HJ, Huh JW, Lee SR, Lee HS, Lee DS. | 11/28/2020 |
| Loss of Prdx4 boosts the pro-inflammatory potential of extracellular vesicles | Prdx4 limits caspase-1 activation and restricts inflammasome-mediated signaling by extracellular vesicles.
Lipinski S, Pfeuffer S, Arnold P, Treitz C, Aden K, Ebsen H, Falk-Paulsen M, Gisch N, Fazio A, Kuiper J, Luzius A, Billmann-Born S, Schreiber S, Nuñez G, Beer HD, Strowig T, Lamkanfi M, Tholey A, Rosenstiel P., Free PMC Article | 01/11/2020 |
| These features indicate that PRDX4 plays an important role in protecting against liver injury following BDL and might be a promising therapeutic modality for cholestatic diseases. | Protective Effects of Peroxiredoxin 4 (PRDX4) on Cholestatic Liver Injury.
Zhang J, Guo X, Hamada T, Yokoyama S, Nakamura Y, Zheng J, Kurose N, Ishigaki Y, Uramoto H, Tanimoto A, Yamada S., Free PMC Article | 12/22/2018 |
| DKO mice spontaneously develop severe liver failure at a relatively young stage, they have the potential for use as a model for hepatic disorders and for testing other potential treatments. | Double Knockout of Peroxiredoxin 4 (Prdx4) and Superoxide Dismutase 1 (Sod1) in Mice Results in Severe Liver Failure.
Homma T, Kurahashi T, Lee J, Nabeshima A, Yamada S, Fujii J., Free PMC Article | 10/27/2018 |
| Prdx4 expression was closely related to follicular development and has aprominent role in protecting human and mouse granulosa cells from reactive oxygen species damage. | Implication of Differential Peroxiredoxin 4 Expression with Age in Ovaries of Mouse and Human for Ovarian Aging.
Qian Y, Shao L, Yuan C, Jiang CY, Liu J, Gao C, Gao L, Cui YG, Jiang SW, Liu JY, Meng Y. | 12/17/2016 |
| data provide the first evidence of the beneficial effects of PRDX4 on intestinal function in the reduction of the severity of NAFLD, by ameliorating oxidative stress-induced local and systemic injury | Overexpression of Peroxiredoxin 4 Affects Intestinal Function in a Dietary Mouse Model of Nonalcoholic Fatty Liver Disease.
Nawata A, Noguchi H, Mazaki Y, Kurahashi T, Izumi H, Wang KY, Guo X, Uramoto H, Kohno K, Taniguchi H, Tanaka Y, Fujii J, Sasaguri Y, Tanimoto A, Nakayama T, Yamada S., Free PMC Article | 08/20/2016 |
| The ventral signal observed for Prdx4 from early stages colocalized with motor neuron markers Isl1/2 and FoxP1 and the strong ventral signal colocalizing with Isl1/2 was observed in all rostrocaudal segments of the spinal cord. | Expression of peroxiredoxins and thioredoxins in the mouse spinal cord during embryonic development.
Pirson M, Knoops B. | 07/16/2016 |
| Prdx4 dimers generated by hydrogen peroxide metabolism oxidize two cysteine residues within the GDE2 enzymatic domain, which blocks GDE2 trafficking to the plasma membrane and prevents GDE2 neurogeneic function. | Prdx4 is a compartment-specific H2O2 sensor that regulates neurogenesis by controlling surface expression of GDE2.
Yan Y, Wladyka C, Fujii J, Sockanathan S., Free PMC Article | 03/5/2016 |
| PRDX4 may protect against nonalcoholic steatohepatitis and type 2 diabetes by ameliorating oxidative stress-induced injury. | Peroxiredoxin 4 protects against nonalcoholic steatohepatitis and type 2 diabetes in a nongenetic mouse model.
Nabeshima A, Yamada S, Guo X, Tanimoto A, Wang KY, Shimajiri S, Kimura S, Tasaki T, Noguchi H, Kitada S, Watanabe T, Fujii J, Kohno K, Sasaguri Y., Free PMC Article | 08/9/2014 |
| data suggest that PRDX4 can be a novel target for glioblastoma multiforme therapies in the future | Suppression of peroxiredoxin 4 in glioblastoma cells increases apoptosis and reduces tumor growth.
Kim TH, Song J, Alcantara Llaguno SR, Murnan E, Liyanarachchi S, Palanichamy K, Yi JY, Viapiano MS, Nakano I, Yoon SO, Wu H, Parada LF, Kwon CH., Free PMC Article | 05/18/2013 |
| combined loss-of-function mutations in genes encoding the ER thiol oxidases ERO1alpha, ERO1beta, and PRDX4 compromised the extracellular matrix and interfered with the intracellular maturation of procollagen | Endoplasmic reticulum thiol oxidase deficiency leads to ascorbic acid depletion and noncanonical scurvy in mice.
Zito E, Hansen HG, Yeo GS, Fujii J, Ron D., Free PMC Article | 01/26/2013 |
| Prx IV-L functions as an H(2)O(2) sensor that mediates protein thiol oxidation required for the maturation of spermatozoa in placental mammals. | Identification and characterization of alternatively transcribed form of peroxiredoxin IV gene that is specifically expressed in spermatids of postpubertal mouse testis.
Yim SH, Kim YJ, Oh SY, Fujii J, Zhang Y, Gladyshev VN, Rhee SG., Free PMC Article | 12/31/2011 |
| The results indicate that spermatogenic cells lacking Prx4 are more susceptible to cell death via oxidative damage than their wild-type counterparts. | Peroxiredoxin 4 knockout results in elevated spermatogenic cell death via oxidative stress.
Iuchi Y, Okada F, Tsunoda S, Kibe N, Shirasawa N, Ikawa M, Okabe M, Ikeda Y, Fujii J. | 01/21/2010 |