| Histones Methyltransferase NSD3 Inhibits Lung Adenocarcinoma Glycolysis Through Interacting with PPP1CB to Decrease STAT3 Signaling Pathway. | Histones Methyltransferase NSD3 Inhibits Lung Adenocarcinoma Glycolysis Through Interacting with PPP1CB to Decrease STAT3 Signaling Pathway.
Zhou Y, Peng X, Fang C, Peng X, Tang J, Wang Z, Long Y, Chen J, Peng Y, Zhang Z, Zhou Y, Tang J, Liao J, Xiao D, Tao Y, Shi Y, Liu S., Free PMC Article | 10/17/2024 |
| The role of NSD1, NSD2, and NSD3 histone methyltransferases in solid tumors. | The role of NSD1, NSD2, and NSD3 histone methyltransferases in solid tumors.
Topchu I, Pangeni RP, Bychkov I, Miller SA, Izumchenko E, Yu J, Golemis E, Karanicolas J, Boumber Y., Free PMC Article | 05/14/2022 |
| Targeting H3K36 methyltransferases NSDs: a promising strategy for tumor targeted therapy. | Targeting H3K36 methyltransferases NSDs: a promising strategy for tumor targeted therapy.
Peng X, Peng Q, Zhong L., Free PMC Article | 03/12/2022 |
| Elevated expression of nuclear receptor-binding SET domain 3 promotes pancreatic cancer cell growth. | Elevated expression of nuclear receptor-binding SET domain 3 promotes pancreatic cancer cell growth.
Sun Y, Xie J, Cai S, Wang Q, Feng Z, Li Y, Lu JJ, Chen W, Ye Z., Free PMC Article | 02/5/2022 |
| A common binding motif in the ET domain of BRD3 forms polymorphic structural interfaces with host and viral proteins. | A common binding motif in the ET domain of BRD3 forms polymorphic structural interfaces with host and viral proteins.
Aiyer S, Swapna GVT, Ma LC, Liu G, Hao J, Chalmers G, Jacobs BC, Montelione GT, Roth MJ., Free PMC Article | 01/15/2022 |
| Histone and DNA binding ability studies of the NSD subfamily of PWWP domains. | Histone and DNA binding ability studies of the NSD subfamily of PWWP domains.
Zhang M, Yang Y, Zhou M, Dong A, Yan X, Loppnau P, Min J, Liu Y. | 11/27/2021 |
| NSD3S stabilizes MYC through hindering its interaction with FBXW7. | NSD3S stabilizes MYC through hindering its interaction with FBXW7.
Gonzalez-Pecchi V, Kwan AK, Doyle S, Ivanov AA, Du Y, Fu H., Free PMC Article | 08/14/2021 |
| NSD3-Induced Methylation of H3K36 Activates NOTCH Signaling to Drive Breast Tumor Initiation and Metastatic Progression. | NSD3-Induced Methylation of H3K36 Activates NOTCH Signaling to Drive Breast Tumor Initiation and Metastatic Progression.
Jeong GY, Park MK, Choi HJ, An HW, Park YU, Choi HJ, Park J, Kim HY, Son T, Lee H, Min KW, Oh YH, Lee JY, Kong G. | 05/8/2021 |
| Elevated NSD3 histone methylation activity drives squamous cell lung cancer. | Elevated NSD3 histone methylation activity drives squamous cell lung cancer.
Yuan G, Flores NM, Hausmann S, Lofgren SM, Kharchenko V, Angulo-Ibanez M, Sengupta D, Lu X, Czaban I, Azhibek D, Vicent S, Fischle W, Jaremko M, Fang B, Wistuba II, Chua KF, Roth JA, Minna JD, Shao NY, Jaremko Ł, Mazur PK, Gozani O., Free PMC Article | 03/20/2021 |
| Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases. | Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases.
Li W, Tian W, Yuan G, Deng P, Sengupta D, Cheng Z, Cao Y, Ren J, Qin Y, Zhou Y, Jia Y, Gozani O, Patel DJ, Wang Z., Free PMC Article | 03/20/2021 |
| The observation that certain metabolic pathways are differentially regulated by NSD3s and Pdp3 suggests that, despite the structural similarity between their PWWP domains, the two proteins act by unique mechanisms and may recruit different downstream signaling complexes. | (1) H NMR metabolomics reveals increased glutaminolysis upon overexpression of NSD3s or Pdp3 in Saccharomyces cerevisiae.
Rona GB, Almeida NP, Santos GC Jr, Fidalgo TK, Almeida FC, Eleutherio EC, Pinheiro AS. | 07/18/2020 |
| Studies showed that depletion of NSD3 in osteosarcoma cell lines inhibited cell proliferation and survival, and induced cell apoptosis. RNA sequence analysis of tumor cell lines with NSD3 deletion revealed that NSD3 functions as either a transcriptional activator or a repressor. These results suggest that NSD3 may function as an oncogenic driver in osteosarcoma. | Silencing of histone methyltransferase NSD3 reduces cell viability in osteosarcoma with induction of apoptosis.
Liu Z, Piao L, Zhuang M, Qiu X, Xu X, Zhang D, Liu M, Ren D., Free PMC Article | 06/9/2018 |
| Results extend the in vitro results and show that targeted expression of NSD3 to the mammary gland of FVB mice is oncogenic, consistent with the hypothesis that NSD3 is an important driver oncogene in human breast cancer. | Development of mammary hyperplasia, dysplasia, and invasive ductal carcinoma in transgenic mice expressing the 8p11 amplicon oncogene NSD3.
Turner-Ivey B, Smith EL, Rutkovsky AC, Spruill LS, Mills JN, Ethier SP., Free PMC Article | 03/24/2018 |
| WHSC1L1 and H3K36me2 are enriched in the gene bodies of the cell cycle-related genes CDC6 and CDK2, implying that WHSC1L1 directly regulates the transcription of these gene | WHSC1L1 drives cell cycle progression through transcriptional regulation of CDC6 and CDK2 in squamous cell carcinoma of the head and neck.
Saloura V, Vougiouklakis T, Zewde M, Kiyotani K, Park JH, Gao G, Karrison T, Lingen M, Nakamura Y, Hamamoto R., Free PMC Article | 01/20/2018 |
| This study demonstrates that over-expression of WHSC1L1 is linked to over-expression of ER-alpha in SUM-44 breast cancer cells and in primary human breast cancers. | Amplification of WHSC1L1 regulates expression and estrogen-independent activation of ERα in SUM-44 breast cancer cells and is associated with ERα over-expression in breast cancer.
Irish JC, Mills JN, Turner-Ivey B, Wilson RC, Guest ST, Rutkovsky A, Dombkowski A, Kappler CS, Hardiman G, Ethier SP., Free PMC Article | 11/4/2017 |
| Studies indicate that the NSD methyltransferases NSD1, NSD2/WHSC1/MMSET and NSD3/WHSC1L1 were overexpressed, amplified or somatically mutated in multiple types of cancer, suggesting their critical role in cancer. | The NSD family of protein methyltransferases in human cancer.
Vougiouklakis T, Hamamoto R, Nakamura Y, Saloura V. | 08/13/2016 |
| Results demonstrate that the AML maintenance function of BRD4 requires its interaction with the short isoform of NSD3 lacking the methyltransferase domain. This protein is an adaptor that sustains leukemia by linking BRD4 to the CHD8 chromatin remodeler. | NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler.
Shen C, Ipsaro JJ, Shi J, Milazzo JP, Wang E, Roe JS, Suzuki Y, Pappin DJ, Joshua-Tor L, Vakoc CR., Free PMC Article | 04/30/2016 |
| The results describe the binding of NSD1, 2 and 3 catalytic domains (CD) on histone tails through recognition of histone-lysine and methylation properties. | In vitro histone lysine methylation by NSD1, NSD2/MMSET/WHSC1 and NSD3/WHSC1L.
Morishita M, Mevius D, di Luccio E., Free PMC Article | 10/17/2015 |
| The involvement of the NSD3 methyltransferase as a component of the NUT fusion protein oncogenic complex identifies a new potential therapeutic target. | NSD3-NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism.
French CA, Rahman S, Walsh EM, Kühnle S, Grayson AR, Lemieux ME, Grunfeld N, Rubin BP, Antonescu CR, Zhang S, Venkatramani R, Dal Cin P, Howley PM., Free PMC Article | 04/4/2015 |
| PPAPDC1B and WHSC1L1 played a major role in regulating the survival of breast cancer, pancreatic adenocarcinoma and small-cell lung cancer-derived cell lines. | PPAPDC1B and WHSC1L1 are common drivers of the 8p11-12 amplicon, not only in breast tumors but also in pancreatic adenocarcinomas and lung tumors.
Mahmood SF, Gruel N, Nicolle R, Chapeaublanc E, Delattre O, Radvanyi F, Bernard-Pierrot I. | 06/14/2014 |
| Data indicate that siRNA attenuated the expression levels of CCNG1 and NEK7, implying that WHSC1L1 appears to activate the expression of CCNG1 and NEK7 in cancer cells. | The histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesis.
Kang D, Cho HS, Toyokawa G, Kogure M, Yamane Y, Iwai Y, Hayami S, Tsunoda T, Field HI, Matsuda K, Neal DE, Ponder BA, Maehara Y, Nakamura Y, Hamamoto R. | 05/25/2013 |
| methyltransferase NSD3 has chromatin-binding motifs, PHD5-C5HCH, that are distinct from other NSD (nuclear receptor SET domain) family members in their histone H3 recognition | The methyltransferase NSD3 has chromatin-binding motifs, PHD5-C5HCH, that are distinct from other NSD (nuclear receptor SET domain) family members in their histone H3 recognition.
He C, Li F, Zhang J, Wu J, Shi Y., Free PMC Article | 05/4/2013 |
| Functional studies with Brd4 indicate that the ET domain mediates pTEFb-independent transcriptional activation through a subset of these associated factors, including NSD3. | The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.
Rahman S, Sowa ME, Ottinger M, Smith JA, Shi Y, Harper JW, Howley PM., Free PMC Article | 08/27/2011 |
| Overexpression of WHSC1L1 gene is associated with breast cancer. | Transforming properties of 8p11-12 amplified genes in human breast cancer.
Yang ZQ, Liu G, Bollig-Fischer A, Giroux CN, Ethier SP., Free PMC Article | 01/1/2011 |
| NSD3L depletion increased the invasiveness of MDA-MB-231 breast cancer cells indicating that NSD3L normally restrain cellular metastatic potential. Together the presented data indicates that NSD3L is a candidate tumor suppressor. | The NSD3L histone methyltransferase regulates cell cycle and cell invasion in breast cancer cells.
Zhou Z, Thomsen R, Kahns S, Nielsen AL. | 09/13/2010 |