| The Alk receptor tyrosine kinase regulates Sparkly, a novel activity regulating neuropeptide precursor in the Drosophila central nervous system. | The Alk receptor tyrosine kinase regulates Sparkly, a novel activity regulating neuropeptide precursor in the Drosophila central nervous system.
Sukumar SK, Antonydhason V, Molander L, Sandakly J, Kleit M, Umapathy G, Mendoza-Garcia P, Masudi T, Schlosser A, Nässel DR, Wegener C, Shirinian M, Palmer RH., Free PMC Article | 06/30/2024 |
| Patient-associated mutations in Drosophila Alk perturb neuronal differentiation and promote survival. | Patient-associated mutations in Drosophila Alk perturb neuronal differentiation and promote survival.
Pfeifer K, Wolfstetter G, Anthonydhason V, Masudi T, Arefin B, Bemark M, Mendoza-Garcia P, Palmer RH., Free PMC Article | 08/27/2022 |
| DamID transcriptional profiling identifies the Snail/Scratch transcription factor Kahuli as an Alk target in the Drosophila visceral mesoderm. | DamID transcriptional profiling identifies the Snail/Scratch transcription factor Kahuli as an Alk target in the Drosophila visceral mesoderm.
Mendoza-Garcia P, Basu S, Sukumar SK, Arefin B, Wolfstetter G, Anthonydhason V, Molander L, Uçkun E, Lindehell H, Lebrero-Fernandez C, Larsson J, Larsson E, Bemark M, Palmer RH., Free PMC Article | 02/12/2022 |
| The neuronal receptor tyrosine kinase Alk is a target for longevity. | The neuronal receptor tyrosine kinase Alk is a target for longevity.
Woodling NS, Aleyakpo B, Dyson MC, Minkley LJ, Rajasingam A, Dobson AJ, Leung KHC, Pomposova S, Fuentealba M, Alic N, Partridge L., Free PMC Article | 07/3/2021 |
| Identification of the Wallenda JNKKK as an Alk suppressor reveals increased competitiveness of Alk-expressing cells. | Identification of the Wallenda JNKKK as an Alk suppressor reveals increased competitiveness of Alk-expressing cells.
Wolfstetter G, Pfeifer K, Backman M, Masudi TA, Mendoza-García P, Chen S, Sonnenberg H, Sukumar SK, Uçkun E, Varshney GK, Uv A, Palmer RH., Free PMC Article | 12/12/2020 |
| Opa protein is a novel regulator of embryonic Alk expression. | The Zic family homologue Odd-paired regulates Alk expression in Drosophila.
Mendoza-García P, Hugosson F, Fallah M, Higgins ML, Iwasaki Y, Pfeifer K, Wolfstetter G, Varshney G, Popichenko D, Gergen JP, Hens K, Deplancke B, Palmer RH., Free PMC Article | 05/6/2017 |
| mutations in Nf1 produce a sexually dimorphic short sleep phenotype, and suppress the long sleep phenotype of Alk. Thus Alk and Nf1 interact in both learning and sleep regulation, highlighting a common pathway in these two processes | Anaplastic Lymphoma Kinase Acts in the Drosophila Mushroom Body to Negatively Regulate Sleep.
Bai L, Sehgal A., Free PMC Article | 06/4/2016 |
| This study demonistrated that Signaling through the anaplastic lymphoma kinase directly regulates neuronal survival in visual pathway. | Sequential axon-derived signals couple target survival and layer specificity in the Drosophila visual system.
Pecot MY, Chen Y, Akin O, Chen Z, Tsui CY, Zipursky SL., Free PMC Article | 06/7/2014 |
| Role of Lmd transcription factor in visceral mesoderm development in relationship to Jeb/Alk signal transduction. Alk signalling negatively regulates Lmd activity through the MAPK cascade resulting in a relocalisation of Lmd from nucleus to cytoplasm. | Jeb/Alk signalling regulates the Lame duck GLI family transcription factor in the Drosophila visceral mesoderm.
Popichenko D, Hugosson F, Sjögren C, Dogru M, Yamazaki Y, Wolfstetter G, Schönherr C, Fallah M, Hallberg B, Nguyen H, Palmer RH. | 09/28/2013 |
| These results identify dAlk as an upstream activator of dNf1-regulated Ras signaling responsible for several dNf1 defects, and they implicate human Alk as a potential therapeutic target in NF1 | The receptor tyrosine kinase Alk controls neurofibromin functions in Drosophila growth and learning.
Gouzi JY, Moressis A, Walker JA, Apostolopoulou AA, Palmer RH, Bernards A, Skoulakis EM., Free PMC Article | 01/28/2012 |
| Alk plays an evolutionary conserved role in ethanol-related behaviors | An evolutionary conserved role for anaplastic lymphoma kinase in behavioral responses to ethanol.
Lasek AW, Lim J, Kliethermes CL, Berger KH, Joslyn G, Brush G, Xue L, Robertson M, Moore MS, Vranizan K, Morris SW, Schuckit MA, White RL, Heberlein U., Free PMC Article | 12/10/2011 |
| Alk maintains PI3-kinase signaling during nutrient restriction as its ligand, Jelly belly, is constitutively expressed from a glial cell niche surrounding neuroblasts. | Anaplastic lymphoma kinase spares organ growth during nutrient restriction in Drosophila.
Cheng LY, Bailey AP, Leevers SJ, Ragan TJ, Driscoll PC, Gould AP. | 10/1/2011 |
| the main function of Drosophila Alk during early embryogenesis is in visceral mesoderm development | A crucial role for the Anaplastic lymphoma kinase receptor tyrosine kinase in gut development in Drosophila melanogaster.
Lorén CE, Englund C, Grabbe C, Hallberg B, Hunter T, Palmer RH., Free PMC Article | 01/21/2010 |
| Alk is the receptor for Jeb in the developing visceral mesoderm, and Jeb binding stimulates an Alk-driven, extracellular signal-regulated kinase-mediated signalling pathway, resulting in the expression of duf needed for muscle fusion | Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion.
Englund C, Lorén CE, Grabbe C, Varshney GK, Deleuil F, Hallberg B, Palmer RH. | 01/21/2010 |
| localized Jeb activates Alk and the downstream Ras/mitogen-activated protein kinase cascade to specify a select group of visceral muscle precursors as muscle-patterning pioneers | Jelly belly protein activates the receptor tyrosine kinase Alk to specify visceral muscle pioneers.
Lee HH, Norris A, Weiss JB, Frasch M. | 01/21/2010 |
| Alk-mediated signal transduction drives the expression of the bHLH transcription factor Hand in vivo. | The bHLH transcription factor Hand is regulated by Alk in the Drosophila embryonic gut.
Varshney GK, Palmer RH. | 01/21/2010 |
| these findings suggest that Jeb/Alk signaling helps R-cell axons to shape their environment for target recognition. | Anterograde Jelly belly and Alk receptor tyrosine kinase signaling mediates retinal axon targeting in Drosophila.
Bazigou E, Apitz H, Johansson J, Lorén CE, Hirst EM, Chen PL, Palmer RH, Salecker I. | 01/21/2010 |