| Suppression of RCAN1 alleviated lipid accumulation and mitochondrial fission in diabetic cardiomyopathy. | Suppression of RCAN1 alleviated lipid accumulation and mitochondrial fission in diabetic cardiomyopathy.
Shu S, Cui H, Liu Z, Zhang H, Yang Y, Chen X, Zeng Z, Du L, Fu M, Yang Z, Wang P, Wang C, Gao H, Yang Q, Lin X, Yang T, Chen Z, Wu S, Wang X, Zhao R, Hu S, Song J. | 09/19/2024 |
| Mice with double knockout of Egr-1 and RCAN1 exhibit reduced inflammation during Pseudomonas aeruginosa lung infection. | Mice with double knockout of Egr-1 and RCAN1 exhibit reduced inflammation during Pseudomonas aeruginosa lung infection.
Pang Z, Lin TJ. | 06/22/2023 |
| DSCR1 deficiency ameliorates the Abeta pathology of Alzheimer's disease by enhancing microglial activity. | DSCR1 deficiency ameliorates the Aβ pathology of Alzheimer's disease by enhancing microglial activity.
Choi C, Kim H, Oh J, Park C, Kim M, Kim CS, Park J., Free PMC Article | 01/7/2023 |
| Upregulation of RCAN1.4 by HIF1alpha alleviates OGD-induced inflammatory response in astrocytes. | Upregulation of RCAN1.4 by HIF1α alleviates OGD-induced inflammatory response in astrocytes.
Yang X, Yun Y, Wang P, Zhao J, Sun X., Free PMC Article | 08/27/2022 |
| RCAN1 knockout and overexpression recapitulate an ensemble of rest-activity and circadian disruptions characteristic of Down syndrome, Alzheimer's disease, and normative aging. | RCAN1 knockout and overexpression recapitulate an ensemble of rest-activity and circadian disruptions characteristic of Down syndrome, Alzheimer's disease, and normative aging.
Wong H, Buck JM, Borski C, Pafford JT, Keller BN, Milstead RA, Hanson JL, Stitzel JA, Hoeffer CA., Free PMC Article | 06/11/2022 |
| Down Syndrome Candidate Region 1 Isoform 1L regulated tumor growth by targeting both angiogenesis and tumor cells. | Down Syndrome Candidate Region 1 Isoform 1L regulated tumor growth by targeting both angiogenesis and tumor cells.
Chen C, Cui P, Zhao K, Niu G, Hou S, Zhao D, Zeng H., Free PMC Article | 03/12/2022 |
| DSCR1 upregulation enhances dural meningeal lymphatic drainage to attenuate amyloid pathology of Alzheimer's disease. | DSCR1 upregulation enhances dural meningeal lymphatic drainage to attenuate amyloid pathology of Alzheimer's disease.
Choi C, Park J, Kim H, Chang KT, Park J, Min KT. | 01/1/2022 |
| Combination effects of a fatty diet and exercise on the depressive state and cardioprotection in apolipoprotein E knockout mice with a change in RCAN1 expression. | Combination effects of a fatty diet and exercise on the depressive state and cardioprotection in apolipoprotein E knockout mice with a change in RCAN1 expression.
Shuo W, Li H, Muneko N, Yoshikazu N, Kato N, Kasamaki Y, Ueda T, Kanda T., Free PMC Article | 08/21/2021 |
| Loss of Down syndrome critical region-1 leads to cholesterol metabolic dysfunction that exaggerates hypercholesterolemia in ApoE-null background. | Loss of Down syndrome critical region-1 leads to cholesterol metabolic dysfunction that exaggerates hypercholesterolemia in ApoE-null background.
Muramatsu M, Osawa T, Miyamura Y, Nakagawa S, Tanaka T, Kodama T, Aburatani H, Sakai J, Ryeom S, Minami T., Free PMC Article | 08/21/2021 |
| Obesity-Induced Regulator of Calcineurin 1 Overexpression Leads to beta-Cell Failure Through Mitophagy Pathway Inhibition. | Obesity-Induced Regulator of Calcineurin 1 Overexpression Leads to β-Cell Failure Through Mitophagy Pathway Inhibition.
Li X, Chan LWC, Li X, Liu C, Yang G, Gao J, Dai M, Wang Y, Xie Z, Liu J, Zhou F, Zheng T, Feng D, Guo S, Li H, Sun K, Yang S. | 07/3/2021 |
| Down Syndrome Critical Region 1 Reduces Oxidative Stress-Induced Retinal Ganglion Cells Apoptosis via CREB-Bcl-2 Pathway. | Down Syndrome Critical Region 1 Reduces Oxidative Stress-Induced Retinal Ganglion Cells Apoptosis via CREB-Bcl-2 Pathway.
Shi Y, Ye D, Huang R, Xu Y, Lu P, Chen H, Huang J., Free PMC Article | 05/8/2021 |
| Regulators of calcineurin 1 deficiency attenuates tubulointerstitial fibrosis through improving mitochondrial fitness. | Regulators of calcineurin 1 deficiency attenuates tubulointerstitial fibrosis through improving mitochondrial fitness.
Sang XY, Xiao JJ, Liu Q, Zhu R, Dai JJ, Zhang C, Yu H, Yang SJ, Zhang BF. | 05/1/2021 |
| Loss of Down Syndrome Critical Region-1 Mediated-Hypercholesterolemia Accelerates Corneal Opacity Via Pathological Neovessel Formation. | Loss of Down Syndrome Critical Region-1 Mediated-Hypercholesterolemia Accelerates Corneal Opacity Via Pathological Neovessel Formation.
Muramatsu M, Nakagawa S, Osawa T, Toyono T, Uemura A, Kidoya H, Takakura N, Usui T, Ryeom S, Minami T., Free PMC Article | 11/28/2020 |
| Methylation of RCAN1.4 mediated by DNMT1 and DNMT3b enhances hepatic stellate cell activation and liver fibrogenesis through Calcineurin/NFAT3 signaling. | Methylation of RCAN1.4 mediated by DNMT1 and DNMT3b enhances hepatic stellate cell activation and liver fibrogenesis through Calcineurin/NFAT3 signaling.
Pan XY, You HM, Wang L, Bi YH, Yang Y, Meng HW, Meng XM, Ma TT, Huang C, Li J., Free PMC Article | 08/15/2020 |
| Findings suggest a new translational regulatory mechanism for DSCR1.4 expressions and a novel function of DAP5 as a positive regulator of DSCR1.4 mRNA translation induced in soma and axon of hippocampal neurons. | DAP5 increases axonal outgrowth of hippocampal neurons by enhancing the cap-independent translation of DSCR1.4 mRNA.
Seo JY, Jung Y, Kim DY, Ryu HG, Lee J, Kim SW, Kim KT., Free PMC Article | 04/4/2020 |
| RCAN1 up-regulation enhanced mitochondrial fusion and conferred protection from myocardial reperfusion injury. | Down Syndrome Critical Region 1 Gene, Rcan1, Helps Maintain a More Fused Mitochondrial Network.
Parra V, Altamirano F, Hernández-Fuentes CP, Tong D, Kyrychenko V, Rotter D, Pedrozo Z, Hill JA, Eisner V, Lavandero S, Schneider JW, Rothermel BA., Free PMC Article | 08/17/2019 |
| Regulator of Calcineurin 1 (RCAN1), a feedback inhibitor of the calcium-activated protein phosphatase calcineurin (CN), acts to suppress two distinctly different mechanisms of non-shivering thermogenesis. | Regulator of Calcineurin 1 helps coordinate whole-body metabolism and thermogenesis.
Rotter D, Peiris H, Grinsfelder DB, Martin AM, Burchfield J, Parra V, Hull C, Morales CR, Jessup CF, Matusica D, Parks BW, Lusis AJ, Nguyen NUN, Oh M, Iyoke I, Jakkampudi T, McMillan DR, Sadek HA, Watt MJ, Gupta RK, Pritchard MA, Keating DJ, Rothermel BA., Free PMC Article | 07/20/2019 |
| Study found that RCAN1 RNA expression was suppressed in glomeruli in human diabetic nephropathy, IgA nephropathy, and lupus nephritis, and in mouse models of HIV-associated nephropathy and diabetic nephropathy. Findings suggest that epigenetic suppression of RCAN1 aggravates podocyte injury in the setting of HIV infection and diabetic nephropathy. | Epigenetic regulation of RCAN1 expression in kidney disease and its role in podocyte injury.
Li H, Zhang W, Zhong F, Das GC, Xie Y, Li Z, Cai W, Jiang G, Choi J, Sidani M, Hyink DP, Lee K, Klotman PE, He JC. | 07/6/2019 |
| Our results suggest that Rcan1 might act as endogenous negative modulator of COX-2 expression and activity by inhibiting calcineurin and NF-kB pathways to maintain normal contractility and vascular stiffness in aorta and small mesenteric arteries, respectively. | Regulator of calcineurin 1 modulates vascular contractility and stiffness through the upregulation of COX-2-derived prostanoids.
García-Redondo AB, Esteban V, Briones AM, Díaz Del Campo LS, González-Amor M, Méndez-Barbero N, Campanero MR, Redondo JM, Salaices M. | 03/2/2019 |
| This study demonstrated that Rcan1 is regulated by oxidative stress and identified RCAN1 as a potential diagnostic marker of acute pancreatitis. | RCAN1 is a marker of oxidative stress, induced in acute pancreatitis.
Norberg KJ, Nania S, Li X, Gao H, Szatmary P, Segersvärd R, Haas S, Wagman A, Arnelo U, Sutton R, Heuchel RL, Löhr JM. | 01/12/2019 |
| Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture. | Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture.
Villahoz S, Yunes-Leites PS, Méndez-Barbero N, Urso K, Bonzon-Kulichenko E, Ortega S, Nistal JF, Vazquez J, Offermanns S, Redondo JM, Campanero MR., Free PMC Article | 12/22/2018 |
| These findings demonstrate a novel regulatory role of RCAN1 in TLR signaling, which differentially regulates MyD88 and TRIF pathways. | Regulator of calcineurin 1 differentially regulates TLR-dependent MyD88 and TRIF signaling pathways.
Pang Z, Junkins RD, Raudonis R, MacNeil AJ, McCormick C, Cheng Z, Lin TJ., Free PMC Article | 12/1/2018 |
| The expression of DSCR1-4 increased strongly at P16 after OIR. There was no change in messenger RNA (mRNA) expression of DSCR1-1 at P16 after oxygen-induced retinopathy. The increased DSCR1 was mainly located in the RGCs of avascular retina. In addition, DSCR1-4 expression was increased in primary RGCs after hypoxia exposure. | Secretion of Down Syndrome Critical Region 1 Isoform 4 in Ischemic Retinal Ganglion Cells Displays Anti-Angiogenic Properties Via NFATc1-Dependent Pathway.
Xu Y, Yang B, Hu Y, Lu L, Lu X, Wang J, Shu Q, Cheng Q, Yu S, Xu F, Huang J, Liang X. | 07/14/2018 |
| RCANs play critical roles in bone homeostasis by regulating both osteoclastogenesis and osteoblastogenesis, and they serve as inhibitors for calcineurin-NFATc1 signaling both in vivo and in vitro. | RCANs regulate the convergent roles of NFATc1 in bone homeostasis.
Kim JH, Kim K, Kim I, Seong S, Jeong BC, Nam KI, Kim KK, Molkentin JD, Kim N., Free PMC Article | 06/9/2018 |
| The present study demonstrates that RCAN1 deficiency protects against Salmonella intestinal infection by enhancing proinflammatory JNK signaling. | RCAN1 deficiency protects against Salmonella intestinal infection by modulating JNK activation.
Lei QQ, Hu GQ, Chen W, Yu SX, Qi S, Du CT, Gu JM, Lin TJ, Yang YJ. | 08/26/2017 |