| beta-COP Suppresses the Surface Expression of the TREK2. | β-COP Suppresses the Surface Expression of the TREK2.
Kim SS, Park J, Kim E, Hwang EM, Park JY., Free PMC Article | 06/14/2023 |
| Effects of ionic strength on gating and permeation of TREK-2 K2P channels. | Effects of ionic strength on gating and permeation of TREK-2 K2P channels.
Conrad LJ, Proks P, Tucker SJ., Free PMC Article | 11/27/2021 |
| The M2-glycine hinge controls the macroscopic currents of TREK1 channels. | The glycine hinge of transmembrane segment 2 modulates the subcellular localization and gating properties in TREK channels.
Zhuo RG, Peng P, Zheng JQ, Zhang YL, Wen L, Wei XL, Ma XY. | 08/12/2017 |
| This study showed that KCNK10 gene involved in neuronal growth and cerebellum development and associated with neurological and psychological disorders. | The association of DNA methylation and brain volume in healthy individuals and schizophrenia patients.
Liu J, Siyahhan Julnes P, Chen J, Ehrlich S, Walton E, Calhoun VD., Free PMC Article | 10/1/2016 |
| The selectivity filter conformations of alternative translation initiation isoforms and wild type human TREK-2 are similar in the S4 site and pHo position. | The isoforms generated by alternative translation initiation adopt similar conformation in the selectivity filter in TREK-2.
Zhuo RG, Peng P, Liu XY, Zhang SZ, Xu JP, Zheng JQ, Wei XL, Ma XY. | 09/24/2016 |
| Results suggest that the cytosolic C-terminal domain and the bottom of transmembrane segment M2 are required for the 2-aminoethoxydiphenyl borate activation on TREK-2 channels | Insights into the stimulatory mechanism of 2-aminoethoxydiphenyl borate on TREK-2 potassium channel.
Zhuo RG, Liu XY, Zhang SZ, Wei XL, Zheng JQ, Xu JP, Ma XY. | 04/2/2016 |
| How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2. | How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2.
Brohawn SG. | 12/26/2015 |
| Modulation of K2P 2.1 and K2P 10.1 K(+) channel sensitivity to carvedilol by alternative mRNA translation initiation | Modulation of K2P 2.1 and K2P 10.1 K(+) channel sensitivity to carvedilol by alternative mRNA translation initiation.
Kisselbach J, Seyler C, Schweizer PA, Gerstberger R, Becker R, Katus HA, Thomas D., Free PMC Article | 08/15/2015 |
| PLD2, but not PLD1, directly binds to the C terminus of TREK1 and TREK2. | Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid.
Comoglio Y, Levitz J, Kienzler MA, Lesage F, Isacoff EY, Sandoz G., Free PMC Article | 04/25/2015 |
| crystal structures of TREK-2 channel in 2 conformations and in complex with norfluoxetine, a state-dependent blocker of TREK channels; results provide an explanation for TREK channel mechanosensitivity, regulation by diverse stimuli and possible off-target effects of Prozac | K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
Dong YY, Pike AC, Mackenzie A, McClenaghan C, Aryal P, Dong L, Quigley A, Grieben M, Goubin S, Mukhopadhyay S, Ruda GF, Clausen MV, Cao L, Brennan PE, Burgess-Brown NA, Sansom MS, Tucker SJ, Carpenter EP., Free PMC Article | 03/21/2015 |
| High TREK-2 expression is associated with epithelial ovarian cancer. | Expression and effects of modulation of the K2P potassium channels TREK-1 (KCNK2) and TREK-2 (KCNK10) in the normal human ovary and epithelial ovarian cancer.
Innamaa A, Jackson L, Asher V, van Schalkwyk G, Warren A, Keightley A, Hay D, Bali A, Sowter H, Khan R. | 05/31/2014 |
| Tissue-specific mRNA splicing regulates alternative translation initiation (ATI) of human K(2P)10.1 K+ background channels via recombination of 5 nucleotide motifs. | Alternative splicing determines mRNA translation initiation and function of human K(2P)10.1 K+ channels.
Staudacher K, Baldea I, Kisselbach J, Staudacher I, Rahm AK, Schweizer PA, Becker R, Katus HA, Thomas D., Free PMC Article | 04/21/2012 |
| Predicts the role of TREK-2 in brain ischemia, memory and other tissues.[REVIEW] | Recent advance and possible future in TREK-2: a two-pore potassium channel may involved in the process of NPP, brain ischemia and memory impairment.
Huang D, Yu B. | 01/21/2010 |
| Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2. | Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2.
Gu W, Schlichthörl G, Hirsch JR, Engels H, Karschin C, Karschin A, Derst C, Steinlein OK, Daut J., Free PMC Article | 01/21/2010 |