| PinX1-Promoted Autophagy Inhibits Cell Proliferation and Induces Cell Apoptosis by Inhibiting the NF-kappaB/p65 Signaling Pathway in Nasopharyngeal Carcinoma. | PinX1-Promoted Autophagy Inhibits Cell Proliferation and Induces Cell Apoptosis by Inhibiting the NF-κB/p65 Signaling Pathway in Nasopharyngeal Carcinoma.
Yang M, Chen F, Yu C, Cai Z, Zhong Q, Feng J, Li G, Shen C, Wen Z. | 09/13/2023 |
| Association of the PINX1 Variant rs6984094, Which Lengthens Telomeres, with Systemic Lupus Erythematosus Susceptibility in Chinese Populations. | Association of the PINX1 Variant rs6984094, Which Lengthens Telomeres, with Systemic Lupus Erythematosus Susceptibility in Chinese Populations.
Qi YY, Liu XR, He YX, Zhou M, Ning XH, Zhai YL, Zhang XX, Wang XY, Zhao YF, Cui Y, Zhao ZZ., Free PMC Article | 01/8/2022 |
| Oncogenic role of PinX1 in prostate cancer cells through androgen receptor dependent and independent mechanisms. | Oncogenic role of PinX1 in prostate cancer cells through androgen receptor dependent and independent mechanisms.
Flores-Ramírez I, Rivas-Torres MÁ, Rodríguez-Dorantes M, Gutiérrez-Sagal R, Baranda-Avila N, Langley E. | 08/28/2021 |
| PinX1 represses renal cancer angiogenesis through mir-125a-3p/VEGF signal pathway. The miR-125a-3p may be a candidate clinical prognostic marker and a novel therapeutic target in RCC. | PinX1 represses renal cancer angiogenesis via the mir-125a-3p/VEGF signaling pathway.
Hou P, Li H, Yong H, Chen F, Chu S, Zheng J, Bai J. | 07/4/2020 |
| Epstein-Barr virus led to reduced PINX1 expression through LMP1-NF-kappaB-PINX1 axis, which up-regulated telomerase activity in nasopharyngeal carcinoma. | Insufficient PINX1 expression stimulates telomerase activation by direct inhibition of EBV LMP1-NF-κB axis during nasopharyngeal carcinoma development.
Liu Y, Gong P, Zhou N, Zhang J, He C, Wang S, Peng H. | 06/27/2020 |
| PINX1 expression was associated with several clinicopathological factors and had a significant influence on recurrence in patients with papillary thyroid carcinoma. | The clinical significance of PINX1 expression in papillary thyroid carcinoma.
Kang J, Han K, Kim HJ, Park JH, Kong JS, Park S, Myung JK. | 10/26/2019 |
| This process would be an applicable way for obtaining recombinant hPinX1 using P. pastoris expression system. This is the first report on recombinant production of hPinX1 in P. pastoris | Efficient expression of recombinant human telomerase inhibitor 1 (hPinX1) in Pichia pastoris.
Unver Y, Yildiz M, Kilic D, Taskin M, Firat A, Askin H. | 01/26/2019 |
| PinX1 silencing in CD133+ CSCs significantly decreased TRF1, Mad1, and p53 mRNA levels, while it increased hTERT and c-Myc mRNA levels. | The Pinx1 Gene Downregulates Telomerase and Inhibits Proliferation of CD133+ Cancer Stem Cells Isolated from a Nasopharyngeal Carcinoma Cell Line by Regulating Trfs and Mad1/C-Myc/p53 Pathways.
Shen C, Chen F, Wang H, Li G, Yu C, Wang X, Wen Z. | 09/22/2018 |
| NF-kappaB p65 potentiated tumor growth via suppressing a novel target LPTS | NF-κB potentiates tumor growth by suppressing a novel target LPTS.
Liu D, Miao H, Zhao Y, Kang X, Shang S, Xiang W, Shi R, Hou A, Wang R, Zhao K, Liu Y, Ma Y, Luo H, Miao H, He F., Free PMC Article | 06/23/2018 |
| Our findings suggested that PinX1 could be a potential tumour suppressor in non-small-cell lung cancer and that loss of PinX1 promoted non-small-cell lung cancer progression. | PinX1 Is a Potential Prognostic Factor for Non-Small-Cell Lung Cancer and Inhibits Cell Proliferation and Migration.
Wang S, Zhang H, Zhu J, Li C, Zhu J, Shi B, Zhang B, Wang C., Free PMC Article | 04/28/2018 |
| Low expression of PinX1 is associated with malignant behavior in basal-like breast cancer. | Low expression of PinX1 is associated with malignant behavior in basal-like breast cancer.
Feng YZ, Zhang QY, Fu MT, Zhang ZF, Wei M, Zhou JY, Shi R., Free PMC Article | 04/7/2018 |
| The cost-effective expression of PinX1 could constitute a novel molecular predictor/marker for NSCLC management. | The depletion of PinX1 involved in the tumorigenesis of non-small cell lung cancer promotes cell proliferation via p15/cyclin D1 pathway.
Tian XP, Jin XH, Li M, Huang WJ, Xie D, Zhang JX., Free PMC Article | 07/29/2017 |
| PINX1 Polymorphisms are associated with Hepatocellular Carcinoma in Thai Patients with Chronic Hepatitis B Virus Infection. | Association of PINX1 but not TEP1 Polymorphisms with Progression to Hepatocellular Carcinoma in Thai Patients with Chronic Hepatitis B Virus Infection.
Sriprapun M, Chuaypen N, Khlaiphuengsin A, Pinjaroen N, Payungporn S, Tangkijvanich P. | 02/4/2017 |
| The stability of PinX1 is maintained in nucleolus in the presence of TERT. | Increased Stability of Nucleolar PinX1 in the Presence of TERT.
Keo P, Choi JS, Bae J, Shim YH, Oh BK., Free PMC Article | 07/30/2016 |
| PinX1 negatively regulated ccRCC metastasis and the expression of MMP-2 and NF-kappaB-p65 | PinX1 serves as a potential prognostic indicator for clear cell renal cell carcinoma and inhibits its invasion and metastasis by suppressing MMP-2 via NF-κB-dependent transcription.
Li HL, Han L, Chen HR, Meng F, Liu QH, Pan ZQ, Bai J, Zheng JN., Free PMC Article | 06/11/2016 |
| High PinX1 expression significantly correlated with a worse 5-year overall and disease-specific survival in gliomas. | PinX1 is up-regulated and associated with poor patients' survival in gliomas.
Bai J, Chen YS, Mei PJ, Liu QH, Du Y, Zheng JN., Free PMC Article | 06/4/2016 |
| Data show a novel molecular mechanism for PINX1 as an attenuator of estrogen receptor activity in breast cancer cell lines, furthering its role as a tumor suppressor gene in breast cancer. | Novel role for PINX1 as a coregulator of nuclear hormone receptors.
Noriega-Reyes MY, Rivas-Torres MA, Oñate-Ocaña LF, Vallés AJ, Baranda-Avila N, Langley E. | 06/4/2016 |
| PinX1 protein expression is decreased in colorectal cancer patients and predicts a poor prognosis. | Decreased expression of PinX1 protein predicts poor prognosis of colorectal cancer patients receiving 5-FU adjuvant chemotherapy.
Deng W, Jiao N, Li N, Wan X, Luo S, Zhang Y. | 05/7/2016 |
| PinX1 inhibits cell proliferation, migration and invasion in glioma cells. | PinX1 inhibits cell proliferation, migration and invasion in glioma cells.
Mei PJ, Chen YS, Du Y, Bai J, Zheng JN. | 03/19/2016 |
| PinX1 expression was an independent negative prognostic factor for breast cancer patients. | PinX1 inhibits the invasion and metastasis of human breast cancer via suppressing NF-κB/MMP-9 signaling pathway.
Shi M, Cao M, Song J, Liu Q, Li H, Meng F, Pan Z, Bai J, Zheng J., Free PMC Article | 01/16/2016 |
| Two novel markers, rs7840785 (PINX1) and rs7844465 (ZHX2), are significantly associated with carotid intima-media thickness. | Genetic association and gene-smoking interaction study of carotid intima-media thickness at five GWAS-indicated genes: the Bogalusa Heart Study.
Li C, Chen W, Jiang F, Simino J, Srinivasan SR, Berenson GS, Mei H. | 05/30/2015 |
| These results confirmed the role of PinX1 as a major tumor suppressor gene in breast cancer cell lines. | The role of PinX1 in growth control of breast cancer cells and its potential molecular mechanism by mRNA and lncRNA expression profiles screening.
Shi R, Zhou JY, Zhou H, Zhao Z, Liang SH, Zheng WL, Ma WL., Free PMC Article | 05/16/2015 |
| Data confirmed that levels of PinX1 and caspase 3, 8 and 9 expression were closely linked to the poor prognosis of colorectal cancer. | PinX1 without the G-patch motif suppresses proliferation, induces senescence, but does not inhibit telomerase activity in colorectal cancer SW480 cells.
Zhang R, Zhao J, Wang X, Wang LL, Xu J, Song C. | 01/17/2015 |
| the expression of PinX1 in CSCC patients is likely a predictor of the response to paclitaxel chemotherapy. | The telomere/telomerase binding factor PinX1 regulates paclitaxel sensitivity depending on spindle assembly checkpoint in human cervical squamous cell carcinomas.
Tian XP, Qian D, He LR, Huang H, Mai SJ, Li CP, Huang XX, Cai MY, Liao YJ, Kung HF, Zeng YX, Xie D. | 11/8/2014 |
| The results suggest that activation of Prp43p by Gno1p/PINX1 within early pre-ribosomal particles is crucial for their subsequent maturation. | The telomerase inhibitor Gno1p/PINX1 activates the helicase Prp43p during ribosome biogenesis.
Chen YL, Capeyrou R, Humbert O, Mouffok S, Kadri YA, Lebaron S, Henras AK, Henry Y., Free PMC Article | 08/23/2014 |