| The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension. | The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension.
Sporbeck K, Haas ML, Pastor-Maldonado CJ, Schüssele DS, Hunter C, Takacs Z, Diogo de Oliveira AL, Franz-Wachtel M, Charsou C, Pfisterer SG, Gubas A, Haller PK, Knorr RL, Kaulich M, Macek B, Eskelinen EL, Simonsen A, Proikas-Cezanne T., Free PMC Article | 09/1/2023 |
| WIPI1 promotes fission of endosomal transport carriers and formation of autophagosomes through distinct mechanisms. | WIPI1 promotes fission of endosomal transport carriers and formation of autophagosomes through distinct mechanisms.
De Leo MG, Berger P, Mayer A., Free PMC Article | 03/26/2022 |
| WIPI-1 inhibits metastasis and tumour growth via the WIPI-1-TRIM21 axis and MYC regulation in nasopharyngeal carcinoma. | WIPI-1 inhibits metastasis and tumour growth via the WIPI-1-TRIM21 axis and MYC regulation in nasopharyngeal carcinoma.
Zhao Y, Li WF, Li QJ, He SW, He QM, Long LF, Liu N, Ma J. | 02/5/2022 |
| WIPI1 promotes osteosarcoma cell proliferation by inhibiting CDKN1A. | WIPI1 promotes osteosarcoma cell proliferation by inhibiting CDKN1A.
Ran T, Ke S, Song X, Ma T, Xu Y, Wang M. | 04/17/2021 |
| WIPI1 is a conserved mediator of right ventricular failure. | WIPI1 is a conserved mediator of right ventricular failure.
Tzimas C, Rau CD, Buergisser PE, Jean-Louis G Jr, Lee K, Chukwuneke J, Dun W, Wang Y, Tsai EJ., Free PMC Article | 09/26/2020 |
| BAG1, CHMP2B, PEX3, and WIPI1 confirmed a strong differential gene expression, in 355 melanoma samples. | WIPI1, BAG1, and PEX3 Autophagy-Related Genes Are Relevant Melanoma Markers.
D'Arcangelo D, Giampietri C, Muscio M, Scatozza F, Facchiano F, Facchiano A., Free PMC Article | 03/23/2019 |
| The specific autophagosomal localization of both WIPI1 and WIPI2 (refered to as WIPI puncta) has been employed to assess autophagy using fluorescence microscopy methods, such as confocal and live-cell video microscopy | Fluorescence-based imaging of autophagy progression by human WIPI protein detection.
Thost AK, Dönnes P, Kohlbacher O, Proikas-Cezanne T. | 11/28/2015 |
| Data suggest WIPI1/WIPI2 co-localize with microtubule-associated light chain 3 and autophagy related proteins 2/14L, participate in biogenesis of phagosomes, autophagy, and mobilization of lipids to/from intracellular droplets. [review-like article] | WIPI β-propellers at the crossroads of autophagosome and lipid droplet dynamics.
Pfisterer SG, Bakula D, Cezanne A, Robenek H, Proikas-Cezanne T. | 06/6/2015 |
| WIPI-1 and WIPI-2 are functionally required in mediating the PI3P signal at the onset of autophagy in NB4 cells. | WIPI-dependent autophagy during neutrophil differentiation of NB4 acute promyelocytic leukemia cells.
Brigger D, Proikas-Cezanne T, Tschan MP., Free PMC Article | 06/6/2015 |
| the detection of WIPI1 mRNA is likely to be a convenient method of monitoring autophagosome formation in a wide range of cell types | Detection of WIPI1 mRNA as an indicator of autophagosome formation.
Tsuyuki S, Takabayashi M, Kawazu M, Kudo K, Watanabe A, Nagata Y, Kusama Y, Yoshida K., Free PMC Article | 04/4/2015 |
| Freeze-fracture replica immunolabelling reveals WD-repeat protein interacting with phosphoinositides 1 and 2 (WIPI-1 and WIPI-2) as membrane components of autophagosomes and the plasma membrane (PM). | Freeze-fracture replica immunolabelling reveals human WIPI-1 and WIPI-2 as membrane proteins of autophagosomes.
Proikas-Cezanne T, Robenek H., Free PMC Article | 01/7/2012 |
| Studies define a distinct role for WIPI1 and TORC1 signaling in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy. | WIPI1 coordinates melanogenic gene transcription and melanosome formation via TORC1 inhibition.
Ho H, Kapadia R, Al-Tahan S, Ahmad S, Ganesan AK., Free PMC Article | 07/23/2011 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.
Chasman DI, Paré G, Mora S, Hopewell JC, Peloso G, Clarke R, Cupples LA, Hamsten A, Kathiresan S, Mälarstig A, Ordovas JM, Ripatti S, Parker AN, Miletich JP, Ridker PM., Free PMC Article | 01/20/2010 |
| Quantification of WIPI-1 puncta should be suitable to assay mammalian autophagy | Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy.
Proikas-Cezanne T, Ruckerbauer S, Stierhof YD, Berg C, Nordheim A. | 01/21/2010 |
| share an evolutionary conserved function in autophagy and that autophagic capacity may be compromised in human cancers | WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy.
Proikas-Cezanne T, Waddell S, Gaugel A, Frickey T, Lupas A, Nordheim A. | 01/21/2010 |