| Astrocytic DLL4-NOTCH1 signaling pathway promotes neuroinflammation via the IL-6-STAT3 axis. | Astrocytic DLL4-NOTCH1 signaling pathway promotes neuroinflammation via the IL-6-STAT3 axis.
Mora P, Laisné M, Bourguignon C, Rouault P, Jaspard-Vinassa B, Maître M, Gadeau AP, Renault MA, Horng S, Couffinhal T, Chapouly C., Free PMC Article | 10/18/2024 |
| KLF13 restrains Dll4-muscular Notch2 axis to improve the muscle atrophy. | KLF13 restrains Dll4-muscular Notch2 axis to improve the muscle atrophy.
Yang S, Xiong L, Yang G, Xiang J, Li L, Kang L, Liang Z., Free PMC Article | 10/9/2024 |
| LRP1 induces anti-PD-1 resistance by modulating the DLL4-NOTCH2-CCL2 axis and redirecting M2-like macrophage polarisation in bladder cancer. | LRP1 induces anti-PD-1 resistance by modulating the DLL4-NOTCH2-CCL2 axis and redirecting M2-like macrophage polarisation in bladder cancer.
Lin H, Fu L, Zhou X, Yu A, Chen Y, Liao W, Shu G, Zhang L, Tan L, Liang H, Wang Z, Deng Q, Wang J, Jin M, Chen Z, Wei J, Cao J, Chen W, Li X, Li P, Lu J, Luo J. | 09/5/2024 |
| Delta like 4 regulates cerebrovascular development and endothelial integrity via DLL4-NOTCH-CLDN5 pathway and is vulnerable to neonatal hyperoxia. | Delta like 4 regulates cerebrovascular development and endothelial integrity via DLL4-NOTCH-CLDN5 pathway and is vulnerable to neonatal hyperoxia.
Ke X, Xia S, Yu W, Mabry S, Fu Q, Menden HL, Sampath V, Lane RH. | 06/3/2024 |
| Palmitic acid in type 2 diabetes mellitus promotes atherosclerotic plaque vulnerability via macrophage Dll4 signaling. | Palmitic acid in type 2 diabetes mellitus promotes atherosclerotic plaque vulnerability via macrophage Dll4 signaling.
Wang X, Zhu L, Liu J, Ma Y, Qiu C, Liu C, Gong Y, Yuwen Y, Guan G, Zhang Y, Pan S, Wang J, Liu Z., Free PMC Article | 02/17/2024 |
| Epsin1-mediated exosomal sorting of Dll4 modulates the tubular-macrophage crosstalk in diabetic nephropathy. | Epsin1-mediated exosomal sorting of Dll4 modulates the tubular-macrophage crosstalk in diabetic nephropathy.
Liu JL, Zhang L, Huang Y, Li XH, Liu YF, Zhang SM, Zhao YE, Chen XJ, Liu Y, He LY, Dong Z, Liu FY, Sun L, Xiao L., Free PMC Article | 05/10/2023 |
| Notch1 and Notch4 core binding domain peptibodies exhibit distinct ligand-binding and anti-angiogenic properties. | Notch1 and Notch4 core binding domain peptibodies exhibit distinct ligand-binding and anti-angiogenic properties.
Sargis T, Youn SW, Thakkar K, Naiche LA, Paik NY, Pajcini KV, Kitajewski JK., Free PMC Article | 04/26/2023 |
| Delta-like ligand-4 regulates Notch-mediated maturation of second heart field progenitor-derived pharyngeal arterial endothelial cells. | Delta-like ligand-4 regulates Notch-mediated maturation of second heart field progenitor-derived pharyngeal arterial endothelial cells.
De Zoysa P, Toubat O, Harvey DC, Yi C, Liu J, Cavallero S, Hong YK, Sucov HM, Kumar SR., Free PMC Article | 10/22/2022 |
| Dll4 Inhibition Promotes Graft Retention in Fat Grafting Enriched with Adipose-Derived Stem Cells. | Dll4 Inhibition Promotes Graft Retention in Fat Grafting Enriched with Adipose-Derived Stem Cells.
Lee CK, Park BY, Jo T, Park CH, Kim JH, Chung KJ, Kim YH, Park DY, Kim IK., Free PMC Article | 07/30/2022 |
| The endothelial Dll4-muscular Notch2 axis regulates skeletal muscle mass. | The endothelial Dll4-muscular Notch2 axis regulates skeletal muscle mass.
Fujimaki S, Matsumoto T, Muramatsu M, Nagahisa H, Horii N, Seko D, Masuda S, Wang X, Asakura Y, Takahashi Y, Miyamoto Y, Usuki S, Yasunaga KI, Kamei Y, Nishinakamura R, Minami T, Fukuda T, Asakura A, Ono Y. | 04/30/2022 |
| Delta-like 4 is required for pulmonary vascular arborization and alveolarization in the developing lung. | Delta-like 4 is required for pulmonary vascular arborization and alveolarization in the developing lung.
Xia S, Menden HL, Townley N, Mabry SM, Johnston J, Nyp MF, Heruth DP, Korfhagen T, Sampath V., Free PMC Article | 01/22/2022 |
| Dll4 Blockade Promotes Angiogenesis in Nonhealing Wounds of Sox7-Deficient Mice. | Dll4 Blockade Promotes Angiogenesis in Nonhealing Wounds of Sox7-Deficient Mice.
Yang JM, Ryu J, Kim I, Chang H, Kim IK., Free PMC Article | 08/28/2021 |
| Anti-DLL4 ameliorates toluene diisocyanate-induced experimental asthma by inhibiting Th17 response. | Anti-DLL4 ameliorates toluene diisocyanate-induced experimental asthma by inhibiting Th17 response.
Deng Y, Chen S, Song S, Huang Y, Chen R, Tao A. | 06/26/2021 |
| Delta-like ligand 4-mediated Notch signaling controls proliferation of second heart field progenitor cells by regulating Fgf8 expression. | Delta-like ligand 4-mediated Notch signaling controls proliferation of second heart field progenitor cells by regulating Fgf8 expression.
De Zoysa P, Liu J, Toubat O, Choi J, Moon A, Gill PS, Duarte A, Sucov HM, Kumar SR., Free PMC Article | 04/13/2021 |
| Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH2. | Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH2.
Kakuda S, LoPilato RK, Ito A, Haltiwanger RS., Free PMC Article | 03/13/2021 |
| Notch ligand Dll4 impairs cell recruitment to aortic clusters and limits blood stem cell generation. | Notch ligand Dll4 impairs cell recruitment to aortic clusters and limits blood stem cell generation.
Porcheri C, Golan O, Calero-Nieto FJ, Thambyrajah R, Ruiz-Herguido C, Wang X, Catto F, Guillén Y, Sinha R, González J, Kinston SJ, Mariani SA, Maglitto A, Vink CS, Dzierzak E, Charbord P, Göttgens B, Espinosa L, Sprinzak D, Bigas A., Free PMC Article | 12/19/2020 |
| Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis. | Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis.
Hultgren NW, Fang JS, Ziegler ME, Ramirez RN, Phan DTT, Hatch MMS, Welch-Reardon KM, Paniagua AE, Kim LS, Shon NN, Williams DS, Mortazavi A, Hughes CCW., Free PMC Article | 11/21/2020 |
| Dll4 Suppresses Transcytosis for Arterial Blood-Retinal Barrier Homeostasis. | Dll4 Suppresses Transcytosis for Arterial Blood-Retinal Barrier Homeostasis.
Yang JM, Park CS, Kim SH, Noh TW, Kim JH, Park S, Lee J, Park JR, Yoo D, Jung HH, Takase H, Shima DT, Schwaninger M, Lee S, Kim IK, Lee J, Ji YS, Jon S, Oh WY, Kim P, Uemura A, Ju YS, Kim I. | 10/31/2020 |
| Delta-like 1 and Delta-like 4 differently require their extracellular domains for triggering Notch signaling in mice. | Delta-like 1 and Delta-like 4 differently require their extracellular domains for triggering Notch signaling in mice.
Hirano KI, Suganami A, Tamura Y, Yagita H, Habu S, Kitagawa M, Sato T, Hozumi K., Free PMC Article | 10/3/2020 |
| MicroRNA-384-5p Promotes Endothelial Progenitor Cell Proliferation and Angiogenesis in Cerebral Ischemic Stroke through the Delta-Likeligand 4-Mediated Notch Signaling Pathway. | MicroRNA-384-5p Promotes Endothelial Progenitor Cell Proliferation and Angiogenesis in Cerebral Ischemic Stroke through the Delta-Likeligand 4-Mediated Notch Signaling Pathway.
Fan J, Xu W, Nan S, Chang M, Zhang Y. | 09/26/2020 |
| the Galpha12/Galpha13-coupled receptors LPA4 and LPA6 synergistically regulate endothelial Dll4 expression through YAP/TAZ activation | Lysophosphatidic acid-induced YAP/TAZ activation promotes developmental angiogenesis by repressing Notch ligand Dll4.
Yasuda D, Kobayashi D, Akahoshi N, Ohto-Nakanishi T, Yoshioka K, Takuwa Y, Mizuno S, Takahashi S, Ishii S., Free PMC Article | 06/6/2020 |
| endothelial Dll4/Notch-function mediates tumor hypoxia-driven increase of epithelial-to-mesenchymal transition (EMT). | Metastasis is impaired by endothelial-specific Dll4 loss-of-function through inhibition of epithelial-to-mesenchymal transition and reduction of cancer stem cells and circulating tumor cells.
Mendonça L, Trindade A, Carvalho C, Correia J, Badenes M, Gigante J, Duarte A. | 03/28/2020 |
| Notch signaling mediated by Dll1 and Dll4 is necessary for the development and persistence of chronic graft-versus-host disease. | Notch signaling mediated by Delta-like ligands 1 and 4 controls the pathogenesis of chronic GVHD in mice.
Radojcic V, Paz K, Chung J, Du J, Perkey ET, Flynn R, Ivcevic S, Zaiken M, Friedman A, Yan M, Pletneva MA, Sarantopoulos S, Siebel CW, Blazar BR, Maillard I., Free PMC Article | 07/27/2019 |
| TR3/Nur77 regulated the expression of DLL4 and Jagged1 in culture endothelial cells. DLL4 and Jagged1 play important roles in the angiogenic responses induced by TR3/Nur77. | DLL4 and Jagged1 are angiogenic targets of orphan nuclear receptor TR3/Nur77.
Peng J, Zhao S, Li Y, Niu G, Chen C, Ye T, Zhao D, Zeng H., Free PMC Article | 06/22/2019 |
| Notch1 inactivation in keratinocytes is sufficient to cancel the repressive effects of the Dll4-Notch1 loop on wound healing in diabetes, thus making Notch1 signaling an attractive locally therapeutic target for the treatment of Diabetic foot ulcerations. | Triggering of a Dll4-Notch1 loop impairs wound healing in diabetes.
Zheng X, Narayanan S, Sunkari VG, Eliasson S, Botusan IR, Grünler J, Catrina AI, Radtke F, Xu C, Zhao A, Ekberg NR, Lendahl U, Catrina SB., Free PMC Article | 05/25/2019 |