| Gingival crevicular fluid periodontal ligament-associated protein-1, sclerostin, and tumor necrosis factor-alpha levels in periodontitis. | Gingival crevicular fluid periodontal ligament-associated protein-1, sclerostin, and tumor necrosis factor-alpha levels in periodontitis.
Gür B, Afacan B, Çevik Ö, Köse T, Emingil G. | 11/22/2023 |
| MicroRNA-631 Resensitizes Doxorubicin-Resistant Chondrosarcoma Cells by Targeting Apelin. | MicroRNA-631 Resensitizes Doxorubicin-Resistant Chondrosarcoma Cells by Targeting Apelin.
Chen JC, Shih HC, Lin CY, Guo JH, Huang C, Huang HC, Chong ZY, Tang CH., Free PMC Article | 02/11/2023 |
| Asporin Promotes TGF-beta-induced Lung Myofibroblast Differentiation by Facilitating Rab11-Dependent Recycling of TbetaRI. | Asporin Promotes TGF-β-induced Lung Myofibroblast Differentiation by Facilitating Rab11-Dependent Recycling of TβRI.
Huang S, Lai X, Yang L, Ye F, Huang C, Qiu Y, Lin S, Pu L, Wang Z, Huang W. | 02/19/2022 |
| Frequency of Growth Differentiation Factor 5 rs143383 and asporin D-repeat polymorphisms in patients with hand and knee osteoarthritis in Kurdistan province, Iran. | Frequency of Growth Differentiation Factor 5 rs143383 and asporin D-repeat polymorphisms in patients with hand and knee osteoarthritis in Kurdistan province, Iran.
Moghimi N, Nasseri S, Ghafouri F, Jalili A. | 12/4/2021 |
| Cancer-related gene mutations of ASPN in colon cancers. | Cancer-related gene mutations of ASPN in colon cancers.
Son HJ, Choi EJ, Yoo NJ, Lee SH. | 09/18/2021 |
| LncRNA DCST1-AS1 inhibits PDLCs' proliferation in periodontitis and may bind with miR-21 precursor to upregulate PLAP-1. | LncRNA DCST1-AS1 inhibits PDLCs' proliferation in periodontitis and may bind with miR-21 precursor to upregulate PLAP-1.
Wang X, Wang Y. | 03/20/2021 |
| Expression of asporin reprograms cancer cells to acquire resistance to oxidative stress. | Expression of asporin reprograms cancer cells to acquire resistance to oxidative stress.
Sasaki Y, Takagane K, Konno T, Itoh G, Kuriyama S, Yanagihara K, Yashiro M, Yamada S, Murakami S, Tanaka M., Free PMC Article | 03/20/2021 |
| Asporin is a Potential Promising Biomarker for Common Heart Failure. | Asporin is a Potential Promising Biomarker for Common Heart Failure.
Zhang K, Wu M, Qin X, Wen P, Wu Y, Zhuang J. | 02/27/2021 |
| Data establish a role for ASPN as a critical MSC factor that extensively affects the tumor microenvironment and induces metastatic progression. | Asporin Restricts Mesenchymal Stromal Cell Differentiation, Alters the Tumor Microenvironment, and Drives Metastatic Progression.
Hughes RM, Simons BW, Khan H, Miller R, Kugler V, Torquato S, Theodros D, Haffner MC, Lotan T, Huang J, Davicioni E, An SS, Riddle RC, Thorek DLJ, Garraway IP, Fertig EJ, Isaacs JT, Brennen WN, Park BH, Hurley PJ., Free PMC Article | 04/11/2020 |
| The allelic alteration on ASPN and COMP genes is linked to a role in the development of knee osteoarthritis. | Identifying the role of ASPN and COMP genes in knee osteoarthritis development.
Mishra A, Awasthi S, Raj S, Mishra P, Srivastava RN., Free PMC Article | 04/4/2020 |
| Asporin (ASPN) interacts with proteasome 26S subunit non-ATPase 2 (PSMD2) and promotes the proliferation of gastric cancer (GC) cells. | Asporin promotes cell proliferation via interacting with PSMD2 in gastric cancer.
Zhang Z, Li H, Zhao Y, Guo Q, Yu Y, Zhu S, Zhang S, Min L, Li P. | 01/4/2020 |
| our study provides evidence that asporin is an important risk factor in intervertebral disc degeneration. The identification of the intrinsic expression mechanisms of asporin provides further understanding of disc degeneration. | IL-1β increases asporin expression via the NF-κB p65 pathway in nucleus pulposus cells during intervertebral disc degeneration.
Wang S, Liu C, Sun Z, Yan P, Liang H, Huang K, Li C, Tian J., Free PMC Article | 01/5/2019 |
| D-repeat of ASPN gene is mainly associated with male patients. The D13 polymorphism plays a protective role for osteoarthritis in Caucasians male individuals while D14 plays a risk factor for knee osteoarthritis in male patients. | Association between the aspartic acid D-repeat polymorphisms and osteoarthritis susceptibility: An updated systematic review and meta-analyses.
Wang H, Zhang X, Wu W, Zhang M, Sam NB, Niu L., Free PMC Article | 11/24/2018 |
| Suggest that the D14 allele of the ASPN polymorphism could exert an influence on primary osteoarthritis of the knee etiology in a Mexican Mestizo population. | D14 repeat polymorphism of the asporin gene is associated with primary osteoarthritis of the knee in a Mexican Mestizo population.
González-Huerta NC, Borgonio-Cuadra VM, Zenteno JC, Cortés-González S, Duarte-Salazar C, Miranda-Duarte A. | 08/11/2018 |
| ASPN D-repeat polymorphism is not associated with an increased Knee Osteoarthritis risk. | Association between aspartic acid repeat polymorphism of the asporin gene and risk of knee osteoarthritis: A systematic review and meta-analysis.
Sobhan MR, Mehdinejad M, Jamaladini MH, Mazaheri M, Zare-Shehneh M, Neamatzadeh H., Free PMC Article | 06/16/2018 |
| Meta-analysis result based on previously published studies demonstrated that the ASPN D13 allele was a protective factor for OA of knee, hip, and hand. For D14 and D15 allele, meta-analysis did not demonstrate statistically significant association. | Association of aspartic acid repeat polymorphism in the asporin gene with osteoarthritis of knee, hip, and hand: A PRISMA-compliant meta-analysis.
Zhu X, Jiang L, Lu Y, Wang C, Zhou S, Wang H, Tian T., Free PMC Article | 05/5/2018 |
| higher expression of asporin was noticed in CRC tissues and it was correlated with later clinical stage of the patients. Asporin promoted the migration and invasion of the tumor cells partially through an EGFR/Src/cortactin- signaling pathway. | Asporin enhances colorectal cancer metastasis through activating the EGFR/src/cortactin signaling pathway.
Wu H, Jing X, Cheng X, He Y, Hu L, Wu H, Ye F, Zhao R., Free PMC Article | 03/10/2018 |
| ASPN D15 is associated with increased risk of symmetrical hand osteoarthritis particularly in individuals with low variation in work tasks. | Functional polymorphisms in asporin and CILP together with joint loading predispose to hand osteoarthritis.
Taipale M, Solovieva S, Leino-Arjas P, Männikkö M., Free PMC Article | 01/20/2018 |
| we found that asporin can be downregulated by bone morphogenetic protein 4 in Hs578T cells and its upregulation may be facilited by serum-free cultivation or by three dimensional growth | The dual role of asporin in breast cancer progression.
Simkova D, Kharaishvili G, Korinkova G, Ozdian T, Suchánková-Kleplová T, Soukup T, Krupka M, Galandakova A, Dzubak P, Janikova M, Navratil J, Kahounova Z, Soucek K, Bouchal J., Free PMC Article | 01/13/2018 |
| Asporin promotes epithelial mesenchymal transformation, invasion, and migration of pancreatic cancer cellss by activating CD44-AKT/ERK-NF-kappaB pathway in paracrine and autocrine manner. | Asporin promotes pancreatic cancer cell invasion and migration by regulating the epithelial-to-mesenchymal transition (EMT) through both autocrine and paracrine mechanisms.
Wang L, Wu H, Wang L, Zhang H, Lu J, Liang Z, Liu T. | 08/26/2017 |
| High ASPN expression in stroma is associated with prostate cancer progression. | Asporin is a stromally expressed marker associated with prostate cancer progression.
Rochette A, Boufaied N, Scarlata E, Hamel L, Brimo F, Whitaker HC, Ramos-Montoya A, Neal DE, Dragomir A, Aprikian A, Chevalier S, Thomson AA., Free PMC Article | 05/27/2017 |
| To test the associations of ASPN variations with risk of subsequent oncologic outcomes. | Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer.
Hurley PJ, Sundi D, Shinder B, Simons BW, Hughes RM, Miller RM, Benzon B, Faraj SF, Netto GJ, Vergara IA, Erho N, Davicioni E, Karnes RJ, Yan G, Ewing C, Isaacs SD, Berman DM, Rider JR, Jordahl KM, Mucci LA, Huang J, An SS, Park BH, Isaacs WB, Marchionni L, Ross AE, Schaeffer EM., Free PMC Article | 10/22/2016 |
| Collectively, our findings indicate that ASPN is upregulated and plays an oncogenic role in gastric cancer progression and metastasis by influencing the EGFR signaling pathway. | Asporin participates in gastric cancer cell growth and migration by influencing EGF receptor signaling.
Ding Q, Zhang M, Liu C. | 02/6/2016 |
| Our results showed that ASPN rs13301537 T to C change and variant C genotype may contribute to knee OA risk in a Chinese Han population. | Association between single nucleotide polymorphisms of asporin (ASPN) and BMP5 with the risk of knee osteoarthritis in a Chinese Han population.
Liang W, Gao B, Xu G, Weng D, Xie M, Qian Y. | 07/25/2015 |
| this is the first case-control study in Mexican women that suggests that menopause and the D-repeat polymorphism in the ASPN gene are associated with knee OA | [D-repeat polymorphism in the ASPN gene in knee osteoarthritis in females in Torreón, Coahuila. Case-control study].
Arellano-Pérez-Vertti RD, Argüello-Astorga JR, Cortéz-López ME, Zamarripa-Mottú JI, García-Salcedo JJ, Luna-Ceniceros DA. | 06/27/2015 |