| Pde3a and Pde3b regulation of murine pulmonary artery smooth muscle cell growth and metabolism. | Pde3a and Pde3b regulation of murine pulmonary artery smooth muscle cell growth and metabolism.
Krause PN, McGeorge G, McPeek JL, Khalid S, Nelin LD, Liu Y, Chen B., Free PMC Article | 10/31/2024 |
| Nitration of protein kinase G-Ialpha modulates cyclic nucleotide crosstalk via phosphodiesterase 3A: Implications for acute lung injury. | Nitration of protein kinase G-Iα modulates cyclic nucleotide crosstalk via phosphodiesterase 3A: Implications for acute lung injury.
Zemskov EA, Wu X, Aggarwal S, Yegambaram M, Gross C, Lu Q, Wang H, Tang H, Wang T, Black SM., Free PMC Article | 08/28/2024 |
| Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure. | Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure.
Skogestad J, Albert I, Hougen K, Lothe GB, Lunde M, Eken OS, Veras I, Huynh NTT, Børstad M, Marshall S, Shen X, Louch WE, Robinson EL, Cleveland JC Jr, Ambardekar AV, Schwisow JA, Jonas E, Calejo AI, Morth JP, Taskén K, Melleby AO, Lunde PK, Sjaastad I, Carlson CR, Aronsen JM. | 08/11/2023 |
| High PDE3A expression is associated with adverse cardiac remodeling. | Phosphodiesterase type 3A (PDE3A), but not type 3B (PDE3B), contributes to the adverse cardiac remodeling induced by pressure overload.
Polidovitch N, Yang S, Sun H, Lakin R, Ahmad F, Gao X, Turnbull PC, Chiarello C, Perry CGR, Manganiello V, Yang P, Backx PH. | 07/4/2020 |
| Study demonstrated the presence of PDE3 protein and mRNA in human and murine airway tissues and concluded that PDE3A or PDE3B deficiency or pharmacological inhibition of PDE3 may alleviate the symptoms of allergic airway inflammation in a house dust mite-driven allergic airway inflammation mouse model. | A pathophysiological role of PDE3 in allergic airway inflammation.
Beute J, Lukkes M, Koekoek EP, Nastiti H, Ganesh K, de Bruijn MJ, Hockman S, van Nimwegen M, Braunstahl GJ, Boon L, Lambrecht BN, Manganiello VC, Hendriks RW, KleinJan A., Free PMC Article | 11/2/2019 |
| NO-GC modulates PDE3A expression. | Phosphodiesterase 3A expression and activity in the murine vasculature is influenced by NO-sensitive guanylyl cyclase.
Dünnes S, Voussen B, Aue A, Groneberg K, Nikolaev V, Groneberg D, Friebe A. | 04/6/2019 |
| Data show that phosphodiesterase 3A (PDE3A) was expressed throughout interstitial cells of Cajal (ICC) development and that ICC density was halved in PDE3A-deficient mice. | Phosphodiesterase 3A: a new player in development of interstitial cells of Cajal and a prospective target in gastrointestinal stromal tumors (GIST).
Vandenberghe P, Hagué P, Hockman SC, Manganiello VC, Demetter P, Erneux C, Vanderwinden JM., Free PMC Article | 04/14/2018 |
| PDE3A is a low-affinity and high-velocity enzyme for hydrolysis of cUMP in cardiac myocytes. | cUMP hydrolysis by PDE3A.
Berrisch S, Ostermeyer J, Kaever V, Kälble S, Hilfiker-Kleiner D, Seifert R, Schneider EH. | 02/25/2017 |
| These together indicate that PDE3A1 negatively regulates beta-AR signaling and protects against I/R injury by inhibiting cardiomyocyte apoptosis. | Cyclic nucleotide phosphodiesterase 3A1 protects the heart against ischemia-reperfusion injury.
Oikawa M, Wu M, Lim S, Knight WE, Miller CL, Cai Y, Lu Y, Blaxall BC, Takeishi Y, Abe J, Yan C., Free PMC Article | 06/14/2014 |
| PDE3A is the primary isozyme modulating basal myocardial contractility and sarcoplasmic reticulum divalent calcium ion (Ca2+) content. | Phosphodiesterase type 3A regulates basal myocardial contractility through interacting with sarcoplasmic reticulum calcium ATPase type 2a signaling complexes in mouse heart.
Beca S, Ahmad F, Shen W, Liu J, Makary S, Polidovitch N, Sun J, Hockman S, Chung YW, Movsesian M, Murphy E, Manganiello V, Backx PH., Free PMC Article | 03/9/2013 |
| Discussion of role of PDE3A, not PDE3B, in cell cycle progression in vascular smooth muscle and oocytes via regulation of cAMP levels. Is inhibition of PDE3A a possible target for treatment of cardiovascular diseases or female infertility? [REVIEW] | Role of PDE3A in regulation of cell cycle progression in mouse vascular smooth muscle cells and oocytes: implications in cardiovascular diseases and infertility.
Begum N, Shen W, Manganiello V., Free PMC Article | 04/28/2012 |
| PDE3A regulates VSMC growth via two complementary pathways | Phosphodiesterase 3A (PDE3A) deletion suppresses proliferation of cultured murine vascular smooth muscle cells (VSMCs) via inhibition of mitogen-activated protein kinase (MAPK) signaling and alterations in critical cell cycle regulatory proteins.
Begum N, Hockman S, Manganiello VC., Free PMC Article | 09/17/2011 |
| phosphodiesterase-III inhibitor prevents the hemorrhagic transformation induced by focal cerebral ischemia in mice treated with tPA | Phosphodiesterase-III inhibitor prevents hemorrhagic transformation induced by focal cerebral ischemia in mice treated with tPA.
Ishiguro M, Mishiro K, Fujiwara Y, Chen H, Izuta H, Tsuruma K, Shimazawa M, Yoshimura S, Satoh M, Iwama T, Hara H., Free PMC Article | 07/9/2011 |
| Gpr3 is epistatic to Pde3a and fertility as well as meiotic arrest in the PDE3A-deficient oocyte is dependent on the activity of GPR3. | Generation of mouse oocytes defective in cAMP synthesis and degradation: endogenous cyclic AMP is essential for meiotic arrest.
Vaccari S, Horner K, Mehlmann LM, Conti M., Free PMC Article | 01/21/2010 |
| Role of Pde3a in regulating platelet and cardiac function using subtype-selective knockout mice is reported. | Role of phosphodiesterase type 3A and 3B in regulating platelet and cardiac function using subtype-selective knockout mice.
Sun B, Li H, Shakur Y, Hensley J, Hockman S, Kambayashi J, Manganiello VC, Liu Y. | 01/21/2010 |
| Results provide evidence indicating that resumption of meiosis in vivo and in vitro requires cyclic nucleotide phosphodiesterase 3A activity. | Cyclic nucleotide phosphodiesterase 3A-deficient mice as a model of female infertility.
Masciarelli S, Horner K, Liu C, Park SH, Hinckley M, Hockman S, Nedachi T, Jin C, Conti M, Manganiello V., Free PMC Article | 01/21/2010 |
| These data indicate that activation of PDE3A by PKB/Akt-mediated phosphorylation plays a role in the control of PDE3A activity in mammalian oocytes. | Protein kinase B/Akt phosphorylation of PDE3A and its role in mammalian oocyte maturation.
Han SJ, Vaccari S, Nedachi T, Andersen CB, Kovacina KS, Roth RA, Conti M., Free PMC Article | 01/21/2010 |