| Purification, identification and Cryo-EM structure of prostatic acid phosphatase in human semen. | Purification, identification and Cryo-EM structure of prostatic acid phosphatase in human semen.
Liu X, Yu L, Xia Z, Li J, Meng W, Min L, Li F, Wang X. | 02/27/2024 |
| Multifunctionality of prostatic acid phosphatase in prostate cancer pathogenesis. | Multifunctionality of prostatic acid phosphatase in prostate cancer pathogenesis.
Alpert E, Akhavan A, Gruzman A, Hansen WJ, Lehrer-Graiwer J, Hall SC, Johansen E, McAllister S, Gulati M, Lin MF, Lingappa VR., Free PMC Article | 02/5/2022 |
| Enhanced TDPase and TMPase activities may contribute to the reduction of TDP level in AD patients. The results imply that an imbalance of phosphorylation-dephosphorylation related to thiamine and glucose metabolism may be a potential target for AD prevention and therapy. | Enhanced Activities of Blood Thiamine Diphosphatase and Monophosphatase in Alzheimer's Disease.
Pan X, Sang S, Fei G, Jin L, Liu H, Wang Z, Wang H, Zhong C., Free PMC Article | 08/19/2017 |
| Thirteen single nucleotide polymorphism (SNPs) in acid phosphatase prostate (ACPP) were suggested as candidate causal alleles that underlie ACPP regulation and expression. | Variants in ACPP are associated with cerebrospinal fluid Prostatic Acid Phosphatase levels.
Staley LA, Ebbert MT, Bunker D, Bailey M, Alzheimer’s Disease Neuroimaging Initiative, Ridge PG, Goate AM, Kauwe JS., Free PMC Article | 08/5/2017 |
| we have measured the intramolecular diffusion of the full length and 8-residue deletion peptides at two different pHs and found a correlation with fibrillization lag time. These results can be explained by a simple kinetic model of the early stages of aggregation in which oligomerization is controlled by the rate of peptide reconfiguration. | Intramolecular diffusion controls aggregation of the PAPf39 peptide.
Srivastava KR, French KC, Tzul FO, Makhatadze GI, Lapidus LJ., Free PMC Article | 05/20/2017 |
| Prostatic acid phosphatase delays prostate cancer cell growth in G1 phase of the cell cycle. | Transmembrane prostatic acid phosphatase (TMPAP) delays cells in G1 phase of the cell cycle.
Araujo CL, Quintero IB, Ovaska K, Herrala AM, Hautaniemi S, Vihko PT. | 05/21/2016 |
| Studies suggest that understanding of prostatic acid phosphatase function and regulation of expression will have a significant impact on understanding prostate cancer (PCa) progression and therapy. | Human prostatic acid phosphatase: structure, function and regulation.
Muniyan S, Chaturvedi NK, Dwyer JG, Lagrange CA, Chaney WG, Lin MF., Free PMC Article | 10/24/2015 |
| Certain factors identified within semen, termed semen-derived enhancers of virus infection (SEVI), fragments of prostatic acid phosphatase, have been shown to significantly enhance HIV-1 infectivity. | Characterization of the Influence of Semen-Derived Enhancer of Virus Infection on the Interaction of HIV-1 with Female Reproductive Tract Tissues.
Allen SA, Carias AM, Anderson MR, Okocha EA, Benning L, McRaven MD, Kelley ZL, Lurain J, Veazey RS, Hope TJ., Free PMC Article | 07/25/2015 |
| ACPP increases significantly in epithelial cells of ovarian carcinoma, which indicates that it may be a candidate biomarker for diagnosis of epithelia-derived ovarian cancer in women. | Avian prostatic acid phosphatase: estrogen regulation in the oviduct and epithelial cell-derived ovarian carcinomas.
Bae H, Lim W, Bae SM, Bazer FW, Choi Y, Song G. | 02/21/2015 |
| Data indicate that hypoxia regulates prostatic acid phosphatase (PAP) through hypoxia-inducible factor 2 alpha (HIF2alpha) and from stimulated A2B adenosine receptors. | The HIF-2alpha dependent induction of PAP and adenosine synthesis regulates glioblastoma stem cell function through the A2B adenosine receptor.
Liu TZ, Wang X, Bai YF, Liao HZ, Qiu SC, Yang YQ, Yan XH, Chen J, Guo HB, Zhang SZ. | 11/22/2014 |
| GCNT1 is over-expressed in prostate cancer and is associated with higher levels of core 2 O-sLe(x) in PSA, PAP and MUC1 proteins. | Increased expression of GCNT1 is associated with altered O-glycosylation of PSA, PAP, and MUC1 in human prostate cancers.
Chen Z, Gulzar ZG, St Hill CA, Walcheck B, Brooks JD., Free PMC Article | 08/9/2014 |
| Data indicate that prostate acid phosphatase-based peptide vaccine PAP-114-128 peptide appears to be a relevant for the treatment of prostate cancer. | Novel prostate acid phosphatase-based peptide vaccination strategy induces antigen-specific T-cell responses and limits tumour growth in mice.
Saif JM, Vadakekolathu J, Rane SS, McDonald D, Ahmad M, Mathieu M, Pockley AG, Durrant L, Metheringham R, Rees RC, McArdle SE. | 06/28/2014 |
| Soluble ecto-5'-nucleotidase (5'-NT), alkaline phosphatase, and adenosine deaminase (ADA1) activities in neonatal blood favor elevated extracellular adenosine. | Soluble ecto-5'-nucleotidase (5'-NT), alkaline phosphatase, and adenosine deaminase (ADA1) activities in neonatal blood favor elevated extracellular adenosine.
Pettengill M, Robson S, Tresenriter M, Millán JL, Usheva A, Bingham T, Belderbos M, Bergelson I, Burl S, Kampmann B, Gelinas L, Kollmann T, Bont L, Levy O., Free PMC Article | 11/30/2013 |
| PAPf39 is a 39 residue peptide fragment from human prostatic acidic phosphatase. Recombinant PAPf39 showed amyloid fibril formation. | Bacterial expression and purification of the amyloidogenic peptide PAPf39 for multidimensional NMR spectroscopy.
Shanmuganathan A, Bishop AC, French KC, McCallum SA, Makhatadze GI., Free PMC Article | 08/31/2013 |
| in the in vivo environment, PAP(248-286) is likely to form fibrils efficiently, thus providing an explanation for the presence of semen-derived enhancer of viral infection in human semen. | Seminal plasma accelerates semen-derived enhancer of viral infection (SEVI) fibril formation by the prostatic acid phosphatase (PAP248-286) peptide.
Olsen JS, DiMaio JT, Doran TM, Brown C, Nilsson BL, Dewhurst S., Free PMC Article | 06/9/2012 |
| Peptide fragments derived from N-proximal and C-proximal of the PAP form fibrillar structures and increase virion attachment to cells. | Naturally occurring fragments from two distinct regions of the prostatic acid phosphatase form amyloidogenic enhancers of HIV infection.
Arnold F, Schnell J, Zirafi O, Stürzel C, Meier C, Weil T, Ständker L, Forssmann WG, Roan NR, Greene WC, Kirchhoff F, Münch J., Free PMC Article | 02/25/2012 |
| PAP is strongly expressed in prostate cancer bone metastases in 7/7 patients, while prostate-specific antigen (PSA) is only weakly expressed. | Prostatic acid phosphatase is expressed in human prostate cancer bone metastases and promotes osteoblast differentiation.
Kirschenbaum A, Liu XH, Yao S, Leiter A, Levine AC. | 01/7/2012 |
| Our studies confirmed that, while prostatic acid phosphatase expression is not restricted to prostate tissues, its expression in other human tissues is approximately 1-2 orders of magnitude less than that observed in the prostate. | Prostatic acid phosphatase expression in human tissues.
Graddis TJ, McMahan CJ, Tamman J, Page KJ, Trager JB., Free PMC Article | 08/13/2011 |
| Most of the features of PAP including gene regulation, gene/protein structure, functions, its role in tumor progression and evolutionary features are discussed. Review. | Structural and functional analysis of human prostatic acid phosphatase.
Hassan MI, Aijaz A, Ahmad F. | 11/6/2010 |
| prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth | Human prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth.
Chuang TD, Chen SJ, Lin FF, Veeramani S, Kumar S, Batra SK, Tu Y, Lin MF., Free PMC Article | 09/20/2010 |
| Data show that prostatic acid phosphatase(PAP) as a sensitive tumor marker for prostate cancer. | Protein complexes/aggregates as potential cancer biomarkers revealed by a nanoparticle aggregation immunoassay.
Huo Q. | 08/23/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| PSAP might be predictive of tumor stage in incidental prostate cancer and represent a valuable adjunct for clinical decisions in terms of individual therapeutic management. | Expression of prostatic acid phosphatase (PSAP) in transurethral resection specimens of the prostate is predictive of histopathologic tumor stage in subsequent radical prostatectomies.
Gunia S, Koch S, May M, Dietel M, Erbersdobler A. | 03/1/2010 |
| The obtained N-terminal amino-acid sequence of boar PTAP showed 92% identity with the N-terminal amino-acid sequence of human PAP. The determined sequence of a 354 bp nucleotide fragment showed 90% identity with the corresponding sequence of human PAP. | High sequence homology between protein tyrosine acid phosphatase from boar seminal vesicles and human prostatic acid phosphatase.
Wysocki P, Płucienniczak G, Strzezek J. | 01/21/2010 |
| molecular details of PAPf39 peptide fibril formation may aid in elucidating the mechanism of how PAPf39 fibrils are involved in HIV etiology | Mechanism of fibril formation by a 39-residue peptide (PAPf39) from human prostatic acidic phosphatase.
Ye Z, French KC, Popova LA, Lednev IK, Lopez MM, Makhatadze GI. | 01/21/2010 |