| Kalirin mediates Rac1 activation downstream of calcium/calmodulin-dependent protein kinase II to stimulate glucose uptake during muscle contraction. | Kalirin mediates Rac1 activation downstream of calcium/calmodulin-dependent protein kinase II to stimulate glucose uptake during muscle contraction.
Liu S, Qi R, Zhang J, Zhang C, Chen L, Yao Z, Niu W. | 12/31/2022 |
| KALRN mutations promote antitumor immunity and immunotherapy response in cancer. | KALRN mutations promote antitumor immunity and immunotherapy response in cancer.
Li M, Ma Y, Zhong Y, Liu Q, Chen C, Qiang L, Wang X., Free PMC Article | 10/9/2021 |
| Rapid 3D Enhanced Resolution Microscopy Reveals Diversity in Dendritic Spinule Dynamics, Regulation, and Function. | Rapid 3D Enhanced Resolution Microscopy Reveals Diversity in Dendritic Spinule Dynamics, Regulation, and Function.
Zaccard CR, Shapiro L, Martin-de-Saavedra MD, Pratt C, Myczek K, Song A, Forrest MP, Penzes P., Free PMC Article | 10/24/2020 |
| Kalirin reduction in APPswe/PSEN1dE9 mice significantly attenuated psychosis-associated behavior at 12 months of age without changing spatial memory performance. | Kalirin reduction rescues psychosis-associated behavioral deficits in APPswe/PSEN1dE9 transgenic mice.
Krivinko JM, Erickson SL, Abrahamson EE, Wills ZP, Ikonomovic MD, Penzes P, Sweet RA., Free PMC Article | 11/18/2017 |
| Kalirin-7 plays a prominent role in nociceptive sensitization via activity-dependent modulation of spinal synapses. | A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses.
Lu J, Luo C, Bali KK, Xie RG, Mains RE, Eipper BA, Kuner R., Free PMC Article | 01/16/2016 |
| lack of Kalrn expression in POMC cells closely mimicked the effects of global Kalrn knockout on anxiety-like behavior and passive avoidance conditioning | Elimination of Kalrn expression in POMC cells reduces anxiety-like behavior and contextual fear learning.
Mandela P, Yan Y, LaRese T, Eipper BA, Mains RE., Free PMC Article | 04/25/2015 |
| Kal7 may allow coordination of the many signaling pathways contributing to dendritic spine morphogenesis. | Nonenzymatic domains of Kalirin7 contribute to spine morphogenesis through interactions with phosphoinositides and Abl.
Ma XM, Miller MB, Vishwanatha KS, Gross MJ, Wang Y, Abbott T, Lam TT, Mains RE, Eipper BA., Free PMC Article | 02/7/2015 |
| Kalirin may play a role in paracrine and/or endocrine signaling events that control skeletal bone remodeling and the maintenance of bone mass. | The Rho-GEF Kalirin regulates bone mass and the function of osteoblasts and osteoclasts.
Huang S, Eleniste PP, Wayakanon K, Mandela P, Eipper BA, Mains RE, Allen MR, Bruzzaniti A., Free PMC Article | 10/25/2014 |
| Kalerin-7 knock-out mice exhibit increased self-administration of cocaine compared to wild-type mice. | Constitutive knockout of kalirin-7 leads to increased rates of cocaine self-administration.
Kiraly DD, Nemirovsky NE, LaRese TP, Tomek SE, Yahn SL, Olive MF, Eipper BA, Mains RE., Free PMC Article | 11/30/2013 |
| Many of the widespread and diverse deficits observed both within and outside of the nervous system when expression of Kalrn is eliminated may reflect its role in secretory granule function and its expression outside of the nervous system. | Kalrn plays key roles within and outside of the nervous system.
Mandela P, Yankova M, Conti LH, Ma XM, Grady J, Eipper BA, Mains RE., Free PMC Article | 06/8/2013 |
| Kalirin functions as a guanine nucleotide exchange factor for Rac1 in smooth muscle cells, promoting migration and proliferation. | Kalirin promotes neointimal hyperplasia by activating Rac in smooth muscle cells.
Wu JH, Fanaroff AC, Sharma KC, Smith LS, Brian L, Eipper BA, Mains RE, Freedman NJ, Zhang L., Free PMC Article | 05/4/2013 |
| Kalirin-7 is an selectively essential modulator of NMDA receptor-dependent synaptic plasticity in the hippocampus. | Kalirin-7 is necessary for normal NMDA receptor-dependent synaptic plasticity.
Lemtiri-Chlieh F, Zhao L, Kiraly DD, Eipper BA, Mains RE, Levine ES., Free PMC Article | 08/25/2012 |
| Identification of kalirin-7 as a potential post-synaptic density signaling hub | Identification of kalirin-7 as a potential post-synaptic density signaling hub.
Kiraly DD, Stone KL, Colangelo CM, Abbott T, Wang Y, Mains RE, Eipper BA., Free PMC Article | 10/29/2011 |
| This study demonstrated a novel and functionally important interaction between the NR2B subunit of the NMDA receptor and Kalirin, proteins known to be essential for normal synaptic plasticity. | Kalirin binds the NR2B subunit of the NMDA receptor, altering its synaptic localization and function.
Kiraly DD, Lemtiri-Chlieh F, Levine ES, Mains RE, Eipper BA., Free PMC Article | 10/22/2011 |
| These data suggest that hippocampal structure and function are more resilient to the complete loss of kalirin, and reveal impairments in fear learning. | Hippocampal phenotypes in kalirin-deficient mice.
Xie Z, Cahill ME, Radulovic J, Wang J, Campbell SL, Miller CA, Sweatt JD, Penzes P., Free PMC Article | 07/9/2011 |
| Thus cocaine-mediated changes in alternative splicing of the Kalrn gene may contribute importantly to the behavioral, morphological and biochemical responses observed. | Kalrn promoter usage and isoform expression respond to chronic cocaine exposure.
Mains RE, Kiraly DD, Eipper-Mains JE, Ma XM, Eipper BA., Free PMC Article | 06/25/2011 |
| Studies indicate that hippocampal CA1 pyramidal neurons of Kal7 knockout (Kal7KO) mice exhibit decreased frequency of spontaneous excitatory postsynaptic current (sEPSC). | Kalirin-7 is a key player in the formation of excitatory synapses in hippocampal neurons.
Ma XM., Free PMC Article | 11/27/2010 |
| These data demonstrate important roles for kalirin in the regulation of cortical structure, ultrastructure, and spine structural plasticity. | Kalirin loss results in cortical morphological alterations.
Xie Z, Cahill ME, Penzes P., Free PMC Article | 05/3/2010 |
| Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes. | Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes.
Cahill ME, Xie Z, Day M, Photowala H, Barbolina MV, Miller CA, Weiss C, Radulovic J, Sweatt JD, Disterhoft JF, Surmeier DJ, Penzes P., Free PMC Article | 01/21/2010 |