| Exploring the enigmatic association between PNLIP variants and risk of chronic pancreatitis in a large Chinese cohort. | Exploring the enigmatic association between PNLIP variants and risk of chronic pancreatitis in a large Chinese cohort.
Cassidy BM, Jiang F, Lin J, Chen JM, Curry GE, Ma GX, Wilhelm SJ, Deng SJ, Zhu G, Liao Z, Lowe ME, Xiao XK, Zou WB., | 09/19/2024 |
| Identification of protease-sensitive but not misfolding PNLIP variants in familial and hereditary pancreatitis. | Identification of protease-sensitive but not misfolding PNLIP variants in familial and hereditary pancreatitis.
Masson E, Berthet S, Le Gac G, Le Rhun M, Ka C, Autret S, Gourlaouen I, French GREPAN Study Group, Cooper DN, Férec C, Rebours V, Chen JM. | 01/31/2024 |
| Pancreatic lipase and its related proteins: where are we now? | Pancreatic lipase and its related proteins: where are we now?
Yadav N, Paul AT. | 01/26/2024 |
| In vitro anti-obesity activity by pancreatic lipase inhibition - Simple HPLC approach using EVOO as natural substrate. | In vitro anti-obesity activity by pancreatic lipase inhibition - Simple HPLC approach using EVOO as natural substrate.
Blasi F, Ianni F, Mangiapelo L, Pinna N, Cossignani L. | 10/23/2023 |
| Missense PNLIP mutations impeding pancreatic lipase secretion cause protein misfolding and endoplasmic reticulum stress. | Missense PNLIP mutations impeding pancreatic lipase secretion cause protein misfolding and endoplasmic reticulum stress.
Toldi V, Kassay N, Szabó A. | 02/19/2022 |
| Pancreatic triglyceride lipase mediates lipotoxic systemic inflammation. | Pancreatic triglyceride lipase mediates lipotoxic systemic inflammation.
de Oliveira C, Khatua B, Noel P, Kostenko S, Bag A, Balakrishnan B, Patel KS, Guerra AA, Martinez MN, Trivedi S, McCullough A, Lam-Himlin DM, Navina S, Faigel DO, Fukami N, Pannala R, Phillips AE, Papachristou GI, Kershaw EE, Lowe ME, Singh VP., Free PMC Article | 01/2/2021 |
| Our data indicate that protease-sensitive PNLIP variants are novel genetic risk factors for the development of CP. | Protease-Sensitive Pancreatic Lipase Variants Are Associated With Early Onset Chronic Pancreatitis.
Lasher D, Szabó A, Masamune A, Chen JM, Xiao X, Whitcomb DC, Barmada MM, Ewers M, Ruffert C, Paliwal S, Issarapu P, Bhaskar S, Mani KR, Chandak GR, Laumen H, Masson E, Kume K, Hamada S, Nakano E, Seltsam K, Bugert P, Müller T, Groneberg DA, Shimosegawa T, Rosendahl J, Férec C, Lowe ME, Witt H, Sahin-Tóth M., Free PMC Article | 02/29/2020 |
| Serum lipase subtype analysis cannot replace the standard lipase measurement for the diagnosis of acute pancreatitis, but the test demonstrated adequate sensitivity for use in triage or as an add-on test for serum lipase elevation. | Clinical efficacy of serum lipase subtype analysis for the differential diagnosis of pancreatic and non-pancreatic lipase elevation.
Bang CS, Kim JB, Park SH, Baik GH, Su KT, Yoon JH, Kim YS, Kim DJ., Free PMC Article | 05/20/2017 |
| Presence of methionine at position 221 in the PNLIP protein sequence causes protein misfolding and aggregation. | A novel mutation in PNLIP causes pancreatic triglyceride lipase deficiency through protein misfolding.
Szabó A, Xiao X, Haughney M, Spector A, Sahin-Tóth M, Lowe ME., Free PMC Article | 08/29/2015 |
| All these findings support the use of YLLIP2 in enzyme replacement therapy for the treatment of pancreatic exocrine insufficiency, a pathological situation in which an acidification of intestinal contents occurs. | An interfacial and comparative in vitro study of gastrointestinal lipases and Yarrowia lipolytica LIP2 lipase, a candidate for enzyme replacement therapy.
Bénarouche A, Point V, Carrière F, Cavalier JF. | 02/14/2015 |
| In patients with intraductal papillary mucinous neoplasm without a history of pancreatitis, serum pancreatic lipase and amylase outside normal range are associated with risk of malignancy. | Abnormal serum pancreatic enzymes, but not pancreatitis, are associated with an increased risk of malignancy in patients with intraductal papillary mucinous neoplasms.
Roch AM, Parikh JA, Al-Haddad MA, DeWitt JM, Ceppa EP, House MG, Nakeeb A, Schmidt CM. | 11/22/2014 |
| a novel mutation in the PNLIP gene in two brothers with congenital pancreatic lipase deficiency | Identification of a novel mutation in the PNLIP gene in two brothers with congenital pancreatic lipase deficiency.
Behar DM, Basel-Vanagaite L, Glaser F, Kaplan M, Tzur S, Magal N, Eidlitz-Markus T, Haimi-Cohen Y, Sarig G, Bormans C, Shohat M, Zeharia A., Free PMC Article | 10/4/2014 |
| Low PNLIP expression is associated with pancreatic cancer. | Integration of metabolomics and transcriptomics revealed a fatty acid network exerting growth inhibitory effects in human pancreatic cancer.
Zhang G, He P, Tan H, Budhu A, Gaedcke J, Ghadimi BM, Ried T, Yfantis HG, Lee DH, Maitra A, Hanna N, Alexander HR, Hussain SP., Free PMC Article | 09/6/2014 |
| Triacylglycerol lipase and alpha-amylase are highly over-expressed in pancreatic cyst fluids in patients with mucinous pancreatic neoplasms. | Glycomic and proteomic profiling of pancreatic cyst fluids identifies hyperfucosylated lactosamines on the N-linked glycans of overexpressed glycoproteins.
Mann BF, Goetz JA, House MG, Schmidt CM, Novotny MV., Free PMC Article | 11/3/2012 |
| Combination of two mutations with a promising one at the entrance of the catalytic cavity (K80E) negatively affected the lipase activity at neutral pH but not that at acidic pH. | Modification of pancreatic lipase properties by directed molecular evolution.
Colin DY, Deprez-Beauclair P, Silva N, Infantes L, Kerfelec B. | 08/23/2010 |
| the amplitude of the lid opening measured in solution or in a frozen solution in the presence of amphiphiles | Amplitude of pancreatic lipase lid opening in solution and identification of spin label conformational subensembles by combining continuous wave and pulsed EPR spectroscopy and molecular dynamics.
Ranaldi S, Belle V, Woudstra M, Bourgeas R, Guigliarelli B, Roche P, Vezin H, Carrière F, Fournel A. | 03/29/2010 |
| Trp-107 and Trp-253 contribute to the change in steady state fluorescence that is triggered by mixed micelles of inhibitor and bile salt. | Trp-107 and trp-253 account for the increased steady state fluorescence that accompanies the conformational change in human pancreatic triglyceride lipase induced by tetrahydrolipstatin and bile salt.
Bourbon-Freie A, Dub RE, Xiao X, Lowe ME., Free PMC Article | 01/21/2010 |
| The disulfide bridge between the hinges of the lid kept the secondary structure of the lid intact, whereas the HPL was completely unfolded. | Lid opening and unfolding in human pancreatic lipase at low pH revealed by site-directed spin labeling EPR and FTIR spectroscopy.
Ranaldi S, Belle V, Woudstra M, Rodriguez J, Guigliarelli B, Sturgis J, Carriere F, Fournel A. | 01/21/2010 |
| Introducing a negative charge close to the catalytic histidine induced a shift of the pH optimum toward acidic values but strongly reduced the lipase activity. | Exploring the active site cavity of human pancreatic lipase.
Colin DY, Deprez-Beauclair P, Allouche M, Brasseur R, Kerfelec B. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesA scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A. Polymorphisms in PNLIP, encoding pancreatic lipase, and associations with metabolic traits.
Hegele RA, Ramdath DD, Ban MR, Carruthers MN, Carrington CV, Cao H. | 03/13/2008 |
| pancreatic lipase-colipase interactions in the presence of bile salt micelles are mediated by Val-407 and Ile-408 of PL | Val-407 and Ile-408 in the beta5'-loop of pancreatic lipase mediate lipase-colipase interactions in the presence of bile salt micelles.
Freie AB, Ferrato F, Carrière F, Lowe ME., Free PMC Article | 01/21/2010 |
| examination of tryptophan changes in pancreatic lipase | Time-resolved fluorescence allows selective monitoring of Trp30 environmental changes in the seven-Trp-containing human pancreatic lipase.
Ramos P, Coste T, Piémont E, Lessinger JM, Bousquet JA, Chapus C, Kerfelec B, Férard G, Mély Y. | 01/21/2010 |
| Review. The structure and function of the pancreatic lipase C2 domains, based on the recent 3D structures and improved sequence alignments are reviewed. | The C-terminal domain of pancreatic lipase: functional and structural analogies with c2 domains.
Chahinian H, Sias B, Carrière F. | 01/21/2010 |
| Electron paramagnetic resonance spectroscopy along with site-directed spin labeling was used to monitor the conformational changes in the human PL lid in solution to assess the effects of partners of the lipase, i.e. colipase and bile salts. | Probing the opening of the pancreatic lipase lid using site-directed spin labeling and EPR spectroscopy.
Belle V, Fournel A, Woudstra M, Ranaldi S, Prieri F, Thomé V, Currault J, Verger R, Guigliarelli B, Carrière F. | 01/21/2010 |
| a specific method of measuring classical pancreatic lipase in human serum | Critical evaluation of a specific ELISA and two enzymatic assays of pancreatic lipases in human sera.
Grandval P, De Caro A, De Caro J, Sias B, Carrière F, Verger R, Laugier R. | 01/21/2010 |