| Nuclear export of PML promotes p53-mediated apoptosis and ferroptosis. | Nuclear export of PML promotes p53-mediated apoptosis and ferroptosis.
Ni Y, Chen H, Zhan Q, Zhuang Z. | 07/29/2024 |
| PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells. | PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells.
Katerndahl CDS, Rogers ORS, Day RB, Xu Z, Helton NM, Ramakrishnan SM, Miller CA, Ley TJ., Free PMC Article | 05/7/2024 |
| Mutations at proximal cysteine residues in PML impair ATO binding by destabilizing the RBCC domain. | Mutations at proximal cysteine residues in PML impair ATO binding by destabilizing the RBCC domain.
Dubey S, Mishra N, Shelke R, Varma AK. | 04/4/2024 |
| PML-mediated nuclear loosening permits immunomodulation of mesenchymal stem/stromal cells under inflammatory conditions. | PML-mediated nuclear loosening permits immunomodulation of mesenchymal stem/stromal cells under inflammatory conditions.
Chu Y, Jiang Z, Gong Z, Ji X, Zhu M, Shang Q, Gong P, Cao L, Chen Y, Li P, Shao C, Shi Y., Free PMC Article | 04/4/2024 |
| PML modulates epigenetic composition of chromatin to regulate expression of pro-metastatic genes in triple-negative breast cancer. | PML modulates epigenetic composition of chromatin to regulate expression of pro-metastatic genes in triple-negative breast cancer.
Fracassi C, Ugge' M, Abdelhalim M, Zapparoli E, Simoni M, Magliulo D, Mazza D, Lazarevic D, Morelli MJ, Collas P, Bernardi R., Free PMC Article | 11/18/2023 |
| Promyelocytic leukemia protein regulates angiogenesis and epithelial-mesenchymal transition to limit metastasis in MDA-MB-231 breast cancer cells. | Promyelocytic leukemia protein regulates angiogenesis and epithelial-mesenchymal transition to limit metastasis in MDA-MB-231 breast cancer cells.
Vogiatzoglou AP, Spanou S, Sachini N, Drakos E, Nikolaou C, Makatounakis T, Kretsovali A, Papamatheakis J., Free PMC Article | 10/6/2023 |
| The spotted gar expresses a homolog of human PML isoform 1 (PML-I), that unlike the human gene, encodes an active exonuclease domain. Nonetheless, both gar PML and human PML-I share the evolutionary conserved ability to repress LINE-1 retrotransposons, where human PML-I shuttles to the cytoplasm to promote the proteasome-dependent degradation of LINE-1 ORF1p that in turn inhibits cGAS activity and retrotransposition. | PML and PML-like exonucleases restrict retrotransposons in jawed vertebrates.
Mathavarajah S, Vergunst KL, Habib EB, Williams SK, He R, Maliougina M, Park M, Salsman J, Roy S, Braasch I, Roger AJ, Langelaan DN, Dellaire G., Free PMC Article | 04/12/2023 |
| PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment. | PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment.
Missiroli S, Perrone M, Gafà R, Nicoli F, Bonora M, Morciano G, Boncompagni C, Marchi S, Lebiedzinska-Arciszewska M, Vezzani B, Lanza G, Kricek F, Borghi A, Fiorica F, Ito K, Wieckowski MR, Di Virgilio F, Abelli L, Pinton P, Giorgi C., Free PMC Article | 03/1/2023 |
| Multi-omics and machine learning reveal context-specific gene regulatory activities of PML::RARA in acute promyelocytic leukemia. | Multi-omics and machine learning reveal context-specific gene regulatory activities of PML::RARA in acute promyelocytic leukemia.
Villiers W, Kelly A, He X, Kaufman-Cook J, Elbasir A, Bensmail H, Lavender P, Dillon R, Mifsud B, Osborne CS., Free PMC Article | 02/15/2023 |
| Crosstalk between PML and p53 in response to TGF-beta1: A new mechanism of cardiac fibroblast activation. | Crosstalk between PML and p53 in response to TGF-β1: A new mechanism of cardiac fibroblast activation.
Huang D, Zhao D, Li M, Chang SY, Xue YD, Xu N, Li SJ, Tang NN, Gong LL, Liu YN, Yu H, Li QS, Li PY, Liu JL, Chen HX, Liu MB, Zhang WY, Zhao XM, Lang XZ, Li ZD, Liu Y, Ma ZY, Li JM, Wang N, Tian H, Cai BZ., Free PMC Article | 02/15/2023 |
| Promyelocytic Leukemia Protein Potently Restricts Human Cytomegalovirus Infection in Endothelial Cells. | Promyelocytic Leukemia Protein Potently Restricts Human Cytomegalovirus Infection in Endothelial Cells.
Seitz S, Heusel AT, Stamminger T, Scherer M., Free PMC Article | 10/22/2022 |
| PRMT5-mediated RNF4 methylation promotes therapeutic resistance of APL cells to As2O3 by stabilizing oncoprotein PML-RARalpha. | PRMT5-mediated RNF4 methylation promotes therapeutic resistance of APL cells to As(2)O(3) by stabilizing oncoprotein PML-RARα.
Huang X, Yang Y, Zhu D, Zhao Y, Wei M, Li K, Zhu HH, Zheng X., Free PMC Article | 06/18/2022 |
| Promyelocytic leukemia protein (PML) and stem cells: from cancer to pluripotency. | Promyelocytic leukemia protein (PML) and stem cells: from cancer to pluripotency.
Vogiatzoglou AP, Moretto F, Makkou M, Papamatheakis J, Kretsovali A. | 05/28/2022 |
| The Paget's disease of bone risk gene PML is a negative regulator of osteoclast differentiation and bone resorption. | The Paget's disease of bone risk gene PML is a negative regulator of osteoclast differentiation and bone resorption.
Wani S, Daroszewska A, Salter DM, van 't Hof RJ, Ralston SH, Albagha OME., Free PMC Article | 05/7/2022 |
| New Evidence of the Importance of Weak Interactions in the Formation of PML-Bodies. | New Evidence of the Importance of Weak Interactions in the Formation of PML-Bodies.
Fonin AV, Silonov SA, Fefilova AS, Stepanenko OV, Gavrilova AA, Petukhov AV, Romanovich AE, Modina AL, Zueva TS, Nedelyaev EM, Pleskach NM, Kuranova ML, Kuznetsova IM, Uversky VN, Turoverov KK., Free PMC Article | 03/19/2022 |
| PML-II regulates ERK and AKT signal activation and IFNalpha-induced cell death. | PML-II regulates ERK and AKT signal activation and IFNα-induced cell death.
Meng X, Chen Y, Macip S, Leppard K., Free PMC Article | 02/26/2022 |
| PML Nuclear Body Biogenesis, Carcinogenesis, and Targeted Therapy. | PML Nuclear Body Biogenesis, Carcinogenesis, and Targeted Therapy.
Li Y, Ma X, Wu W, Chen Z, Meng G. | 09/25/2021 |
| A PML/RARalpha direct target atlas redefines transcriptional deregulation in acute promyelocytic leukemia. | A PML/RARα direct target atlas redefines transcriptional deregulation in acute promyelocytic leukemia.
Tan Y, Wang X, Song H, Zhang Y, Zhang R, Li S, Jin W, Chen S, Fang H, Chen Z, Wang K., Free PMC Article | 08/28/2021 |
| Acute promyelocytic leukemia derived extracellular vesicles conserve PML-RARalpha transcript from storage-inflicted degradation: a stable diagnosis tool in APL patients. | Acute promyelocytic leukemia derived extracellular vesicles conserve PML-RARα transcript from storage-inflicted degradation: a stable diagnosis tool in APL patients.
Barzegar M, Farsani MA, Rafiee M, Amiri V, Parkhihdeh S, Rad F, Mohammadi MH. | 08/21/2021 |
| PML Differentially Regulates Growth and Invasion in Brain Cancer. | PML Differentially Regulates Growth and Invasion in Brain Cancer.
Tampakaki M, Oraiopoulou ME, Tzamali E, Tzedakis G, Makatounakis T, Zacharakis G, Papamatheakis J, Sakkalis V., Free PMC Article | 07/17/2021 |
| PML-II recruits ataxin-3 to PML-NBs and inhibits its deubiquitinating activity. | PML-II recruits ataxin-3 to PML-NBs and inhibits its deubiquitinating activity.
Zhang Y, Shao AW, Tang J, Geng Y. | 07/17/2021 |
| Targeting PML in triple negative breast cancer elicits growth suppression and senescence. | Targeting PML in triple negative breast cancer elicits growth suppression and senescence.
Arreal L, Piva M, Fernández S, Revandkar A, Schaub-Clerigué A, Villanueva J, Zabala-Letona A, Pujana M, Astobiza I, Cortazar AR, Hermanova I, Bozal-Basterra L, Arruabarrena-Aristorena A, Crespo JR, Valcarcel-Jimenez L, Zúñiga-García P, Canals F, Torrano V, Barrio R, Sutherland JD, Alimonti A, Martin-Martin N, Carracedo A., Free PMC Article | 07/3/2021 |
| No prognostic significance of normalized copy number of PML-RARA transcript at diagnosis in patients with acute promyelocytic leukemia. | No prognostic significance of normalized copy number of PML-RARA transcript at diagnosis in patients with acute promyelocytic leukemia.
Rasekh EO, Elsayed GM, Fathy S. | 06/19/2021 |
| Autophagic degradation of PML promotes susceptibility to HSV-1 by stress-induced corticosterone. | Autophagic degradation of PML promotes susceptibility to HSV-1 by stress-induced corticosterone.
Li W, Luo Z, Yan CY, Wang XH, He ZJ, Ouyang SH, Yan C, Liu LF, Zhou QQ, Mu HL, Gong HB, Duan WJ, Liang L, Kurihara H, Feng D, Li YF, He RR., Free PMC Article | 06/5/2021 |
| Acetylation of SUMO1 Alters Interactions with the SIMs of PML and Daxx in a Protein-Specific Manner. | Acetylation of SUMO1 Alters Interactions with the SIMs of PML and Daxx in a Protein-Specific Manner.
Mascle XH, Gagnon C, Wahba HM, Lussier-Price M, Cappadocia L, Sakaguchi K, Omichinski JG. | 05/1/2021 |