| A comprehensively prognostic and immunological analysis of chloride intracellular channel protein 5 (CLIC5) in pan-cancer and identification in ovarian cancer. | A comprehensively prognostic and immunological analysis of chloride intracellular channel protein 5 (CLIC5) in pan-cancer and identification in ovarian cancer.
Huang Q, Lv Q, Tang W, Pan Y, Xing Y, He M, Wu H, Huang J, Huang C, Lan H, Chen J, Xiao G. | 08/20/2023 |
| Bi-Allelic Novel Variants in CLIC5 Identified in a Cameroonian Multiplex Family with Non-Syndromic Hearing Impairment. | Bi-Allelic Novel Variants in CLIC5 Identified in a Cameroonian Multiplex Family with Non-Syndromic Hearing Impairment.
Wonkam-Tingang E, Schrauwen I, Esoh KK, Bharadwaj T, Nouel-Saied LM, Acharya A, Nasir A, Adadey SM, Mowla S, Leal SM, Wonkam A., Free PMC Article | 07/24/2021 |
| loss of ETV6 leads to significant overexpression of CLIC5, which in turn leads to decreased lysosome-mediated apoptosis. Our data suggest that heightened CLIC5 activity could promote a permissive environment for oxidative stress-induced DNA damage accumulation, and thereby contribute to leukemogenesis. | CLIC5: a novel ETV6 target gene in childhood acute lymphoblastic leukemia.
Neveu B, Spinella JF, Richer C, Lagacé K, Cassart P, Lajoie M, Jananji S, Drouin S, Healy J, Hickson GR, Sinnett D., Free PMC Article | 07/1/2017 |
| EZR, CLIC5 and PODXL are overexpressed in hepatocellular carcinoma and may have a role in cell migration and invasiveness | Co-Expression of Ezrin-CLIC5-Podocalyxin Is Associated with Migration and Invasiveness in Hepatocellular Carcinoma.
Flores-Téllez TN, Lopez TV, Vásquez Garzón VR, Villa-Treviño S., Free PMC Article | 04/23/2016 |
| The mechanism of CLIC5A action involves clustered plasma membrane phosphatidylinositol 4,5-bisphosphate accumulation, in turn facilitating ezrin activation and actin-dependent cell surface remodeling. | Clustered PI(4,5)P₂ accumulation and ezrin phosphorylation in response to CLIC5A.
Al-Momany A, Li L, Alexander RT, Ballermann BJ. | 11/21/2015 |
| CLIC5 is a novel gene involved in progressive hearing impairment, vestibular and possibly mild renal dysfunction. | Progressive hearing loss and vestibular dysfunction caused by a homozygous nonsense mutation in CLIC5.
Seco CZ, Oonk AM, Domínguez-Ruiz M, Draaisma JM, Gandía M, Oostrik J, Neveling K, Kunst HP, Hoefsloot LH, del Castillo I, Pennings RJ, Kremer H, Admiraal RJ, Schraders M., Free PMC Article | 10/3/2015 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| CLIC5A colocalizes with ezrin and podocalyxin in podocytes and is required for the development/maintenance of the proper glomerular endothelial cell and podocyte architecture. | CLIC5A, a component of the ezrin-podocalyxin complex in glomeruli, is a determinant of podocyte integrity.
Wegner B, Al-Momany A, Kulak SC, Kozlowski K, Obeidat M, Jahroudi N, Paes J, Berryman M, Ballermann BJ., Free PMC Article | 06/28/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | A high-density association screen of 155 ion transport genes for involvement with common migraine.
Nyholt DR, LaForge KS, Kallela M, Alakurtti K, Anttila V, Färkkilä M, Hämaläinen E, Kaprio J, Kaunisto MA, Heath AC, Montgomery GW, Göbel H, Todt U, Ferrari MD, Launer LJ, Frants RR, Terwindt GM, de Vries B, Verschuren WM, Brand J, Freilinger T, Pfaffenrath V, Straube A, Ballinger DG, Zhan Y, Daly MJ, Cox DR, Dichgans M, van den Maagdenberg AM, Kubisch C, Martin NG, Wessman M, Peltonen L, Palotie A., Free PMC Article | 08/13/2008 |
| Data showed that CLIC1 and CLIC5, but not CLIC4, were strongly and reversibly inhibited (or inactivated) by F-actin. | Functional reconstitution of mammalian 'chloride intracellular channels' CLIC1, CLIC4 and CLIC5 reveals differential regulation by cytoskeletal actin.
Singh H, Cousin MA, Ashley RH. | 01/21/2010 |
| CLIC5 was demonstrated in cultured lymphoblasts. | Gene transcript amplification from cell lysates in continuous-flow microfluidic devices.
Gonzalez A, Ciobanu D, Sayers M, Sirr N, Dalton T, Davies M. | 01/21/2010 |
| association with Golgi apparatus AKAP350 | AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member.
Shanks RA, Larocca MC, Berryman M, Edwards JC, Urushidani T, Navarre J, Goldenring JR. | 01/21/2010 |
| CLIC-5A has a role as a chloride channel in vitro and binds to cortical actin cytoskeleton | CLIC-5A functions as a chloride channel in vitro and associates with the cortical actin cytoskeleton in vitro and in vivo.
Berryman M, Bruno J, Price J, Edwards JC. | 01/21/2010 |