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    PLK1 polo like kinase 1 [ Homo sapiens (human) ]

    Gene ID: 5347, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    USP18 promotes the proliferation, invasion, and migration of head and neck squamous cell carcinoma by deubiquitinating PLK1.

    USP18 promotes the proliferation, invasion, and migration of head and neck squamous cell carcinoma by deubiquitinating PLK1.
    Geng L, Liu F, Yang L, Liu Y, Wu G.

    11/6/2024
    Polo-like kinase 1 (PLK1) is a novel CARD14-binding protein in keratinocytes.

    Polo-like kinase 1 (PLK1) is a novel CARD14-binding protein in keratinocytes.
    Iliaki S, Kreike M, Ferreras Moreno N, De Meyer F, Aidarova A, Braun H, Libert C, Afonina IS, Beyaert R.

    09/19/2024
    Role of protein kinase PLK1 in the epigenetic maintenance of centromeres.

    Role of protein kinase PLK1 in the epigenetic maintenance of centromeres.
    Conti D, Verza AE, Pesenti ME, Cmentowski V, Vetter IR, Pan D, Musacchio A.

    09/6/2024
    PLK1 phosphorylation of ZW10 guides accurate chromosome segregation in mitosis.

    PLK1 phosphorylation of ZW10 guides accurate chromosome segregation in mitosis.
    Bellah SF, Xiong F, Dou Z, Yang F, Liu X, Yao X, Gao X, Zhang L., Free PMC Article

    08/27/2024
    A miR-361-5p/ ORC6/ PLK1 axis regulates prostate cancer progression.

    A miR-361-5p/ ORC6/ PLK1 axis regulates prostate cancer progression.
    Liu Z, Zhang Y, Yu L, Zhang Z, Li G.

    07/19/2024
    Phosphorylation of LZTS2 by PLK1 activates the Wnt pathway.

    Phosphorylation of LZTS2 by PLK1 activates the Wnt pathway.
    Liu R, Zhou D, Yu B, Zhou Z.

    06/21/2024
    PLK1 and FoxM1 expressions positively correlate in papillary thyroid carcinoma and their combined inhibition results in synergistic anti-tumor effects.

    PLK1 and FoxM1 expressions positively correlate in papillary thyroid carcinoma and their combined inhibition results in synergistic anti-tumor effects.
    Poyil PK, Siraj AK, Padmaja D, Parvathareddy SK, Thangavel S, Alobaisi K, Diaz R, Begum R, Haqawi W, Al-Sobhi SS, Al-Dayel F, Al-Kuraya KS., Free PMC Article

    03/13/2024
    DLGAP5 promotes lung adenocarcinoma growth via upregulating PLK1 and serves as a therapeutic target.

    DLGAP5 promotes lung adenocarcinoma growth via upregulating PLK1 and serves as a therapeutic target.
    Chen M, Zhang S, Wang F, He J, Jiang W, Zhang L., Free PMC Article

    02/29/2024
    PLK1 and its substrate MISP facilitate intrahepatic cholangiocarcinoma progression by promoting lymphatic invasion and impairing E-cadherin adherens junctions.

    PLK1 and its substrate MISP facilitate intrahepatic cholangiocarcinoma progression by promoting lymphatic invasion and impairing E-cadherin adherens junctions.
    Pan YR, Lai JC, Huang WK, Peng PH, Jung SM, Lin SH, Chen CP, Wu CE, Hung TH, Yu AL, Wu KJ, Yeh CN., Free PMC Article

    02/22/2024
    Specific Polo-Like Kinase 1 Expression in Nodular Lymphocyte-Predominant Hodgkin Lymphoma Suggests an Intact Immune Surveillance Program.

    Specific Polo-Like Kinase 1 Expression in Nodular Lymphocyte-Predominant Hodgkin Lymphoma Suggests an Intact Immune Surveillance Program.
    Weiss J, Gibbons K, Ehyaee V, Perez-Silos V, Zevallos A, Maienschein-Cline M, Brister E, Sverdlov M, Shah E, Balakrishna J, Symes E, Frederiksen JK, Gann PH, Post R, Lopez-Hisijos N, Reneau J, Venkataraman G, Bailey N, Brown NA, Xu ML, Wilcox RA, Inamdar K, Murga-Zamalloa C.,

    01/6/2024
    PLK1 promotes the mitotic surveillance pathway by controlling cytosolic 53BP1 availability.

    PLK1 promotes the mitotic surveillance pathway by controlling cytosolic 53BP1 availability.
    Burigotto M, Vigorito V, Gliech C, Mattivi A, Ghetti S, Bisio A, Lolli G, Holland AJ, Fava LL., Free PMC Article

    12/18/2023
    The expression and clinical significance of PLK1/p-PLK1 protein in NK/T cell Lymphoma.

    The expression and clinical significance of PLK1/p-PLK1 protein in NK/T cell Lymphoma.
    Zhang Z, Liu E, Zhang D, Zhao W, Wang G, Zhang Y, Huo Y, Zhang C, Li W., Free PMC Article

    12/6/2023
    Crystal Structures of Plk1 Polo-Box Domain Bound to the Human Papillomavirus Minor Capsid Protein L2-Derived Peptide.

    Crystal Structures of Plk1 Polo-Box Domain Bound to the Human Papillomavirus Minor Capsid Protein L2-Derived Peptide.
    Jung S, Lee HS, Shin HC, Choi JS, Kim SJ, Ku B.

    10/10/2023
    Mild replication stress causes premature centriole disengagement via a sub-critical Plk1 activity under the control of ATR-Chk1.

    Mild replication stress causes premature centriole disengagement via a sub-critical Plk1 activity under the control of ATR-Chk1.
    Dwivedi D, Harry D, Meraldi P., Free PMC Article

    10/2/2023
    Poltheta; is phosphorylated by PLK1 to repair double-strand breaks in mitosis.

    Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis.
    Gelot C, Kovacs MT, Miron S, Mylne E, Haan A, Boeffard-Dosierre L, Ghouil R, Popova T, Dingli F, Loew D, Guirouilh-Barbat J, Del Nery E, Zinn-Justin S, Ceccaldi R., Free PMC Article

    09/18/2023
    PLK1 as a cooperating partner for BCL2-mediated antiapoptotic program in leukemia.

    PLK1 as a cooperating partner for BCL2-mediated antiapoptotic program in leukemia.
    Shah K, Nasimian A, Ahmed M, Al Ashiri L, Denison L, Sime W, Bendak K, Kolosenko I, Siino V, Levander F, Palm-Apergi C, Massoumi R, Lock RB, Kazi JU., Free PMC Article

    09/13/2023
    Plk1 promotes renal tubulointerstitial fibrosis by targeting autophagy/lysosome axis.

    Plk1 promotes renal tubulointerstitial fibrosis by targeting autophagy/lysosome axis.
    Du Y, Shang Y, Qian Y, Guo Y, Chen S, Lin X, Cao W, Tang X, Zhou A, Huang S, Zhang A, Jia Z, Zhang Y., Free PMC Article

    08/31/2023
    Characteristics and prognostic significance of polo-like kinase-1 (PLK1) expression in breast cancer.

    Characteristics and prognostic significance of polo-like kinase-1 (PLK1) expression in breast cancer.
    Lashen AG, Toss MS, Wootton L, Green AR, Mongan NP, Madhusudan S, Rakha E.

    08/22/2023
    Inhibition of Polo-like kinase 1 (PLK1) triggers cell apoptosis via ROS-caused mitochondrial dysfunction in colorectal carcinoma.

    Inhibition of Polo-like kinase 1 (PLK1) triggers cell apoptosis via ROS-caused mitochondrial dysfunction in colorectal carcinoma.
    Feng Y, Li T, Lin Z, Li Y, Han X, Pei X, Fu Z, Wu Q, Shao D, Li C.

    08/1/2023
    The toxicity of dysregulated Plk1 activity revealed by its suppressor mutations.

    The toxicity of dysregulated Plk1 activity revealed by its suppressor mutations.
    Kamakura N, Takahashi M, Jo M.

    07/17/2023
    USP1 promotes the aerobic glycolysis and progression of T-cell acute lymphoblastic leukemia via PLK1/LDHA axis.

    USP1 promotes the aerobic glycolysis and progression of T-cell acute lymphoblastic leukemia via PLK1/LDHA axis.
    Liu S, Xiang Y, Wang B, Gao C, Chen Z, Xie S, Wu J, Liu Y, Zhao X, Yang C, Yue Z, Wang L, Wen X, Zhang R, Zhang F, Xu H, Zhai X, Zheng H, Zhang H, Qian M., Free PMC Article

    07/6/2023
    UBAP2L-dependent coupling of PLK1 localization and stability during mitosis.

    UBAP2L-dependent coupling of PLK1 localization and stability during mitosis.
    Guerber L, Vuidel A, Liao Y, Kleiss C, Grandgirard E, Sumara I, Pangou E., Free PMC Article

    06/12/2023
    The Role of Polo-Like Kinase 1 in Regulating the Forkhead Box Family Transcription Factors.

    The Role of Polo-Like Kinase 1 in Regulating the Forkhead Box Family Transcription Factors.
    Moore XTR, Gheghiani L, Fu Z., Free PMC Article

    05/19/2023
    Phospho PTEN mediated dephosphorylation of mitotic kinase PLK1 and Aurora Kinase A prevents aneuploidy and preserves genomic stability.

    Phospho PTEN mediated dephosphorylation of mitotic kinase PLK1 and Aurora Kinase A prevents aneuploidy and preserves genomic stability.
    Ghosh G, Misra S, Ray R, Chowdhury SG, Karmakar P.

    04/19/2023
    Polo-like kinase 1 promotes Cdc42-induced actin polymerization for asymmetric division in oocytes.

    Polo-like kinase 1 promotes Cdc42-induced actin polymerization for asymmetric division in oocytes.
    Yuen WS, Zhang QH, Bourdais A, Adhikari D, Halet G, Carroll J., Free PMC Article

    03/10/2023
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