| Dysregulated expression of slingshot protein phosphatase 1 (SSH1) disrupts circadian rhythm and WNT signaling associated to hepatocellular carcinoma pathogenesis. | Dysregulated expression of slingshot protein phosphatase 1 (SSH1) disrupts circadian rhythm and WNT signaling associated to hepatocellular carcinoma pathogenesis.
Lai SW, Cheng YC, Huang WC, Yadav VK, Fong IH, Yeh CT, Yang CK, Lee WH, Chen MY., Free PMC Article | 11/7/2023 |
| Slingshot homolog-1-mediated Nrf2 sequestration tips the balance from neuroprotection to neurodegeneration in Alzheimer's disease. | Slingshot homolog-1-mediated Nrf2 sequestration tips the balance from neuroprotection to neurodegeneration in Alzheimer's disease.
Cazzaro S, Woo JA, Wang X, Liu T, Rego S, Kee TR, Koh Y, Vázquez-Rosa E, Pieper AA, Kang DE., Free PMC Article | 07/24/2023 |
| SSH1 promotes progression of intrahepatic cholangiocarcinoma via p38 MAPK-CXCL8 axis. | SSH1 promotes progression of intrahepatic cholangiocarcinoma via p38 MAPK-CXCL8 axis.
Chen F, Aye L, Yu L, Liu L, Liu Y, Lin Y, Gao D, Gao Q, Zhang S. | 06/1/2023 |
| Slingshot homolog-1 amplifies mitochondrial abnormalities by distinctly impairing health and clearance of mitochondria. | Slingshot homolog-1 amplifies mitochondrial abnormalities by distinctly impairing health and clearance of mitochondria.
Cazzaro S, Zhao X, Zhao VK, Kim YK, Woo JA., Free PMC Article | 05/11/2023 |
| Role of SSH1 in colorectal cancer prognosis and tumor progression. | Role of SSH1 in colorectal cancer prognosis and tumor progression.
Song X, Xie D, Xia X, Tan F, Pei Q, Li Y, Zhou Z, Zhou Y, Li C, Wang K, Pei H. | 11/21/2020 |
| genetic variants at the genes SSH1 and ST8SIA1 were related to the genetic predisposition to early-onset periodontitis that is in part triggered by smoking | Smoking Modifies the Genetic Risk for Early-Onset Periodontitis.
Freitag-Wolf S, Munz M, Wiehe R, Junge O, Graetz C, Jockel-Schneider Y, Staufenbiel I, Bruckmann C, Lieb W, Franke A, Loos BG, Jepsen S, Dommisch H, Schaefer AS. | 07/25/2020 |
| SSH1 binds to gelsolin via actin filaments in the cytosolic fraction. Gelsolin promoted solubilization of actin filaments and SSH1 in cell-free assays and in cultured cells. | Activation of cytosolic Slingshot-1 phosphatase by gelsolin-generated soluble actin filaments.
Takahashi K, Kanno S, Mizuno K. | 09/23/2017 |
| the N-terminal PH-like domain plays a critical role in F-actin binding and F-actin-mediated activation of the cofilin-phosphatase activity of SSH1 | A pleckstrin homology-like domain is critical for F-actin binding and cofilin-phosphatase activity of Slingshot-1.
Takahashi K, Okabe H, Kanno SI, Nagai T, Mizuno K. | 06/10/2017 |
| Results reveal that SSH1L is upregulated in a subset of PCs and that the SSH1L/cofilin-1 signal pathway is associated positively in PC with cell migration. | Cofilin-phosphatase slingshot-1L (SSH1L) is over-expressed in pancreatic cancer (PC) and contributes to tumor cell migration.
Wang Y, Kuramitsu Y, Kitagawa T, Baron B, Yoshino S, Maehara S, Maehara Y, Oka M, Nakamura K. | 05/23/2015 |
| Authors show that viral penetration-induced calcium release facilitated herpes simplex virus type 1 intracellular trafficking through activating slingshot 1 (SSH), a phosphatase regulating actin filament dynamics. | Calcium-signal facilitates herpes simplex virus type 1 nuclear transport through slingshot 1 and calpain-1 activation.
Zheng K, Xiang Y, Wang Q, Jin F, Chen M, Ma K, Ren Z, Wang Y. | 02/28/2015 |
| The association of IRS4 with SSH1 contributes to localized activation of cofilin in membrane protrusions. | Insulin receptor substrate-4 binds to Slingshot-1 phosphatase and promotes cofilin dephosphorylation.
Homma Y, Kanno SI, Sasaki K, Nishita M, Yasui A, Asano T, Ohashi K, Mizuno K., Free PMC Article | 02/7/2015 |
| Slingshot 1 downregulation in neuronal cells inactivates cofilin to facilitate HSV-1 replication. | Ubiquitin-proteasome-dependent slingshot 1 downregulation in neuronal cells inactivates cofilin to facilitate HSV-1 replication.
Xiang Y, Zheng K, Zhong M, Chen J, Wang X, Wang Q, Wang S, Ren Z, Fan J, Wang Y. | 04/12/2014 |
| Results identify a novel frameshift mutation in this gene implicated in disseminated superficial actinic porokeratosis in 4 Chinese families | Identification of three novel frameshift mutations of the MVK gene in four Chinese families with disseminated superficial actinic porokeratosis.
Zhou Y, Liu J, Fu X, Yu Y, Shi B, Yu G, Shi Z, Wu W, Pan F, Tian H, Liu H, Zhang F. | 02/1/2014 |
| Thus this study provides evidence for a novel role of LIMK1 and SSH-1L in selectively regulating endothelial cell inflammation associated with intravascular coagulation. | Thrombin selectively engages LIM kinase 1 and slingshot-1L phosphatase to regulate NF-κB activation and endothelial cell inflammation.
Leonard A, Marando C, Rahman A, Fazal F., Free PMC Article | 01/4/2014 |
| Our work provides evidence that supports the positive role of SSH1L in the mechanism of stem cell differentiation into cardiomyocyte-like cells. | The role of slingshot-1L (SSH1L) in the differentiation of human bone marrow mesenchymal stem cells into cardiomyocyte-like cells.
Zhao JW, Zhang MR, Ji QY, Xing FJ, Meng LJ, Wang Y., Free PMC Article | 06/1/2013 |
| A high expression of SSH-1L in peripheral eosinophils in acute exacerbations of asthma may play a role in the activation and migration of eosinophils. | [Localization and expression of Slingshot-1L in peripheral eosinophils from patients with acute asthma exacerbation].
Zhang WZ, Zhao HJ, Zhou F, Li WJ, Cai SX. | 03/9/2013 |
| EphA signaling promotes actin-based dendritic spine remodeling through slingshot 1. | EphA signaling promotes actin-based dendritic spine remodeling through slingshot phosphatase.
Zhou L, Jones EV, Murai KK., Free PMC Article | 06/16/2012 |
| identified Ser 402 as a new phosphorylation site within the catalytic domain of human slingshot 1 (SSH1). | Phosphorylation of Ser 402 impedes phosphatase activity of slingshot 1.
Barišić S, Nagel AC, Franz-Wachtel M, Macek B, Preiss A, Link G, Maier D, Hausser A., Free PMC Article | 09/17/2011 |
| Results show the significance of SSH1L in estrogen-induced osteoblastogenic differentiation in favor of adipogenic differentiation from hMSCs. | Differentiation of human mesenchymal stem cells: the potential mechanism for estrogen-induced preferential osteoblast versus adipocyte differentiation.
Zhao JW, Gao ZL, Mei H, Li YL, Wang Y. | 08/6/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Mutational analysis of mononucleotide repeats in dual specificity tyrosine phosphatase genes in gastric and colon carcinomas with microsatellite instability.
Song SY, Kang MR, Yoo NJ, Lee SH. | 06/30/2010 |
| Results suggest that the formation of ROS by NADPH oxidases engages a SSH-1L-cofilin pathway to regulate cytoskeletal organization and cell migration. | Reactive oxygen species regulate a slingshot-cofilin activation pathway.
Kim JS, Huang TY, Bokoch GM., Free PMC Article | 01/21/2010 |
| Data identify PKD as a central regulator of the cofilin signaling network via direct phosphorylation and regulation of SSH1L. | Protein kinase D regulates cell migration by direct phosphorylation of the cofilin phosphatase slingshot 1 like.
Peterburs P, Heering J, Link G, Pfizenmaier K, Olayioye MA, Hausser A. | 01/21/2010 |
| These results implicate 14-3-3zeta/tau heterodimers as key regulators of SSH1 activity in keratinocytes and suggest they play a role in cytoskeleton remodeling during cell migration. | 14-3-3zeta/tau heterodimers regulate Slingshot activity in migrating keratinocytes.
Kligys K, Yao J, Yu D, Jones JC., Free PMC Article | 01/21/2010 |
| the conserved SSH-N domain of slingshot-1 plays critical roles in P-cofilin recognition, F-actin-mediated activation, and subcellular localization of SSH1 | Molecular dissection of the mechanisms of substrate recognition and F-actin-mediated activation of cofilin-phosphatase Slingshot-1.
Kurita S, Watanabe Y, Gunji E, Ohashi K, Mizuno K. | 01/21/2010 |
| PDGF participates in actin dynamics by dual regulation of cofilin activity via LIMK and SSH1L in aortic smooth muscle cells | Dual regulation of cofilin activity by LIM kinase and Slingshot-1L phosphatase controls platelet-derived growth factor-induced migration of human aortic smooth muscle cells.
San Martín A, Lee MY, Williams HC, Mizuno K, Lassègue B, Griendling KK. | 01/21/2010 |